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61.发明授权
公开(公告)号：US6080829A
公开(公告)日：2000-06-27
申请号：US103879
申请日：1998-06-24
申请人： Mark A. Tapsak , Edward Di Domenico
发明人： Mark A. Tapsak , Edward Di Domenico
CPC分类号： C08G77/50 , C08G77/485 , C08L83/14
摘要： Symmetric and asymmetric cyclic silalkylenesiloxane monomers and copolymers thereof are disclosed, as well as crosslinked and/or reinforced silalkylenesiloxane copolymers, medical devices containing such materials, and methods of preparation.
摘要翻译： 公开了对称和不对称的环状硅烷基二硅氧烷单体及其共聚物，以及交联和/或增强的硅烷基二硅氧烷共聚物，含有这些材料的医疗装置和制备方法。
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62.发明授权公开(公告)号：US08050731B2
公开(公告)日：2011-11-01
申请号：US11280672
申请日：2005-11-16
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
摘要： The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
摘要翻译： 本发明提供了一种用于调节分析物通过其的运输的可植入膜，其包括包含第一聚合物的基质; 和分散在整个基质中的第二种聚合物，其中第二种聚合物形成微区网络，当400×放大倍率或更小时，使用光学显微镜不能观察到水合。 在一个方面，本发明的均质膜具有基本上分散在疏水性基质上的亲水性畴，以提供氧和葡萄糖转运到电化学葡萄糖传感器之间的最佳平衡。
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公开(公告)号：US20100160760A1
公开(公告)日：2010-06-24
申请号：US12696003
申请日：2010-01-28
IPC分类号： A61B5/145
CPC分类号： C12Q1/006 , A61B5/0031 , A61B5/14532 , A61B5/14558 , A61B5/14865
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
摘要翻译： 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以在长时间内获得准确的数据。
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公开(公告)号：US07136689B2
公开(公告)日：2006-11-14
申请号：US11039269
申请日：2005-01-19
CPC分类号： C12Q1/006 , A61B5/0031 , A61B5/14532 , A61B5/14558 , A61B5/14865
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that slows accurate date to be obtained over long periods of time.
摘要翻译： 描述用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以减慢长时间获得的准确日期。
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65.发明授权公开(公告)号：US06984700B2
公开(公告)日：2006-01-10
申请号：US10246807
申请日：2002-09-17
申请人： Michael Eric Benz , Christopher M. Hobot , David L. Miller , David A. Pearson , Mark A. Tapsak , Edward DiDomenico , Randall V. Sparer
发明人： Michael Eric Benz , Christopher M. Hobot , David L. Miller , David A. Pearson , Mark A. Tapsak , Edward DiDomenico , Randall V. Sparer
IPC分类号： C08L83/05
摘要： Compounds that include silicon-containing groups, and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.
摘要翻译： 包括含硅基团和任选的氨基甲酸酯基团，脲基团或其组合（即聚氨酯，聚脲或聚氨酯 - 脲）的化合物以及用于制备这些化合物的材料和方法。
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公开(公告)号：US06862465B2
公开(公告)日：2005-03-01
申请号：US09916858
申请日：2001-07-27
CPC分类号： C12Q1/006 , A61B5/0031 , A61B5/14532 , A61B5/14558 , A61B5/14865
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
摘要翻译： 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以在长时间内获得准确的数据。
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67.发明授权公开(公告)号：US06534587B1
公开(公告)日：2003-03-18
申请号：US09568200
申请日：2000-05-09
申请人： Mark A. Tapsak , Edward Di Domenico
发明人： Mark A. Tapsak , Edward Di Domenico
IPC分类号： C08L8314
CPC分类号： C08G77/50 , C08G77/485 , C08L83/14 , C08L83/00
摘要： Symmetric and asymmetric cyclic silalkylenesiloxane monomers and copolymers thereof, as well as crosslinked and/or reinforced silalkylenesiloxane copolymers, medical devices containing such materials, and methods of preparation.
摘要翻译： 对称和不对称的环状硅烷基二硅氧烷单体及其共聚物，以及交联和/或增强的硅烷基聚硅氧烷共聚物，含有这些材料的医疗装置及其制备方法。
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公开(公告)号：US5921933A
公开(公告)日：1999-07-13
申请号：US135468
申请日：1998-08-17
IPC分类号： A61N1/05 , A61B8/00 , A61B8/08 , A61B19/00 , A61F2/82 , A61F2/84 , A61L29/00 , A61L31/14 , A61M1/00 , A61M25/00 , A61M25/16
CPC分类号： A61L31/18 , A61B8/0833 , A61B8/0841 , A61L31/14 , A61B2090/3925 , A61M25/0108
摘要： A medical device for insertion into human body having an echogenic portion of enhanced visibility in an ultrasound scan. The echogenic portion includes an echogenic material comprising a plastic impregnated with sonically reflective particles, the particles having an average size of less than 500 nanometers and formed of a substance having a specific gravity of 5 or greater. Preferably the particles have an average size of less than 100 nanometers and the sonically reflective particles are 5% to 40% of the echogenic material.
摘要翻译： 一种用于插入人体的医疗装置，其具有在超声波扫描中具有增强的可视性的回声部分。 回声部分包括回声材料，其包括浸渍有声反射颗粒的塑料，该颗粒具有小于500纳米的平均尺寸并由比重为5或更大的物质形成。 优选地，颗粒具有小于100纳米的平均尺寸，并且声反射颗粒是回声材料的5％至40％。
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公开(公告)号：US20120258162A1
公开(公告)日：2012-10-11
申请号：US13202682
申请日：2011-04-07
申请人： Mark A. Tapsak
发明人： Mark A. Tapsak
IPC分类号： A61K9/00 , A61P31/00 , A61P23/00 , A61P7/02 , A61K31/80 , A61P9/00 , A61P7/00 , A61P29/00 , A61P37/06
CPC分类号： A61K31/22 , A61K9/0024 , A61K31/436 , A61K31/573 , A61K31/661 , A61K38/13 , A61K47/59 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2300/606
摘要： Disclosed are methods and apparatuses for delivery of bioactive molecules. The drug delivery systems include an implantable medical device which significantly reduces or suppresses adverse biological responses associated with implantable devices and also promotes vascularization in tissues surrounding the implanted device. The disclosure also relates to drug delivery systems designed to vary the rate of delivery of bioactive molecules with a change in the physiological environment.
摘要翻译： 公开了用于递送生物活性分子的方法和装置。 药物递送系统包括显着降低或抑制与可植入装置相关的不利生物反应的可植入医疗装置，并且还促进植入装置周围组织的血管化。 本公开还涉及设计用于改变生物活性分子随着生理环境变化的递送速率的药物递送系统。
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公开(公告)号：US20120179014A1
公开(公告)日：2012-07-12
申请号：US13411414
申请日：2012-03-02
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/1455 , A61B5/14558 , A61B5/1459 , A61B5/1486 , A61B5/14865 , A61B2562/17 , C12Q1/006
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
摘要翻译： 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以在长时间内获得准确的数据。
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