公开(公告)号：US06256542B1

公开(公告)日：2001-07-03

申请号：US09507960

申请日：2000-02-22

申请人： Mark T. Marshall ,  Bret R. Shoberg ,  Clare E. Padgett ,  Timothy G. Laske ,  Steven L. Waldhauser ,  Mark T. Stewart ,  Catherine E. Taylor ,  Kenneth W. Keeney

发明人： Mark T. Marshall ,  Bret R. Shoberg ,  Clare E. Padgett ,  Timothy G. Laske ,  Steven L. Waldhauser ,  Mark T. Stewart ,  Catherine E. Taylor ,  Kenneth W. Keeney

IPC分类号： A61N105

CPC分类号： A61N1/0563 ,  A61N1/056

摘要： A medical electrical lead with a tip-ring assembly optimized to resist damage during extraction. The lead includes an elongated plastic tube and at least two elongated conductors mounted in the plastic tube. A tip-ring assembly is mounted to the distal end of the tube, the tip-ring assembly including a ring electrode coupled to one of the conductors, a tip electrode located distal to the ring electrode and coupled to another of the conductors and two molded plastic components separately fabricated of a plastic harder than the plastic tube, adhered to one another and together defining a circumferential groove in which the ring electrode is located and mechanically coupled to the tip electrode. The tip electrode may be provided with a proximally extending electrode shank covered by a tine sleeve which is fabricated of a plastic softer than the molded plastic components and is adhered to more distally located molded plastic component. The more distally located molded plastic component preferably overlaps the electrode shank to provide a stronger structure.

公开(公告)号：US06049736A

公开(公告)日：2000-04-11

申请号：US923046

申请日：1997-09-03

申请人： Mark T. Stewart ,  Kenneth E. Cobian ,  Michael J. Ebert

发明人： Mark T. Stewart ,  Kenneth E. Cobian ,  Michael J. Ebert

IPC分类号： A61L29/14 ,  A61L33/00 ,  B05D3/14 ,  B05D7/24 ,  B29C59/10 ,  B29C59/14 ,  C23C16/02 ,  C23C16/04 ,  C23C16/30 ,  C23C16/505 ,  A61N1/05

CPC分类号： B05D1/62 ,  A61L29/141 ,  A61L33/0088 ,  B05D3/144 ,  B29C59/103 ,  B29C59/142 ,  C23C16/0245 ,  C23C16/045 ,  C23C16/30 ,  C23C16/505 ,  H01J37/32082 ,  B29L2023/00 ,  B29L2031/7542

摘要： An implantable medical device has an electrode lead having an outer surface of a polymeric material which has been treated in an inert gas atmosphere by a glow discharge to deposit a monomer substance thereon to produce an outer surface lower in resistance to movement within the body tissue of a patient than untreated material.

摘要翻译： 可植入医疗装置具有电极引线，其具有聚合材料的外表面，其已经在惰性气体气氛中通过辉光放电处理以在其上沉积单体物质以产生较低的抗体内组织内运动的外表面 一个病人比未经处理的材料。

公开(公告)号：US5593550A

公开(公告)日：1997-01-14

申请号：US239007

申请日：1994-05-06

申请人： Mark T. Stewart ,  Mary M. Morris ,  Edward Di Domenico ,  Kenneth W. Keeney

发明人： Mark T. Stewart ,  Mary M. Morris ,  Edward Di Domenico ,  Kenneth W. Keeney

IPC分类号： H05H1/46 ,  B29C59/14 ,  B29C71/04 ,  B29K19/00 ,  B29L23/00 ,  C08J5/16 ,  C08J7/00 ,  H05H1/24

CPC分类号： B29C59/142 ,  B29K2083/00 ,  B29L2031/753 ,  B29L2031/7534

摘要： This invention relates to the preferential glow discharge at the inside diameter (ID) of plastic tubing, particularly very small tubing.

