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113 条记录 (耗时 0.039 秒)

    Deflected septum seal access port
    63.
    发明授权
    Deflected septum seal access port 失效
    偏转隔膜密封件进入口

    公开(公告)号：US5882601A

    公开(公告)日：1999-03-16

    申请号：US877986

    申请日：1997-06-18

    申请人： Gary S. Kath ,  Lihu Yang ,  Gregory W. King

    发明人： Gary S. Kath ,  Lihu Yang ,  Gregory W. King

    IPC分类号： B01J19/00 ,  C40B60/14 ,  G01N1/00 ,  G01N30/18 ,  B01L3/02

    CPC分类号： G01N35/1079 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00335 ,  C40B60/14 ,  G01N2030/185 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： An access port for a reaction or other fluid vessel which maintains the vessel under an inert gas atmosphere and maintains the integrity of the inert gas seal while performing filtered filling or draining operations is presented. The port uses a deflected septum sealing technique. The invention can be used for a number of laboratory and clinical operations on a variety of size and shape vessels. The combination of the appropriate vessel with this access port is very well suited for use in lab automation systems, such as automated solid phase chemical synthesis, biological screening, combinatorial chemistry and other areas where reaction chemistry is conducted.

    摘要翻译： 提供用于反应或其它流体容器的进入口，其将容器保持在惰性气体气氛下并且在执行过滤的填充或排出操作时保持惰性气体密封的完整性。 港口采用偏转隔膜密封技术。 本发明可用于多种尺寸和形状的血管的多个实验室和临床操作。 适当的容器与该进出口的组合非常适用于实验室自动化系统，例如自动化固相化学合成，生物筛选，组合化学和其他进行反应化学反应的区域。

    Piperidines and hexahydro-1H-azepines spiro substituted at the 4-position promote release of growth hormone
    64.
    发明授权
    Piperidines and hexahydro-1H-azepines spiro substituted at the 4-position promote release of growth hormone 失效
    在4-位上被螺环取代的哌啶和六氢-1H-吖庚因促进生长激素的释放

    公开(公告)号：US5783582A

    公开(公告)日：1998-07-21

    申请号：US776041

    申请日：1997-01-16

    申请人： Liangquin Guo ,  Arthur Patchett ,  Lihu Yang

    发明人： Liangquin Guo ,  Arthur Patchett ,  Lihu Yang

    IPC分类号： C07D471/10 ,  A01N43/42 ,  A61K31/44 ,  C07D211/00

    CPC分类号： C07D471/10

    摘要： Di and trisubstituted Piperidines, pyrrolidines and hexahydro-1H-azepines which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible mea products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such di- and trisubstituted piperidines and pyrrolidines as the active ingredient thereof are also disclosed.

    摘要翻译： PCT No.PCT / US95 / 08854 Sec。 371日期1997年1月16日 102（e）日期1997年1月16日PCT提交1995年7月17日PCT公布。 公开号WO96 / 02530 日期1996年2月1日Di和促进人和动物中生长激素释放的三取代哌啶，吡咯烷和六氢-1H-吖庚因。 这种性质可以用于促进食用动物的生长，使食用食品的生产更有效，并且在人类中，以治疗生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童和治疗由生长激素的合成代谢作用改善的医疗状况。 还公开了含有这种二取代和三取代的哌啶和吡咯烷作为其活性成分的生长激素释放组合物。

    4-Heterocyclic peperidines promote release of growth hormone
    65.
    发明授权
    4-Heterocyclic peperidines promote release of growth hormone 失效
    4-杂环peperidines促进生长激素的释放

    公开(公告)号：US5767118A

    公开(公告)日：1998-06-16

    申请号：US329357

    申请日：1994-10-26

    申请人： Ravi Nargund ,  Arthur A. Patchett ,  Lihu Yang

    发明人： Ravi Nargund ,  Arthur A. Patchett ,  Lihu Yang

    IPC分类号： A23K1/16 ,  A61K31/66 ,  A61K38/00 ,  A61K38/04 ,  A61K38/27 ,  A61P3/04 ,  A61P5/00 ,  A61P17/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07K5/06 ,  A61K31/535 ,  A01N43/40 ,  A01N43/54 ,  A61K31/54 ,  C07D211/36 ,  C07D211/68 ,  C07D401/00 ,  C07D409/00

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14

    摘要： The present invention is directed to certain novel compounds identified as 4-heterocycle substituted piperidines of the general structural formula: ##STR1## wherein R.sup.1, R.sup.4, R.sup.5, A, R.sup.3 and the dashed line are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及鉴定为以下结构式的4-杂环取代的哌啶的某些新化合物：其中R1，R4，R5，A，R3和虚线如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。

