-
公开(公告)号：US08620430B2
公开(公告)日：2013-12-31
申请号：US11479877
申请日：2006-06-30
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/36514 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/36578 , A61N1/36592
摘要： Systems and methods for selection of electrodes and related pacing configuration parameters used to pace a heart chamber are described. A change in the hemodynamic state of a patient is detected. Responsive to the detected change, a distribution of an electrical, mechanical, or electromechanical parameter related to contractile function of a heart chamber with respect to locations of multiple electrodes disposed within the heart chamber is determined. A pacing output configuration, including one or more electrodes of the multiple electrodes, is selected and the heart chamber is paced using the selected pacing output configuration.
-
公开(公告)号：US08594805B2
公开(公告)日：2013-11-26
申请号：US13586432
申请日：2012-08-15
申请人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
发明人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61B5/0492 , A61B5/0488 , A61B5/4035 , A61N1/0556 , A61N1/36053 , A61N1/36114
摘要： Some embodiments provide a system for delivering neurostimulation. Some system embodiments comprise a lead configured to be implanted in the body, a stimulation output circuit configured to deliver neurostimulation pulses to the vagus nerve through the lead, an EMG sensing circuit configured to use the lead to sense EMG signals from laryngeal muscle activity, and an evoked muscular response detection circuit configured to use the EMG signals sensed by the EMG sensing circuit to detect evoked laryngeal muscle activity evoked by the neurostimulation pulse.
摘要翻译： 一些实施例提供用于递送神经刺激的系统。 一些系统实施例包括被配置为植入体内的引线，刺激输出电路，其经配置以通过引线将神经刺激脉冲输送到迷走神经; EMG感测电路，被配置为使用引线来感测来自喉部肌肉活动的EMG信号;以及 诱发肌肉反应检测电路，被配置为使用由EMG感测电路感测的EMG信号来检测由神经刺激脉冲诱发的诱发喉部肌肉活动。
-
公开(公告)号：US08548586B2
公开(公告)日：2013-10-01
申请号：US12361353
申请日：2009-01-28
申请人： Shantha Arcot-Krishnamurthy , John R. Zielinski , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros , Robert Shipley
发明人： Shantha Arcot-Krishnamurthy , John R. Zielinski , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros , Robert Shipley
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3688
摘要： This document discusses, among other things, an apparatus comprising at least one implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The implantable cardiac depolarization sensing circuit is configured to obtain a sensed depolarization signal from a ventricle and the electrical stimulation circuit is configured to provide pacing electrical stimulation energy to at least one implantable ventricular electrode. The pacing mode controller delivers pacing therapy according to a first pacing mode that is a normal operating mode, and delivers pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode.
摘要翻译： 本文件尤其涉及包括至少一个可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。 可植入心脏去极化感测电路被配置为从心室获得感测的去极化信号，并且电刺激电路被配置为向至少一个可植入心室电极提供起搏电刺激能量。 起搏模式控制器按照正常运行模式的第一起搏模式提供起搏治疗，并根据第二和第三起搏模式提供起搏治疗。 与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。 当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替。
-
公开(公告)号：US08412326B2
公开(公告)日：2013-04-02
申请号：US12709867
申请日：2010-02-22
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译： 起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。 监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。 在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。 在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。 在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。
-
公开(公告)号：US08412325B2
公开(公告)日：2013-04-02
申请号：US12419074
申请日：2009-04-06
IPC分类号： A61N1/362
CPC分类号： A61N1/3621 , A61N1/3906
摘要： Embodiments of the invention are related to medical devices and methods for delivery high-energy anti-tachycardia therapy to a subject, amongst other things. In an embodiment, the invention includes a medical device including a controller module configured to administer a plurality of electrical pulses to a patient in response to a detected tachycardia, the electrical pulses comprising an amplitude of greater than 3 Volts and less than 40 Volts, the controller configured to modulate the amplitude of the electrical pulses. In an embodiment, the invention includes a method of treating a tachyarrhythmia including administering a first series of electrical pulses to a patient with an implantable medical device, the electrical pulses including an amplitude of greater than 8 Volts and less than 40 Volts, the first series of electrical pulses having an interval of less than about 600 ms in between individual pulses. Other embodiments are also included herein.
摘要翻译： 本发明的实施例涉及用于向对象递送高能抗心动过速疗法的医疗装置和方法。 在一个实施例中，本发明包括医疗装置，其包括控制器模块，其被配置为响应于检测到的心动过速向患者施加多个电脉冲，所述电脉冲包括大于3伏且小于40伏的振幅， 控制器被配置为调制电脉冲的幅度。 在一个实施方案中，本发明包括治疗快速性心律失常的方法，包括用可植入医疗装置向患者施用第一系列电脉冲，所述电脉冲包括大于8伏且小于40伏特的振幅，第一系列 在各个脉冲之间具有小于约600ms的间隔的电脉冲。 本文还包括其它实施例。
-
66.发明申请公开(公告)号：US20120172742A1
公开(公告)日：2012-07-05
申请号：US13309320
申请日：2011-12-01
CPC分类号： A61N1/36053 , A61B5/0538 , A61N1/36117 , A61N1/36135 , A61N1/36521
摘要： A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.