公开(公告)号：US10039502B2

公开(公告)日：2018-08-07

申请号：US13084853

申请日：2011-04-12

申请人： Mark T. Stewart ,  Scott W. Davie ,  Giles Desrochers

发明人： Mark T. Stewart ,  Scott W. Davie ,  Giles Desrochers

IPC分类号： A61B5/05 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/042 ,  A61B6/12 ,  A61B6/00 ,  A61B8/08 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/055 ,  A61B5/145

摘要： A method of mapping electrophysiological information, including receiving imaging information for a tissue region; receiving a monophasic action potential signal from the tissue region; assigning a value corresponding to a depolarization segment of the monophasic action potential signal; receiving location information associated with the monophasic action potential signal; and generating an image based on the imaging information, the assigned value, and the location information.

公开(公告)号：US08565851B2

公开(公告)日：2013-10-22

申请号：US12533903

申请日：2009-07-31

申请人： Michael Lau ,  Randell Werneth ,  Timothy J. Corvi ,  Sumita Bhola ,  Mark T. Stewart ,  Michel Haïssaguerre ,  Meleze Hocini

发明人： Michael Lau ,  Randell Werneth ,  Timothy J. Corvi ,  Sumita Bhola ,  Mark T. Stewart ,  Michel Haïssaguerre ,  Meleze Hocini

IPC分类号： A61B5/042 ,  A61B18/14 ,  A61N1/05

CPC分类号： A61B5/042 ,  A61B5/6858 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61N1/06

摘要： Catheters and methods for obtaining monophasic action potential (“MAP”) electrograms include a flexible catheter body defining a longitudinal axis, and a distal assembly affixed to the catheter body distal end defining a distal tip. The distal assembly has at least three MAP recording electrodes, and at least one reference electrode for determining reference potential. The recording electrodes are each positioned a radial distance from the longitudinal axis in at least three different radial directions, defining a recording geometry substantially having radial symmetry. The reference electrode is a longitudinal distance from the recording geometry. Optional features include a steerable catheter shaft, one or more radio-frequency ablation electrodes, and a dedicated pacing electrode. Different possible embodiments include a dome housing having the recording electrodes in a fixed spatial arrangement, and a distal loop assembly having an array of electrodes on at least three flexible loop elements.

公开(公告)号：US08257351B2

公开(公告)日：2012-09-04

申请号：US12760807

申请日：2010-04-15

申请人： Mark T. Stewart ,  James R. Skarda

发明人： Mark T. Stewart ,  James R. Skarda

IPC分类号： A61B18/04

CPC分类号： A61B18/1492 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2018/00065 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00375 ,  A61B2018/00404 ,  A61B2018/00898 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61B2018/1472

摘要： A catheter assembly for treatment of cardiac arrhythmia. The catheter assembly includes a catheter body and an ablative energy source. The catheter body includes a proximal portion, an intermediate portion, and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and includes an ablation section and a tip. The ablation section forms a loop defining a diameter greater than an outer dimension of a pulmonary vein ostium. The tip extends distally from the ablation section and is configured to locate a pulmonary vein. Finally, the ablative energy source is associated with the ablation section. With this configuration, upon activation of the energy source, the ablation section ablates a desired lesion pattern. In one preferred embodiment, the ablation section forms a distally decreasing radius helix, whereas the tip includes a relatively linear leader section. With this one preferred configuration, the tip readily locates a pulmonary vein and guides the ablation section to a seated relationship about a pulmonary vein ostium (or extra-ostial).

摘要翻译： 用于治疗心律失常的导管组件。 导管组件包括导管主体和消融能源。 导管主体包括近端部分，中间部分和远端部分。 中间部分从近端部分延伸并且限定纵向轴线。 远侧部分从中间部分延伸并且包括消融部分和尖端。 消融部分形成限定直径大于肺静脉口的外部尺寸的环。 尖端从消融部分向远端延伸并且被配置为定位肺静脉。 最后，烧蚀能源与消融部分相关联。 利用这种配置，在激活能量源时，消融部分消除所需的损伤模式。 在一个优选实施例中，消融部分形成远端减小的半径螺旋，而尖端包括相对线性的引导部分。 利用这一优选的构造，尖端容易地定位肺静脉，并将消融部分引导到关于肺静脉口（或口外）的就座关系。

