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128 条记录 (耗时 0.043 秒)

    Phenylalanine enamide derivatives
    64.
    发明授权
    Phenylalanine enamide derivatives 失效
    苯丙氨酸烯酰胺衍生物

    公开(公告)号：US07786177B2

    公开(公告)日：2010-08-31

    申请号：US12415546

    申请日：2009-03-31

    申请人： Stephen Brand ,  Stuart Bailey ,  Julien A. Brown ,  James A. Johnson ,  John R. Porter ,  John C. Head

    发明人： Stephen Brand ,  Stuart Bailey ,  Julien A. Brown ,  James A. Johnson ,  John R. Porter ,  John C. Head

    IPC分类号： C07D215/14 ,  A61K31/47 ,  A61K31/438 ,  A61P11/06 ,  A61P29/00

    CPC分类号： C07D213/81 ,  C04B35/632 ,  C07C229/10 ,  C07C229/46 ,  C07C233/81 ,  C07C233/82 ,  C07C323/30 ,  C07C2601/04 ,  C07C2603/94 ,  C07C2603/96 ,  C07D213/79 ,  C07D213/89 ,  C07D311/96 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

    摘要： Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a group Ar1 L2Ar2Alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted arylene or heteroarylene group; and Alk is a chain —CH2—CH(R)—, —CH═C(R)— or in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; X is an —O— or —S— atom or —N(R2)— group in which: Rx, Ry and Rz which may be the same or different is each a hydrogen atom or an optional substituent; or Rz is an atom or group as previously defined and Rx and Ry are joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.

    摘要翻译： 描述了式（1）的苯丙氨酸烯酰胺衍生物：其中R1是基团Ar1 L2Ar2Alk-，其中：Ar1是任选取代的芳族或杂芳族基团; L2是共价键或连接原子或基团; Ar 2是任选取代的亚芳基或亚杂芳基; 并且Alk是链-CH 2 -CH（R） - ， - CH = C（R） - 或其中R是羧酸（-CO 2 H）或其衍生物或生物试剂; X是-O-或-S-原子或-N（R 2） - 基团，其中：可以相同或不同的R x，R y和R z各自为氢原子或任选的取代基; 或R z是如先前定义的原子或基团，并且R x和R y连接在一起以形成任选取代的螺环连接的脂环族或杂环脂族基团; 及其盐，溶剂合物，水合物和N-氧化物。 该化合物能够抑制整联蛋白与其配体的结合，并且可用于预防和治疗涉及细胞不适当生长或迁移的免疫或炎性疾病或病症。

    Removal of impurities from liquid hydrocarbon streams
    66.
    发明授权
    Removal of impurities from liquid hydrocarbon streams 失效
    从液态烃流中去除杂质

    公开(公告)号：US07128829B1

    公开(公告)日：2006-10-31

    申请号：US10447752

    申请日：2003-05-29

    申请人： Santi Kulprathipanja ,  Suheil F. Abdo ,  James A. Johnson ,  Daniel A. Kauff

    发明人： Santi Kulprathipanja ,  Suheil F. Abdo ,  James A. Johnson ,  Daniel A. Kauff

    IPC分类号： C10G17/00 ,  C10G29/00 ,  C10G25/00 ,  C07C7/12

    CPC分类号： C10G25/003 ,  C10G25/05 ,  C10G29/16

    摘要： A novel process effective for the removal of organic sulfur compounds, organic nitrogen compounds and light olefins from liquid hydrocarbons is disclosed. The process more specifically addresses the removal of these contaminants from aromatic compounds including benzene and toluene and from naphtha. The liquid hydrocarbons are contacted with a blend of at least one metal oxide and an acidic zeolite. Preferably, the metal oxide comprises nickel oxide and molybdenum oxide and the acidic zeolite is acidic stabilized zeolite Y. This blend has a significant capacity for adsorption of impurities and can be regenerated by oxidative treatment.

    摘要翻译： 公开了一种有效从液态烃中去除有机硫化合物，有机氮化合物和轻质烯烃的新方法。 该方法更具体地涉及从芳族化合物（包括苯和甲苯）和石脑油中除去这些污染物。 液体烃与至少一种金属氧化物和酸性沸石的共混物接触。 优选地，金属氧化物包括氧化镍和氧化钼，酸性沸石是酸性稳定的沸石Y.该共混物具有显着的吸附杂质的能力，可以通过氧化处理再生。

    Process for the reduction of oxiranyl epothilones to olefinic epothilones
    67.
    发明授权
    Process for the reduction of oxiranyl epothilones to olefinic epothilones 有权
    将环氧乙酰基埃坡霉素还原为烯属埃坡霉素的方法

