METHOD FOR PRODUCING LANGERHANS CELLS OR INTERSTITIAL DENDRITIC CELLS OR BOTH FROM CD14+ MONOCYTES
    61.
    发明申请
    METHOD FOR PRODUCING LANGERHANS CELLS OR INTERSTITIAL DENDRITIC CELLS OR BOTH FROM CD14+ MONOCYTES 审中-公开
    用于生产来自CD14 +单核细胞的兰格细胞或间质细胞的方法

    公开(公告)号:US20100297765A1

    公开(公告)日:2010-11-25

    申请号:US12851592

    申请日:2010-08-06

    IPC分类号: C12N5/0784 C12N5/0786

    摘要: The present invention relates to a method for preparing Langerhans cells or interstitial dendritic cells or both from CD14+ monocytes stemming from the peripheral circulatory blood of a living being, wherein the method comprises differentiation of CD 14+ monocytes into either Langerhans cells, interstitial dendritic cells, or into both types of cells by placing the CD14+ monocytes in the presence of a cell environment comprising epithelial cells and/or mesenchymatous cells.The present invention also relates to cell or tissue models comprising such prepared Langerhans cells and/or interstitial dendritic cells, and optionally macrophages and endothelial cells, and to the uses of such cell or tissue models.

    摘要翻译: 本发明涉及一种从活体的外周循环血中产生的CD14 +单核细胞或两者从朗姆汉斯细胞或间质树突状细胞制备的方法,其中所述方法包括将CD14 +单核细胞分为朗格汉斯细胞,间质树突状细胞, 或通过在包含上皮细胞和/或间充质细胞的细胞环境的存在下放置CD14 +单核细胞来进入两种类型的细胞。 本发明还涉及包含这种制备的朗格汉斯细胞和/或间质树突状细胞,以及任选的巨噬细胞和内皮细胞的细胞或组织模型,以及这种细胞或组织模型的用途。

    Cosmetic product in the form of compact powder comprising a message informing the user
    63.
    发明申请
    Cosmetic product in the form of compact powder comprising a message informing the user 审中-公开
    以致密粉末形式的化妆品,包括通知用户的消息

    公开(公告)号:US20090041698A1

    公开(公告)日:2009-02-12

    申请号:US11977516

    申请日:2007-10-25

    IPC分类号: A61K8/00 A45D33/18 A61Q1/00

    摘要: A compressed powder product (60) intended for cosmetic use comprises at least one string of alphanumeric characters (24) displayed essentially throughout said usable thickness h and forming a message that is intended to inform the user of said product about at least one commercial, technical or regulatory characteristic of said product, said characters themselves consisting of a cosmetically acceptable substance, preferably also a compact powder, and being visually distinct from the rest of said product so that said message remains legible on the surface of said product during use, thereby implementing a method of informing the user about the cosmetic product.

    摘要翻译: 用于化妆品使用的压缩粉末产品(60)包括基本上在所述可用厚度h上显示的至少一串字母数字字符(24),并形成旨在向用户通知所述产品关于至少一种商业技术 或所述产品的调节特征,所述字符本身由美容上可接受的物质组成,优选地也是紧凑的粉末,并且在视觉上与所述产品的其余部分不同,使得所述信息在使用期间保持在所述产品的表面上清晰可见,从而实现 一种向用户通知化妆品的方法。

    Cyclodextrins preferentially substituted on their primary face by acid or amine functions
    67.
    发明授权
    Cyclodextrins preferentially substituted on their primary face by acid or amine functions 有权
    环糊精在其主要表面上优先被酸或胺官能取代

    公开(公告)号:US06524595B1

    公开(公告)日:2003-02-25

    申请号:US09613773

    申请日:2000-07-11

    IPC分类号: A61K700

    摘要: Non-hydroxyalkylated cyclodextrins are disclosed wherein at least one primary alcohol function (CH2OH) is substituted, the —OH portion being replaced by a substituent with formula —O—CO—R or —NR1R2, where: R, R1 and R2 independently represent a linear or cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated alkyl group containing 1 to 30 carbon atoms, preferably 1 to 22 carbon atoms, more preferably a fatty chain containing 2 to 22 carbon atoms. These cyclodextrins are used as vectors for at least one active ingredient, in particular to encourage tissue penetration, in a cosmetic application, or for the production of pharmaceutical compositions, in particular dermopharmaceuticals.

    摘要翻译: 公开了非羟基烷基化的环糊精,其中至少一个伯醇官能团(CH 2 OH)被取代,-OH部分由具有式-O-CO-R或-NR1R2的取代基取代,其中:R,R1和R2独立地表示 具有1至30个碳原子,优选1至22个碳原子的直链或环状,饱和或不饱和的羟基化或非羟基化烷基,更优选含有2至22个碳原子的脂肪链。 这些环糊精用作至少一种活性成分的载体,特别是用于在化妆品应用中促进组织穿透,或用于制备药物组合物,特别是皮肤药物。