    Treatment of osteoporosis with substituted piperidines, pyrrolidines and hexahydro-1H-azepines in combination with bisphosphonates
    67.
    发明授权
    Treatment of osteoporosis with substituted piperidines, pyrrolidines and hexahydro-1H-azepines in combination with bisphosphonates 失效
    用取代的哌啶，吡咯烷和六氢-1H-吖庚因与双膦酸盐组合治疗骨质疏松症

    公开(公告)号：US5622973A

    公开(公告)日：1997-04-22

    申请号：US464982

    申请日：1995-06-05

    申请人： Gregori J. Morriello ,  Arthur A. Patchett ,  Lihu Yang

    发明人： Gregori J. Morriello ,  Arthur A. Patchett ,  Lihu Yang

    IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/083 ,  A61K31/445 ,  A61K31/41 ,  A61K31/425 ,  A61K31/505

    CPC分类号： C07K5/06139 ,  C07K5/0202 ,  C07K5/06034 ,  C07K5/0808 ,  A61K38/00

    摘要： The present invention is directed to certain novel compounds identified as di- and tri-substituted piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R.sub.1, R.sub.4, R.sub.5, A, X, Y, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such di and tri substituted piperidines, pyrrolidines, and hexahydro-1H-azepines as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及鉴定为二 - 和三 - 取代的哌啶，吡咯烷和六氢-1H-吖庚因的一些新化合物，其通式为：其中R1，R4，R5，A，X，Y和 n如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这种二取代和三取代的哌啶，吡咯烷酮和六氢-1H-吖庚因作为其活性成分的生长激素释放组合物。

    Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
    68.
    发明授权
    Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone 失效
    二取代和三取代的哌啶，吡咯烷和六氢-1H-吖庚因促进生长激素的释放

    公开(公告)号：US5492916A

    公开(公告)日：1996-02-20

    申请号：US323988

    申请日：1994-10-17

    申请人： Gregori J. Morriello ,  Arthur A. Patchett ,  Lihu Yang

    发明人： Gregori J. Morriello ,  Arthur A. Patchett ,  Lihu Yang

    IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/083 ,  A61K31/445 ,  C07D209/04 ,  C07D401/06

    CPC分类号： C07K5/06139 ,  C07K5/0202 ,  C07K5/06034 ,  C07K5/0808 ,  A61K38/00

    摘要： The present invention is directed to certain novel compounds identified as di- and tri-substituted piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R.sub.1, R.sub.4, R.sub.5, A,X,Y, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such di and tri substituted piperidines, pyrrolidines, and hexahydro-1H-azepines as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及鉴定为二 - 和三 - 取代的哌啶，吡咯烷和六氢-1H-吖庚因的一些新化合物，其通式为：其中R1，R4，R5，A，X，Y和 n如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这种二取代和三取代的哌啶，吡咯烷酮和六氢-1H-吖庚因作为其活性成分的生长激素释放组合物。

    EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS
    69.
    发明申请
    EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS 有权
    使用芒硝转移酶抑制剂有效生产异位蛋白

    公开(公告)号：US20130316398A1

    公开(公告)日：2013-11-28

    申请号：US13588022

    申请日：2012-08-17

    申请人： RANJIT DESAI ,  Lihu Yang

    发明人： RANJIT DESAI ,  Lihu Yang

    IPC分类号： C12P21/00 ,  C07D277/36

    CPC分类号： C12P21/005 ,  C07D277/36 ,  C12P21/02

    摘要： Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.

    摘要翻译： 描述了用于生产具有降低量的O-连接糖基化的蛋白质组合物的化合物和方法。 该方法包括在某些亚苄基噻唑烷二酮类Pmt介导的O-连接糖基化抑制剂存在下培养的细胞中产生蛋白质。

    Efficient production of heterologous proteins using mannosyl transferase inhibitors
    70.
    发明授权
    Efficient production of heterologous proteins using mannosyl transferase inhibitors 有权
    使用甘露糖基转移酶抑制剂有效生产异源蛋白

    公开(公告)号：US08309325B2

    公开(公告)日：2012-11-13

    申请号：US12993716

    申请日：2009-05-18

    申请人： Ranjit Desai ,  Lihu Yang

    发明人： Ranjit Desai ,  Lihu Yang

    IPC分类号： C12P21/02 ,  C07D277/36

    CPC分类号： C12P21/005 ,  C07D277/36 ,  C12P21/02

    摘要： Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.

    摘要翻译： 描述了用于生产具有降低量的O-连接糖基化的蛋白质组合物的化合物和方法。 该方法包括在某些亚苄基噻唑烷二酮类Pmt介导的O-连接糖基化抑制剂存在下培养的细胞中产生蛋白质。