    公开(公告)号：US06320045B1

    公开(公告)日：2001-11-20

    申请号：US09316796

    申请日：1999-05-21

    申请人： Soong-Hoon Kim ,  James A. Johnson

    发明人： Soong-Hoon Kim ,  James A. Johnson

    IPC分类号： C07D49304

    CPC分类号： C07D417/06

    摘要： The invention as claimed is directed to a process for making an epothilone having the following structures from ones having an oxiranyl moiety, by reacting a compound having the latter structure with a metal or metal-assisted reagent. Said metal or metal-assisted reagent is selected from the group consisting of a) reactive metallocenes; b) [N2C(CO2Me)2, cat Rh2,(OAC)4]; c) [N2C(CO2Me)2, cat[(n-C7H15CO2)2 Rh]2]; d) [Zn—Cu, EtOH]; e) [Mg(Hg), MgBr]; f) Cr; g) [FeCl3, n-BuLi]; h) [TiCl3, LiAlH4]; i) [TiCl4, Zn]; j) [WCl6, LiAlH4,]; k) [NbCl5, NaAlH4]; l) [VCl3,Zn] and m) [WCl6, n-BuLi].

    摘要翻译： 本发明涉及通过使具有后一种结构的化合物与金属或金属辅助试剂反应制备具有下列结构的埃博霉素的方法：具有环氧乙烷基的化合物。 所述金属或金属辅助试剂选自a）反应性金属茂; b）[N2C（CO2Me）2，猫Rh2，（OAC）4]; c）[N2C（CO2Me）2，cat [（n-C7H15CO2）2 Rh] 2]; d）[Zn-Cu，EtOH]; e）[Mg（Hg），MgBr]; f）Cr; g）[FeCl 3，n-BuLi]; h）[TiCl 3，LiAlH 4]; i）[TiCl 4，Zn]; j）[WCl6，LiAlH4]; k）[NbCl 5，NaAlH 4]; l）[VCl 3，Zn]和m）[WCl 6，n-BuLi]。

    Doppler triangulation transmitter location system
    69.
    发明授权
    Doppler triangulation transmitter location system 失效
    多普勒三角测量发射机定位系统

    公开(公告)号：US5982164A

    公开(公告)日：1999-11-09

    申请号：US87145

    申请日：1998-05-29

    申请人： Steven V. Czarnecki ,  James A. Johnson ,  Carl Gerst

    发明人： Steven V. Czarnecki ,  James A. Johnson ,  Carl Gerst

    IPC分类号： G01S3/02 ,  G01S5/00 ,  G01S5/02 ,  G01S11/10 ,  G01S19/48 ,  G01R23/02

    CPC分类号： G01S11/10 ,  G01S5/02 ,  G01S3/02 ,  G01S5/00

    摘要： In a system for locating the position of a transmitter, a platform containing an antenna is moved through a measurement path. The frequency received by the antenna is measured at measurement points distributed along a measurement path. The frequency is measured by cross correlating coherent pulses of the received frequency signal. An inertial navigation system on the platform indicates the position of the measurement path. A computer determines estimated locations by non-linear least squares convergence starting from trial locations. The non-linear least squares convergence is based on the frequency equation for the received frequency ##EQU1## in which f.sub.0, is the transmitter frequency, V is the antenna velocity and r is the range of the transmitter. The computer evaluates a cost function derived from the frequency equation, for each location estimated by the non-linear least squares convergence and selects the estimated location with the lowest cost function as the best solution.

    摘要翻译： 在用于定位发射机的位置的系统中，包含天线的平台被移动通过测量路径。 在沿着测量路径分布的测量点处测量由天线接收的频率。 频率通过接收频率信号的相干相干脉冲来测量。 平台上的惯性导航系统指示测量路径的位置。 计算机通过从试验地点开始的非线性最小二乘法收敛来确定估计位置。 非线性最小二乘收敛基于接收频率的频率方程，其中f0是发射机频率，+ E，ovs V + EE是天线速度，+ E，ovs r + EE是 发射机。 计算机评估从频率方程导出的成本函数，对于由非线性最小二乘收敛估计的每个位置，并选择具有最低成本函数的估计位置作为最佳解。

    Fabricating lens array structures for imaging devices
    70.
    发明授权
    Fabricating lens array structures for imaging devices 失效
    制造用于成像装置的透镜阵列结构

    公开(公告)号：US5384231A

    公开(公告)日：1995-01-24

    申请号：US111361

    申请日：1993-08-24

    申请人： James A. Johnson ,  Madhav Mehra

    发明人： James A. Johnson ,  Madhav Mehra

    IPC分类号： G03F7/00 ,  G03F7/26

    CPC分类号： G03F7/0035 ,  G03F7/001

    摘要： A method of forming a planarized layer on a CCD device to permit a lens array to be formed which includes etching a B.sub.2 O.sub.3 layer provided on a conformally coated SiO.sub.2 layer until a sufficient amount of the deposited B.sub.2 O.sub.3 layer is removed to provide a planarized surface.

    摘要翻译： 在CCD器件上形成平坦化层以允许形成透镜阵列的方法，其包括蚀刻在保形涂覆的SiO 2层上提供的B 2 O 3层，直到去除了足够量的沉积的B 2 O 3层以提供平坦化表面。