利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

111 条记录 (耗时 0.126 秒)

    MHC multimers in borrelia diagnostics and disease
    61.
    发明授权
    MHC multimers in borrelia diagnostics and disease 有权

    公开(公告)号：US10968269B1

    公开(公告)日：2021-04-06

    申请号：US12919405

    申请日：2008-12-30

    申请人： Jørgen Schøller ,  Liselotte Brix ,  Henrik Pedersen

    发明人： Jørgen Schøller ,  Liselotte Brix ,  Henrik Pedersen

    IPC分类号： C07K14/74 ,  A61K39/00

    摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules containing one or more Borrelia derived peptides are disclosed. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the sample-mounted use of MHC complexes and MHC multimers.
    Also comprised by the invention is the field of therapy and vaccine, including therapeutic/vaccine methods and therapeutic/vaccine compositions.

    Combinatorial analysis and repair
    62.
    发明授权
    Combinatorial analysis and repair 有权

    公开(公告)号：US10722562B2

    公开(公告)日：2020-07-28

    申请号：US13055321

    申请日：2009-07-22

    申请人： Henrik Pedersen ,  Liselotte Brix

    发明人： Henrik Pedersen ,  Liselotte Brix

    IPC分类号： A61K39/00 ,  A61K39/02

    摘要： A method for the repair of a unit, by specific diagnosis of the undesired state, and its appropriate repair, using said specific diagnosis as a means to repair in an appropriate way said unit. The diagnosis and repair processes may involve chemical, physical, or mechanical means. The units being diagnosed and repaired include live matter (e.g. human beings, animals, plants) as well as non-live matter (e.g. buildings, electronic equipment, polymer materials).

    Quasirandom structure and function guided synthesis methods
    65.
    发明授权
    Quasirandom structure and function guided synthesis methods 有权
    曲斯兰结构和功能指导合成方法

    公开(公告)号：US09121110B2

    公开(公告)日：2015-09-01

    申请号：US10539288

    申请日：2003-12-19

    申请人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    发明人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    IPC分类号： C40B50/00 ,  C40B20/04 ,  C40B30/00 ,  C40B50/10 ,  C12Q1/68 ,  C07H21/02 ,  C40B30/04 ,  C12N15/10 ,  C40B40/06 ,  C40B50/08 ,  C40B50/04

    CPC分类号： C40B30/04 ,  C12N15/1068 ,  C40B20/04 ,  C40B40/06 ,  C40B50/04 ,  C40B50/08 ,  Y10T436/145555

    摘要： The present invention is directed to the synthesis of molecules guided by connector polynucleotides (CPNs) capable of hybridizing to complementary connector polynucleotides (CCPNs) harboring at least one functional entity comprising at least one reactive group. At least one of the CCPNs is capable of hybridizing to at least two CPNs. Each CPN will “call” for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of reactive groups results in the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNs” to at least one “acceptor CCPN” with which the transferred functional entities were not associated prior to the transfer.

    摘要翻译： 本发明涉及由能够与包含至少一个反应性基团的至少一个功能实体的互补连接多核苷酸（CCPN）杂交的连接体多核苷酸（CPN）引导的分子的合成。 至少有一个CCPN能够与至少两个CPN杂交。 每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN。 在形成包含多个CPN和多个CCPN的超分子杂交复合物之后，反应性基团的反应导致包含共价连接的功能性实体的分子的形成。 分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移至至少一个转移的功能实体在转移之前与之不相关的“受体CCPN”。

    Combinatorial Analysis and Repair
    68.
    发明申请
    Combinatorial Analysis and Repair 审中-公开
    组合分析与修复

    公开(公告)号：US20110212090A1

    公开(公告)日：2011-09-01

    申请号：US13055321

    申请日：2009-07-22

    申请人： Henrik Pedersen ,  Liselotte Brix

    发明人： Henrik Pedersen ,  Liselotte Brix

    IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K31/704 ,  A61P31/04 ,  A61P31/06 ,  A61K31/496 ,  A61K39/00 ,  A61K39/02

    摘要： A method for the repair of a unit, by specific diagnosis of the undesired state, and its appropriate repair, using said specific diagnosis as a means to repair in an appropriate way said unit. The diagnosis and repair processes may involve chemical, physical, or mechanical means. The units being diagnosed and repaired include live matter (e.g. human beings, animals, plants) as well as non-live matter (e.g. buildings, electronic equipment, polymer materials).

    摘要翻译： 通过特定诊断不期望的状态及其适当的修复，使用所述特定诊断作为以适当方式修复所述单元的手段来修复单元的方法。 诊断和修复过程可能涉及化学，物理或机械手段。 被诊断和修复的单位包括活物（例如人类，动物，植物）以及非活体物质（例如建筑物，电子设备，聚合物材料）。

    Oxaloacetate hydrolase deficient fungal host cells
    70.
    发明授权
    Oxaloacetate hydrolase deficient fungal host cells 有权
    草酰乙酸水解酶缺陷型真菌宿主细胞

    公开(公告)号：US07919275B2

    公开(公告)日：2011-04-05

    申请号：US12719648

    申请日：2010-03-08

    申请人： Carsten Mailand Hjort ,  Henrik Pedersen ,  Jens Nielsen

    发明人： Carsten Mailand Hjort ,  Henrik Pedersen ,  Jens Nielsen

    IPC分类号： C12N1/15 ,  C12P21/00

    CPC分类号： C12Q1/6895 ,  C12N9/14

    摘要： An isolated mutant host cell produced by disrupting or deleting, in a parent cell, a nucleic acid sequence encoding an oxaloacetate hydrolase, or a promoter thereof, which results in the mutant cell producing less of the oxaloacetate hydrolase than the parent cell is disclosed. The disclosure also relates to recombinant methods for producing the products such as polypeptides.

    摘要翻译： 公开了一种分离的突变宿主细胞，其通过在母体细胞中破坏或缺失编码草酰乙酸水解酶的核酸序列或其启动子，导致突变体细胞产生比母细胞少的草酰乙酸酯水解酶。 本公开还涉及用于生产诸如多肽的产物的重组方法。