公开(公告)号：US08859205B2

公开(公告)日：2014-10-14

申请号：US12683950

申请日：2010-01-07

Applicant: Xiao-Song Gong ,  John Sullivan ,  Rongdian Fu ,  Yan Wang ,  Evan H. Bursey ,  Man Cheng

Inventor： Xiao-Song Gong ,  John Sullivan ,  Rongdian Fu ,  Yan Wang ,  Evan H. Bursey ,  Man Cheng

IPC: C12Q1/68 ,  C12P19/34 ,  C07K1/00 ,  C12N9/12 ,  C07K16/40

CPC classification number: C12P19/34 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2319/80 ,  C12N9/1252 ,  C12Q1/6804 ,  C12Q1/686 ,  C12Q2531/113 ,  C12Q2527/125 ,  C12Q2521/101

Abstract: The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonuclease activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.

Abstract translation: 本发明提供了提高核酸扩增反应效率的方法和组合物。 本发明包括显示比野生型聚合酶增加的活性以及降低的外切核酸酶活性的杂合聚合酶。 本发明还包括用于进行核酸合成和扩增反应的方法，组合物和试剂盒，其中引物的非特异性扩增减少。

公开(公告)号：US08377133B2

公开(公告)日：2013-02-19

申请号：US12721485

申请日：2010-03-10

Applicant: Hansen Yuan ,  Matthew F. Gornet ,  John Sullivan ,  Jeffrey L. Trudeau ,  Brian P. Janowski

Inventor： Hansen Yuan ,  Matthew F. Gornet ,  John Sullivan ,  Jeffrey L. Trudeau ,  Brian P. Janowski

IPC: A61F2/44

CPC classification number: A61F2/44 ,  A61B17/1671 ,  A61B17/1757 ,  A61F2/30965 ,  A61F2/4425 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/3008 ,  A61F2002/30112 ,  A61F2002/30383 ,  A61F2002/30387 ,  A61F2002/30393 ,  A61F2002/30485 ,  A61F2002/30492 ,  A61F2002/305 ,  A61F2002/30571 ,  A61F2002/30578 ,  A61F2002/30579 ,  A61F2002/30594 ,  A61F2002/30601 ,  A61F2002/30662 ,  A61F2002/30677 ,  A61F2002/30823 ,  A61F2002/30841 ,  A61F2002/30846 ,  A61F2002/30884 ,  A61F2002/30894 ,  A61F2002/30899 ,  A61F2002/30904 ,  A61F2002/449 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2220/0025 ,  A61F2230/0004 ,  A61F2250/0098 ,  A61F2310/00407 ,  A61F2310/00796

Abstract: A prosthetic spinal implant having a securing member for fixing the implant relative to an adjacent bone. In one form, the securing member is deployable into a portion of the vertebral space for affixing the implant between the vertebrae. The securing member may be disposed substantially within the body of a bearing member of the implant when the securing member is in an undeployed orientation. In other forms, the securing member is provided separately from the implant such that it may be inserted into the intervertebral space after the implant has been placed in an implanted orientation between the vertebrae. In such forms, the securing member is configured for ease of insertion between an outer bearing surface of the implant and an adjacent bone via linear or rotary motion.

Abstract translation: 一种假体脊柱植入物，其具有用于相对于相邻骨固定植入物的固定构件。 在一种形式中，固定构件可展开到脊椎空间的一部分中，用于将植入物固定在椎骨之间。 当固定构件处于取消部署方向时，固定构件可以基本上设置在植入物的轴承构件的主体内。 在其它形式中，固定构件与植入物分开设置，使得其可以在植入物被植入在椎骨之间的植入方位之后插入到椎间空间中。 在这种形式中，固定构件构造成便于通过线性或旋转运动在植入物的外承载表面和相邻骨之间插入。

公开(公告)号：US20120254404A1

公开(公告)日：2012-10-04

申请号：US13101643

申请日：2011-05-05

Applicant: Michael Shane Wilkinson ,  Thomas Bause ,  Arturo Vermolen ,  Sheau Ng ,  John Sullivan

Inventor： Michael Shane Wilkinson ,  Thomas Bause ,  Arturo Vermolen ,  Sheau Ng ,  John Sullivan

IPC: G06F15/173

CPC classification number: H04L67/303 ,  G06F16/185 ,  G06F16/41 ,  G06Q30/02 ,  H04N21/2407 ,  H04N21/25808 ,  H04N21/25866 ,  H04N21/2668 ,  H04N21/44008 ,  H04N21/4788 ,  H04N21/6582 ,  H04N21/8352 ,  H04N21/8358 ,  H04N21/84

Abstract: A multi-tiered approach to identifying digital content and acting upon the identification includes transmitting data from a device on which the content is stored or played to a first tier entity where the content and the device are identified. The first tier entity may use any one of many techniques for identifying the data and device. Once the identification data is determined, the information is transmitted to any one of multiple second tier entities that work in cooperation with the first tier entity. The second tier entities may then perform any desired functions based on the identification, such as providing offers, content, products and/or services to the device, or to other devices associated with the device or the device user. Other tiers may be employed for carrying out particular functions or activities, such as under the direction of the second tier entities.

