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    Method for attachment of biomolecules to medical device surfaces
    62.
    发明授权
    Method for attachment of biomolecules to medical device surfaces 失效
    将生物分子附着到医疗器械表面的方法

    公开(公告)号：US06617142B2

    公开(公告)日：2003-09-09

    申请号：US09257543

    申请日：1999-02-24

    申请人： James R. Keogh ,  Paul V. Trescony

    发明人： James R. Keogh ,  Paul V. Trescony

    IPC分类号： C12N1100

    CPC分类号： A61L33/18 ,  A61L27/24 ,  A61L27/28 ,  A61L27/34 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0047 ,  A61L33/0082 ,  A61L33/12 ,  A61L33/128 ,  C08L89/00 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/815 ,  Y10S530/816

    摘要： Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule such as a glycoprotein having an unsubstituted amide moiety is combined with an amine forming agent to form an amine-functional biomolecule. The amine-functional biomolecule is combined with a medical device surface having a chemical moiety such as aldehyde, epoxide, isocyanate, 1,2-dicarbonyl, phosphate, sulphate or carboxylate to form a chemical bond immobilizing the biomolecule on the surface. The chemical bond may be combined with a reducing agent or a stabilizing agent. The aldehyde moiety may be formed by combining a periodate with a 2-aminoalcohol moiety or a 1,2-dihydroxy moiety. Alternatively, an amine-functional medical device surface is combined with a biomolecule having a chemical moiety that reacts with an amine moiety. In another embodiment, the amine-functional biomolecule is converted to a guanidino-functional biomolecule and is combined with a medical device surface having a chemical moiety that reacts with a guanidino moiety. Alternatively, an amine-functional medical device surface is converted to a guanidino-functional surface and is combined with a biomolecule having the chemical moiety. Biomolecules may be crosslinked by combining the amine-functional or guanidino-functional biomolecule with a biomolecule having a chemical moiety that forms a chemical bond with an amine moiety or a guanidino moiety.

    摘要翻译： 提供了用于在医疗装置的表面上形成固定的生物分子的涂层的方法，以提高用于接触组织和体液的生物相容性。 将具有未取代的酰胺部分的生物分子例如具有未取代的酰胺部分的糖蛋白与胺形成剂合并以形成胺官能的生物分子。 将胺官能的生物分子与具有化学部分的医疗装置表面结合，例如醛，环氧化物，异氰酸酯，1,2-二羰基，磷酸酯，硫酸酯或羧酸酯，以形成将生物分子固定在表面上的化学键。 化学键可以与还原剂或稳定剂组合。 醛部分可以通过将高碘酸酯与2-氨基醇部分或1,2-二羟基部分结合而形成。 或者，将胺官能医疗器械表面与具有与胺部分反应的化学部分的生物分子组合。 在另一个实施方案中，将胺官能的生物分子转化为胍基官能的生物分子，并与具有与胍基部分反应的化学部分的医疗装置表面组合。 或者，将胺官能医疗器械表面转化为胍基官能表面，并与具有化学部分的生物分子组合。 生物分子可以通过将胺官能或胍基官能的生物分子与具有与胺部分或胍基部分形成化学键的化学部分的生物分子结合而交联。

    Fixed tissue medical devices comprising albumin-binding dyes
    63.
    发明授权
    Fixed tissue medical devices comprising albumin-binding dyes 失效
    包含白蛋白结合染料的固定组织医疗装置

    公开(公告)号：US5509932A

    公开(公告)日：1996-04-23

    申请号：US044846

    申请日：1993-04-08

    申请人： James R. Keogh ,  David A. Pearson ,  John W. Eaton

    发明人： James R. Keogh ,  David A. Pearson ,  John W. Eaton

    IPC分类号： A61F2/24 ,  A61L27/28 ,  A61L27/34 ,  A61F2/02

    CPC分类号： A61L27/28 ,  A61L27/34 ,  A61F2/2412

    摘要： An implantable medical device is provided which comprises a fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. These albumin-binding dyes have been found to significantly reduce calcification when incorporated in tissue heart valves. A method of increasing the albumin-binding ability of an implantable medical device is also provided.

