公开(公告)号：US20070201614A1

公开(公告)日：2007-08-30

申请号：US11743273

申请日：2007-05-02

Applicant: Samuel Goldman ,  Jeff Chen ,  Jerry Battista

Inventor： Samuel Goldman ,  Jeff Chen ,  Jerry Battista

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1042 ,  G06F19/00 ,  G06F19/3481

Abstract: Described embodiments relate to improved methods and systems for computationally efficient optimization of radiation dose delivery. The optimization involves determining an improved form of objective function to be used for mapping radiotherapy beams to a patient body volume having at least one target volume and at least one non-target volume. The objective function has a first term related to the at least one target volume and a second term related to the at least one non-target volume. The optimization further involves determining a minimum of the objective function, whereby beams, comprising a plurality of beamlets, mapped to pass through the at least one non-target volume, comprising a plurality of non-target volume portions, are limited such that the second term is zero only if, a product of the intensity of a beamlet mapped to pass through a non-target volume portion and the dose deposited by said beamlet is equal to a first predetermined average dose constraint value for the respective non-target volume portion, for all beamlets mapped to pass through the at least one non-target volume. This limit aims to reduce the occurrence of negative beam weights, thereby facilitating computationally efficient determination of the minimum of the objective function and achieving more physically realistic beamlet intensities. In another embodiment, the objective function has a smoothing term for biasing the intensity of beamlets, for a respective beam mapped to pass through the at least one target volume and the at least non-target volume, towards a uniform distribution within the respective beam. Following the optimization, radiotherapy is delivered based on the determined minimum of the objective function.

Abstract translation: 描述的实施例涉及用于辐射剂量递送的计算上有效优化的改进的方法和系统。 优化包括确定用于将放射治疗束映射到具有至少一个目标体积和至少一个非目标体积的患者体积体积的目标函数的改进形式。 目标函数具有与至少一个目标体积相关的第一项和与该至少一个非目标体相关的第二项。 该优化进一步涉及确定目标函数的最小值，由此包括多个子束的被映射以通过包含多个非目标体积部分的至少一个非目标体积的束被限制，使得第二 只有当映射成通过非目标体积部分的子束的强度的乘积和由所述子束沉积的剂量的乘积等于相应的非目标体积部分的第一预定平均剂量约束值时，术语为零， 对于映射成通过至少一个非目标卷的所有子束。 这个限制旨在减少负光束权重的发生，从而有助于计算有效地确定目标函数的最小值，并实现更加物理上实际的子束强度。 在另一个实施例中，目标函数具有平滑项，用于对于映射成穿过至少一个目标体积和至少非目标体积的相应波束朝向相应波束内的均匀分布来偏置子波束的强度。 优化后，根据所确定的目标函数的最小值进行放射治疗。

公开(公告)号：US20070127623A1

公开(公告)日：2007-06-07

申请号：US10581885

申请日：2004-12-10

Applicant: Samuel Goldman ,  Jerry Battista ,  Jeff Chen

Inventor： Samuel Goldman ,  Jerry Battista ,  Jeff Chen

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1042 ,  G06F19/00 ,  G06F19/3481

Abstract: The invention relates to improved methods and systems for computationally efficient optimization of radiation dose delivery. The optimization involves determining an improved form of objective function to be used for mapping radiotherapy beams to a patient body volume having at least one target volume and at least one non-target volume. The objective function has a first term related to the at least one target volume and a second term related to the at least one non-target volume. The optimization further involves determining a minimum of the objective function, whereby beams mapped so as to pass through the at least one non-target volume are limited such that the second term is zero only if the weights of beamlets passing through the at least one non-target volume are zero. This limit helps to avoid the occurrence of negative beam weights, thereby facilitating computationally efficient determination of the minimum of the objective function using matrix inversion. Following the optimization, radiotherapy is delivered based on the determined minimum of the objective function.

