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公开(公告)号：US07598241B2
公开(公告)日：2009-10-06
申请号：US10543109
申请日：2004-01-08
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christoph van Amsterdam
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christoph van Amsterdam
IPC分类号： A61K31/535 , A61K31/5375 , A61K31/4965 , A61K31/4412 , C07D265/06 , C07D241/02 , C07D213/127 , C07D295/02
CPC分类号： C07D213/64 , C07D241/18 , C07D265/06 , C07D265/10 , C07D265/32 , C07F9/58 , C07F9/59 , C07F9/650952 , C07F9/653 , C07F9/6533
摘要： Novel compounds of the formula (I) in which R1, D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新型化合物，其中R 1，D，X，W，Y和T具有专利权利要求（1）所述的含义， （II）是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20060084648A1
公开(公告)日：2006-04-20
申请号：US10547130
申请日：2004-01-30
申请人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
发明人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
IPC分类号： A61K31/537 , A61K31/4172 , C07D265/30 , C07D413/02
CPC分类号： C07D213/64 , C07D233/46 , C07D265/32 , C07D401/12 , C07D403/12 , C07F9/6533
摘要： Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors ocoagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新化合物，其中R 1，R 2，R 3，X和Y具有专利中所示的含义 权利要求1是抑制凝血因子Xa，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US07579346B2
公开(公告)日：2009-08-25
申请号：US10535246
申请日：2003-10-30
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Hanns Wurziger , Johannes Gleitz , Christoph van Amsterdam
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Hanns Wurziger , Johannes Gleitz , Christoph van Amsterdam
IPC分类号： A61K31/535 , A61K31/497 , A61K31/415 , C07D413/00 , C07D409/00 , C07D231/00 , C07D333/36
CPC分类号： C07D409/12 , C07D265/32 , C07D413/12
摘要： Novel compounds of the formula (I), in which D, W, X, Y, T, m and R1 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T，m和R 1具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于预防和/或治疗 的血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20060052376A1
公开(公告)日：2006-03-09
申请号：US10535246
申请日：2003-10-30
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Hanns Wurziger , Johannes Gleitz , Christoph Van Amsterdam
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Hanns Wurziger , Johannes Gleitz , Christoph Van Amsterdam
IPC分类号： C07D413/02 , A61K31/55 , A61K31/5377 , A61K31/4965 , A61K31/50
CPC分类号： C07D409/12 , C07D265/32 , C07D413/12
摘要： Novel compounds of the formula (I), in which D, W, X, Y, T, m and R1 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T，m和R 1具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可以是 用于预防和/或治疗血栓栓塞性疾病和用于治疗肿瘤
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公开(公告)号：US07427618B2
公开(公告)日：2008-09-23
申请号：US10547130
申请日：2004-01-30
申请人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
发明人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
IPC分类号： C07D265/32 , C07D233/46 , C07D213/64 , C07D413/12 , A61K31/5375 , A61K31/5377 , A61K31/4168 , A61K31/4412
CPC分类号： C07D213/64 , C07D233/46 , C07D265/32 , C07D401/12 , C07D403/12 , C07F9/6533
摘要： Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新化合物，其中R 1，R 2，R 3，X和Y具有专利中所示的含义 权利要求1是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20060074072A1
公开(公告)日：2006-04-06
申请号：US10543109
申请日：2004-01-08
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christoph Van Amsterdam
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christoph Van Amsterdam
IPC分类号： A61K31/675 , A61K31/5513 , A61K31/5377 , A61K31/496 , A61K31/495 , A61K31/4545 , A61K31/444 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D213/64 , C07D241/18 , C07D265/06 , C07D265/10 , C07D265/32 , C07F9/58 , C07F9/59 , C07F9/650952 , C07F9/653 , C07F9/6533
