公开(公告)号：US20070233394A1

公开(公告)日：2007-10-04

申请号：US11394839

申请日：2006-03-31

申请人： Lars Kangas ,  Richard Smith ,  Konstantinos Petritis

发明人： Lars Kangas ,  Richard Smith ,  Konstantinos Petritis

IPC分类号： G06F19/00 ,  G01N33/50

CPC分类号： G01N33/6848

摘要： A method of predicting whether a peptide present in a biological sample will be detected by analysis with a mass spectrometer. The method uses at least one mass spectrometer to perform repeated analysis of a sample containing peptides from proteins with known amino acids. The method then generates a data set of peptides identified as contained within the sample by the repeated analysis. The method then calculates the probability that a specific peptide in the data set was detected in the repeated analysis. The method then creates a plurality of vectors, where each vector has a plurality of dimensions, and each dimension represents a property of one or more of the amino acids present in each peptide and adjacent peptides in the data set. Using these vectors, the method then generates an algorithm from the plurality of vectors and the calculated probabilities that specific peptides in the data set were detected in the repeated analysis. The algorithm is thus capable of calculating the probability that a hypothetical peptide represented as a vector will be detected by a mass spectrometry based proteomic platform, given that the peptide is present in a sample introduced into a mass spectrometer.

摘要翻译： 通过用质谱仪分析来检测存在于生物样品中的肽的方法。 该方法使用至少一种质谱仪对含有已知氨基酸的蛋白质的含有肽的样品进行重复分析。 然后，该方法通过重复分析产生被鉴定为包含在样品内的肽的数据集。 然后，该方法计算在重复分析中检测到数据集中的特定肽的概率。 该方法然后创建多个向量，其中每个载体具有多个维度，并且每个维度表示存在于每个肽中的一个或多个氨基酸和数据集中的相邻肽的性质。 使用这些向量，该方法然后从多个向量生成算法，并且在重复分析中检测出数据集中的特定肽的计算概率。 因此，鉴于该肽存在于引入质谱仪的样品中，该算法因此能够计算出通过基于质谱的蛋白质组学平台检测表示为载体的假定肽的概率。

公开(公告)号：US20070228349A1

公开(公告)日：2007-10-04

申请号：US11393972

申请日：2006-03-30

申请人： Richard Smith

发明人： Richard Smith

IPC分类号： E01F7/02

CPC分类号： E01F13/028 ,  E04H12/2215

摘要： An assembly for creating a portable enclosure includes a plurality of individual and elongated ground engaging units, each having an elongated body and an end extending ground engaging portion. A magazine fixedly secures in vertically extending fashion along each of the units, a screen adapted to being withdrawn from the magazine and including hooks defined along a forward withdrawable edge. A plurality of rings extend along a further vertically extending edge associated with each of the units, and which is adapted to receive the hooks associated with a screen withdrawn from a succeeding located unit, in order to construct a barrier between the units.

摘要翻译： 用于创建便携式外壳的组件包括多个单独和细长的地面接合单元，每个具有细长主体和延伸地面接合部分的端部。 盒子沿着每个单元以垂直延伸的方式固定地固定，一个适于从盒中取出并包括沿着可向前抽出的边缘限定的钩子的屏幕。 多个环沿着与每个单元相关联的另一个垂直延伸的边缘延伸，并且其适于接收与从后续位置单元退出的屏幕相关联的钩，以便在单元之间构造屏障。

公开(公告)号：US20070194224A1

公开(公告)日：2007-08-23

申请号：US11346799

申请日：2006-02-02

申请人： Keqi Tang ,  Jason Page ,  Quanzhou Luo ,  Richard Smith

发明人： Keqi Tang ,  Jason Page ,  Quanzhou Luo ,  Richard Smith

IPC分类号： H01J49/10

CPC分类号： H01J49/167 ,  G01N30/7266

摘要： Electrospray ionization (ESI) apparatuses and methods of making the same are disclosed. In one embodiment, an ESI emitter comprises a capillary tube filled with a porous monolithic material, wherein the end of the emitter is tapered and the tip of the tapered end comprises a protrusion of the porous monolithic material. One embodiment of the method for making ESI emitters comprises filling a capillary tube with a porous monolithic material and tapering the end of the capillary tube, thereby exposing a portion of the porous material. The exposed portion of the porous material at the tapered end, rather than the capillary tube itself, forms the tip of the ESI emitter.

