公开(公告)号：US4461760A

公开(公告)日：1984-07-24

申请号：US396294

申请日：1982-07-08

申请人： Nobuhiko Sugano ,  Chiyokichi Iizuka ,  Hiroaki Maeda

发明人： Nobuhiko Sugano ,  Chiyokichi Iizuka ,  Hiroaki Maeda

IPC分类号： A61K36/07 ,  A61K36/06 ,  A61K36/899 ,  A61K38/00 ,  C07K14/375 ,  C12P1/02 ,  C12P21/00 ,  C12R1/645 ,  A61K37/02 ,  C12P19/02

CPC分类号： C12R1/645 ,  A61K36/07 ,  A61K36/899 ,  C07K14/375 ,  C12P1/02 ,  A61K38/00

摘要： Anticancer drugs consisting of sugar and protein composed primarily of xylose which are obtained from the nutrient medium and tissue-medium of Basidiomycetes such as Lentinus edodes which has been cultured in a solid medium rich is xylose such as bagasse is described.

摘要翻译： 描述了由营养培养基和辅助担子菌的组织培养基（例如富含固体培养基培养的香菇）组成的主要由木糖组成的糖和蛋白质组成的抗癌药物是木糖如甘蔗渣。

公开(公告)号：US4254672A

公开(公告)日：1981-03-10

申请号：US23993

申请日：1979-03-26

申请人： Kiyofumi Mizuno ,  Masanori Sato ,  Hiroaki Maeda ,  Shigeo Takahashi ,  Satomi Suzuki

发明人： Kiyofumi Mizuno ,  Masanori Sato ,  Hiroaki Maeda ,  Shigeo Takahashi ,  Satomi Suzuki

IPC分类号： F16H45/00 ,  F16H47/04 ,  F16H61/66 ,  B60K41/04 ,  B60K41/12

CPC分类号： F16H61/66 ,  B60W10/04 ,  B60W10/101 ,  F16H61/46 ,  F16H61/462 ,  F16H2061/6601 ,  F16H47/04 ,  Y10T477/637 ,  Y10T74/19037

摘要： A control system for a stepless variable speed transmission of power splitting type for use in a vehicle in which the power from an engine is transmitted with a controllable speed and wherein part of the power is converted into hydraulic power by means of hydraulic pump motor. The system comprises an up shift valve which switches a hydraulic pressure of a clutch and brake in the transmission to change the transmission to a high speed ratio range when a speed ratio increasing hydraulic pressure in a speed ratio control actuator exceeds a given value, a down shift valve which switches the hydraulic pressure of the clutch and brake to change the transmission to a low speed ratio range when a speed ratio decreasing hydraulic pressure exceeds a given value and a directional control valve which reverse the direction of the speed ratio increasing and the speed ratio decreasing hydraulic pressure to the actuator in accordance with a pressure difference between the hydraulic pressure of the clutch and brake in the low speed ratio range and the hydraulic pressure of the clutch and brake in the high speed range.

摘要翻译： 一种用于车辆的无级变速传动控制系统，其中发动机的动力以可控速度传递，其中部分动力通过液压泵马达转换为液压动力。 该系统包括升档换档阀，当变速比控制致动器中的液压增加的速度比超过给定值时，该换档阀在变速器中切换离合器和制动器的液压，以将变速器改变为高速比范围，向下 当变速比降低液压超过给定值时，切换离合器和制动器的液压的换挡阀将变速器改变为低速比范围;以及方向控制阀，其使速比增加的方向和速度 根据低速比范围内的离合器和制动器的液压之间的压力差以及离合器和制动器在高速范围内的液压而使致动器的液压降低。

公开(公告)号：US4229998A

公开(公告)日：1980-10-28

申请号：US917034

申请日：1978-06-19

申请人： Kiyofumi Mizuno ,  Hiroaki Maeda ,  Shigeo Takahashi ,  Masanori Sato ,  Satomi Suzuki

发明人： Kiyofumi Mizuno ,  Hiroaki Maeda ,  Shigeo Takahashi ,  Masanori Sato ,  Satomi Suzuki

IPC分类号： B60K17/10 ,  F16H47/04 ,  F16H61/40 ,  F16H61/66 ,  B60K41/12 ,  B60K41/16

CPC分类号： F16H61/46 ,  B60W10/04 ,  B60W10/06 ,  B60W10/101 ,  B60W30/18027 ,  B60W30/1819 ,  F16H47/04 ,  F16H61/462 ,  B60W2540/106 ,  F16H2037/0886 ,  Y10S74/01 ,  Y10T477/636

