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135 条记录 (耗时 0.03 秒)

    Pyrimidine compounds
    61.
    发明授权
    Pyrimidine compounds 有权
    嘧啶化合物

    公开(公告)号：US06693097B2

    公开(公告)日：2004-02-17

    申请号：US10000742

    申请日：2001-11-30

    申请人： Mitsunori Ono ,  Shijie Zhang ,  Teresa Przewloka ,  K. Koya ,  Elena Kostik ,  Yuniko Wada ,  Lijun Sun ,  Weiwen Ying

    发明人： Mitsunori Ono ,  Shijie Zhang ,  Teresa Przewloka ,  K. Koya ,  Elena Kostik ,  Yuniko Wada ,  Lijun Sun ,  Weiwen Ying

    IPC分类号： C07D41704

    CPC分类号： C07D239/48 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    摘要： This invention features pyrimidine compounds of formula (I): aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.

    摘要翻译： 本发明的特征在于式（I）的嘧啶化合物：芳基或杂芳基; R 2和R 4各自独立地是R c，卤素，硝基，氰基，异硫代，SR c或OR c; 或R 2和R 4一起是羰基; R 3是R c，链烯基，炔基，OR c，OC（O）R c，SO 2 R c，S（O）R c，S（O 2）NR c NR c C（O）OR d，NR c C（O）NR c， R d，NR c，SO 2 R d，COR c，C（O）OR c或C（O）NR c R d; R5是H或烷基; n是0，1，2，3，4，5或6; X是O，S，S（O），S（O 2）或NR c; Y是共价键，CH 2，C（O），C = NR c，C = N-OR c，C = N-SR c，O，S，S（O） ）或NR ; Z是N或CH; U和V之一是N，另一个是CR ; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R 1和R 2各自独立地是H，烷基，芳基，杂芳基; R c和R d各自独立地是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基。

    2,4,6-trisubstituted-pyrimidine compounds
    62.
    发明授权
    2,4,6-trisubstituted-pyrimidine compounds 有权
    2,4,6-三取代 - 嘧啶化合物

    公开(公告)号：US06660733B2

    公开(公告)日：2003-12-09

    申请号：US10192347

    申请日：2002-07-10

    申请人： Lijun Sun ,  Mitsunori Ono ,  Teresa Przewloka ,  Elena Kostic ,  Yumiko Wada

    发明人： Lijun Sun ,  Mitsunori Ono ,  Teresa Przewloka ,  Elena Kostic ,  Yumiko Wada

    IPC分类号： C07D23924

    CPC分类号： C07D239/48 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    摘要： This invention features pyrimidine compounds of formula (I): R1 is  each of R2 and R4 is H; R3 is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and Rc is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.

    摘要翻译： 本发明的特征在于式（I）的嘧啶化合物：R1是R2，R4是H; R3是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基; R5是H或烷基; n是0，1，2，3，4，5或6; X是NR c; Y是共价键，CH 2，C（O），C = NR c，C = N-OR c，C = N-SR c，O，S，S（O） ，或NR ; Z是N或CH; U和V之一是N，另一个是CR ; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R 1和R 2各自独立地是H，烷基，芳基，杂芳基; R c是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基。

    Polypeptide thin film from amphiphilic compounds
    64.
    发明授权
    Polypeptide thin film from amphiphilic compounds 失效
    来自两亲化合物的多肽薄膜

    公开(公告)号：US5095090A

    公开(公告)日：1992-03-10

    申请号：US507540

    申请日：1992-04-11

    申请人： Mitsunori Ono ,  Tsutomu Miyasaka ,  Naoyuki Nishikawa

    发明人： Mitsunori Ono ,  Tsutomu Miyasaka ,  Naoyuki Nishikawa

    IPC分类号： C07K14/00 ,  C08G69/10

    CPC分类号： B82Y30/00 ,  B82Y40/00 ,  B82Y5/00 ,  C07K14/001 ,  C08G69/10

    摘要： A polypeptide thin film obtained by polymerizing a monomolecular film comprising a monomer mixture of(a) an amphiphilic compound having a hydrophobic moiety and a hydrophilic moiety having an amino acid ester structure per molecule, the conjugated acid of the elimination group of the ester having a pKa of not higher than 14, and(b) an amphiphilic compound having two amino groups per molecule or an amphiphilic compound having two ester structures per molecule, the conjugated acid of the elimination group of the ester having a pKa of not higher than 16,or a built-up film of the monomolecular film; and a process for preparing a material carrying the polypeptide thin film.

    摘要翻译： 通过使包含单体混合物（a）具有疏水部分的两亲性化合物和每分子具有氨基酸酯结构的亲水部分的单体混合物聚合获得的多肽薄膜，所述酯的消除基团的共轭酸具有 pKa不高于14，和（b）每分子具有两个氨基的两亲化合物或每分子具有两个酯结构的两亲化合物，所述酯的消除基团的共轭酸的pKa不高于16， 或单分子膜的叠层膜; 以及制备携带多肽薄膜的材料的方法。

    Silver halide photographic materials comprising blocked photographic reagants releasing plug groups
    65.
    发明授权
    Silver halide photographic materials comprising blocked photographic reagants releasing plug groups 失效
    卤化银照相材料包括封闭的摄影试剂释放插塞组

    公开(公告)号：US4888268A

    公开(公告)日：1989-12-19

    申请号：US234008

    申请日：1988-08-16

    申请人： Isamu Itoh ,  Mitsunori Ono ,  Yoshio Inagaki

    发明人： Isamu Itoh ,  Mitsunori Ono ,  Yoshio Inagaki

    IPC分类号： G03C7/305

    CPC分类号： G03C7/30511 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/159 ,  Y10S430/161

    摘要： A silver halide photographic material, which contains at least one blocked photographic reagent having in the molecule thereof at least one group selected from ##STR1## group and capable of releasing a photographically useful reagent by cleavage of the --N--C--bond by a nucleophilic attack of a nucleophilic reagent on the carbonyl group and a subsequent intramolecular electron transfer reaction or intramolecular nucleophilic reaction and which has at least one photosensitive silver halide emulsion layer, is photographically processed in the presence of an amine. A photographic material which includes, in combination, a photographic reagent precursor capable of releasing a photographically useful reagent timely on photographic processing and a photosensitive silver halide emulsion layer is provided along with a method of processing the photographic material.

