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    Oxidized heparin fractions and their use in inhibiting angiogenesis
    63.
    发明授权
    Oxidized heparin fractions and their use in inhibiting angiogenesis 有权
    氧化肝素部分及其在抑制血管生成中的应用

    公开(公告)号：US08071569B2

    公开(公告)日：2011-12-06

    申请号：US13029584

    申请日：2011-02-17

    Applicant: Shaker A. Mousa

    Inventor： Shaker A. Mousa

    IPC: A61K31/727 ,  C08B37/10 ,  C07H11/00

    CPC classification number: A61K31/727 ,  A61K31/737 ,  A61K45/06 ,  C08B37/0078 ,  A61K2300/00

    Abstract: The present invention relates to a heparin fraction comprising constituents having molecular weights of from about 2,000 to about 4,000 daltons, wherein from about 1% to about 100% of hydroxyl residues of the constituents are oxidized. The present invention also relates to methods of inhibiting angiogenesis and treating an angiogenesis-mediated disorder in a subject by administering a heparin fraction comprising constituents having molecular weights of from about 2,000 to about 30,000 daltons, wherein from about 1% to about 100% of hydroxyl residues of the constituents are oxidized. Another aspect of the present invention relates to compositions including the heparin fractions of the present invention.

    Abstract translation: 本发明涉及包含分子量为约2,000至约4,000道尔顿的成分的肝素级分，其中约1％至约100％的组分的羟基残基被氧化。 本发明还涉及通过施用包含分子量为约2,000至约30,000道尔顿的组分的肝素级分，其中约1％至约100％的羟基，通过施用抑制血管发生并治疗受试者血管生成介导的病症的方法 组分的残基被氧化。 本发明的另一方面涉及包含本发明的肝素级分的组合物。

    SILVER NANOPARTICLES AS ANTI-MICROBIAL
    66.
    发明申请
    SILVER NANOPARTICLES AS ANTI-MICROBIAL 有权
    银纳米微粒作为抗微生物

    公开(公告)号：US20100317617A1

    公开(公告)日：2010-12-16

    申请号：US12796907

    申请日：2010-06-09

    Applicant: Shaker A. Mousa ,  Robert Linhardt

    Inventor： Shaker A. Mousa ,  Robert Linhardt

    IPC: A01N43/16 ,  C08B37/00 ,  C08B37/10 ,  C08B37/08 ,  A61K31/728 ,  A01P1/00 ,  A61K31/727 ,  A61K31/726

    CPC classification number: A61K31/727 ,  A01N59/16 ,  A61K9/5115 ,  A61K31/726 ,  A61K31/728 ,  A61K33/38 ,  A61K45/06 ,  A61K47/6923 ,  A61L15/46 ,  A61L26/0066 ,  A61L27/446 ,  A61L27/54 ,  A61L29/126 ,  A61L29/16 ,  A61L31/128 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/236 ,  A61L2300/624 ,  A61L2400/12 ,  B82Y5/00 ,  C08B37/0075 ,  C08L5/08 ,  C08L5/10 ,  A01N25/34 ,  A01N43/16 ,  A01N2300/00 ,  A61K2300/00

    Abstract: A silver nanocomposite, a formation method for forming the silver nanocomposite, and an application method utilizing the silver nanocomposite. The silver nanocomposite includes a silver nanoparticle conjugated to a glycosaminoglycan (GAG) or glucose. The formation method includes chemically reacting silver nitrate with a reducing agent to form a silver nanoparticle conjugated to the reducing agent of a GAG or glucose. The application method may include topically applying the silver nanocomposite to a wound or burn as an anti-microbial with respect to an antibiotic-resistant genotype in the wound or burn, wherein the silver nanocomposite topically applied includes the silver nanoparticle conjugated to the GAG of 2,6-diaminopyridinyl heparin (DAPHP) or hyaluronan (HA). The application method may include applying the silver nanocomposite as a coating to plastic, a catheter, or a surgical tool, wherein the silver nanocomposite applied as the coating includes the silver nanoparticle conjugated to the GAG of DAPHP.

    Abstract translation: 银纳米复合材料，形成银纳米复合材料的形成方法和利用银纳米复合材料的涂布方法。 银纳米复合材料包括与糖胺聚糖（GAG）或葡萄糖缀合的银纳米颗粒。 形成方法包括使硝酸银与还原剂化学反应以形成与GAG或葡萄糖的还原剂缀合的银纳米颗粒。 施用方法可以包括将伤口上的银纳米复合材料局部施用作为抗生素抗性基因型在伤口或烧伤中作为抗微生物剂，其中局部施用的银纳米复合材料包括与GAG缀合的银纳米颗粒2 ，6-二氨基吡啶基肝素（DAPHP）或透明质酸（HA）。 应用方法可以包括将银纳米复合物作为涂层施用于塑料，导管或外科工具，其中作为涂层施用的银纳米复合材料包括与DAPHP的GAG缀合的银纳米颗粒。

    NOVEL FILTER COMPOSITES FOR DRUG DETOXIFICATION
    67.
    发明申请
    NOVEL FILTER COMPOSITES FOR DRUG DETOXIFICATION 有权
    用于药物脱氧的新型过滤器复合物

    公开(公告)号：US20100316694A1

    公开(公告)日：2010-12-16

    申请号：US12815453

    申请日：2010-06-15

    Applicant: Shaker A. Mousa ,  Robert Linhardt

    Inventor： Shaker A. Mousa ,  Robert Linhardt

    IPC: A61K9/70 ,  B01D29/00 ,  B01D37/00 ,  A61L33/10 ,  A61K31/727 ,  A61P7/02

    CPC classification number: A61L33/0029 ,  A61B17/06166 ,  A61B2017/00526

    Abstract: A filter and a method of forming a suture structure. The filter includes layered structure(s) interior to the filter. Each layered structure includes a carbon structure comprising carbon and a coating on a surface of the carbon structure. Each layered structure may further include a heparin layer that includes heparin and is on the coating. The coating of the filter includes cellulose, PMMA, PEMA, or PHEMA. The carbon structure may include an activated charcoal layer or carbon nanotube(s). The layered structure is configured to remove a contaminant flowing through the filter. The method of forming the suture structure includes forming a film on a suture that has been previously formed on a mammal. The film includes both a coating on the suture and a heparin layer that includes heparin and is on the coating. The coating of the suture structure includes cellulose, PMMA, PEMA, or PHEMA.

    Abstract translation: 一种形成缝线结构的过滤器和方法。 过滤器包括过滤器内部的分层结构。 每个层状结构包括碳结构，其包含碳和碳结构表面上的涂层。 每个层状结构还可以包括包含肝素并且在涂层上的肝素层。 过滤器的涂层包括纤维素，PMMA，PEMA或PHEMA。 碳结构可以包括活性炭层或碳纳米管。 分层结构被配置为去除流过过滤器的污染物。 形成缝线结构的方法包括在预先形成于哺乳动物上的缝线上形成膜。 该膜包括缝合线上的涂层和包含肝素并且在涂层上的肝素层。 缝合结构的涂层包括纤维素，PMMA，PEMA或PHEMA。

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