Abstract translation: 识别数字内容并对标识作用的多层次方法包括从内容被存储或播放的设备将数据发送到识别内容和设备的第一层实体。 第一层实体可以使用用于识别数据和设备的许多技术中的任何一种。 一旦确定了识别数据，该信息被传送到与第一层实体协同工作的多个第二层实体中的任一个。 然后，第二层实体可以基于标识执行任何期望的功能，例如向设备或与设备或设备用户相关联的其他设备提供优惠，内容，产品和/或服务。 其他层可用于执行特定功能或活动，例如在第二层实体的指导下。

公开(公告)号：US20120061522A1

公开(公告)日：2012-03-15

申请号：US12807727

申请日：2010-09-13

Applicant: John Sullivan ,  Collin Robert Sullivan

Inventor： John Sullivan ,  Collin Robert Sullivan

IPC: B64C3/14 ,  F03D11/04 ,  F03D7/04 ,  F03D1/00

CPC classification number: F03D1/0633 ,  B64C3/10 ,  B64C3/14 ,  B64C3/16 ,  F03D3/061 ,  F05B2250/611 ,  F05B2260/96 ,  Y02E10/721 ,  Y02E10/74 ,  Y02T50/12

Abstract: This invention uses a novel shape of airfoil to achieve an improved lift to drag ratio and to improve performance at higher angles of attack. The airfoil has a three dimensional wave pattern that modifies the shape of a traditional airfoil to coordinate the airflow through channels on both the top and bottom sides. The uniquely shaped airfoil of this invention could have many uses including a wind turbine blade. This invention not only provides for a more efficient device by improving the effective angle of attack and lift/drag ratio, but also provides for a quiet airflow thus greatly reducing nuisance noise over conventional devices.

Abstract translation: 本发明使用翼型的新颖形状来获得改进的提升阻力比并且在较高的迎角下提高性能。 翼型件具有三维波纹，其改变传统翼型的形状，以通过顶部和底部两侧的通道来协调气流。 本发明的独特形状的翼型件可以具有许多用途，包括风力涡轮机叶片。 本发明不仅通过提高有效的迎角和提升/阻力比来提供更有效的装置，而且还提供了一种安静的气流，从而大大减少了传统装置的麻烦噪音。

公开(公告)号：US20110054535A1

公开(公告)日：2011-03-03

申请号：US12871893

申请日：2010-08-30

Applicant: Matthew P. Gephart ,  Thomas S. Kilpela ,  John Sullivan

Inventor： Matthew P. Gephart ,  Thomas S. Kilpela ,  John Sullivan

IPC: A61B17/70 ,  A61B17/88

CPC classification number: A61B17/7004 ,  A61B17/7025 ,  A61B17/7026 ,  A61B17/7031 ,  A61B17/705

Abstract: Spinal rods are provided that transition from one diameter to another without an extended transition region to which coupling devices may not be attached, allowing coupling devices for mounting the spinal rod to the spine to be secured almost anywhere along the rod's length without having a weakened transition point.

Abstract translation: 提供脊柱，其从一个直径转换到另一个直径，而没有延伸的过渡区域，耦合装置可能不连接到该过渡区域，允许用于将脊柱杆安装到脊柱上的联接装置几乎沿杆长度的任何位置被固定，而没有弱化的转变 点。

公开(公告)号：US20110041544A1

公开(公告)日：2011-02-24

申请号：US12546647

申请日：2009-08-24

Applicant: Tom Ferguson ,  Mark Balog ,  Mark Gumbel ,  Marie Prugar ,  John Sullivan

Inventor： Tom Ferguson ,  Mark Balog ,  Mark Gumbel ,  Marie Prugar ,  John Sullivan

IPC: F25D3/00 ,  A63H5/00

CPC classification number: B65D81/3876 ,  B65D2203/12

Abstract: An insulating can cooler, which plays sounds. The cooler consists of a cylindrical enclosure, which is open on top and enclosed on the bottom. The cooler also consists of a sound device that will activate when a can or bottle is inserted in or extracted from the cooler. Have the ability to record a sound when a button is held in for a period of time; and the ability to download music from the Internet or other devices; and the ability to shut off and change the sound with a switch.

Abstract translation: 一个绝热的冷却器，播放声音。 冷却器由圆柱形外壳组成，顶部敞开，封闭在底部。 冷却器还包括一个声音装置，当罐子或瓶子被插入或从冷却器中抽出时，该装置将被激活。 当按钮持续一段时间时，有能力录制声音; 以及从互联网或其他设备下载音乐的能力; 以及通过开关切断和更改声音的能力。

公开(公告)号：US20100064061A1

公开(公告)日：2010-03-11

申请号：US12205085

申请日：2008-09-05

Applicant: Daniel A. Warren ,  Matthew Rogers ,  John Sullivan

Inventor： Daniel A. Warren ,  Matthew Rogers ,  John Sullivan

IPC: G06F3/00

CPC classification number: G06F3/0418 ,  G06F3/0416

Abstract: Apparatus and methods for setting up an action on an electronic device before an input is confirmed and performing the action once the input is confirmed are provided. The amount of time needed to perform the action in response to detecting an input may be reduced by an amount of time equivalent to the lesser of the wait time used to confirm the input or the time needed to set up the action. The electronic device may set up a predicted action to be performed substantially immediately following confirmation of the input.