摘要： An automatic speed ratio control system of integration servo mechanism type for a stepless transmission of an automotive vehicle. Speed ratio is controlled by a hydraulic pump motor of variable displacement type, which in turn is controlled by an actuator having a piston and a cylinder to which hydraulic oil is supplied. The system comprises a desired value signal generator which produces a desired value signal for an engine speed corresponding to a throttle opening or an output torque of an engine or which produces a desired value signal for an engine output torque corresponding to a throttle opening or an engine speed, a detector for producing a signal indicative of an engine speed or an output torque of an engine, a control signal generator for comparing the signal from the detector against the signal from the target desired value signal generator to produce a control signal in accordance with a deviation therebetween, and a controller responsive to the control signal to drive the actuator to change a speed ratio of the stepless transmission. The system is characterized by further comprising means for producing a signal indicative of the differential or pseudo-differential of a throttle opening during the time the throttle opening increases, a signal from said means being added algebraically in opposing relationship with the signal from the desired value signal generator in the control signal generator or in opposing relationship with the signal from the control signal generator in the controller to prevent an abnormal rise in rotational speed of an engine of the vehicle during a rapid starting.

摘要翻译： 一种用于机动车辆的无级变速的集成伺服机构的自动变速比控制系统。 变速比由可变排量型的液压泵电动机控制，该马达又由具有提供液压油的活塞和气缸的致动器控制。 该系统包括期望值信号发生器，其产生对应于发动机的节气门开度或输出扭矩的发动机速度的期望值信号，或者产生对应于节气门开度或发动机的发动机输出转矩的期望值信号 用于产生指示发动机的发动机转速或输出转矩的信号的检测器，用于将来自检测器的信号与来自目标期望值信号发生器的信号进行比较的控制信号发生器，以产生根据 它们之间的偏差，以及响应于控制信号的控制器来驱动致动器来改变无级变速器的速比。 该系统的特征在于还包括用于产生指示在节气门开度增加期间节气门开度的差分或伪差分的信号的装置，来自所述装置的信号与来自期望值的信号以代数相加的信号 控制信号发生器中的信号发生器或与控制器中的控制信号发生器的信号相反的关系，以防止在快速启动期间车辆发动机的转速异常上升。

公开(公告)号：US4131035A

公开(公告)日：1978-12-26

申请号：US789739

申请日：1977-04-21

申请人： Kiyohumi Mizuno ,  Hiroaki Maeda ,  Shigeo Takahashi ,  Tsukasa Watanabe

发明人： Kiyohumi Mizuno ,  Hiroaki Maeda ,  Shigeo Takahashi ,  Tsukasa Watanabe

IPC分类号： F16H47/04 ,  F16H59/24 ,  F16H59/42 ,  F16H59/44 ,  F16H61/02 ,  B60K41/04

CPC分类号： F16H47/04 ,  F16H2037/0886 ,  Y10T477/636 ,  Y10T477/637

摘要： In a hydromechanical transmission, low and high range clutches are selectively operated in response to variation of an actual speed ratio between an input shaft and an output shaft to complete low or high speed drive power train. The transmission comprises a speed ratio detecting valve for detecting lower and higher limits of a predetermined speed ratio and a clutch control valve for selectively operating the low and high range clutches when the actual speed ratio reaches in a range defined by the lower and higher limits of the predetermined speed ratio. The operation of the clutch control valve is controlled by a pressure control valve in accordance with a difference in value between a first signal responsive to a throttle opening angle and a second signal responsive to the rotation speed of the input shaft such that the low and high range clutches are selectively operated only when the difference between the first and second signals becomes a predetermined value.

摘要翻译： 在液力机械变速器中，响应于输入轴和输出轴之间的实际速比的变化选择性地操作低档和高档离合器以完成低速或高速驱动动力传动系。 变速器包括用于检测预定速比的下限和上限的速比检测阀和用于选择性地操作低档和高档离合器的离合器控制阀，当实际速比达到由下限和上限限定的范围时 预定速比。 离合器控制阀的操作由压力控制阀根据响应于节气门开度的第一信号与响应于输入轴的转速的第二信号之间的差异值来控制，使得低和高 仅当第一和第二信号之间的差成为预定值时，选择性地操作范围离合器。

公开(公告)号：US09421299B2

公开(公告)日：2016-08-23

申请号：US14005906

申请日：2012-03-09

申请人： Naoaki Kawakami ,  Hiroaki Maeda

发明人： Naoaki Kawakami ,  Hiroaki Maeda

IPC分类号： A61L24/04 ,  C09J175/04 ,  C09J175/08 ,  C08G18/48 ,  C08G18/77

CPC分类号： A61L24/046 ,  C08G18/4837 ,  C08G18/4845 ,  C08G18/773 ,  C09J175/04 ,  C09J175/08 ,  C08L75/04

摘要： The present invention is directed to providing a safe medical adhesive, a cured body of which is hard to be degraded and decomposed and thus stable and the cured body generates less amount of acid, aldehyde, etc. due to degradation/decomposition. The medical adhesive includes a hydrophilic urethane prepolymer (UP) obtained by reacting a polyisocyanate component (A) containing a fluorine-containing non-aromatic polyisocyanate compound (A1) as an essential ingredient and a polyol component (B) containing a hydrophilic polyol (B1) as an essential ingredient, wherein a chlorine content in a chlorine-containing organic compound based on the weight of the hydrophilic urethane prepolymer (UP) is 0.005 wt % or less.