Abstract translation: 本发明涉及用于辐射剂量递送的计算有效优化的改进的方法和系统。 优化包括确定用于将放射治疗束映射到具有至少一个目标体积和至少一个非目标体积的患者体积体积的目标函数的改进形式。 目标函数具有与至少一个目标体积相关的第一项和与该至少一个非目标体相关的第二项。 所述优化进一步涉及确定所述目标函数的最小值，由此映射以便穿过所述至少一个非目标体积的波束被限制，使得仅当通过所述至少一个非目标体积的子束的权重为零时，所述第二项为零， 目标体积为零。 这个限制有助于避免发生负光束权重，从而有助于使用矩阵求逆来计算有效地确定目标函数的最小值。 优化后，根据所确定的目标函数的最小值进行放射治疗。

公开(公告)号：US20060211709A1

公开(公告)日：2006-09-21

申请号：US10513081

申请日：2003-05-02

Applicant: Chris Buhr ,  Tae-Gon Baik ,  Sunghoon Ma ,  Zerom Tesfai ,  Longcheng Wang ,  Erick Co ,  Sergey Epshteyn ,  Abigail Kennedy ,  Baili Chen ,  Larisa Dubenko ,  Neel Anand ,  Tsze Tsang ,  John Nuss ,  Csabaj Peto ,  Kenneth Rice ,  Mohamed Ibrahim ,  Xian Shi ,  James Leahy ,  Jeff Chen ,  Lisa Dalrymple ,  Timothy Forsyth ,  Tai Huynh ,  Grace Mann ,  Larry Mann ,  Craig Takeuchi

Inventor： Chris Buhr ,  Tae-Gon Baik ,  Sunghoon Ma ,  Zerom Tesfai ,  Longcheng Wang ,  Erick Co ,  Sergey Epshteyn ,  Abigail Kennedy ,  Baili Chen ,  Larisa Dubenko ,  Neel Anand ,  Tsze Tsang ,  John Nuss ,  Csabaj Peto ,  Kenneth Rice ,  Mohamed Ibrahim ,  Xian Shi ,  James Leahy ,  Jeff Chen ,  Lisa Dalrymple ,  Timothy Forsyth ,  Tai Huynh ,  Grace Mann ,  Larry Mann ,  Craig Takeuchi

IPC: A61K31/497 ,  C07D403/02

CPC classification number: C07D241/26 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12

Abstract: Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.

Abstract translation: 公开了取代的芳基1,4-吡嗪衍生物及其在治疗焦虑症，抑郁症和应激相关疾病中的用途。

公开(公告)号：USD500436S1

公开(公告)日：2005-01-04

申请号：US29189632

申请日：2003-09-09

Applicant: Jeff Chen

Designer： Jeff Chen

公开(公告)号：US06564318B1

公开(公告)日：2003-05-13

申请号：US09336352

申请日：1999-06-18

Applicant: Laurent K. Gharda ,  Jeff Chen ,  Dan Kikinis

Inventor： Laurent K. Gharda ,  Jeff Chen ,  Dan Kikinis

IPC: G06F9445

CPC classification number: G06F8/60 ,  G06F9/4401

Abstract: A special BIOS includes a program application manager (PAM) and a file system structure (FSS) that points to addresses on a mass storage device (MSD) for an application and at least one presentation playable by the application. The BIOS calls the PAM on startup, and the PAM checks for an application, and finding same loads and executes the application before loading the operating system (OS). In a preferred embodiment the FSS is programmable, and the system after OS boot is started checks MSD devices for new FSS parameters, and finding same loads the parameters to the programmable FSS of the BIOS. In some embodiments parameters may cause presentations and associated applications to be accessed and executed in a rotating or serial order. In other embodiments the BIOS represents its own address space in RAM to the OS at OS boot to include the application, enabling the application to continue to execute during OS boot. In further embodiments a special driver is executed after OS boot to bind the application into the OS configuration so the application may continue to operate in a stable manner.