Abstract translation: 提供在确认输入之前在电子设备上建立动作的装置和方法，并且一旦输入被确认就执行该动作。 响应于检测到输入而执行动作所需的时间量可以减少等于用于确认输入的等待时间中较小的时间的时间量或设置动作所需的时间。 电子设备可以在确认输入之后基本上立即执行预设动作。

公开(公告)号：US20090210205A1

公开(公告)日：2009-08-20

申请号：US12033133

申请日：2008-02-19

Applicant: John Sullivan ,  Harlan Yates ,  Mark Rahmes ,  Timothy B. Faulkner ,  Brian Hicks

Inventor： John Sullivan ,  Harlan Yates ,  Mark Rahmes ,  Timothy B. Faulkner ,  Brian Hicks

IPC: G06G7/48

CPC classification number: G06T17/05 ,  G06K9/00657 ,  G06T17/10

Abstract: A geospatial modeling system may include a geospatial model data storage device containing geospatial model data including a plurality of groups of tree crown vegetation points and a display. The system may further include a processor cooperating with the geospatial model data storage device and the display for displaying a simulated tree trunk beneath a group of tree crown vegetation points, and displaying at least one level of simulated tree branches for the simulated tree trunk. Each tree branch may be positioned based upon determining a branch distal reference point beneath a cluster of tree crown vegetation points from among the group of tree crown vegetation points.

Abstract translation: 地理空间建​​模系统可以包括包含地理空间模型数据的地理空间模型数据存储设备，该地理空间模型数据包括多组树冠植被点和显示器。 该系统还可以包括与地理空间模型数据存储装置和显示器配合的处理器，用于在一组树冠植被点下方显示模拟树干，并为模拟树干显示至少一个模拟树枝的水平。 每个树枝可以基于确定树冠植被点群中的树冠植被点簇之下的分支远端参考点来定位。

公开(公告)号：US07396914B2

公开(公告)日：2008-07-08

申请号：US10911838

申请日：2004-08-04

Applicant: Donna Ambrosino ,  Hector Hernandez ,  Thomas Greenough ,  Katherine Luzuriaga ,  Mohan Somasundaran ,  Gregory J. Babcock ,  William D. Thomas, Jr. ,  John Sullivan

Inventor： Donna Ambrosino ,  Hector Hernandez ,  Thomas Greenough ,  Katherine Luzuriaga ,  Mohan Somasundaran ,  Gregory J. Babcock ,  William D. Thomas, Jr. ,  John Sullivan

IPC: C12P21/08 ,  C07K16/00

CPC classification number: A61K39/215 ,  A01K2267/01 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/55566 ,  C07H21/04 ,  C07K14/005 ,  C07K16/10 ,  C07K2317/21 ,  C07K2317/34 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12Q1/701 ,  G01N33/56983 ,  G01N2333/165

Abstract: Codon-optimized nucleic acids, polypeptides, and antibodies are described herein.

Abstract translation: 密码子优化的核酸，多肽和抗体在本文中描述。

公开(公告)号：US20060230121A1

公开(公告)日：2006-10-12

申请号：US11104319

申请日：2005-04-12

Applicant: Karla Arndt ,  Mark Cavage ,  John McGarvey ,  John Sullivan

Inventor： Karla Arndt ,  Mark Cavage ,  John McGarvey ,  John Sullivan

IPC: G06F15/16

CPC classification number: G06F17/30575 ,  H04L61/1523 ,  H04L67/10 ,  H04L67/2814 ,  Y10S707/99933 ,  Y10S707/99953

Abstract: A system and method for autonomically maintaining group referential integrity across a distributed directory. When a server receives an operation request from a client regarding an entry in the distributed directory, the server sends a request to the particular server containing the entry to be modified that instructs the server to modify the entry, but without performing a referential integrity check. The server then determines whether the request returned successfully. If so, the server sends a request to each server in the network to perform the requested operation on all group references for the entry, but without actually performing the requested operation on the entry itself. If all of these requests return successfully, the server notifies the requesting client that the requested operation has been performed.

Abstract translation: 一种用于在分布式目录中自主维护组参照完整性的系统和方法。 当服务器从客户端收到关于分发目录中的条目的操作请求时，服务器向包含要修改的条目的特定服务器发送请求，指示服务器修改条目，但不执行参照完整性检查。 然后，服务器确定请求是否成功返回。 如果是这样，服务器向网络中的每个服务器发送一个请求，以便对该条目的所有组引用执行所请求的操作，但是实际上不对该条目执行所请求的操作。 如果所有这些请求都成功返回，则服务器通知请求客户机已执行所请求的操作。