Sterile filling machine having needle filling station within E-Beam chamber
    62.
    发明申请
    Sterile filling machine having needle filling station within E-Beam chamber 有权
    无菌灌装机在E-Beam室内装有注射灌装台

    公开(公告)号:US20050173020A1

    公开(公告)日:2005-08-11

    申请号:US11103803

    申请日:2005-04-11

    Applicant: Daniel Py

    Inventor: Daniel Py

    Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a heat resealable stopper and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the stopper and chamber for sterilizing the container. The previously sterilized containers are then transported through an e-beam chamber, wherein an electron beam is directed onto a penetrable surface of the stopper to sterilize the penetrable surface. A needle is mounted within the e-beam chamber and moved into engagement with the stopper to pierce the sterilized penetrable surface of the stopper and inject the substance through the needle and into the chamber of the container. The needle is then withdrawn from the stopper and the filled container is transported outside of the e-beam chamber. Laser energy is then transmitted onto the penetrated surface of the stopper to fuse the stopper material and hermetically re-seal the stopper.

    Abstract translation: 提供了一种无菌灌装机及相关方法,用于无菌填充具有物质的容器。 容器包括可热再封塞的塞子和用于在其中容纳物质的腔室。 密封的空容器经受能够穿过塞子和室的辐射,以对容器进行灭菌。 先前灭菌的容器然后通过电子束室传送,其中电子束被引导到塞子的可穿透表面上以对可穿透表面进行消毒。 针安装在电子束室内并与止动器接合,以刺穿塞子的消毒的可渗透表面并将物质通过针头注入容器的腔室。 然后将针从止动器中取出,并将填充的容器运送到电子束室外部。 然后将激光能量传递到塞子的穿透表面上,以使塞子材料熔化并密封地重新密封塞子。

    Container and valve assembly for storing and dispensing substances, and related method
    64.
    发明申请
    Container and valve assembly for storing and dispensing substances, and related method 有权
    用于储存和分配物质的容器和阀门组件及相关方法

    公开(公告)号:US20050155987A1

    公开(公告)日:2005-07-21

    申请号:US10976349

    申请日:2004-10-28

    Abstract: A container including a nozzle and body depending therefrom. The body is preferably tubular and defines an interior which retains a product to be dispensed. A cap engages the nozzle to prevent inadvertent release of the product. In order to dispense the product, the cap is removed and pressure is applied to the body and the nozzle allows release of the product. The nozzle releases the product without exposing the remaining product to the external atmosphere, thus the sterility of the interior of the body is maintained and the shelf life of the product is increased. The nozzle includes an inner body, coupled to the tubular body, surrounded by a flexible outer cover. A seam between the inner body and flexible outer cover forms a one-way release valve wherein a portion of the seam remains closed during dispensing the product.

    Abstract translation: 一种容器,其包括从其排出的喷嘴和主体。 主体优选地是管状的并且限定保持要分配的产品的内部。 盖子与喷嘴接合以防止产品的意外释放。 为了分配产品,盖被去除并且压力施加到主体上,并且喷嘴允许释放产品。 喷嘴释放产品而不将剩余的产品暴露于外部大气,从而维持身体内部的不整洁性并且提高了产品的保质期。 该喷嘴包括一个连接到管状主体的内部主体,被一个柔性的外盖包围。 内体和柔性外盖之间的接缝形成单向释放阀,其中在分配产品期间,接缝的一部分保持关闭。

    System and method for a two piece spray nozzle
    67.
    发明授权
    System and method for a two piece spray nozzle 有权
    两件式喷嘴的系统和方法

