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108 条记录 (耗时 0.035 秒)

    Methods for treating cardiac pacing conditions
    62.
    发明授权
    Methods for treating cardiac pacing conditions 有权
    治疗心脏起搏病症的方法

    公开(公告)号：US08734780B2

    公开(公告)日：2014-05-27

    申请号：US13096135

    申请日：2011-04-28

    申请人： Vinod Sharma ,  Xiaohong Qiu

    发明人： Vinod Sharma ,  Xiaohong Qiu

    IPC分类号： A61K31/7088 ,  A61K35/00 ,  A61P9/00 ,  C12N5/10

    CPC分类号： C12N15/86 ,  A61K35/13 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4705 ,  C12N2750/14143

    摘要： The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA.

    摘要翻译： 该方法可以包括向有需要的受试者施用有效量的HCN多核苷酸。 HCN多核苷酸包括编码具有通道活性的HCN多肽的核苷酸序列。 HCN多肽的氨基酸序列和参考多肽的氨基酸序列具有至少80％的同一性，其中参考多肽以选自氨基酸92-214的氨基酸开始，并以选自氨基酸的氨基酸结束 SEQ ID NO：8的723-1188。 参考多肽的实例是SEQ ID NO：8的氨基酸214-723。 HCN多核苷酸可以是DNA或RNA。

    Genetic modification of targeted regions of the cardiac conduction system
    63.
    发明授权
    Genetic modification of targeted regions of the cardiac conduction system 有权
    心脏传导系统目标区域的遗传修饰

    公开(公告)号：US08642747B2

    公开(公告)日：2014-02-04

    申请号：US13224593

    申请日：2011-09-02

    申请人： Vinod Sharma ,  Walter H. Olson

    发明人： Vinod Sharma ,  Walter H. Olson

    IPC分类号： A61K48/00 ,  C12N15/00 ,  C07H21/02

    CPC分类号： C12N15/86 ,  A61K38/177 ,  A61K48/00 ,  A61K48/005 ,  C12N2750/14143

    摘要： Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.

    摘要翻译： 公开了通过心脏传导系统的遗传修饰来预防或治疗心脏功能障碍，特别是心脏起搏功能障碍的方法和系统。 在一个实施方案中，本发明提供了通过向细胞递送能够修饰细胞的离子通道的表达的遗传构建体中的一个或多个编码序列来遗传修饰细胞的方法。

    Implantable medical device having optical fiber for sensing electrical activity
    66.
    发明授权
    Implantable medical device having optical fiber for sensing electrical activity 有权
    具有用于感测电活动的光纤的可植入医疗装置

    公开(公告)号：US08396539B2

    公开(公告)日：2013-03-12

    申请号：US11676128

    申请日：2007-02-16

    申请人： Vinod Sharma ,  Xiaohong Zhou

    发明人： Vinod Sharma ,  Xiaohong Zhou

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

    摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

    摘要翻译： 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

    Queued Cooperative Wireless Networks Configuration Using Rateless Codes
    68.
    发明申请
    Queued Cooperative Wireless Networks Configuration Using Rateless Codes 有权
    排队的无线网络配置使用无线代码

    公开(公告)号：US20100296432A1

    公开(公告)日：2010-11-25

    申请号：US12550177

    申请日：2009-08-28

    申请人： Neelesh B. Mehta ,  Vinod Sharma ,  Gaurav Bansal

    发明人： Neelesh B. Mehta ,  Vinod Sharma ,  Gaurav Bansal

    IPC分类号： H04B7/14 ,  H04L12/56

    CPC分类号： H04B7/15 ,  H04B7/15592 ,  H04B7/2606 ,  H04L47/14 ,  H04W28/10

    摘要： A system using cooperative communication with rateless codes is presented that uses communication transmission aspects of cooperative communication with rateless codes over Rayleigh fading channels and queuing aspects for buffering messages at intermediate relays. The system transmits a subsequent message while a current message is en route to the destination by receiving and buffering the current message in queues at intermediate relays. A relay with a best instantaneous communication link to the source may receive a message first and forward the received message to the destination. Alternatively, if inter-relay communication links are strong, all relays may cooperate simultaneously.

