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61.发明授权Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses 失效吡唑烷-1,2-二羧基二苯胺衍生物作为治疗血栓形成的凝血因子Xa抑制剂公开(公告)号：US07557102B2
公开(公告)日：2009-07-07
申请号：US10551559
申请日：2004-03-09
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/454 , A61K31/4439 , C07D413/02
CPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D453/06
摘要： Novel compounds of the formula (I), in which R, R1, R2 and R3 have the meanings indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新型化合物，其中R，R 1，R 2和R 3具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病， 治疗肿瘤。
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62.发明授权Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products 失效制备吡咯烷-1,2-二甲酸-1-（苯基（ - 酰胺））-2（苯基（ - 酰胺））衍生物和1-（苯基氨基甲酰基） - 吡咯烷-2-甲酸衍生物作为中间产物的方法公开(公告)号：US07504500B2
公开(公告)日：2009-03-17
申请号：US10551670
申请日：2004-03-09
IPC分类号： C07D413/02 , A61K31/5377
CPC分类号： C07D207/16 , C07D413/12
摘要： Process for the preparation of compounds of the formula I in which R, R1, R2 and R3 are as defined in Patent claim 1, and compounds of the formula IV in which R and R1 are as defined in Patent claim 1, are intermediates for the preparation of the compounds of the formula I.
摘要翻译： 制备式I化合物的方法，其中R 1，R 2，R 3和R 3如专利权利要求1中所定义，和其中R和R 1如权利要求1中所定义的式Ⅳ化合物是 制备式I化合物
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公开(公告)号：US07427618B2
公开(公告)日：2008-09-23
申请号：US10547130
申请日：2004-01-30
申请人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
发明人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
IPC分类号： C07D265/32 , C07D233/46 , C07D213/64 , C07D413/12 , A61K31/5375 , A61K31/5377 , A61K31/4168 , A61K31/4412
CPC分类号： C07D213/64 , C07D233/46 , C07D265/32 , C07D401/12 , C07D403/12 , C07F9/6533
摘要： Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新化合物，其中R 1，R 2，R 3，X和Y具有专利中所示的含义 权利要求1是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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64.发明申请Carbonyl Compounds Which Can be Used as Inhibitors of Coagulation Factor Xa 审中-公开可用作凝血因子Xa抑制剂的羰基化合物公开(公告)号：US20080081814A1
公开(公告)日：2008-04-03
申请号：US11576207
申请日：2005-09-01
IPC分类号： A61K31/4412 , A61K31/4965 , A61K31/535 , C07D401/14 , C07D413/10 , C07D413/14
CPC分类号： C07D413/12 , C07D401/12
摘要： Novel compounds of the formula (I), in which D, E, G, W, X, Y, T, R1 and R2 have the meaning indicated in Patent Claim (1), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中D，E，G，W，X，Y，T，R 1和R 2的式（I）的新化合物具有专利中所示的含义 权利要求（1）是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US07183277B2
公开(公告)日：2007-02-27
申请号：US10512478
申请日：2003-03-31
申请人： Dieter Dorsch , Werner Mederski , Johannes Gleitz , Bertram Cezanne , Christos Tsaklakidis , Christopher Barnes
发明人： Dieter Dorsch , Werner Mederski , Johannes Gleitz , Bertram Cezanne , Christos Tsaklakidis , Christopher Barnes
IPC分类号： A61K31/5375 , A61K31/451 , A61K31/40 , A61K31/4168 , A61K31/433 , C07D211/72 , C07D207/22
CPC分类号： C07D207/22 , C07D211/72 , C07D213/73 , C07D233/46 , C07D233/48 , C07D265/30 , C07D401/12 , C07D403/12 , C07D409/12 , C07D453/06
摘要： Novel compounds of the formula I in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中D，W，X，Y，T和R 1如专利权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于预防和/ 或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20060074072A1
公开(公告)日：2006-04-06
申请号：US10543109
申请日：2004-01-08
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christoph Van Amsterdam
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christoph Van Amsterdam
IPC分类号： A61K31/675 , A61K31/5513 , A61K31/5377 , A61K31/496 , A61K31/495 , A61K31/4545 , A61K31/444 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D213/64 , C07D241/18 , C07D265/06 , C07D265/10 , C07D265/32 , C07F9/58 , C07F9/59 , C07F9/650952 , C07F9/653 , C07F9/6533
