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    Optical system for mapping signal light onto a detector
    61.
    发明授权
    Optical system for mapping signal light onto a detector 失效
    用于将信号光映射到检测器上的光学系统

    公开(公告)号：US07947946B2

    公开(公告)日：2011-05-24

    申请号：US11909638

    申请日：2006-03-27

    申请人： Marcello Balistreri ,  Derk Jan Wilfred Klunder ,  Maarten Van Herpen

    发明人： Marcello Balistreri ,  Derk Jan Wilfred Klunder ,  Maarten Van Herpen

    IPC分类号： G01D5/36

    CPC分类号： G01N21/645 ,  G02B27/0037 ,  G02B27/4205 ,  G02B27/4277

    摘要： The invention relates to an optical system that particularly allows an improved detection of signal light propagating from a light source (1) through a flat glass substrate (11). SC-modes of this signal light that would normally be totally internally reflected at the backside (10) of the substrate (11) are coupled out by a first diffractive optical element DOE (21). To map all signal light leaving the substrate (11) onto a single target location (51), a focusing lens (31) and a second DOE (41) are disposed in the optical path behind the substrate (11). The DOEs (21, 41) may for example be a ID sinusoidal grating or a 2D blaze grating. The optical system may particularly be applied in an investigation apparatus for detecting multiple spots of a fluorescent sample material.

    摘要翻译： 本发明涉及一种特别允许改进从光源（1）通过平板玻璃基板（11）传播的信号光的检测的光学系统。 通常在基板（11）的背面（10）处内部反射的该信号光的SC模式由第一衍射光学元件DOE（21）耦合出来。 为了将离开基板（11）的所有信号光映射到单个目标位置（51）上，在基板（11）后面的光路中设置聚焦透镜（31）和第二DOE（41）。 DOE（21,41）可以例如是ID正弦光栅或2D火焰光栅。 光学系统可以特别应用于用于检测荧光样品材料的多个点的检查装置中。

    MICROELECTRONIC OPIACAL EVANESCENT FIELD SENSOR
    64.
    发明申请
    MICROELECTRONIC OPIACAL EVANESCENT FIELD SENSOR 审中-公开
    微电子光学现场传感器

    公开(公告)号：US20100252751A1

    公开(公告)日：2010-10-07

    申请号：US12740149

    申请日：2008-10-30

    申请人： Derk Jan Wilfred Klunder ,  Christianne Rossetta Maria De Witz ,  Roel Penterman ,  Ruth Wilhelmine Ireen De Boer ,  Erik Martinus Hubertus Petrus Van Dijk

    发明人： Derk Jan Wilfred Klunder ,  Christianne Rossetta Maria De Witz ,  Roel Penterman ,  Ruth Wilhelmine Ireen De Boer ,  Erik Martinus Hubertus Petrus Van Dijk

    IPC分类号： G01J1/58 ,  G01N21/64

    CPC分类号： G01N21/648 ,  B82Y15/00 ,  G01N21/552 ,  G01N21/554 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/6432 ,  G01N2021/7786 ,  G02B6/0229 ,  G02B2006/12138

    摘要： There is provided a microelectronic sensor device (100) for the detection of target components (10) near a binding surface (12), comprising a source (21) for emitting a beam (101) of radiation having a wavelength incident at the binding surface (12); an optical structure (11) near the binding surface (12), for providing evanescent radiation, in response to the radiation incident at the binding surface (12), in a detection volume (4) bound by the binding surface (12) and extending over a decaylength away from the binding surface (12) into a sample chamber (2); and a detector (31) for detecting radiation (102) from the target component (10)1 present in the detection volume (4), in response to the emitted incident radiation (101) from the source (21) wherein the binding surface (12) is provided with upstanding walls of a dielectric material (3), for providing one or more detection volumes (4) bound to a maximum in plane detection volume dimension (W1) smaller than a diffraction limit, the diffraction limit defined by the radiation wavelength and the medium (2) for containing the target components (10).

