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公开(公告)号：US07632833B2
公开(公告)日：2009-12-15
申请号：US11630231
申请日：2005-06-27
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
IPC分类号： C07D498/04 , A61K31/5383 , A61K31/551 , A61K31/542
CPC分类号： C07D498/04 , C07D519/00
摘要： The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的根据式（I）的三环吡唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07625936B2
公开(公告)日：2009-12-01
申请号：US11886274
申请日：2006-03-10
IPC分类号： A61K31/415 , C07D231/06
CPC分类号： C07D231/06
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US07618971B2
公开(公告)日：2009-11-17
申请号：US11630224
申请日：2005-06-27
IPC分类号： A61K31/496 , A61K31/4196 , A61K31/4155 , C07D403/06 , C07D249/08 , C07D231/06
CPC分类号： C07D231/12 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/08 , C07D491/107 , C07D491/113
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US07235580B2
公开(公告)日：2007-06-26
申请号：US10531495
申请日：2003-10-14
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Brenda J. Mariano
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Brenda J. Mariano
IPC分类号： A61K31/4025 , A61K31/4439 , C07D401/02 , C07D207/20 , C07D413/02
CPC分类号： C07D405/12 , C07D207/20 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07718687B2
公开(公告)日：2010-05-18
申请号：US11630303
申请日：2005-06-27
IPC分类号： A61K31/415 , C07D231/06
CPC分类号： C07D231/06 , C07F9/65031
摘要： The present invention relates to prodrugs of dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡唑化合物的前药。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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66.发明授权Fluorinated 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP 失效有丝分裂驱动蛋白KSP的氟化2,4-二芳基-2,5-二氢吡咯抑制剂公开(公告)号：US07465746B2
公开(公告)日：2008-12-16
申请号：US10915743
申请日：2004-08-11
IPC分类号： A61K31/4468
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20080287414A1
公开(公告)日：2008-11-20
申请号：US11630231
申请日：2005-06-27
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Robert M. Garbaccio , George D. Hartman , Chunze Li , Lou Anne Neilson , Christy M. Olson , Edward S. Tasber
IPC分类号： A61K31/5383 , A61P35/00 , A61K31/551 , A61K31/542 , C07D498/04
CPC分类号： C07D498/04 , C07D519/00
摘要： The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的根据式（I）的三环吡唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US08629274B2
公开(公告)日：2014-01-14
申请号：US13723869
申请日：2012-12-21
IPC分类号： C07D213/00 , A01N43/00 , A61K31/445 , A01N41/06 , A61K31/18 , A01N37/18 , A61K31/165
CPC分类号： C07D401/06 , A61K31/167 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/407 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/513 , A61K31/52 , A61K31/522 , A61K31/536 , A61K31/5375 , A61K31/551 , A61K31/675 , A61K31/7072 , A61K38/21 , A61K45/06 , C07C311/46 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/48 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/50 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/96 , C07D213/74 , C07D213/82 , C07D265/30 , C07D265/32 , C07D295/195 , C07D295/26 , C07D401/12 , A61K2300/00
摘要： The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
摘要翻译： 本发明包括在有需要的个体中抑制，抑制或预防HBV感染的方法，包括向个体施用治疗有效量的至少一种本发明的化合物。
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公开(公告)号：US07625912B2
公开(公告)日：2009-12-01
申请号：US10582826
申请日：2004-12-15
IPC分类号： C07D239/36 , A61K31/513
CPC分类号： C07D239/36
摘要： The present invention relates to 2-phenylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的2-苯基嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US06358956B1
公开(公告)日：2002-03-19
申请号：US09516750
申请日：2000-03-01
申请人： George D. Hartman , William C. Lumma, Jr. , John T. Sisko , Anthony M. Smith , Thomas J. Tucker , Gerald E. Stokker
发明人： George D. Hartman , William C. Lumma, Jr. , John T. Sisko , Anthony M. Smith , Thomas J. Tucker , Gerald E. Stokker
IPC分类号： A06L31295
CPC分类号： C07D233/64 , C07D401/12 , C07D405/12
摘要： The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases, including-farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.
摘要翻译： 本发明包括抑制异戊烯基 - 蛋白质转移酶的含哌嗪化合物，包括法呢基蛋白转移酶和er牛鞭毛蛋白转移酶I型。这种治疗化合物可用于治疗癌症。
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