公开(公告)号：US09072059B2

公开(公告)日：2015-06-30

申请号：US13518476

申请日：2009-12-23

申请人： Klaus Ingemann Pedersen ,  Luis Garcia

发明人： Klaus Ingemann Pedersen ,  Luis Garcia

IPC分类号： H04B7/00 ,  H04W52/24

CPC分类号： H04W52/243

摘要： When it is determined that a first estimate of the total level of interference towards transmissions associated with a first access node from transmissions associated with other access nodes exceeds a predetermined target maximum value; then in dependence on the extent to which said first estimate exceeds said target maximum value, selecting one or more of said other access nodes to which to make a request to reduce the transmission power of interfering transmissions, and/or selecting an amount by which to request any one or more of said other access nodes to reduce the transmission power of interfering transmissions.

摘要翻译： 当确定从与其他接入节点相关联的传输到与第一接入节点相关联的传输的总干扰水平的第一估计超过预定目标最大值时; 然后根据所述第一估计超过所述目标最大值的程度，选择一个或多个所述其他接入节点，以向其请求以降低干扰传输的传输功率，和/或选择一个 请求任何一个或多个所述其他接入节点以降低干扰传输的传输功率。

公开(公告)号：US08934932B2

公开(公告)日：2015-01-13

申请号：US13322997

申请日：2009-05-29

申请人： Klaus Ingemann Pedersen ,  Luis Garcia

发明人： Klaus Ingemann Pedersen ,  Luis Garcia

IPC分类号： H04W16/10

CPC分类号： H04W16/10

摘要： In a communication network including a plurality of base stations, a method including the steps of: sending a signal from said base station indicating that it will enter a period of inactivity, to at least one other base station; storing at that least one current parameter(s) relating to interference between base stations and/or updating said parameter(s) for forward use. The parameter(s) may relate to interference between first base station and at least one operationally neighboring base station and may be Background Interference Matrix (BIM) data.

摘要翻译： 在包括多个基站的通信网络中，一种方法包括以下步骤：向至少一个其他基站发送指示其将进入非活动时段的来自所述基站的信号; 存储与基站之间的干扰有关的至少一个当前参数和/或更新所述参数以供正向使用。 参数可以涉及第一基站与至少一个操作上相邻的基站之间的干扰，并且可以是背景干扰矩阵（BIM）数据。

公开(公告)号：US20140107186A1

公开(公告)日：2014-04-17

申请号：US14004379

申请日：2012-03-12

申请人： Luis Garcia ,  Cyriaque Beley ,  Thomas Voit ,  Robert Michael Kotin

发明人： Luis Garcia ,  Cyriaque Beley ,  Thomas Voit ,  Robert Michael Kotin

IPC分类号： C12N15/86

CPC分类号： C12N15/86 ,  C12N2750/14143 ,  C12N2750/14171 ,  C12N2800/24

摘要： An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.

摘要翻译： 一种分离的线性核酸分子，其以以下顺序包含：第一腺相关病毒（AAV）倒置末端重复（ITR），目的核苷酸序列和第二AAV ITR，其中所述核酸分子缺乏AAV衣壳蛋白编码 序列。 所述核酸分子可以重复施用于宿主而不引发免疫应答。 还提供了用于产生和纯化该核酸分子的方法及其用于治疗目的的用途。

公开(公告)号：US08586560B2

公开(公告)日：2013-11-19

申请号：US13501892

申请日：2010-10-18

申请人： Nicolas Levy ,  Martin Krahn ,  Marc Bartoli ,  Luis Garcia

发明人： Nicolas Levy ,  Martin Krahn ,  Marc Bartoli ,  Luis Garcia

IPC分类号： C12N15/11 ,  C12N15/00

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2320/33

摘要： The present invention relates to methods for restoring the function of a mutated dysferlin comprising the step of preventing splicing of one or more exons which encode amino acid sequences that cause said dysferlin dysfunction. Particularly, the splicing of exon 32 is prevented. The present invention also relates to a method for treating a dysferlinopathy in a patient in need thereof, comprising the step of administering to said patient antisense oligonucleotides complementary to nucleic acid sequences that are necessary for correct splicing of one or more exons which encode amino acid sequences that cause said dysfunction. Particularly, the splicing of exon 32 is prevented.

