公开(公告)号：US06469176B1

公开(公告)日：2002-10-22

申请号：US09831400

申请日：2001-05-09

申请人： Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Baumann

发明人： Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Baumann

IPC分类号： C07D26104

CPC分类号： C07D413/10 ,  C07C251/48 ,  C07C319/14 ,  C07D261/04 ,  C07D261/08 ,  C07C323/09

摘要： The present invention describes a process for preparing isoxazoles of the formula I where: R1 is hydrogen, C1-C6-alkyl, R2 is hydrogen, C1-C6-alkyl, R3, R4, R5 are each hydrogen, C1-C6-alkyl or R4 and R5 together from a bond, R6 is a heterocysclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are each as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Furthermore, the invention describes novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates.

摘要翻译： 本发明描述了制备式I的异恶唑的方法，其中R 1是氢，C 1 -C 6烷基，R 2是氢，C 1 -C 6烷基，R 3，R 4，R 5各自是氢，C 1 -C 6烷基或R 4 和R 5一起来自键，R 6是杂环环，n是0,1或2;其中包括制备式VI的中间体，其中R 1，R 3，R 4和R 5各自如上定义，随后进行卤化，硫甲基化，氧化 和酰化得到式I化合物。此外，本发明描述了制备式I化合物的新中间体和制备中间体的新方法。

公开(公告)号：US06388135B1

公开(公告)日：2002-05-14

申请号：US09894006

申请日：2001-06-29

申请人： Rene Lochtman ,  Michael Keil ,  Joachim Gebhardt ,  Michael Rack ,  Wolfgang von Deyn

发明人： Rene Lochtman ,  Michael Keil ,  Joachim Gebhardt ,  Michael Rack ,  Wolfgang von Deyn

IPC分类号： C07C20900

CPC分类号： C07D261/04

摘要： A process for preparing 4-bromoaniline derivatives of the formula I where: R1 is C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, halogen R2 is C1-C6-alkyl, C1-C6-alkoxy, C3-C8-cycloalkyl, C2-C6-alkenyl, cyano or a heterocyclic radical is described.

摘要翻译： 制备式I的4-溴苯胺衍生物的方法，其中R 1是C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷氧基，C 1 -C 6卤代烷氧基，C 3 -C 8环烷基，卤素R 2是C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，C 3 -C 8 - 环烷基，C 2 -C 6 - 烯基，氰基或杂环基。

公开(公告)号：US20140155451A1

公开(公告)日：2014-06-05

申请号：US14236362

申请日：2012-08-10

申请人： Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frasetto ,  Gemma Veitch ,  Markus Kordes ,  Marco Naujok

发明人： Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frasetto ,  Gemma Veitch ,  Markus Kordes ,  Marco Naujok

IPC分类号： A01N43/50 ,  A01N41/12

CPC分类号： A01N43/56 ,  A01N37/28 ,  A01N41/12 ,  A01N43/50 ,  A01N43/80 ,  C07B2200/13 ,  C07C381/10 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention relates to compounds of the formula (I) wherein R1 and R2 independently of one another are hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C10-cycloalkyl, C3-C10-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl or together represent an aliphatic chain, or the like; R3 is halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C8-alkenyl, C2-C8-haloalkenyl, C1-C8-alkoxy, phenyl, or the like; R4 is hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl, phenyl, or the like; t is 0 or 1; p is 0, 1, 2, 3 or 4. The present invention also relates to a process for preparing a compound of the formula (I) which comprises reacting a compound of the formula II with a compound of the formulae III or IV: where t, p, R1 R3, R3 and R4 are as defined in any of claims 1 to 6 and where A− is an equivalent of an anion having a pKB of at least 10 (determined under standard conditions in water).

摘要翻译： 本发明涉及式（I）化合物，其中R 1和R 2彼此独立地是氢，C 1 -C 10 - 烷基，C 1 -C 10 - 卤代烷基，C 3 -C 10 - 环烷基，C 3 -C 10 - 卤代环烷基，C 2 -C 10 烯基，C 2 -C 10 - 卤代链烯基或一起代表脂族链等; R3是卤素，氰基，C1-C8-烷基，C1-C8-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C8-烯基，C2-C8-卤代烯基，C1-C8-烷氧基，苯基， 或类似物; R4是氢，C1-C10-烷基，C1-C10-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C10-烯基，C2-C10-卤代烯基，苯基等; t为0或1; 本发明还涉及制备式（I）化合物的方法，其包括使式II化合物与式III或IV化合物反应：其中 t，p，R 1，R 3，R 3和R 4如权利要求1至6中任一项所定义，其中A-是pKB为至少10（在水中标准条件下测定）的阴离子的当量。