摘要： Novel compounds of the formula (I) in which R1, D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中R 1，D，X，W，Y和T的新的式（I）化合物具有专利权利要求（1）所述的含义，例如， （II）是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US07732481B2
公开(公告)日：2010-06-08
申请号：US10583094
申请日：2004-11-26
IPC分类号： A61K31/4015 , C07D207/04
CPC分类号： C07D207/16 , C07D401/12
摘要： Novel compounds of the formula (I), in which R, R1, R2, R3, X, X′ and Y have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新型化合物，其中R，R 1，R 2，R 3，X，X'和Y具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于预防和/或 治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20070123509A1
公开(公告)日：2007-05-31
申请号：US10582850
申请日：2004-11-19
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/497 , A61K31/496 , C07D413/02 , C07D403/02
CPC分类号： C07D213/74 , C07D211/16 , C07D211/26 , C07D211/32 , C07D211/46 , C07D211/52 , C07D211/58 , C07D213/38 , C07D239/42 , C07D295/192 , C07D333/24 , C07D401/04 , C07D409/06 , C07D409/14 , C07D487/08
摘要： Novel compounds of the formula (I) in which D, E, Q, T, X, Y, Z, Z′, R1, R4 and R4′ have the meanings indicated in patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours
摘要翻译： 其中D，E，Q，T，X，Y，Z，Z'，R 1，R 4和R 4的新的式（I）化合物 > 4'具有专利权利要求1所述的含义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤
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9.发明申请N-'4-(2-imino-pyrrolidin-1-yl)phenyl!-acetamide and corresponding piperidine derivatives as factor xa inhibitors for the treatment of thrombo-embolic diseases 审中-公开N-4-（2-亚氨基 - 吡咯烷-1-基）苯基 - 乙酰胺和相应的哌啶衍生物作为因子xa抑制剂用于治疗血栓栓塞性疾病公开(公告)号：US20050176760A1
公开(公告)日：2005-08-11
申请号：US10510046
申请日：2003-03-07
申请人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Christopher Barnes , Johannes Gleitz
发明人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Christopher Barnes , Johannes Gleitz
IPC分类号： C07D211/76 , A61K31/402 , A61K31/4178 , A61K31/423 , A61K31/439 , A61K31/451 , A61K31/4725 , A61P7/02 , A61P9/10 , A61P25/06 , A61P29/00 , A61P35/00 , C07D207/22 , C07D207/24 , C07D211/72 , C07D401/12 , C07D403/12 , C07D413/12 , C07D453/06 , A61K31/4709 , A61K31/40 , A61K31/445
CPC分类号： C07D401/12 , C07D207/22 , C07D207/24 , C07D211/72 , C07D403/12 , C07D413/12 , C07D453/06
摘要： Novel compounds of the formula I in which D, M, W, X, Y, T and R1 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中D，M，W，X，Y，T和R 1如专利权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于预防 和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20050171102A1
公开(公告)日：2005-08-04
申请号：US10513451
申请日：2003-04-07
申请人： Werner Mederski , Dieter Dorsch , Christos Tsaklakidis , Christopher Barnes , Bertram Cezanne , Johannes Gleitz
发明人： Werner Mederski , Dieter Dorsch , Christos Tsaklakidis , Christopher Barnes , Bertram Cezanne , Johannes Gleitz
IPC分类号： C07D295/12 , A61K31/402 , A61K31/421 , A61K31/439 , A61K31/4418 , A61K31/451 , A61K31/495 , A61K31/50 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/06 , A61P29/00 , A61P35/00 , A61P35/04 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D221/22 , C07D223/10 , C07D237/14 , C07D241/08 , C07D241/18 , C07D263/22 , C07D265/32 , C07D295/135 , C07D453/06 , C07D413/02 , A61K31/4245 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/5377
CPC分类号： C07D207/26 , C07D211/76 , C07D213/64 , C07D223/10 , C07D237/14 , C07D241/08 , C07D263/22 , C07D265/32 , C07D295/135 , C07D453/06
摘要： Novel compounds of the formula I in which R, R1, R1, X are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中R 1，R 1，R 1，X 1如权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于 预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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