    摘要翻译： 提供了用于在绑定表面（12）附近检测目标部件（10）的微电子传感器装置（100），包括用于发射具有入射在结合表面处的波长的辐射束（101）的源（21） （12）; 在结合表面（12）附近的光学结构（11），用于响应于在结合表面（12）处入射的辐射，在由结合表面（12）限定的检测体积（4）中提供ev逝辐射，并延伸 超过从结合表面（12）离开到样品室（2）的衰减长度; 以及检测器（31），用于响应于来自所述源（21）的所述发射入射辐射（101），检测来自所述检测体积（4）中的目标成分（10）1的辐射（102），其中所述结合表面 12）设置有介电材料（3）的直立壁，用于提供一个或多个检测体积（4），该检测体积（4）与小于衍射极限的平面检测体积尺寸（W1）中的最大值相关联，由辐射限定的衍射极限 波长和用于容纳目标成分（10）的介质（2）。

    DETECTING TARGET MOLECULES IN A SAMPLE
    65.
    发明申请
    DETECTING TARGET MOLECULES IN A SAMPLE 审中-公开
    在样品中检测目标分子

    公开(公告)号：US20100197515A1

    公开(公告)日：2010-08-05

    申请号：US12446461

    申请日：2007-10-19

    申请人： Maarten Marinus Johannes Wilhelm Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    发明人： Maarten Marinus Johannes Wilhelm Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    IPC分类号： C40B30/04 ,  C40B40/04

    CPC分类号： G01N33/5306 ,  C40B30/10 ,  G01N21/6428

    摘要： The invention relates to detection the presence of a target molecule in a sample, wherein the sample is contacted with a substrate, the substrate subsequently being washed in a wash step. In particular, the invention relates to a method of detecting the presence of a target molecule in a sample, the method comprising: (a) contacting the sample (37) with a substrate having immobilized thereon probe molecules that specifically binds to the target molecule; (b) washing the substrate (38) in a wash step by a wash fluid in order to remove or dilute unbound target molecules; (c) detect the presence of resultant binding complexes (39) on the substrate to determine whether the target molecule is present in the sample. The wash fluid being substantially refractive index matched to the substrate.

    摘要翻译： 本发明涉及检测样品中靶分子的存在，其中样品与底物接触，随后在洗涤步骤中洗涤底物。 特别地，本发明涉及检测样品中目标分子的存在的方法，该方法包括：（a）使样品（37）与其上固定有特异性结合靶分子的探针分子的底物接触; （b）通过洗涤液在洗涤步骤中洗涤基质（38）以去除或稀释未结合的靶分子; （c）检测所得结合复合物（39）在底物上的存在，以确定靶分子是否存在于样品中。 洗涤液体基本上与基材的折射率匹配。

    METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION
    67.
    发明申请
    METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION 审中-公开
    用于检测前辐射的方法和系统

    公开(公告)号：US20100096561A1

    公开(公告)日：2010-04-22

    申请号：US12443863

    申请日：2007-10-03

    申请人： Mark Thomas Johnson ,  Marc Wilhelmus Gijsbert Ponjee ,  Marcello Leonardo Mario Balistreri ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Derk Jan Wilfred Klunder

    发明人： Mark Thomas Johnson ,  Marc Wilhelmus Gijsbert Ponjee ,  Marcello Leonardo Mario Balistreri ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Derk Jan Wilfred Klunder

    IPC分类号： G01N21/01 ,  G01J1/58

    CPC分类号： G01N21/6428 ,  B01L3/5027 ,  G01N21/6454

    摘要： A radiation detection system (100) is described comprising a measurement region (104) in a measurement chamber adapted for receiving at least one sample (108) to be examined and adapted for receiving excitation radiation for impingement on the at least one sample (108) and for generating sample radiation. The radiation detection system (100) furthermore comprises at least one detector element (106) for detection of the generated sample radiation. The radiation detection system thereby is a front irradiation system, i.e. the excitation radiation is incident on a first side of the measurement region (104) in a measurement chamber and the at least one detector element (106) is positioned at a second side of the measurement region (104) in a measurement chamber, the second side being opposite to the first side with respect to the measurement region (104) in a measurement chamber, such that detection occurs at the side facing the first side. The detection system (100) also comprises optical means (112) adapted for guiding said excitation radiation aside the at least one detector element (106).