公开(公告)号：US20130274109A1

公开(公告)日：2013-10-17

申请号：US13996046

申请日：2011-12-23

申请人： Ruediger Reingruber ,  Helmut Kraus ,  Johannes Hutzler ,  Trevor William Newton ,  Matthias Witschel ,  William Karl Moberg ,  Liliana Parra Rapado ,  Gilbert Besong ,  Michael Rack ,  Andree Van Der Kloet ,  Thomas Seitz ,  Jens Lerchl ,  Klaus Kreuz ,  Klaus Grossmann ,  Richard Roger Evans

发明人： Ruediger Reingruber ,  Helmut Kraus ,  Johannes Hutzler ,  Trevor William Newton ,  Matthias Witschel ,  William Karl Moberg ,  Liliana Parra Rapado ,  Gilbert Besong ,  Michael Rack ,  Andree Van Der Kloet ,  Thomas Seitz ,  Jens Lerchl ,  Klaus Kreuz ,  Klaus Grossmann ,  Richard Roger Evans

IPC分类号： A01N43/90

CPC分类号： A01N43/90 ,  C07D495/04

摘要： The present invention provides substituted pyrazine compounds of the formula I or N-oxides or agriculturally suitable salts thereof, wherein the variables in the formula I are defined as in the description. Substituted pyrazines of formula I are useful as herbicides.

摘要翻译： 本发明提供式I的取代的吡嗪化合物或其N-氧化物或农业上合适的盐，其中式I中的变量如描述中所定义。 式I的取代的吡嗪可用作除草剂。

公开(公告)号：US08338419B2

公开(公告)日：2012-12-25

申请号：US13400752

申请日：2012-02-21

申请人： Thomas Schmidt ,  Michael Puhl ,  Joachim Dickhaut ,  Henricus Maria Martinus Bastiaans ,  Michael Rack ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Franz-Josef Braun ,  Toni Bucci ,  Henry Van Tuyl Cotter ,  David G. Kuhn ,  Hassan Oloumi-Sadeghi

发明人： Thomas Schmidt ,  Michael Puhl ,  Joachim Dickhaut ,  Henricus Maria Martinus Bastiaans ,  Michael Rack ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Franz-Josef Braun ,  Toni Bucci ,  Henry Van Tuyl Cotter ,  David G. Kuhn ,  Hassan Oloumi-Sadeghi

IPC分类号： A01N43/84 ,  A01N43/56 ,  C07D401/14 ,  C07D413/14 ,  C07D401/04 ,  C07D409/14

CPC分类号： C07D401/04 ,  A01N43/56 ,  A01N43/84 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

摘要： N-Thio-anthranilamid compounds of formula (I) wherein A is a group selected from A1 and A2 wherein the variables and the indices are as defined per the description, processes for preparing the compounds I, pesticidal compositions comprising compounds I, use of compounds I for the control of insects, acarids or nematodes, and methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites by use of compounds of formula I.

摘要翻译： 式（I）的N-硫代 - 邻氨基苯甲酰胺化合物，其中A是选自A1和A2的基团，其中变量和指数如说明书所定义，制备化合物I的方法，包含化合物I的杀虫组合物，化合物的用途 I用于控制昆虫，螨虫或线虫，以及通过使用式I化合物治疗，控制，预防或保护动物免受寄生虫感染或侵害的方法。

公开(公告)号：US07994207B2

公开(公告)日：2011-08-09

申请号：US12519032

申请日：2007-12-20

申请人： Thomas Zierke ,  Michael Rack

发明人： Thomas Zierke ,  Michael Rack

IPC分类号： A61K31/415 ,  C07D231/12

CPC分类号： C07D231/14

摘要： The present invention relates to a process for preparing fluoromethyl-substituted heterocyclic compounds of the general formula (I) in which R1 is H or F; R2 is an -[A-O]m—R3 group in which A is C2-C4-alkanediyl, R3 is C1-C4-alkyl and m is 1 or 2; by converting the corresponding chloromethyl-substituted compounds (II) in the presence of fluorinating agents, to processes for preparing the chloromethyl-substituted compounds (II), to processes for preparing amides of the general formula (IV) and to compounds of the general formulae (I) and (II).