摘要翻译： 公开了电喷雾离子化（ESI）装置及其制备方法。 在一个实施例中，ESI发射器包括填充有多孔整体材料的毛细管，其中发射器的端部是锥形的，锥形末端包括多孔整体材料的突起。 用于制备ESI发射器的方法的一个实施例包括用多孔整体材料填充毛细管并使毛细管的端部逐渐变细，由此暴露多孔材料的一部分。 锥形端部的多孔材料的暴露部分而不是毛细管本身形成ESI发射体的尖端。

公开(公告)号：US20070191411A1

公开(公告)日：2007-08-16

申请号：US11246883

申请日：2005-10-07

申请人： Richard Smith

发明人： Richard Smith

IPC分类号： A61K31/485 ,  A61K31/4745

CPC分类号： A61K31/485 ,  A61K31/4709 ,  A61K31/4745 ,  A61K45/06 ,  A61K47/22 ,  A61K2300/00

摘要： During clinical trials on patients suffering from neurological disorders, it has been observed that some patients obtain dramatic improvements in motor control and/or higher mental functioning, when they receive a combination of dextromethorphan and quinidine, at suitable dosages. Improved motor control has been exemplified to date by improved ability to swallow and/or speak, among victims of stroke, head injury, or ALS. Improved higher mental functioning has been exemplified better job performance, increased ability to analyze and solve problems, and increased ability to have successful and satisfying interactions with other people. These types of effects can be seen in a relatively brief time period, such as within several days to a week.

摘要翻译： 在对患有神经障碍的患者的临床试验期间，已经观察到，当以合适的剂量接受右美沙芬和奎尼丁的组合时，一些患者在运动控制和/或较高的精神功能方面获得显着改善。 在中风，头部受伤或ALS的受害者中，通过改善吞咽和/或说话的能力，已经改进了运动控制。 改善了更高的心理功能已被列为更好的工作表现，增加分析和解决问题的能力，以及增加与其他人取得成功和令人满意的互动的能力。 这些类型的效果可以在相对短的时间内看到，例如在几天到一周之内。

公开(公告)号：US20070135679A1

公开(公告)日：2007-06-14

申请号：US11301912

申请日：2005-12-13

申请人： John Hunt ,  Michael Cropper ,  Richard Smith ,  Richard Schwemberger ,  John Measamer

发明人： John Hunt ,  Michael Cropper ,  Richard Smith ,  Richard Schwemberger ,  John Measamer

IPC分类号： A61B1/00

CPC分类号： A61B1/31 ,  A61B1/00154 ,  A61B17/3421 ,  A61B17/3462 ,  A61B2017/3452 ,  A61B2017/347 ,  A61B2017/3492

摘要： A colonoscopic device stabilizer for stabilizing a colonoscopic device when inserted in an anus of a patient. The stabilizer includes a body adapted for receipt within the anus of a patient. The body has an opening sized and shaped for receiving the colonoscopic device when the device is inserted in the anus of the patient. The stabilizer also includes a clamp attached to the body selectively moveable between a locked position in which the clamp resists movement of the colonoscopic device relative to the body and an unlocked position in which the clamp permits movement of the colonoscopic device relative to the body.

摘要翻译： 一种用于在插入患者肛门时稳定结肠镜装置的结肠镜装置稳定器。 稳定器包括适于在患者的肛门内接收的主体。 身体具有开口尺寸和形状，用于当将装置插入患者的肛门时接收结肠镜装置。 稳定器还包括附接到身体的夹具，其选择性地可在其中夹具抵抗结肠镜检查装置相对于身体的移动的锁定位置和夹具允许结肠镜装置相对于身体移动的解锁位置之间移动。

公开(公告)号：US20070020647A1

公开(公告)日：2007-01-25

申请号：US11354559

申请日：2006-02-14

申请人： Gregory Hageman ,  Richard Smith

发明人： Gregory Hageman ,  Richard Smith

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  A61K9/0048 ,  C07K14/435 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.

摘要翻译： 本发明涉及与升高或降低的AMD风险相关的因子H基因多态性和单体型。 本发明提供用于诊断和治疗AMD的方法和试剂。

公开(公告)号：US20070007939A1

公开(公告)日：2007-01-11

申请号：US11436964

申请日：2006-05-16

申请人： John Miller ,  Richard Smith

发明人： John Miller ,  Richard Smith

IPC分类号： G05F5/00

CPC分类号： B60K6/28 ,  B60K6/26 ,  B60K6/365 ,  B60K6/445 ,  B60K6/448 ,  B60L50/16 ,  B60L50/40 ,  B60L50/61 ,  B60L58/20 ,  B60L2210/12 ,  B60L2210/14 ,  F16H2037/102 ,  Y02T10/6217 ,  Y02T10/6239 ,  Y02T10/6243 ,  Y02T10/7005 ,  Y02T10/7022 ,  Y02T10/7066 ,  Y02T10/7077 ,  Y02T10/7225 ,  Y02T10/7233

摘要： A hybrid vehicle propulsion system with a double-layer capacitor is provided. A low voltage double-layer capacitor energy storage system provides power to a hybrid vehicle propulsion system. A boost converter boosts the voltage of the double-layer capacitor system to a higher operating voltage to power at least one motor/generator of the propulsion system.