    摘要翻译： 一种卤化银照相材料，其含有至少一种在其分子中具有至少一个选自“IMAGE”组的基团的封闭的照相试剂，并且能够通过亲核攻击来切割-NC键而释放照相用试剂 羰基上的亲核试剂和随后的分子内电子转移反应或分子内亲核反应并且具有至少一个光敏卤化银乳剂层，在胺的存在下进行照相处理。 提供了一种照相材料，其组合包括能够及时在照相处理和感光卤化银乳剂层上释放照相用试剂的照相试剂前体以及处理照相材料的方法。

    Pyrimidine compounds
    67.
    发明授权
    Pyrimidine compounds 失效
    嘧啶化合物

    公开(公告)号：US07470685B2

    公开(公告)日：2008-12-30

    申请号：US11041537

    申请日：2005-01-21

    申请人： Lijun Sun ,  Mitsunori Ono ,  Elena Kostik ,  Yumiko Wada

    发明人： Lijun Sun ,  Mitsunori Ono ,  Elena Kostik ,  Yumiko Wada

    IPC分类号： A61K31/506 ,  A61P3/10 ,  A61P17/06 ,  A61P19/02 ,  A61P25/28 ,  C07D239/24 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04

    CPC分类号： C07D239/48 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    摘要： This invention features pyrimidine compounds of formula (I): R1 is in which one of Ra and Rb is H or alkyl, and the other is aryl or heteroaryl optionally substituted with Rd and Rem; each of R2 and R4 is H; R3 is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which Rc is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; Rd is halogen, CN, alkyl, alkyloxy, alkylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, hydroxyalkyl, alkylamino, or alkylaminocarbonyl; Re is halogen, CN, hydroxyl, alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, or heteroaryloxyl; and m is 0, 1, 2, 3, or 4. The pyrimidine compounds can be used to treat an IL-12 overproduction-related disorder (e.g., rheumatoid arthritis, sepsis, Crohn's disease, multiple sclerosis, psoriasis, or insulin-dependent diabetes mellitus).

    摘要翻译： 本发明的特征在于式（I）的嘧啶化合物：其中R 1和R b中的一个是H或烷基，另一个是任选被Rd和Rem取代的芳基或杂芳基; R2和R4各自为H; R3是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基; R5是H或烷基; n是0，1，2，3，4，5或6; X是NRc; Y是共价键，CH2，C（O），C-N-Rc，C-N-ORc，C-N-SRc，O，S，S（O），S（O 2）或NRc; Z是N或CH; U和V之一是N，另一个是CRc; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R c是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基; Rd是卤素，CN，烷基，烷氧基，烷基羰基，烷氧基羰基，芳氧基羰基，杂芳氧基羰基，羟基烷基，烷基氨基或烷基氨基羰基; Re是卤素，CN，羟基，烷基，芳基，杂芳基，烷氧基，芳氧基或杂芳氧基; 嘧啶化合物可用于治疗IL-12过度生产相关疾病（例如类风湿性关节炎，败血症，克罗恩病，多发性硬化，牛皮癣或胰岛素依赖型 糖尿病）。

    Compositions for treating diabetes or obesity
    69.
    发明申请
    Compositions for treating diabetes or obesity 审中-公开
    用于治疗糖尿病或肥胖的组合物

    公开(公告)号：US20060188590A1

    公开(公告)日：2006-08-24

    申请号：US11326102

    申请日：2006-01-04

    申请人： Mitsunori Ono

    发明人： Mitsunori Ono

    IPC分类号： A61K36/906 ,  A61K36/185 ,  A61K31/7048 ,  A61K31/353 ,  A61K31/522 ,  A61K36/63

    CPC分类号： A61K36/45 ,  A61K31/353 ,  A61K31/522 ,  A61K31/7048 ,  A61K36/48 ,  A61K36/87 ,  A61K45/06 ,  A61K2300/00

    摘要： This invention relates to a composition that includes two compounds selected from a group of nine members, i.e., an α-glucosidase inhibitor, an intestinal glucose transporter inhibitor, a glycation inhibitor, a nitric oxide production inhibitor, an aldose reductase inhibitor, a PPAR agonist, an adipocytokine activator, a glucose uptake enhancer, and a thermogenesis enhancer, in which the two compounds are two different members; and each compound is naturally occurring in a plant and is provided in the form of a plant extract. This invention also relates to a method of treating diabetes or obesity with the above-mentioned composition.

    摘要翻译： 本发明涉及一种组合物，其包含两种选自九个成员的化合物，即α-葡糖苷酶抑制剂，肠葡萄糖转运蛋白抑制剂，糖化抑制剂，一氧化氮产生抑制剂，醛糖还原酶抑制剂，PPAR激动剂 ，脂肪细胞因子激活剂，葡萄糖摄取增强剂和生热促进剂，其中两种化合物是两种不同的成员; 并且每种化合物天然存在于植物中并且以植物提取物的形式提供。 本发明还涉及用上述组合物治疗糖尿病或肥胖症的方法。