    摘要翻译： 描述了辐射检测系统（100），其包括在测量室中的测量区域（104），其适于接收待检查的至少一个样品（108）并适于接收用于冲击至少一个样品（108）的激发辐射， 并用于产生样品辐射。 辐射检测系统（100）还包括用于检测所产生的样品辐射的至少一个检测器元件（106）。 因此，辐射检测系统是前照射系统，即激发辐射入射在测量室中的测量区域（104）的第一侧上，并且所述至少一个检测器元件（106）位于第二侧 测量室中的测量区域（104），第二侧在测量室中相对于测量区域（104）与第一侧相对，使得在面向第一侧的一侧发生检测。 检测系统（100）还包括适于将所述激发辐射引导到所述至少一个检测器元件（106）旁边的光学装置（112）。

    BIOSENSOR DEVICE AND METHOD FOR DETECTING MOLECULES IN AN ANALYTE
    68.
    发明申请
    BIOSENSOR DEVICE AND METHOD FOR DETECTING MOLECULES IN AN ANALYTE 审中-公开
    生物传感器装置和检测分析物中分子的方法

    公开(公告)号：US20100047919A1

    公开(公告)日：2010-02-25

    申请号：US12513525

    申请日：2007-11-06

    申请人： Derk Jan Wilfred Klunder ,  Maarten Marinus Johannes Wilhelms Van Herpen

    发明人： Derk Jan Wilfred Klunder ,  Maarten Marinus Johannes Wilhelms Van Herpen

    IPC分类号： G01N21/76 ,  G01N33/50

    CPC分类号： G01N21/648 ,  G01N33/54373

    摘要： A biosensor device (10) for detecting molecules (16) in an analyte (14) comprises a binding element (12) which can be brought into contact with the analyte (14) for binding the molecules (16) thereto. The binding element (12) is an optical waveguide (34) comprising a strip (36) on a first layer (38). Light (17) can be applied to the strip (36). The biosensor device (10) further comprises an optical detection system (22) for detecting luminescent light (20) emitted by the excited molecules (16).

    摘要翻译： 用于检测分析物（14）中的分子（16）的生物传感器装置（10）包括可与被分析物（14）接触以将结合分子（16）的结合元件（12）。 装订元件（12）是在第一层（38）上包括条（36）的光波导（34）。 光（17）可以施加到带（36）。 生物传感器装置（10）还包括用于检测被激发的分子（16）发射的发光（20）的光学检测系统（22）。

    RADIATION DETECTORS USING EVANESCENT FIELD EXCITATION
    69.
    发明申请
    RADIATION DETECTORS USING EVANESCENT FIELD EXCITATION 审中-公开
    使用现场激励的辐射探测器

    公开(公告)号：US20090284746A1

    公开(公告)日：2009-11-19

    申请号：US12373995

    申请日：2007-07-04

    申请人： Derk Jan Wilfred Klunder ,  Maarten Marinus Johannes Wilhelm Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson

    发明人： Derk Jan Wilfred Klunder ,  Maarten Marinus Johannes Wilhelm Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson

    IPC分类号： G01N21/55 ,  G01N21/62

    CPC分类号： G01N21/6454 ,  B01L3/5027 ,  G01N21/6428 ,  G01N21/648 ,  G01N2021/7786

    摘要： A detection system (100, 150, 180, 200, 220, 250) for detecting luminescence from at least one sample (108) when excited by incident excitation radiation. Detecting luminescence may allow to detect, for example, biological, chemical or bio-chemical particles. The detection system (100, 150, 180, 200, 220, 250) comprising at least one optical component (102) with at least a first surface (104). The first surface (104) of the at least one optical component (102) is located to internally reflect incident excitation radiation to create an evanescent field outside the at least one optical component (102) for exciting the at least one sample (108). The detection system also comprises at least one detector element (110) that is in direct contact with the at least one optical component (102) to detect the luminescence from at least one excited sample (108) through the at least one optical component (102).

    摘要翻译： 用于当由入射激发辐射激发时用于检测来自至少一个样品（108）的发光的检测系统（100,150,180,200,250,250）。 检测发光可以允许检测例如生物，化学或生物化学颗粒。 所述检测系统（100,150,180,200,250,250）包括具有至少第一表面（104）的至少一个光学部件（102）。 所述至少一个光学部件（102）的第一表面（104）位于内部反射入射的激发辐射，以在所述至少一个光学部件（102）外部产生消逝场，用于激发所述至少一个样品（108）。 检测系统还包括至少一个与至少一个光学部件（102）直接接触的检测器元件（110），以检测来自至少一个激发的样品（108）的至少一个光学部件（102）的发光 ）。