摘要翻译： 本发明旨在提供一种安全的医用粘合剂，其固化体难以降解和分解，因此稳定，固化体由于降解/分解而产生较少量的酸，醛等。 医用胶粘剂包括通过使含有含氟非芳香族多异氰酸酯化合物（A1）作为必需成分的多异氰酸酯成分（A）与含有亲水性多元醇（B1）的多元醇成分（B）反应而得到的亲水性氨基甲酸酯预聚物（UP） ）作为必要成分，其中，基于亲水性氨基甲酸酯预聚物（UP）的重量，含氯有机化合物中的氯含量为0.005重量％以下。

公开(公告)号：US09091969B2

公开(公告)日：2015-07-28

申请号：US14173044

申请日：2014-02-05

申请人： Ryuji Yoshida ,  Hideki Zemba ,  Yusuke Mitani ,  Shotaro Hoshi ,  Masahiko Shakuto ,  Hiroaki Maeda

发明人： Ryuji Yoshida ,  Hideki Zemba ,  Yusuke Mitani ,  Shotaro Hoshi ,  Masahiko Shakuto ,  Hiroaki Maeda

IPC分类号： G03G15/16 ,  G03G15/02 ,  G03G15/06

CPC分类号： G03G15/1675 ,  G03G15/0266 ,  G03G15/065

摘要： An image forming apparatus includes a charging bias output device, a developing bias output device, a transfer bias output device, and a controller. The controller controls the transfer bias output device to supply a transfer bias from a time at which a first position of a photosensitive member arrives at a transfer position after the charging bias output device starts supplying a charging bias. An initial value of the transfer bias is controlled to be smaller than a normal set value for a predetermined time period which is a time after the transfer bias starts to be supplied and within a time corresponding to a rise time during which a surface potential of the photosensitive member reaches a predetermined potential after the charging bias starts to be output. The first position of the photosensitive member is a position at which the charging device starts charging the photosensitive member.

摘要翻译： 图像形成装置包括充电偏压输出装置，显影偏压输出装置，转印偏压输出装置和控​​制器。 控制器控制转印偏压输出装置，以在充电偏压输出装置开始提供充电偏压之后从感光元件的第一位置到达转印位置的时间提供转印偏压。 转移偏压的初始值被控制为小于正常设定值，该预定时间段是在转印偏差开始被提供之后的时间内，并且在与上述时间相对应的时间内， 感光元件在充电偏压开始输出之后达到预定电位。 感光构件的第一位置是充电装置开始对感光构件充电的位置。

公开(公告)号：US08748132B2

公开(公告)日：2014-06-10

申请号：US13125328

申请日：2009-10-21

申请人： Hiroshi Nakatake ,  Akihiro Meta ,  Kiyotaka Suenaga ,  Masaki Hirashima ,  Hiroaki Maeda

发明人： Hiroshi Nakatake ,  Akihiro Meta ,  Kiyotaka Suenaga ,  Masaki Hirashima ,  Hiroaki Maeda

IPC分类号： C12P21/04

CPC分类号： C12N9/6491 ,  C07K2319/02 ,  C12P21/02

摘要： A process for preparing an inclusion body-forming protein is provided. A nucleic acid fragment having a nucleotide sequence coding for a modified alkaline phosphatase signal peptide (modified APSP) where leucine at the 13th position in the amino acid sequence shown in SEQ ID NO: 1 is substituted with proline and/or alanine at the 21st position is substituted with the other amino acid, downstream of which nucleotide sequence is bound a nucleotide sequence of a gene of a protein of interest is also provided.

摘要翻译： 提供了一种制备包涵体形成蛋白的方法。 具有编码改变的碱性磷酸酶信号肽（修饰的APSP）的核苷酸序列的核酸片段，其中在SEQ ID NO：1所示的氨基酸序列中的第13位的亮氨酸被第21位的脯氨酸和/或丙氨酸取代 还提供了另一个氨基酸，其下游的核苷酸序列与目的蛋白质的基因的核苷酸序列结合。