摘要翻译： 设备实施例被配置为将迷走神经刺激治疗（VST）递送到患者的迷走神经。 装置实施例包括神经刺激器，可植入阻抗传感器和阻抗分析器。 神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。 可植入阻抗传感器被配置为检测由喉部振动引起的患者的颈部区域中的阻抗变化。 阻抗传感器被配置为产生感测的阻抗值。 阻抗分析器被配置为分析由传感器产生的感测阻抗值。 分析器被配置为检测来自感测的阻抗值的喉部振动或咳嗽。
-
公开(公告)号：US20120065702A1
公开(公告)日：2012-03-15
申请号：US13220423
申请日：2011-08-29
申请人： Shantha Arcot-Krishnamurthy , David J. Ternes , Jason Hamann , Juan Gabriel Hincapie Ordonez , Stephen Ruble
发明人： Shantha Arcot-Krishnamurthy , David J. Ternes , Jason Hamann , Juan Gabriel Hincapie Ordonez , Stephen Ruble
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36128 , A61N1/36146 , A61N1/36185 , A61N1/37235 , A61N1/37288
摘要： A neurostimulation system includes a neural stimulation lead having a proximal portion and a distal portion and including a plurality of electrodes along the distal portion. The plurality of electrodes are configured for positioning proximate a portion of the autonomic nervous system. A neural stimulation circuit, coupled to the plurality of electrodes, delivers neural stimulation pulses to the plurality of electrodes. A processor and controller is configured to control the neural stimulation circuit to deliver first neural stimulation pulses to each of a plurality of electrode configurations. Each electrode configuration includes one or more of the plurality of electrodes. The processor and controller is further configured to receive information related to motor fiber activity that is induced in response to delivery of the first neural stimulation pulses to each of the plurality of electrode configurations and to identify the electrode configurations that induce the motor fiber activity.
摘要翻译： 神经刺激系统包括神经刺激引线，其具有近端部分和远端部分，并且沿着远端部分包括多个电极。 多个电极被配置用于定位在自主神经系统的一部分附近。 耦合到多个电极的神经刺激电路将神经刺激脉冲传送到多个电极。 处理器和控制器被配置为控制神经刺激电路将第一神经刺激脉冲传送到多个电极配置中的每一个。 每个电极配置包括多个电极中的一个或多个。 所述处理器和控制器进一步被配置为接收与响应于所述第一神经刺激脉冲传送到所述多个电极配置中的每一个而被诱发的电动机纤维活动相关的信息，并且识别诱导所述电机纤维活性的电极配置。
-
68.发明授权Method and apparatus for inspiratory muscle stimulation using implantable device 有权使用可植入装置吸气肌肉刺激的方法和装置公开(公告)号：US08135471B2
公开(公告)日：2012-03-13
申请号：US11895999
申请日：2007-08-28
申请人： Yi Zhang , Shantha Arcot-Krishnamurthy , Lili Liu , Kenneth C. Beck , Kent Lee , Jonathan Kwok , Zheng Lin
发明人： Yi Zhang , Shantha Arcot-Krishnamurthy , Lili Liu , Kenneth C. Beck , Kent Lee , Jonathan Kwok , Zheng Lin
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/0558
摘要： An inspiratory muscle stimulation system uses an implantable medical device to deliver stimulation to control diaphragmatic contractions for slower and deeper breathing, thereby conditioning and strengthening inspiratory muscles. In various embodiments, respiratory and/or cardiac performance are monitored for controlling parameters of the stimulation.
摘要翻译： 吸气肌肉刺激系统使用可植入医疗装置来输送刺激以控制膈肌收缩以减慢和深呼吸，从而调节和加强吸气肌肉。 在各种实施例中，监测呼吸和/或心脏性能以控制刺激的参数。
-
公开(公告)号：US20110190840A1
公开(公告)日：2011-08-04
申请号：US13019818
申请日：2011-02-02
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61N1/3621 , A61N1/365
摘要： Described are methods and devices for improving diastolic function with electrostimulation in heart failure patients who exhibit relatively normal systolic function. Such patients are characterized by impaired myocardial relaxation during diastole that prevents adequate filling of the ventricles during diastole to thereby reduce cardiac output. An implantable device is described for effecting strategic and periodic stimulation of the sympathetic nervous system to elicit myocardial adrenergic activation for improved myocardial relaxation.
摘要翻译： 描述了用于在呈现相对正常的收缩功能的心力衰竭患者中用电刺激改善舒张功能的方法和装置。 这些患者的特征在于舒张期期间的心肌松弛受损，其在舒张期期间阻止充足的心室充盈，从而降低心输出量。 描述了可植入装置，用于促进交感神经系统的战略和周期性刺激，以引发心肌肾上腺素能活化以改善心肌松弛。
-
公开(公告)号：US20110106197A1
公开(公告)日：2011-05-05
申请号：US12709867
申请日：2010-02-22
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译： 起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。 监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。 在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。 在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。 在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。
-
-
-
-
-
-
-
-
-
搜索结果
97 条记录 (耗时 0.027 秒)