Abstract translation: 特殊BIOS包括程序应用程序管理器（PAM）和文件系统结构（FSS），该文件系统结构指向用于应用程序的大容量存储设备（MSD）上的地址以及可应用程序可播放的至少一个显示。 BIOS在启动时调用PAM，PAM检查应用程序，并在加载操作系统（OS）之前查找相同的加载并执行应用程序。 在优选实施例中，FSS是可编程的，并且在OS引导之后的系统开始检查MSD设备以获得新的FSS参数，并且找到相同的参数将参数加载到BIOS的可编程FSS。 在一些实施例中，参数可以导致呈现和相关联的应用以旋转或串行顺序被访问和执行。 在其他实施例中，BIOS在OS引导时将其在RAM中的自己的地址空间表示为OS以包括应用，使得应用能够在OS引导期间继续执行。 在另外的实施例中，在OS引导之后执行特殊驱动程序以将应用程序绑定到OS配置中，使得应用程序可以以稳定的方式继续操作。

公开(公告)号：US6116238A

公开(公告)日：2000-09-12

申请号：US982320

申请日：1997-12-02

Applicant: Thomas R. Jackson ,  Karen Davies ,  Jeff Chen ,  Mike Ligotke ,  Allan Cameron

Inventor： Thomas R. Jackson ,  Karen Davies ,  Jeff Chen ,  Mike Ligotke ,  Allan Cameron

IPC: A61M15/00 ,  A61M16/00 ,  B05D7/14 ,  B65D83/06

CPC classification number: A61M15/0045 ,  A61M15/0006 ,  A61M15/0033 ,  A61M15/0048 ,  A61M15/008 ,  A61M2016/0024

Abstract: A dry powder inhaler has a slider for incrementally advancing a blister disk, to provide successive doses of a dry powder pharmaceutical. A blister disk is rotatably supported on a spindle on a deck plate of the inhaler. A powder port, an advancing slot, and a lifter slot extend through the deck plate. A slider is attached to the deck plate and movable between open and closed positions. As the slider is opened, a litter moves up on a ramp on the slider to shear open a blister, so that the blister contents can be mixed with air and inhaled. As the slider is moved back to the closed position, the lifter is withdrawn and an advancing finger turns the disk to bring the next blister into position for opening to provide the next dose to the patient.

Abstract translation: 干粉吸入器具有用于逐渐前进泡罩盘的滑块，以提供连续剂量的干粉药物。 泡罩盘可旋转地支撑在吸入器的甲板上的心轴上。 粉末端口，前进槽和升降器槽延伸穿过甲板板。 滑块连接到甲板上，并可在打开和关闭位置之间移动。 当滑块打开时，垃圾在滑块上的斜坡上移动以剪切打开水泡，使得泡罩内容物可以与空气混合并吸入。 当滑块移回到关闭位置时，提升器被拉出并且前进的手指转动盘，以使下一个气泡进入位置以打开以向患者提供下一个剂量。

公开(公告)号：US5372518A

公开(公告)日：1994-12-13

申请号：US123241

申请日：1993-09-16

Applicant: Chao J. Liu ,  Ching-ho Lai ,  Jeff Chen ,  Sidney Lu ,  Ton-Yo Chien

Inventor： Chao J. Liu ,  Ching-ho Lai ,  Jeff Chen ,  Sidney Lu ,  Ton-Yo Chien

IPC: H01R12/50 ,  H01R12/70 ,  H01R12/73 ,  H01R13/627 ,  H01R13/52

CPC classification number: H01R12/7005 ,  H01R12/7011 ,  H01R12/737 ,  H01R13/627

Abstract: A circuit board latching device (40, 41) for use with an insulative connector housing (31) includes a retaining wall (82) and a circuit board support post (52) in which the board support post (52) is positioned opposite the retaining wall (82). The latching device (40, 41) of the present invention comprises a main body portion (56) and a mounting mechanism for mounting the main body portion to the housing (31) between the retaining wall (82) and the board support post (52). Furthermore, a latch lug (71) extends from the main body portion (56) which includes a cam surface (72) which is inclined relative to the latch lug (71), and a lock surface (73) which is substantially perpendicular to the main body portion (56). Moreover, the latching device (40, 41) includes a resilient stress reducing arm (79) projecting angularly away from the main body portion (56) toward the retaining wall (82). In one aspect, the mounting mechanism comprises a mounting platform (94) which includes a plate (106) extending from the main body portion (56). A first finger (95) extends substantially downward from one end of the plate (106) while a second finger (96) extends substantially downward from the opposite end of the plate (106) which mountingly engage the housing (31). In another aspect of the present invention, the mounting mechanism comprises an upstanding sleeve (59) mounting member extending from the main body portion (56).