摘要翻译： 本发明涉及恢复突变的dysferlin的功能的方法，其包括防止编码导致所述dysferlin功能障碍的氨基酸序列的一个或多个外显子的剪接的步骤。 特别地，防止外显子32的剪接。 本发明还涉及在有需要的患者中治疗偏头痛的方法，该方法包括给所述患者施用与编码氨基酸序列的一个或多个外显子正确剪接所必需的核酸序列互补的反义寡核苷酸的步骤 导致所述功能障碍。 特别地，防止外显子32的剪接。

公开(公告)号：US20130189225A1

公开(公告)日：2013-07-25

申请号：US13636596

申请日：2011-03-22

申请人： Thomas Voit ,  Luis Garcia ,  Jérôme Denard ,  Fedor Svinartchouk

发明人： Thomas Voit ,  Luis Garcia ,  Jérôme Denard ,  Fedor Svinartchouk

IPC分类号： A61K48/00 ,  A61K38/00 ,  A61K31/522 ,  A61K38/21

CPC分类号： C04B35/10 ,  A61K31/522 ,  A61K38/00 ,  A61K38/1709 ,  A61K38/21 ,  A61K45/06 ,  A61K48/0008 ,  A61K48/0058 ,  C04B35/14 ,  C04B35/565 ,  C04B35/622 ,  C07K14/005 ,  C07K16/081 ,  C07K16/18 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12N2750/14151 ,  C12N2810/6027 ,  A61K2300/00

摘要： Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.

摘要翻译： 提供了增加患者中腺相关病毒（AAV）载体靶组织穿透效率的方法。 在某些方面，该方法涉及抑制血清蛋白半乳凝素3结合蛋白（G3BP）与AAV载体的相互作用。 进一步提供的是通过施用包含G3BP的组合物来减少病毒的组织分布或用于中和由目的地移植或新移植的器官所携带的病毒的方法。

公开(公告)号：US20130182690A1

公开(公告)日：2013-07-18

申请号：US13808768

申请日：2010-07-08

申请人： Istvan Zsolt Kovacs ,  Frank Frederiksen ,  Luis Garcia

发明人： Istvan Zsolt Kovacs ,  Frank Frederiksen ,  Luis Garcia

IPC分类号： H04W72/04

CPC分类号： H04W72/0426 ,  H04W16/06 ,  H04W72/082

摘要： The invention relates generally to mobile communication networks. More particularly, the invention relates to interference management and carrier selection for transmitting data. There is provided a solution for improved selection of a cell-specific base carrier, the solution utilizing a timing framework for the carrier selection. The solution includes determining a maximum allowed time duration, and performing within the determined maximum allowed time duration: obtaining information related to one or more selected carriers from at least one neighboring base station, selecting the at least one cell-specific base carrier for data transmission on the basis of the obtained information, and informing the at least one neighboring base station of the selected cell specific base carrier.

摘要翻译： 本发明一般涉及移动通信网络。 更具体地，本发明涉及用于发送数据的干扰管理和载波选择。 提供了一种用于改进小区特定基站载波选择的解决方案，该解决方案利用用于载波选择的定时框架。 该解决方案包括确定最大允许持续时间，以及在所确定的最大允许持续时间内执行：从至少一个相邻基站获得与一个或多个选定载波相关的信息，选择所述至少一个小区特定基站载波进行数据传输 基于所获得的信息，并且向所述至少一个相邻基站通知所选择的小区特定基站载波。

公开(公告)号：US20130072541A1

公开(公告)日：2013-03-21

申请号：US13458037

申请日：2012-04-27

申请人： Luis Garcia

发明人： Luis Garcia

IPC分类号： C12N5/10 ,  A61P21/00 ,  A61K31/713

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2750/14143

摘要： The invention concerns an adeno-associated viral vector comprising: a U7 type modified snRNA sequence; the native U7 promoter; at least one antisense sequence directed against at least one splice site of at least one exon, the said exon encoding a dispensable domain of dystrophin.