公开(公告)号：US20110190763A1

公开(公告)日：2011-08-04

申请号：US12696239

申请日：2010-01-29

申请人： Jon F. Urban ,  Vinod Sharma ,  Mark T. Stewart

发明人： Jon F. Urban ,  Vinod Sharma ,  Mark T. Stewart

IPC分类号： A61B18/14

CPC分类号： A61N1/0575 ,  A61B5/042 ,  A61B5/6848 ,  A61B5/6852 ,  A61B2017/00053 ,  A61M25/0084 ,  A61M2025/0089 ,  A61M2025/0091

摘要： A system and associated method measure monophasic action potential signals for identifying a targeted tissue location and delivering a therapy to the targeted tissue location. The system includes a hollow needle having a sharpened distal tip, a first electrode at the distal tip and a fluid delivery lumen extending through the needle from a proximal needle end to an opening in the sharpened distal tip.

摘要翻译： 系统和相关联的方法测量用于识别目标组织位置并将治疗递送到目标组织位置的单相动作电位信号。 该系统包括具有锐化的远端尖端的中空针头，远侧末端处的第一电极和从近端针端延伸穿过尖锐远端的开口的流体输送腔。

公开(公告)号：US20100204692A1

公开(公告)日：2010-08-12

申请号：US12760807

申请日：2010-04-15

申请人： Mark T. Stewart ,  James R. Skarda

发明人： Mark T. Stewart ,  James R. Skarda

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2018/00065 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00375 ,  A61B2018/00404 ,  A61B2018/00898 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61B2018/1472

摘要： A catheter assembly for treatment of cardiac arrhythmia. The catheter assembly includes a catheter body and an ablative energy source. The catheter body includes a proximal portion, an intermediate portion, and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and includes an ablation section and a tip. The ablation section forms a loop defining a diameter greater than an outer dimension of a pulmonary vein ostium. The tip extends distally from the ablation section and is configured to locate a pulmonary vein. Finally, the ablative energy source is associated with the ablation section. With this configuration, upon activation of the energy source, the ablation section ablates a desired lesion pattern. In one preferred embodiment, the ablation section forms a distally decreasing radius helix, whereas the tip includes a relatively linear leader section. With this one preferred configuration, the tip readily locates a pulmonary vein and guides the ablation section to a seated relationship about a pulmonary vein ostium (or extra-ostial).

摘要翻译： 用于治疗心律失常的导管组件。 导管组件包括导管主体和消融能源。 导管主体包括近端部分，中间部分和远端部分。 中间部分从近端部分延伸并且限定纵向轴线。 远侧部分从中间部分延伸并且包括消融部分和尖端。 消融部分形成限定直径大于肺静脉口的外部尺寸的环。 尖端从消融部分向远端延伸并且被配置为定位肺静脉。 最后，烧蚀能源与消融部分相关联。 利用这种配置，在激活能量源时，消融部分消除所需的损伤模式。 在一个优选实施例中，消融部分形成远端减小的半径螺旋，而尖端包括相对线性的引导部分。 利用这一优选的构造，尖端容易地定位肺静脉，并将消融部分引导到关于肺静脉口（或口外）的就座关系。

公开(公告)号：US07706894B2

公开(公告)日：2010-04-27

申请号：US11115028

申请日：2005-04-26

申请人： Mark T. Stewart ,  Johnson E. Goode ,  James M. Speckien ,  Mark A. Taube ,  Eduardo N. Warman

发明人： Mark T. Stewart ,  Johnson E. Goode ,  James M. Speckien ,  Mark A. Taube ,  Eduardo N. Warman