摘要翻译： 本发明涉及制备通式（I）的氟甲基取代的杂环化合物的方法，其中R 1为H或F; R2是其中A是C 2 -C 4烷二基，R 3是C 1 -C 4烷基，m是1或2的 - [A-O] m -R 3基团; 通过在氟化剂的存在下将相应的氯甲基取代的化合物（II）转化为制备氯甲基取代的化合物（II）的方法，制备通式（IV）的酰胺的方法和通式 （I）和（II）。

公开(公告)号：US20110144336A1

公开(公告)日：2011-06-16

申请号：US13058677

申请日：2009-07-30

申请人： Thomas Zierke ,  Eike Hupe ,  Michael Rack ,  Liliana Parra Rapado ,  Timo Frassetto

发明人： Thomas Zierke ,  Eike Hupe ,  Michael Rack ,  Liliana Parra Rapado ,  Timo Frassetto

IPC分类号： C07D241/08

CPC分类号： C07D241/08

摘要： A process for preparing piperazinedione derivatives of the formula I in which R1 is hydrogen, alkyl, alkenyl, alkynyl and alkylcarbonyl, R2 is hydrogen, alkyl, alkenyl, C3-C4-alkynyl and C(═O)R11, R3, R4 are each hydrogen, alkyl and haloalkyl, where the groups may be substituted, which comprises reacting amines of the formula II H2N—R1  II in which R1 is hydrogen and alkyl which may optionally be substituted with N-acylated amino acid derivatives of the formula III in which X is halogen, Y is halogen, alkoxy or phenyloxy which may be substituted and R2, R3 and R4 are each as defined at the outset, under basic conditions in an aqueous solvent.

摘要翻译： 其中R 1是氢，烷基，烯基，炔基和烷基羰基，R 2是氢，烷基，烯基，C 3 -C 4炔基和C（= O）R 11，R 3，R 4各自是式I的哌嗪二酮衍生物的方法 氢，烷基和卤代烷基，其中基团可以被取代，其包括使式II的其中R 1是氢的式IIH 2 N-R 1 II的烷基和可以被式III的N-酰化的氨基酸衍生物任选取代的烷基，其中 X是卤素，Y是可以被取代的卤素，烷氧基或苯氧基，R2，R3和R4各自在碱性条件下在水性溶剂中首先定义。

公开(公告)号：US07851411B2

公开(公告)日：2010-12-14

申请号：US10499522

申请日：2002-12-17

申请人： Peter Plath ,  Norbert Götz ,  Michael Rack ,  Andreas Landes ,  Cyrill Zagar ,  Matthias Witschel ,  Klaus Groβmann

发明人： Peter Plath ,  Norbert Götz ,  Michael Rack ,  Andreas Landes ,  Cyrill Zagar ,  Matthias Witschel ,  Klaus Groβmann

IPC分类号： A01N43/36 ,  A01N37/00 ,  A01N37/34 ,  C07D295/104 ,  C07D305/06 ,  C07C255/07

CPC分类号： C07D295/185 ,  A01N37/44 ,  A01N43/08 ,  A01N43/16 ,  C07C255/30 ,  C07C323/60 ,  C07C327/22 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D305/08 ,  C07D307/18 ,  C07D307/20 ,  C07D307/22 ,  C07D309/14 ,  C07D319/06 ,  C07D331/04

摘要： α-Cyanoacrylates of the formula I, where: R1 is ORa wherein Ra is hydrogen, substituted alkyl, branched alkyl, branched alkenyl, cycloloalkyl, heterocyclyl, aryl, phenylalkyl or alkylimino; is NRbRc wherein Rb is hydrogen, alkyl which may be substituted, alkenyl, alkynyl; Rc is hydrogen, alkyl which may be substituted alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, phenylalkyl or alkylimino; or Rb and Rc form an alkandiyl-chain which may be substituted; or is SRd wherein Rd is hydrogen, alkyl which may be substituted, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, phenylalkyl or alkylimino; R2 is alkyl which may be substituted; is alkenyl or alkynyl; R3 is alkyl may be substituted; is alkenyl or alkynyl; R4 is hydrogen, halogen, cyano or alkyl; and their agriculturally useful salts, processes and intermediates for their preparation; and the use of these compounds or of compositions comprising these compounds for controlling undesirable plants are described.

摘要翻译： 式I的α-氰基丙烯酸酯，其中：R 1是OR a，其中R a是氢，取代的烷基，支链烷基，支链烯基，环烷基，杂环基，芳基，苯基烷基或烷基亚氨基; 是NRbRc，其中Rb是氢，可以被取代的烷基，烯基，炔基; Rc是氢，可以被取代的烯基，炔基，环烷基，杂环基，芳基，苯基烷基或烷基亚氨基的烷基; 或R b和R c形成可被取代的烷撑二链; 或者是其中Rd为氢的SRd，可以被取代的烷基，烯基，炔基，环烷基，杂环基，芳基，苯基烷基或烷基亚氨基; R2是可被取代的烷基; 是烯基或炔基; R3是烷基可以被取代; 是烯基或炔基; R4是氢，卤素，氰基或烷基; 及其农业上有用的盐，其制备方法和中间体; 并且描述了这些化合物或包含这些化合物的组合物用于防治不期望的植物的用途。