摘要： Novel compounds of the formula (I) in which R1, D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中R 1，D，X，W，Y和T的新的式（I）化合物具有专利权利要求（1）所述的含义，例如， （II）是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20050272740A1
公开(公告)日：2005-12-08
申请号：US10525001
申请日：2003-07-04
申请人： Dieter Dorsch , Bertram Cezanne , Wrner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Bertram Cezanne , Wrner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
IPC分类号： A61K31/4184 , C07D409/04 , C07D409/14 , C07D413/14 , A61K31/506 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , C07D413/04 , C07D417/04 , C07D43/04
CPC分类号： C07D413/14 , A61K9/0048 , A61K9/02 , A61K9/06 , A61K9/19 , A61K9/2059 , A61K9/2826 , A61K47/02 , C07D409/04 , C07D409/14
摘要： Novel compounds of the formula I in which D, X, X′, W, Y, T and R1 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中D，X，X'，W，Y，T和R 1如专利权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于 预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US06946489B2
公开(公告)日：2005-09-20
申请号：US10239397
申请日：2001-03-23
申请人： Horst Juraszyk , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Christopher Bames , Johannes Gleitz
发明人： Horst Juraszyk , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Christopher Bames , Johannes Gleitz
IPC分类号： C07D317/60 , A61K31/167 , A61K31/216 , A61K31/235 , A61K31/27 , A61K31/36 , A61P7/02 , A61P9/08 , A61P9/10 , A61P29/00 , A61P43/00 , C07C257/18 , C07C317/32 , C07C317/40 , A61K31/165 , C07C233/00
CPC分类号： C07C317/40 , C07C257/18 , Y02P20/55
摘要： The invention relates to compounds of the formula I in which R1, R2, R3, R4 and X have the meaning indicated in the text. The compounds act as inhibitors of factors Xa and VIIa and can therefore be employed for the control and prevention of thromboembolic conditions such as thrombosis, myocardial infarct, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R 1，R 2，R 3，R 4， 和X具有文中指出的含义。 这些化合物作为因子Xa和VIIa的抑制剂，因此可用于控制和预防血栓形成状况如血栓形成，心肌梗死，动脉硬化，炎症，中风，心绞痛，血管成形术后的再狭窄和间歇性跛行。
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公开(公告)号：US20050171154A1
公开(公告)日：2005-08-04
申请号：US10512478
申请日：2003-03-31
申请人： Dieter Dorsch , Werner Mederski , Johannes Gleitz , Bertram Cezanne , Christos Tsaklakidis , Christopher Barnes
发明人： Dieter Dorsch , Werner Mederski , Johannes Gleitz , Bertram Cezanne , Christos Tsaklakidis , Christopher Barnes
IPC分类号： C07D211/56 , A61K31/40 , A61K31/4025 , A61K31/4172 , A61K31/4178 , A61K31/4545 , A61P7/02 , A61P9/00 , A61P25/06 , A61P29/00 , A61P35/00 , C07D207/14 , C07D207/22 , C07D211/72 , C07D213/73 , C07D233/46 , C07D233/48 , C07D265/30 , C07D401/12 , C07D403/12 , C07D409/12 , C07D453/06
CPC分类号： C07D207/22 , C07D211/72 , C07D213/73 , C07D233/46 , C07D233/48 , C07D265/30 , C07D401/12 , C07D403/12 , C07D409/12 , C07D453/06
摘要： Novel compounds of the formula I in which D, W, X, Y, T and R1 are as defined in patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中D，W，X，Y，T和R 1如权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于预防和/ 或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20050119316A1
公开(公告)日：2005-06-02
申请号：US10506801
申请日：2003-02-06
申请人： Werner Mederski , Bertram Cezanne , Christos Tsaklakidis , Dieter Dorsch , Christopher Barnes , Johannes Gleitz
发明人： Werner Mederski , Bertram Cezanne , Christos Tsaklakidis , Dieter Dorsch , Christopher Barnes , Johannes Gleitz
IPC分类号： C07C317/42 , A61K20060101 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/4245 , A61P20060101 , A61P7/02 , A61P9/08 , A61P9/10 , A61P25/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C20060101 , C07C281/06 , C07C311/47 , C07C317/40 , C07D20060101 , C07D271/06
CPC分类号： C07C317/32 , C07C311/47
摘要： Novel compounds of the formula I, in which R, R1, R2 and R3 are as defined in patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式I的新型化合物，其中R，R 1，R 2和R 3如专利权利要求1中所定义，均为抑制剂 的凝血因子Xa，并且可以用于预防和/或治疗血栓栓塞性疾病和用于治疗肿瘤。
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