公开(公告)号：US08158385B2

公开(公告)日：2012-04-17

申请号：US10530696

申请日：2003-10-10

申请人： Shuji Ozaki ,  Masahiro Abe ,  Masayuki Tsuchiya ,  Naoki Kimura ,  Shigeto Kawai

发明人： Shuji Ozaki ,  Masahiro Abe ,  Masayuki Tsuchiya ,  Naoki Kimura ,  Shigeto Kawai

IPC分类号： C12P21/04 ,  C12P21/08

CPC分类号： C07K16/2833 ,  A61K2039/505 ,  C07K14/70539 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/626 ,  C07K2317/73

摘要： To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. The results suggested that the 2D7 antigen is an HLA class I molecule. Based on this finding, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.

摘要翻译： 为了鉴定2D7抗体的抗原，本发明人克隆了2D7抗原。 结果表明，2D7抗原是HLA I类分子。 基于该发现，本发明人检查了2D7抗体是否具有细胞死亡诱导活性。 当2D7抗体与另一种抗体交联时，观察到细胞核碎裂，表明诱导细胞死亡。 此外，发现2D7抗体的双抗体具有非常强的细胞死亡诱导活性，即使没有添加另一种抗体。 这些结果表明HLA识别抗体的小体抗体可以用作细胞死亡诱导剂。

公开(公告)号：US08158284B2

公开(公告)日：2012-04-17

申请号：US12354039

申请日：2009-01-15

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： H01M4/13 ,  H01M4/58 ,  C01B31/00 ,  C01B31/02 ,  C01B31/04

CPC分类号： H01M10/0525 ,  H01M4/366 ,  H01M4/587 ,  Y02E60/122 ,  Y02T10/7011

摘要： A lithium ion secondary battery is capable of improving the energy density and power density and excellent in high rate cycle characteristics applicable to hybrid cars, etc. The lithium ion secondary battery including a positive electrode of a lithium transition metal complex oxide, a negative electrode for absorbing/releasing lithium, and a non-aqueous electrolyte containing a lithium salt, in which the negative electrode has a negative electrode active material using a non-graphitizing carbon (spacing d(002) of 0.360 nm or more by XRD) and a graphitizing carbon (spacing d(002) of 0.339 nm or more and less than 0.360 nm by XRD) surface-modified at a thickness in a range from 10 nm to 100 nm in admixture, comprising the non-graphitizing carbon and the graphitizing carbon at a ratio in the range of 90 to 50 wt % :10 to 50 wt % and, further, graphitizing carbon having a grain size larger than that of the non-graphitizing carbon is used.

摘要翻译： 锂离子二次电池能够提高能量密度和功率密度以及适用于混合动力汽车等的高速循环特性优异。锂离子二次电池包括锂过渡金属复合氧化物的正极，负极 吸收/释放锂，以及含有锂盐的非水电解质，其中负极具有使用非石墨化碳的负极活性物质（通过XRD的间隔d（002）为0.360nm以上）和石墨化 碳（通过XRD测定的0.339nm以上，0.339nm以上且小于0.360nm的间隔d（002））在10nm〜100nm的范围内进行表面改性，包含非石墨化碳和石墨化碳 比率在90〜50重量％的范围内：10〜50重量％，进一步使用比非石墨化碳的粒径大的石墨化碳。

公开(公告)号：US08053970B2

公开(公告)日：2011-11-08

申请号：US12369351

申请日：2009-02-11

申请人： Naoki Kimura ,  Ryuji Suzuki ,  Ken Sakuma ,  Naoto Hirosaki

发明人： Naoki Kimura ,  Ryuji Suzuki ,  Ken Sakuma ,  Naoto Hirosaki

IPC分类号： H05B33/14

CPC分类号： C09K11/7734 ,  C09K11/7774 ,  H01L33/502 ,  H01L2224/45144 ,  H01L2224/48091 ,  Y02B20/181 ,  H01L2924/00014 ,  H01L2924/00