    摘要翻译： 提供了一种植入式医疗装置，其包括固定组织，当该装置与含有白蛋白的生理液体接触时，该固定组织掺入一定量的能够在所述装置上形成内源性白蛋白的涂层的白蛋白结合染料。 已经发现这些白蛋白结合染料当结合到组织心脏瓣膜中时显着降低钙化。 还提供了增加可植入医疗装置的白蛋白结合能力的方法。

    Method for attachment of biomolecules to medical devices surfaces
    70.
    发明授权
    Method for attachment of biomolecules to medical devices surfaces 失效
    将生物分子附着到医疗器械表面的方法

    公开(公告)号：US5925552A

    公开(公告)日：1999-07-20

    申请号：US67188

    申请日：1998-04-27

    申请人： James R. Keogh ,  Paul V. Trescony

    发明人： James R. Keogh ,  Paul V. Trescony

    IPC分类号： A61L27/24 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L31/08 ,  A61L31/10 ,  A61L33/00 ,  A61L33/12 ,  A61L33/18 ,  C12N11/00 ,  A61K38/43 ,  G01N33/543 ,  C07K17/00

    CPC分类号： A61L33/18 ,  A61L27/24 ,  A61L27/28 ,  A61L27/34 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0047 ,  A61L33/0082 ,  A61L33/12 ,  A61L33/128 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/815 ,  Y10S530/816

    摘要： Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule such as a glycoprotein having an unsubstituted amide moiety is combined with an amine forming agent to form an amine-functional biomolecule. The amine-functional biomolecule is combined with a medical device surface having a chemical moiety such as aldehyde, epoxide, isocyanate, 1,2-dicarbonyl, phosphate, sulphate or carboxylate to form a chemical bond immobilizing the biomolecule on the surface. The chemical bond may be combined with a reducing agent or a stabilizing agent. The aldehyde moiety may be formed by combining a periodate with a 2-aminoalcohol moiety or a 1,2-dihydroxy moiety. Alternatively, an amine-functional medical device surface is combined with a biomolecule having a chemical moiety that reacts with an amine moiety. In another embodiment, the amine-functional biomolecule is converted to a guanidino-functional biomolecule and is combined with a medical device surface having a chemical moiety that reacts with a guanidino moiety. Alternatively, an amine-functional medical device surface is converted to a guanidino-functional surface and is combined with a biomolecule having the chemical moiety. Biomolecules may be crosslinked by combining the amine-functional or guanidino-functional biomolecule with a biomolecule having a chemical moiety that forms a chemical bond with an amine moiety or a guanidino moiety.

    摘要翻译： 提供了用于在医疗装置的表面上形成固定的生物分子的涂层的方法，以提高用于接触组织和体液的生物相容性。 将具有未取代的酰胺部分的生物分子例如具有未取代的酰胺部分的糖蛋白与胺形成剂合并以形成胺官能的生物分子。 将胺官能的生物分子与具有化学部分的医疗装置表面结合，例如醛，环氧化物，异氰酸酯，1,2-二羰基，磷酸酯，硫酸酯或羧酸酯，以形成将生物分子固定在表面上的化学键。 化学键可以与还原剂或稳定剂组合。 醛部分可以通过将高碘酸酯与2-氨基醇部分或1,2-二羟基部分结合而形成。 或者，将胺官能医疗器械表面与具有与胺部分反应的化学部分的生物分子组合。 在另一个实施方案中，将胺官能的生物分子转化为胍基官能的生物分子，并与具有与胍基部分反应的化学部分的医疗装置表面组合。 或者，将胺官能医疗器械表面转化为胍基官能表面，并与具有化学部分的生物分子组合。 生物分子可以通过将胺官能或胍基官能的生物分子与具有与胺部分或胍基部分形成化学键的化学部分的生物分子结合而交联。