摘要翻译： 本发明涉及腺相关病毒载体，其包含：U7型修饰的snRNA序列; 天然U7启动子; 至少一个针对至少一个外显子的至少一个剪接位点的反义序列，所述外显子编码肌营养不良蛋白的可分配区域。

公开(公告)号：US20130045538A1

公开(公告)日：2013-02-21

申请号：US13635356

申请日：2011-03-17

申请人： Luis Garcia ,  Denis Furling ,  Cyriaque Beley ,  Thomas Voit

发明人： Luis Garcia ,  Denis Furling ,  Cyriaque Beley ,  Thomas Voit

IPC分类号： C07H21/02 ,  C12N15/113 ,  C12N15/85 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12N15/111 ,  C12N2310/11 ,  C12N2310/531 ,  C12N2320/33 ,  C12N2320/34 ,  C12N2320/50 ,  C12N2330/51

摘要： The present invention relates to a method to improve the activity of engineered U7 snRNAs used in the context of RNA-based therapeutics; particularly in exon skipping, exon inclusion, and mRNA eradication strategies. The resulting modified snRNAs are useful for treating neuromuscular diseases, in particular Duchenne neuromuscular dystrophy, myotonic dystrophy DM1 and spinal muscular atrophy.

摘要翻译： 本发明涉及一种改善在基于RNA的疗法的上下文中使用的工程化U7 snRNA的活性的方法; 特别是在外显子跳跃，外显子包含和mRNA消除策略。 所产生的修饰的snRNA可用于治疗神经肌肉疾病，特别是Duchenne神经肌肉营养不良症，强直性营养不良DM1和脊髓性肌肉萎缩。

公开(公告)号：US20120282960A1

公开(公告)日：2012-11-08

申请号：US13518476

申请日：2009-12-23

申请人： Klaus Ingemann Pedersen ,  Luis Garcia

发明人： Klaus Ingemann Pedersen ,  Luis Garcia

IPC分类号： H04W52/24

CPC分类号： H04W52/243

摘要： When it is determined that a first estimate of the total level of interference towards transmissions associated with a first access node from transmissions associated with other access nodes exceeds a predetermined target maximum value; then in dependence on the extent to which said first estimate exceeds said target maximum value, selecting one or more of said other access nodes to which to make a request to reduce the transmission power of interfering transmissions, and/or selecting an amount by which to request any one or more of said other access nodes to reduce the transmission power of interfering transmissions.

摘要翻译： 当确定从与其他接入节点相关联的传输到与第一接入节点相关联的传输的总干扰水平的第一估计超过预定目标最大值时; 然后根据所述第一估计超过所述目标最大值的程度，选择一个或多个所述其他接入节点，以向其请求以降低干扰传输的传输功率，和/或选择一个 请求任何一个或多个所述其他接入节点以降低干扰传输的传输功率。

公开(公告)号：US20120252437A1

公开(公告)日：2012-10-04

申请号：US13065742

申请日：2011-03-28

申请人： Luis Garcia ,  Frank Frederiksen ,  Klaus Ingemann Pedersen

发明人： Luis Garcia ,  Frank Frederiksen ,  Klaus Ingemann Pedersen

IPC分类号： H04W24/00

CPC分类号： H04J11/0056

摘要： Wireless channel interference information is determined (e.g., a background interference matrix BIM constructed from multiple user equipment measurements). Reliability of the interference information is classified and sent with the interference information to a neighbor network access node such as a HeNB. In various embodiments there are three layers of reliability, the above being the first. The second layer utilizes variability of a plurality of such reliability indications received from the same neighbor HeNB, which is updated as new interference information and reliability indications are received from that same neighbor HeNB. The third layer utilizes a peer review/update process on the neighbor HeNBs themselves, where each HeNB's performance is shared among all and updated by one another as different HeNBs utilize one another's BIM and assesses how reliably it reflected actual interference conditions. This addresses concerns for data/source reliability since communication interfaces among HeNB groups may not be controlled by a single network operator.

摘要翻译： 确定无线信道干扰信息（例如，由多个用户设备测量构成的背景干扰矩阵BIM）。 干扰信息的可靠性被分类并与干扰信息一起发送到诸如HeNB的邻居网络接入节点。 在各种实施例中，存在三层可靠性，上述是第一层。 第二层利用从相同的邻近HeNB接收的多个这样的可靠性指示的可变性，其被更新为新的干扰信息，并且从相同的邻居HeNB接收可靠性指示。 第三层利用对邻居HeNB本身的对等审查/更新过程，其中每个HeNB的性能由所有HeNB彼此共享并且彼此更新，因为HeNB不同的BNB利用彼此的BIM并且评估它们如何可靠地反映实际的干扰条件。 这解决了数据/源可靠性的问题，因为HeNB组之间的通信接口可能不由单个网络运营商控制。