IPC分类号： A61N1/05

CPC分类号： A61M25/0147 ,  A61B18/1492 ,  A61B2017/00243 ,  A61B2018/00916 ,  A61M25/0152 ,  A61M2025/015 ,  A61M2025/0161

摘要： Steerable electrophysiology catheters for use in mapping and/or ablation of accessory pathways in myocardial tissue of the heart wall and methods of use thereof are disclosed. The catheter comprises a catheter body and handle, the catheter body having a proximal section and a distal section and manipulators that enable the deflection of a distal segment of the distal tip section with respect to the independently formed curvature of a proximal segment of the distal tip section through a bending or knuckle motion of an intermediate segment between the proximal and distal segments. A wide angular range of deflection within a very small curve or bend radius in the intermediate segment is obtained. At least one distal tip electrode is preferably confined to the distal segment which can have a straight axis extending distally from the intermediate segment. The curvature of the proximal segment and the bending angle of the intermediate segment are independently selectable. The axial alignment of the distal segment with respect to the nominal axis of the proximal shaft section of the catheter body can be varied between substantially axially aligned (0° curvature) in an abrupt knuckle bend through a range of about −90° to about +180° within a bending radius of between about 2.0 mm and 7.0 mm and preferably less than 5.0 mm. The proximal segment curve can be independently formed in a range of about −180° through about +270° with respect to the axis of the proximal shaft section to provide an optimum angular orientation of the distal electrode(s). The distal segment can comprise a highly flexible elongated distal segment body and electrode(s) that conform with the shape and curvature of the heart wall.

摘要翻译： 公开了用于在心壁的心肌组织中辅助通路的测绘和/或消融的可操纵的电生理学导管及其使用方法。 导管包括导管主体和手柄，导管主体具有近端部分和远端部分以及操纵器，其能够相对于远端尖端的近端段的独立形成的曲率偏转远侧末端部分的远端部分 通过近端段和远端段之间的中间段的弯曲或转向关节运动。 获得在中间段内的非常小的曲线或弯曲半径内的宽的角度范围的偏转。 至少一个远端末端电极优选地限制在远端段，该远段可以具有从中间段向远侧延伸的直轴。 近端段的曲率和中间段的弯曲角度是可独立选择的。 远侧段相对于导管主体的近端轴部分的标称轴线的轴向对准可以在突变关节弯曲部中的大致轴向对准（0°曲率）之间变化约-90°至约+ 弯曲半径为约2.0mm至7.0mm，优选小于5.0mm的180°。 近端段曲线可相对于近轴部分的轴线独立地形成在约-180°至约+ 270°的范围内，以提供远端电极的最佳角度取向。 远端段可以包括高度柔性的细长远端段体和符合心壁的形状和曲率的电极。

公开(公告)号：US08682410B2

公开(公告)日：2014-03-25

申请号：US13044698

申请日：2011-03-10

申请人： Randell L. Werneth ,  Meleze Hocini ,  Mark T. Stewart ,  Dan Wittenberger ,  Timothy J. Corvi ,  Michael Lau ,  Vinod Sharma

发明人： Randell L. Werneth ,  Meleze Hocini ,  Mark T. Stewart ,  Dan Wittenberger ,  Timothy J. Corvi ,  Michael Lau ,  Vinod Sharma

IPC分类号： A61B5/042 ,  A61B18/14

CPC分类号： A61B5/0422 ,  A61B18/1492 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2218/002

摘要： A medical device including a catheter having a shaft with a distal portion; a first plurality of substantially hemispherical electrodes coupled to the distal portion; a second plurality of substantially hemispherical electrodes coupled to the shaft proximal of the first plurality, where the second plurality of electrodes are oriented substantially orthogonal to the first plurality of electrodes; and an additional electrode coupled to the shaft. A console may have a processor in electrical communication with the first and second plurality of electrodes and the reference electrode, the processor programmed to obtaining a monophasic action potential recording from at least one of the first and second plurality of electrodes.

摘要翻译： 一种医疗装置，包括具有远端部的轴的导管; 耦合到所述远端部分的第一多个基本上半球形的电极; 耦合到所述第一多个的所述轴近端的第二多个基本上半球形的电极，其中所述第二多个电极定向成基本上垂直于所述第一多个电极; 以及连接到所述轴的附加电极。 控制台可以具有与第一和第二多个电极和参考电极电连通的处理器，该处理器被编程为从第一和第二多个电极中的至少一个获得单相动作电位记录。