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151 条记录 (耗时 0.124 秒)

    Polynucleotides encoding human secreted proteins
    63.
    发明申请
    Polynucleotides encoding human secreted proteins 审中-公开
    编码人类分泌蛋白的多核苷酸

    公开(公告)号：US20060223090A1

    公开(公告)日：2006-10-05

    申请号：US11366980

    申请日：2006-03-03

    申请人： Craig Rosen ,  Steven Ruben

    发明人： Craig Rosen ,  Steven Ruben

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47

    CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

    摘要翻译： 本发明涉及人分泌多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗过敏性和哮喘性疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

    19 human secreted proteins
    64.
    发明申请
    19 human secreted proteins 审中-公开
    19种人体分泌的蛋白质

    公开(公告)号：US20060188962A1

    公开(公告)日：2006-08-24

    申请号：US11404843

    申请日：2006-04-17

    申请人： Kenneth Carter ,  Ping Feng ,  Craig Rosen ,  Steven Ruben ,  Gregory Endress

    发明人： Kenneth Carter ,  Ping Feng ,  Craig Rosen ,  Steven Ruben ,  Gregory Endress

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

    Heregulin-like factor
    67.
    发明申请
    Heregulin-like factor 失效
    类胰岛素样因子

    公开(公告)号：US20060141522A1

    公开(公告)日：2006-06-29

    申请号：US11354079

    申请日：2006-02-15

    申请人： Paul Young ,  C. King ,  Mia Hijazi ,  Steven Ruben

    发明人： Paul Young ,  C. King ,  Mia Hijazi ,  Steven Ruben

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

    CPC分类号： C07H21/04 ,  C07K14/4702 ,  C07K14/4756 ,  G01N33/574 ,  G01N33/57488 ,  G01N2333/475

    摘要： The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.

    摘要翻译： 本发明涉及一种作为调节蛋白家族成员的新型HLF蛋白。 特别地，提供编码人HLF蛋白的分离的核酸分子。 还提供了HLF多肽，载体，宿主细胞和用于制备其的重组方法。 本发明还涉及用于鉴定HLF活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测细胞生长调节紊乱的诊断方法和用于治疗细胞生长调节紊乱的治疗方法。

    Leukocyte regulatory factors 1 and 2
    70.
    发明申请
    Leukocyte regulatory factors 1 and 2 审中-公开
    白细胞调节因子1和2

    公开(公告)号：US20060063924A1

    公开(公告)日：2006-03-23

    申请号：US11272833

    申请日：2005-11-15

    申请人： Jian Ni ,  Jing-Shan Hu ,  Steven Ruben ,  Reiner Gentz

    发明人： Jian Ni ,  Jing-Shan Hu ,  Steven Ruben ,  Reiner Gentz

    IPC分类号： C07K14/475 ,  C07H21/02 ,  C12P21/06

    CPC分类号： C07K14/4702

    摘要： The present invention relates to novel LRF-1 and LRF-2 proteins which are related to the CRISP family and a protein called “Neutrophil Inhibitory Factor (NIF)” isolated from the canine hookworm (Ancylostoma caninum) that potently inhibits CD11/CD18-dependent neutrophil function. In particular, isolated nucleic acid molecules are provided encoding the human LRF-1 and LRF-2 proteins. LRF-1 and LRF-2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of LRF-1 or LRF-2 activity. Also provided are diagnostic methods for detecting immune system or other LRF-1- or LRF-2-related disorders and therapeutic methods for treating such disorders.

    摘要翻译： 本发明涉及与CRISP家族相关的新型LRF-1和LRF-2蛋白质，以及从犬钩虫（Ancylostoma caninum）中分离的称为“中性嗜中性粒细胞抑制因子（NIF）”的蛋白质，其有效抑制CD11 / CD18依赖性 中性粒细胞功能。 特别地，提供编码人LRF-1和LRF-2蛋白的分离的核酸分子。 还提供了LRF-1和LRF-2多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定LRF-1或LRF-2活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统或其他LRF-1或LRF-2相关疾病的诊断方法以及用于治疗这种疾病的治疗方法。