公开(公告)号：US20090182213A1

公开(公告)日：2009-07-16

申请号：US12405786

申请日：2009-03-17

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20090177059A1

公开(公告)日：2009-07-09

申请号：US12405739

申请日：2009-03-17

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20090173628A1

公开(公告)日：2009-07-09

申请号：US12405568

申请日：2009-03-17

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： G01N27/26

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/00 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20090171179A1

公开(公告)日：2009-07-02

申请号：US12397293

申请日：2009-03-03

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/00 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20090163788A1

公开(公告)日：2009-06-25

申请号：US12367468

申请日：2009-02-06

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/145

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20090093696A1

公开(公告)日：2009-04-09

申请号：US12245618

申请日：2008-10-03

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1473

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20090062634A1

公开(公告)日：2009-03-05

申请号：US12197200

申请日：2008-08-22

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20080167543A1

公开(公告)日：2008-07-10

申请号：US12052489

申请日：2008-03-20

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/05 ,  G06F19/00

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US07003340B2

公开(公告)日：2006-02-21

申请号：US10291969

申请日：2002-11-11

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

IPC分类号： A61B5/05 ,  A61B5/04

CPC分类号： A61B5/14532 ,  A61B5/01 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  C12Q1/001 ,  C12Q1/006

摘要： An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.

公开(公告)号：US6103033A

公开(公告)日：2000-08-15

申请号：US34422

申请日：1998-03-04

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

IPC分类号： G01N27/30 ,  C12Q1/00 ,  G01N27/327 ,  G01N27/416 ,  G01N33/543 ,  B32B31/00

CPC分类号： A61B5/14735 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/001 ,  G01N27/3272 ,  G01N33/5438 ,  G01N33/54393 ,  G01N33/66 ,  A61B2562/0271 ,  A61B2562/125 ,  Y10T156/1064 ,  Y10T156/1082 ,  Y10T29/42 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49128 ,  Y10T29/49155 ,  Y10T29/49208 ,  Y10T29/49798

摘要： A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes the steps of providing a continuous substrate web, and disposing a pattern of a conductive material on the continuous substrate web to form one or more working electrodes and/or counter electrodes.