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135 条记录 (耗时 0.037 秒)

    Pyrimidine compounds
    9.
    发明授权
    Pyrimidine compounds 有权
    嘧啶化合物

    公开(公告)号：US06693097B2

    公开(公告)日：2004-02-17

    申请号：US10000742

    申请日：2001-11-30

    申请人： Mitsunori Ono ,  Shijie Zhang ,  Teresa Przewloka ,  K. Koya ,  Elena Kostik ,  Yuniko Wada ,  Lijun Sun ,  Weiwen Ying

    发明人： Mitsunori Ono ,  Shijie Zhang ,  Teresa Przewloka ,  K. Koya ,  Elena Kostik ,  Yuniko Wada ,  Lijun Sun ,  Weiwen Ying

    IPC分类号： C07D41704

    CPC分类号： C07D239/48 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    摘要： This invention features pyrimidine compounds of formula (I): aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.

    摘要翻译： 本发明的特征在于式（I）的嘧啶化合物：芳基或杂芳基; R 2和R 4各自独立地是R c，卤素，硝基，氰基，异硫代，SR c或OR c; 或R 2和R 4一起是羰基; R 3是R c，链烯基，炔基，OR c，OC（O）R c，SO 2 R c，S（O）R c，S（O 2）NR c NR c C（O）OR d，NR c C（O）NR c， R d，NR c，SO 2 R d，COR c，C（O）OR c或C（O）NR c R d; R5是H或烷基; n是0，1，2，3，4，5或6; X是O，S，S（O），S（O 2）或NR c; Y是共价键，CH 2，C（O），C = NR c，C = N-OR c，C = N-SR c，O，S，S（O） ）或NR ; Z是N或CH; U和V之一是N，另一个是CR ; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R 1和R 2各自独立地是H，烷基，芳基，杂芳基; R c和R d各自独立地是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基。

    Heterocyclic compounds
    10.
    发明授权
    Heterocyclic compounds 有权

    公开(公告)号：US07410990B2

    公开(公告)日：2008-08-12

    申请号：US11542963

    申请日：2006-10-03

    申请人： Lijun Sun ,  Mitsunori Ono ,  Yumiko Wada ,  Weiwen Ying ,  Teresa Przewloka ,  Elena Kostik

    发明人： Lijun Sun ,  Mitsunori Ono ,  Yumiko Wada ,  Weiwen Ying ,  Teresa Przewloka ,  Elena Kostik

    IPC分类号： A61K31/4184 ,  A61K31/5377 ,  C07D265/30 ,  C07D235/30

    CPC分类号： C07D473/34 ,  C07D473/16 ,  C07D473/18

    摘要： This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R3 is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORa, OC(O)Ra, OC(O)NRaRb, NRaRb, NRaC(O)Rb, NRaS(O)RbNRaS(O)2Rb, NRaC(O)NRbRc, NRaC(S)NRbRc, NRaC(NRb)NRcRd, NRaC(O)ORb, S(O)NRaRb, S(O)2NRaRb, S(O)Ra, S(O)2Ra, C(O)Ra, C(O)ORa, or C(O)NRaRb; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is O, S, S(O), S(O)2, or NRe; B is N or CRf; X is O, S, S(O), S(O)2, NRe, or C(O); Y is a covalent bond, C(O), C═NRa, O, S, S(O), S(O)2, or NRe; Z is N or CH; each of U and V, independently, is N or CR; and W is O, S, or NRe; in which each of Ra, Rb, Rc, and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; Re is H, alkyl, aryl, acyl, or sufonyl; and Rf is H, alkyl, aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin-12 overproduction-related disorder.