摘要翻译： 提供了具有双层电容器的混合动力车辆推进系统。 低压双层电容器能量存储系统为混合动力车辆推进系统提供动力。 升压转换器将双层电容器系统的电压升高到更高的工作电压，以为推进系统的至少一个电动机/发电机供电。

公开(公告)号：US20060291623A1

公开(公告)日：2006-12-28

申请号：US11453546

申请日：2006-06-14

申请人： Richard Smith ,  Robert Madden ,  James Connelly

发明人： Richard Smith ,  Robert Madden ,  James Connelly

IPC分类号： G21K5/10

CPC分类号： G01V5/0025 ,  G01N23/20 ,  G01V5/0016 ,  G21K1/02

摘要： An angular analysis system that can be controlled to receive radiation at a defined angle from a defined focus region. The angular analysis system is used for level 2 inspection in an explosive detection system. Level 2 inspection is provided by a three-dimensional inspection system that identifies suspicious regions of items under inspection. The angular analysis system is focused to gather radiation scattered at defined angles from the suspicious regions. Focusing may be achieved in multiple dimensions by movement of source and detector assemblies in a plane parallel to a plane holding the item under inspection. Focusing is achieved by independent motion of the source and detector assemblies. This focusing arrangement provides a compact device, providing simple, low cost and accurate operation.

公开(公告)号：US20060267468A1

公开(公告)日：2006-11-30

申请号：US11500999

申请日：2006-08-09

申请人： John Myers ,  Douglas Pohl ,  Richard Smith

发明人： John Myers ,  Douglas Pohl ,  Richard Smith

IPC分类号： A47B96/04

CPC分类号： F25D23/066 ,  F25D2400/04

摘要： A refrigerator cabinet includes a shell having first and second laterally spaced, upstanding side walls that are interconnected by a top wall, each of the walls includes an in-turned front edge portion defining a liner receiving cavity. The shell further includes a mullion bar, which partitions the shell into first and second liner cavities, and a base member. Both the mullion bar and base member have respective liner receiving portions. With this arrangement, first and second liners are adapted to be inserted into their respective cavities and flexed such that three sides are inserted into the liner receiving cavities, while the remaining side is positioned against a land of the mullion bar or base member. Once in place, the liners are secured through a mullion bar cover and a base member cover. This construction combines the benefits of a front-load process with that of a flex-load process, lowering assembly time without the need to reinforce the liner.

摘要翻译： 冰箱包括壳体，其具有通过顶壁互连的第一和第二横向间隔的直立侧壁，每个壁包括限定衬套接收腔的转向前边缘部分。 壳体还包括将壳分隔成第一和第二衬里空腔的竖框，以及基部构件。 竖框和底部构件都具有相应的衬套接收部分。 利用这种布置，第一和第二衬里适于插入其相应的空腔中并弯曲，使得三个侧面插入到衬套容纳空腔中，而剩余的侧面位于竖框或底座构件的平台上。 一旦到位，衬垫通过竖框杆盖和基座盖固定。 这种结构将前负载过程的优点与柔性加载过程的优点相结合，降低了组装时间，而不需要加固衬套。

公开(公告)号：US20060242230A1

公开(公告)日：2006-10-26

申请号：US11113033

申请日：2005-04-25

申请人： Richard Smith ,  Johanna Wilson

发明人： Richard Smith ,  Johanna Wilson

IPC分类号： G06F15/16

CPC分类号： H04W4/14 ,  H04L12/66 ,  H04L29/06 ,  H04L67/02 ,  H04L69/08 ,  H04W88/184

摘要： A mobile device-to-HTTP protocol gateway (MHG, or “MO Gateway”) which translates between Wireless Mobile Originated commands from an SMSC, and an application server on the Internet (i.e., a “web IP Server”). A wireless Internet gateway establishes communications with one or more relevant SMSCs using standard format SMPP commands, and the MHG utilizes HTTP protocol POST messages to post short messages originated at the mobile device to a particular URL. Return results are received by the MHG via HTTP protocol messages, translated to SMPP messages, and forwarded back to the SMSC for delivery to the mobile device. The wireless Internet Gateway communicates with the MHG using RMI protocol commands. An MHG in accordance with the principles of the present invention enables a developer to create mobile applications using standard web development tools, e.g., Java Servlets. The MHG allows standard format command messages to be used throughout the pathway between a mobile device and an application program on a web IP server at a particular URL.

摘要翻译： 在SMSC的无线移动发起命令和互联网上的应用服务器（即，“Web IP服务器”）之间转换的移动设备到HTTP协议网关（MHG或“MO网关”）。 无线因特网网关使用标准格式的SMPP命令建立与一个或多个相关SMSC的通信，并且MHG利用HTTP协议POST消息将在移动设备发起的短消息发布到特定URL。 返回结果由MHG通过HTTP协议消息接收，转换为SMPP消息，并转发回SMSC以传送到移动设备。 无线因特网网关使用RMI协议命令与MHG进行通信。 根据本发明的原理的MHG使得开发者能够使用标准web开发工具（例如Java Servlet）来创建移动应用。 MHG允许在特定URL的Web IP服务器上的移动设备和应用程序之间的整个路径中使用标准格式命令消息。