    公开(公告)号:US06796510B2

    公开(公告)日:2004-09-28

    申请号:US10729745

    申请日:2003-12-05

    Applicant: Daniel Py

    Inventor: Daniel Py

    Abstract: An aerosol tip mechanism for an aerosol-type dispenser for dispensing liquid content has a flexible outer shell, a rigid cap portion composed of lower and upper portions, and a rigid nozzle portion having a rigid shaft received within the outlet portion of the flexible outer shell. The rigid shaft interfaces the outlet portion of the outer shell, forming a first normally-closed one-way valve. The lower and upper portions of the rigid cap portion form boots adapted to receive an outlet portion of the flexible outer shell, the boots thereby constraining a lateral motion of the outlet portion of the outer shell, and symmetrically centering the outlet portion around the rigid shaft of the nozzle. The rigid nozzle portion includes a plurality of liquid channels for delivering liquid from a reservoir to a swirling chamber defined within the rigid cap portion, which liquid channels are configured to minimize energy losses of the liquid and promote a more homogeneous fluid particle size in the dispensed aerosol. The aerosol tip mechanism provides for long-term sterility of the stored fluid, which in turn allows for preservation of the sterility of non-chemically preserved formulations, which may be in the form of suspension or liquid gels.

    Abstract translation: 用于分配液体内容物的气溶胶型分配器的气溶胶喷嘴机构具有柔性外壳,由下部和上部组成的刚性盖部分,以及刚性喷嘴部分,其具有容纳在柔性外壳的出口部分内的刚性轴 。 刚性轴与外壳的出口部分接合,形成第一常闭单向阀。 刚性盖部分的下部和上部形成适于容纳柔性外壳的出口部分的靴子,靴子因此约束外壳的出口部分的横向运动,并且将出口部分对称地对准刚性轴 的喷嘴。 刚性喷嘴部分包括多个液体通道,用于将液体从储存器输送到限定在刚性盖部分内的旋转室,该液体通道被配置为使液体的能量损失最小化,并促使在分配的液体中更均匀的流体颗粒尺寸 气雾剂。 气溶胶末端机构提供储存的流体的长期无菌性,这又允许保持非化学保存的制剂的无菌性,其可以是悬浮液或液体凝胶的形式。

    System and method for application of medicament into the nasal passage
    70.
    发明授权
    System and method for application of medicament into the nasal passage 失效
    将药物应用于鼻通道的系统和方法

    公开(公告)号:US06505622B2

    公开(公告)日:2003-01-14

    申请号:US09927272

    申请日:2001-08-09

    Applicant: Daniel Py

    Inventor: Daniel Py

    Abstract: A pump-type dispenser for dispensing predetermined doses of medicament in droplets or in spray form to the nasal area incorporates a rigid vial for medicament, an expandable pouch located within the rigid vial, a nasal screen, a one-way actuation mechanism, a one-way valve mechanism in the nozzle area and a spring element, both the valve mechanism and the spring element being formed as integral portions of the pump body. The one-way valve mechanism in the nozzle area ensures a one-way movement of medicament from the dispenser, thereby preserving substantially perfect sterility of the medicament in the dispenser, without requiring the use of preservatives. The one-way actuation mechanism enables the user to load and dispense a uniform quantity of medicament with a uniform actuation force and speed via a single continuous motion of the actuation mechanism. The rigid vial/expandable-pouch combination facilitates improved long term use, as well as uniformity of dosage independent of the pump orientation.

    Abstract translation: 用于将液滴或喷雾形式的预定剂量的药剂分配到鼻区域的泵型分配器包括用于药物的刚性小瓶,位于刚性小瓶内的可膨胀袋,鼻屏,单向致动机构,一个 在喷嘴区域中具有一个阀门机构和一个弹簧元件,阀机构和弹簧元件都形成为泵体的整体部分。 喷嘴区域中的单向阀机构确保药物从分配器的单向运动,从而在分配器中保持药物基本上完美的无菌性,而不需要使用防腐剂。 单向致动机构使得用户能够通过致动机构的单一连续运动以均匀的致动力和速度来加载和分配均匀量的药物。 刚性小瓶/可膨胀袋组合有助于改善长期使用,以及独立于泵取向的剂量均匀性。

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