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公开(公告)号：US07202232B2
公开(公告)日：2007-04-10
申请号：US11090801
申请日：2005-03-24
申请人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
发明人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
IPC分类号： A61K31/724 , A61K31/415 , C07D231/10
CPC分类号： C07D231/12 , C07D231/22 , C07D235/10 , C07D235/18 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10
摘要： What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein.
摘要翻译： 所要求保护的是由以下结构式表示的化合物：
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公开(公告)号：US07705029B2
公开(公告)日：2010-04-27
申请号：US11697207
申请日：2007-04-05
申请人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
发明人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
IPC分类号： A61K31/4196 , A61K31/4155 , C07D249/08 , C07D231/10
CPC分类号： C07D231/12 , C07D231/22 , C07D235/10 , C07D235/18 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10
摘要： What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein.
摘要翻译： 所要求的是由以下结构式表示的化合物：或其药学上可接受的盐，溶剂合物或包合物。 结构式（I）的变量如本文所述。
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公开(公告)号：US20070270478A1
公开(公告)日：2007-11-22
申请号：US11697207
申请日：2007-04-05
申请人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
发明人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
IPC分类号： C07D231/00 , A61K31/415 , C07C255/00 , A61K31/275 , A61P37/00
CPC分类号： C07D231/12 , C07D231/22 , C07D235/10 , C07D235/18 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10
摘要： What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein.
摘要翻译： 所要求的是由以下结构式表示的化合物：或其药学上可接受的盐，溶剂合物或包合物。 结构式（I）的变量如本文所述。
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公开(公告)号：US20050272699A1
公开(公告)日：2005-12-08
申请号：US11090801
申请日：2005-03-24
申请人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
发明人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
IPC分类号： A61K31/415 , A61K31/724 , C07D231/10 , C07D231/12 , C07D231/14 , C07D231/22 , C07D235/10 , C07D235/18 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10
CPC分类号： C07D231/12 , C07D231/22 , C07D235/10 , C07D235/18 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10
摘要： What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein.
摘要翻译： 所要求的是由以下结构式表示的化合物：或其药学上可接受的盐，溶剂合物或包合物。 结构式（I）的变量如本文所述。
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公开(公告)号：US06743919B2
公开(公告)日：2004-06-01
申请号：US10233371
申请日：2002-08-29
申请人： Keizo Koya , Lijun Sun , Mitsunori Ono , David James , Weiwen Ying , Shoujun Chen
发明人： Keizo Koya , Lijun Sun , Mitsunori Ono , David James , Weiwen Ying , Shoujun Chen
IPC分类号： C07D47102
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04
摘要： Disclosed is a compound represented by Structural Formula (I): R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl group. Z1 is ═O, ═S, ═NOR11, or ═NR11. R is represented by a Structural Formula selected from (II)-(VII): The variables in Structural Formulas (II)-(VII) are described below.
摘要翻译： 公开了由结构式（I）表示的化合物：R1是任选地与取代或未取代的芳基稠合的取代或未取代的2-咪唑基.Z1 = O，= S，= NOR11或= NR11.R 由选自（II） - （VII）的结构式表示：结构式（II） - （VII）中的变量如下所述。
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公开(公告)号：US07081466B2
公开(公告)日：2006-07-25
申请号：US10802292
申请日：2004-03-16
申请人： Keizo Koya , Lijun Sun , Mitsunori Ono , David James , Weiwen Ying , Shoujun Chen
发明人： Keizo Koya , Lijun Sun , Mitsunori Ono , David James , Weiwen Ying , Shoujun Chen
IPC分类号： A61K31/44 , A61K31/445 , A61K31/415 , C07D471/02 , C07D209/04
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04
摘要： Disclosed is a compound represented by Structural Formula (I): R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl group. Z1 is ═O, ═S, ═NOR11. R is represented by a Structural Formula selected from (II)–(VII): The variables in Structural Formulas (II)–(VII) are described herein.
摘要翻译： 公开了由结构式（I）表示的化合物：R 1是任选与取代或未取代的芳基稠合的取代或未取代的2-咪唑基。 Z 1是-O，-S，-NOR 11。 R由选自（II） - （VII）的结构式表示：本文描述了结构式（II） - （VII）中的变量。
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公开(公告)号：US08598366B2
公开(公告)日：2013-12-03
申请号：US13558886
申请日：2012-07-26
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： C07D261/02
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US20120289483A1
公开(公告)日：2012-11-15
申请号：US13558886
申请日：2012-07-26
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： A61K31/42 , C07D261/08 , C07F9/653 , C07D413/04 , A61P35/00 , A61K31/4439 , A61K31/4725 , A61K31/4709 , A61K31/422 , A61K31/675 , C07D413/10
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US08269017B2
公开(公告)日：2012-09-18
申请号：US12883883
申请日：2010-09-16
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20110059893A1
公开(公告)日：2011-03-10
申请号：US12883883
申请日：2010-09-16
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： A61K38/06 , A61K31/675 , A61K31/501 , A61K31/4725 , A61K31/4709 , A61K31/4439 , A61K31/42 , C07K5/08 , C07F9/09 , C07D261/08 , C07D413/10 , C07D413/04 , A61K31/422 , A61P35/00 , A61P7/00 , A61P27/02
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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