公开(公告)号：US08364101B2

公开(公告)日：2013-01-29

申请号：US12721064

申请日：2010-03-10

申请人： Yoshinobu Shizawa ,  Hiroaki Maeda ,  Yousuke Okazaki ,  Hirotake Honda

发明人： Yoshinobu Shizawa ,  Hiroaki Maeda ,  Yousuke Okazaki ,  Hirotake Honda

IPC分类号： H04B1/04 ,  H01Q11/12

CPC分类号： H03F1/0288 ,  H03F1/0222 ,  H03F1/3247 ,  H03F2201/3233

摘要： An amplifying device includes an amplifier including a first amplifying element with a drain voltage thereof being controlled, and a second amplifying element, the amplifier amplifying a transmission signal with the first and second amplifying elements, synthesizing the transmission signals amplified by the first and second amplifying elements, and outputting the synthesized transmission signal; a distortion compensator part which performs distortion compensation on the input signal in accordance with a compensation coefficient derived from a difference between a input signal and a feedback signal generated from a portion of a signal output from the amplifier; and a controller part which controls the drain voltage of the first amplifying element in response to a result of a comparison between a power level of the input signal prior to the distortion compensation operation by the distortion compensator part and a threshold value.

摘要翻译： 一种放大装置，包括：放大器，包括其漏极电压被控制的第一放大元件;以及第二放大元件，放大器利用第一和第二放大元件放大发送信号，合成由第一和第二放大元件放大的发送信号 并输出合成的发送信号; 失真补偿部，其根据从输入信号和从放大器输出的信号的一部分产生的反馈信号之间的差导出的补偿系数，对输入信号进行失真补偿; 以及控制器部分，其响应于在失真补偿器部分的失真补偿操作之前的输入信号的功率电平与阈值之间的比较的结果来控制第一放大元件的漏极电压。

公开(公告)号：US08283137B2

公开(公告)日：2012-10-09

申请号：US10566266

申请日：2004-07-28

申请人： Reiko Matsuyama ,  Hiroaki Maeda

发明人： Reiko Matsuyama ,  Hiroaki Maeda

IPC分类号： C12N1/00 ,  C12N5/10 ,  C12N5/16 ,  C12P21/00

CPC分类号： C07K14/75

摘要： When genes encoding three kinds of proteins constituting fibrinogen, an α chain (or variant of α chain), a β chain and a γ chain (or variant of γ chain) are incorporated into an animal cell, a constitutional ratio of respective genes is such that a α chain (and/or variant of γ chain) gene is an equal amount to a 1000-fold amount relative to an α chain (and/or variant of α chain) gene and a β chain gene and, further, by using a baculovirus P35 gene, a recombinant fibrinogen highly producing cell is prepared.

摘要翻译： 当编码构成纤维蛋白原的三种蛋白质的基因，α链（或α链的变体），a＆bgr; 链和γ链（或γ链的变体）并入动物细胞中，各基因的构成比例使得α链（和/或γ链的变体）基因等于1000倍 相对于α链（和/或α链的变体）基因和bgr的量; 链基因，并且通过使用杆状病毒P35基因，制备重组纤维蛋白原高产细胞。

公开(公告)号：US20120225818A1

公开(公告)日：2012-09-06

申请号：US13389215

申请日：2010-08-05

申请人： Shintaro Kamei ,  Asami Shindome ,  Takayoshi Hamamoto ,  Hiroaki Maeda ,  Masaki Hirashima ,  Sachio Okuda ,  Misako Umehashi ,  Sachie Ogawa ,  Megumi Imuta ,  Norio Akaike ,  Kazuo Takahama ,  Ryoko Wada

发明人： Shintaro Kamei ,  Asami Shindome ,  Takayoshi Hamamoto ,  Hiroaki Maeda ,  Masaki Hirashima ,  Sachio Okuda ,  Misako Umehashi ,  Sachie Ogawa ,  Megumi Imuta ,  Norio Akaike ,  Kazuo Takahama ,  Ryoko Wada

IPC分类号： A61K38/36 ,  A61P11/14

CPC分类号： C12N9/6443 ,  A61K38/4846

摘要： The activated Factor XI is provided as an antitussive for cough caused by the stimulation at the tracheal bifurcation such as chronic cough. A pharmaceutical composition for prevention, treatment and/or symptom amelioration of cough, comprising a polypeptide chain as an active ingredient and a pharmaceutically acceptable carrier, wherein the polypeptide chain consists of a full length amino acid sequence constituting activated Factor XI (hereinafter also referred to as “FXIa”), the amino acid sequence with one or several amino acids therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences.

摘要翻译： 提供活化因子XI作为由气管分叉如慢性咳嗽引起的咳嗽的镇咳药。 一种用于预防，治疗和/或症状改善咳嗽的药物组合物，其包含多肽链作为活性成分和药学上可接受的载体，其中所述多肽链由构成活化因子XI的全长氨基酸序列组成（以下也称为 作为“FXIa”），其中具有一个或几个氨基酸的氨基酸序列被缺失，取代或加入，或任一上述氨基酸序列的部分序列，或包含上述任何一种的氨基酸序列 氨基酸序列。