Abstract translation: 一种与绝缘连接器壳体（31）一起使用的电路板锁定装置（40,41）包括一个挡板（82）和一个电路板支撑柱（52），板支撑柱（52）与挡板 墙（82）。 本发明的锁定装置（40,41）包括主体部分（56）和用于将主体部分安装到保持壁（82）和板支撑柱（52）之间的壳体（31）的安装机构 ）。 此外，从主体部分（56）延伸的闩锁凸耳（71）包括相对于闩锁凸耳（71）倾斜的凸轮表面（72），和锁定表面（73）基本垂直于 主体部分（56）。 此外，锁定装置（40,41）包括弹性应力减小臂（79），该弹性应力减小臂从主体部分（56）朝保持壁（82）成角度地突出。 一方面，安装机构包括安装平台（94），其包括从主体部分（56）延伸的板（106）。 第一手指（95）从板（106）的一端大致向下延伸，而第二指状物（96）从板（106）的与安装地接合壳体（31）的相对端大致向下延伸。 在本发明的另一方面，安装机构包括从主体部分（56）延伸的直立套筒（59）安装构件。

公开(公告)号：US20240426133A1

公开(公告)日：2024-12-26

申请号：US18746071

申请日：2024-06-18

Applicant: Jeff Chen

Inventor： Jeff Chen

IPC: E05B9/08 ,  E05B63/00

Abstract: A door lock has a lock latch, a first locking mechanism and a second locking mechanism. The first locking mechanism and the second locking mechanism can be relatively screwed and assembled with the lock latch. When the second locking mechanism is assembled relative to the first locking mechanism, the upper guide rail and the lower guide rails of the lower guide plate of the second locking mechanism are respectively embedded in the upper guide groove and the lower guide grooves of the first locking mechanism, and the internal thread portion of the second locking mechanism is relatively threaded with the external thread portion of the first locking mechanism. In addition, with the design of the internal thread portion and the external thread portion having the inner shaft moving surface and the outer shaft moving surface, respectively, the speed of threaded movement is faster when they are threaded together.

公开(公告)号：US11753850B2

公开(公告)日：2023-09-12

申请号：US17515704

申请日：2021-11-01

Applicant: Jeff Chen

Inventor： Jeff Chen

IPC: E05B47/00 ,  E05B55/00 ,  E05B47/02 ,  E05B63/08 ,  E05B63/00

CPC classification number: E05B47/0012 ,  E05B47/026 ,  E05B55/005 ,  E05B63/08 ,  E05B63/0056 ,  E05B2047/002 ,  E05B2047/0026

Abstract: A control structure of a door lock contains: a body, a slide plate, a clutch assembly, a head, a clutch assembly, and a guider. The body includes a chamber, a receiving groove, a motor, a drive gear, a trench, and a resilient element. The slide plate includes a holder, a trough, a lever, a lock cylinder, and a first connection orifice. The clutch assembly is received in the slide plate and includes a first annular ring, a second annular ring, and a third annular ring. The second annular ring includes two first cutouts, two second cutouts, and two recessed portions. The head includes a defining groove, a second connection orifice, and two bosses. The guider rotatably is fixed in the chamber and includes a space and at least two spiral indentations formed on an outer wall of the guider.

公开(公告)号：US20230135493A1

公开(公告)日：2023-05-04

申请号：US17515699

申请日：2021-11-01

Applicant: Jeff Chen

Inventor： Jeff Chen

IPC: E05B47/00 ,  E05B55/00 ,  E05B47/02 ,  E05B63/08

Abstract: A control structure of a door lock contains: a body, a slidable partition, a motor, a slide cylinder, a deadbolt, a latch, a first resilient element, and a second resilient element. The body includes a first cap, a second cap, an open segment, a close segment, a drive space, a holder, a groove, and an abutting post. The slidable partition is accommodated in the body and includes a slot, two spaced first driving extensions, a second driving extension, a through hole, two symmetrical hooks, and a seat. The motor is accommodated in the holder. The slide cylinder is received in the drive space. The deadbolt is movably received in the opening. The latch is accommodated in the notch. The first resilient element is positioned on the second positioning segment and the first positioning segment. The second resilient element is positioned on the first locating protrusion.