公开(公告)号：US20100174094A1

公开(公告)日：2010-07-08

申请号：US12601966

申请日：2008-05-30

申请人： Thomas Zierke ,  Joachim Rheinheimer ,  Michael Rack ,  Sebastian Peer Smidt ,  Ansgar Gereon Altenhoff ,  Joachim Schmidt-Leithoff ,  Nina Challand

发明人： Thomas Zierke ,  Joachim Rheinheimer ,  Michael Rack ,  Sebastian Peer Smidt ,  Ansgar Gereon Altenhoff ,  Joachim Schmidt-Leithoff ,  Nina Challand

IPC分类号： C07D231/18 ,  C07D231/12

CPC分类号： C07D231/14

摘要： The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which R1 is optionally substituted phenyl or C3-C7-cycloalkyl, R1a is hydrogen or fluorine, or R1a together with R1 is optionally substituted C3-C5-alkanediyl or C5-C7-cycloalkanediyl, R2 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C1-C4-alkoxy-C1-C2-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprises A) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and R2 has one of the meanings given above and B) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R1, R1a and n have one of the meanings given above; in the presence of a palladium catalyst; to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.

摘要翻译： 本发明涉及式（I）的N-取代的（3-二卤代甲基吡唑-4-基）甲酰胺的制备方法，其中R 1为任选取代的苯基或C 3 -C 7 - 环烷基，R 1a为氢或氟，或R 1a R 1是C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，C 2 -C 6炔基或C 1 -C 4 - 烷氧基-C 1 -C 2 - 烷基，其中R 1是任选取代的C 3 -C 5 - 烷二基或C 5 -C 7 - 环烷二基， X是F或Cl，n是0,1,2或3; 其包括A）提供其中X为F或Cl，Y为Cl或Br的式（II）化合物，R 2具有上述含义之一，B）使式（II）化合物与一氧化碳 和其中R1，R1a和n具有上述含义之一的式（III）化合物; 在钯催化剂的存在下; 用于根据本发明的方法制备的中间体，以及其制备方法。

公开(公告)号：US20100167933A1

公开(公告)日：2010-07-01

申请号：US12663756

申请日：2008-06-20

申请人： Eike Hupe ,  Thomas Seitz ,  Matthias Witschel ,  Dschun Song ,  William Karl Moberg ,  Liliana Parra Rapado ,  Frank Stelzer ,  Andrea Vescovi ,  Trevor William Newton ,  Robert Reinhard ,  Bernd Sievernich ,  Klaus Grossmann ,  Thomas Ehrhardt ,  Michael Rack ,  Elmar Kibler

发明人： Eike Hupe ,  Thomas Seitz ,  Matthias Witschel ,  Dschun Song ,  William Karl Moberg ,  Liliana Parra Rapado ,  Frank Stelzer ,  Andrea Vescovi ,  Trevor William Newton ,  Robert Reinhard ,  Bernd Sievernich ,  Klaus Grossmann ,  Thomas Ehrhardt ,  Michael Rack ,  Elmar Kibler

IPC分类号： A01N43/60 ,  C07D241/04 ,  A01P13/00

CPC分类号： C07D239/54 ,  A01N43/60 ,  A01N43/90 ,  C07D239/22 ,  C07D239/49 ,  C07D239/58 ,  C07D239/70 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D413/10 ,  C07D417/10 ,  C07D471/14 ,  C07D487/04 ,  C07D491/10

摘要： The present invention relates to piperazine compounds of the general formula I defined below and to their use as herbicides. Moreover, the invention relates to compositions for crop protection and to a method for controlling unwanted vegetation. In formula I, A1, A2 independently of one another are aryl or heteroaryl, where Ra is attached in the ortho-position to the point of attachment of A1 to a carbon atom or a nitrogen atom of A1, Y1, Y2 are oxygen, sulfur or a group NRy1, and the variables Ra, Rb, Rc, Rd, Re, Rf, R1, R2, R3, R4, R5, R6, R7, and R8 have the meanings mentioned in the claims and the description.

摘要翻译： 本发明涉及下面定义的通式I的哌嗪化合物及其作为除草剂的用途。 此外，本发明涉及用于作物保护的组合物和用于防治不想要的植物的方法。 式Ⅰ中，A 1，A 2彼此独立地为芳基或杂芳基，其中R a与A1连接的位置与A1的碳原子或氮原子的邻位相连，Y 1，Y 2为氧，硫 或NRy1基团，变量Ra，Rb，Rc，Rd，Re，Rf，R1，R2，R3，R4，R5，R6，R7和R8具有权利要求书和说明书中提及的含义。