    摘要翻译： 提出了一种使用与无码代码进行协作通信的系统，该系统使用通过Rayleigh衰落信道进行的无编码代码的通信传输方面的通信和用于在中间继电器处缓冲消息的排队方面。 通过在中间继电器上接收和缓冲当前消息的队列，当前消息正在路由到目的地时，系统发送后续消息。 具有到源的最佳瞬时通信链路的中继器可以首先接收消息，并将接收到的消息转发到目的地。 或者，如果中继间通信链路强，则所有中继可以同时协作。

    Electronic and biological pacemaker systems
    69.
    发明授权
    Electronic and biological pacemaker systems 有权
    电子和生物起搏器系统

    公开(公告)号：US07778705B2

    公开(公告)日：2010-08-17

    申请号：US11554770

    申请日：2006-10-31

    申请人： Daniel C. Sigg ,  Timothy G. Laske ,  Vinod Sharma ,  Orhan Soykan

    发明人： Daniel C. Sigg ,  Timothy G. Laske ,  Vinod Sharma ,  Orhan Soykan

    IPC分类号： A61N1/00

    CPC分类号： A61N1/362 ,  A61N1/3627

    摘要： Heart pacing systems include at least one electronic or biological pacemaker as a primary pacemaker, and at least one electronic or biological pacemaker as a backup pacemaker. When implanted, the primary pacemaker(s) produce primary pacing stimuli that modulate cardiac function. The backup pacemaker(s) provide backup pacing stimuli when the electronic pacemaker is unable to modulate cardiac function at the predetermined pacing rate. The heart pacing systems are implemented by implantation in regions where they can provide pacing stimuli to cardiac tissue.

    摘要翻译： 心脏起搏系统包括至少一个电子或生物起搏器作为主要起搏器，以及至少一个电子或生物起搏器作为备用起搏器。 当植入时，主起搏器产生调节心脏功能的主要起搏刺激。 当电子起搏器不能以预定起搏速度调节心脏功能时，备用起搏器提供备用起搏刺激。 心脏起搏系统通过植入在可以为心脏组织提供起搏刺激的区域中实现。

    IN-SITU DYNAMIC PITCH AND ROLL ADJUSTMENT IN HARD DISK DRIVES
    70.
    发明申请
    IN-SITU DYNAMIC PITCH AND ROLL ADJUSTMENT IN HARD DISK DRIVES 有权
    硬盘驱动器中的现场动态倾斜和滚动调整

    公开(公告)号：US20100177443A1

    公开(公告)日：2010-07-15

    申请号：US12354601

    申请日：2009-01-15

    申请人： Vinod Sharma ,  Hyung Jai Lee

    发明人： Vinod Sharma ,  Hyung Jai Lee

    IPC分类号： G11B21/16

    CPC分类号： G11B5/4826 ,  G11B5/4833 ,  G11B5/4873

    摘要： Disclosed is a head gimbal assembly for a hard disk drive that includes a head pivotally connected to a flexure. The flexure has a longitudinal axis. The assembly includes first and second micro-actuators that are located between the flexure and the head and spaced from the longitudinal axis. By way of example, the first and second micro-actuators may be thin piezo-electric transducers. Control signals can be provided to the micro-actuators to vary the pitch and/or roll of the head.

    摘要翻译： 公开了一种用于硬盘驱动器的头部万向架组件，其包括枢转地连接到挠曲件的头部。 挠曲具有纵向轴线。 组件包括第一和第二微致动器，其位于弯曲部和头部之间并且与纵向轴线间隔开。 作为示例，第一和第二微致动器可以是薄压电换能器。 可以向微致动器提供控制信号以改变头部的俯仰和/或滚动。