摘要： An LED with a semiconductor light emitting element that emits a blue or a blue-violet light, and a fluorescent material that absorbs some or all of the light emitted from the element and emits a fluorescent light of a wavelength different from the absorbed light. The fluorescent material is a mixed fluorescent material obtained by mixing a first fluorescent material that emits a blue-green or a green light, a second fluorescent material that has a peak emission wavelength longer than that of the first fluorescent material and emits a green or a yellow-green light, a third fluorescent material that has a 1 peak emission wavelength longer than that of the second fluorescent material and emits a yellow-green, a yellow or a yellow-red light, and a fourth fluorescent material that has a peak emission wavelength longer than that of the third fluorescent material and emits a yellow-red or a red light.

摘要翻译： 具有发射蓝色或蓝紫色光的半导体发光元件的LED以及吸收从元件发射的一些或全部光并发射与吸收光不同的波长的荧光的荧光材料。 荧光材料是通过混合发射蓝绿色或绿色光的第一荧光材料获得的混合荧光材料，具有比第一荧光材料的峰值发射波长长的发光波长的第二荧光材料，并发出绿色或 黄绿色光，具有比第二荧光材料长的1个峰值发射波长并发射黄绿色，黄色或黄色 - 红色光的第三荧光材料，以及具有峰值发光的第四荧光材料 波长比第三荧光材料长，并发出黄红色或红色光。

公开(公告)号：US20110262929A1

公开(公告)日：2011-10-27

申请号：US12998988

申请日：2009-12-22

申请人： Shigeto Kawai ,  Naoki Kimura

发明人： Shigeto Kawai ,  Naoki Kimura

IPC分类号： C12Q1/68 ,  A61P35/00 ,  C12N9/96 ,  C07K16/40 ,  C12Q1/48

CPC分类号： C07K16/30 ,  C07K16/28 ,  C07K16/40 ,  C07K2317/73 ,  C07K2317/732 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57449

摘要： The present invention provides antibodies that bind to HS6ST2 proteins, pharmaceutical compositions comprising the antibodies as active ingredients, methods for diagnosing cancer using the antibodies, HS6ST2 proteins conjugated to cytotoxic agents and pharmaceutical compositions comprising the HS6ST2 proteins as active ingredients.

摘要翻译： 本发明提供结合HS6ST2蛋白的抗体，包含抗体作为活性成分的药物组合物，使用抗体诊断癌症的方法，与细胞毒性剂缀合的HS6ST2蛋白和包含HS6ST2蛋白作为活性成分的药物组合物。

公开(公告)号：US20110235498A1

公开(公告)日：2011-09-29

申请号：US13158253

申请日：2011-06-10

申请人： Manabu Murakami ,  Shigeru Fukinuki ,  Naoki Kimura

发明人： Manabu Murakami ,  Shigeru Fukinuki ,  Naoki Kimura

IPC分类号： G11B7/125

CPC分类号： G11B7/126 ,  G11B7/1275 ,  G11B2007/0006

摘要： According to one embodiment, an optical disk device includes types of semiconductor laser diodes configured to emit laser light of different wavelengths, an output control circuit configured to control light output of each semiconductor laser diode, and a composite power source configured to generate voltages required for driving the types of semiconductor laser diodes and operating the output control circuit from a single power source voltage and to selectively output the generated voltages. The composite power source includes an input port to input an external control signal at a time of voltage selection and is configured to change the output voltage stepwise in response to the control signal.

摘要翻译： 根据一个实施例，光盘装置包括配置为发射不同波长的激光的半导体激光二极管的类型，被配置为控制每个半导体激光二极管的光输出的输出控制电路和被配置为产生 驱动类型的半导体激光二极管，并从单个电源电压操作输出控制电路并选择性地输出所产生的电压。 复合电源包括在电压选择时输入外部控制信号的输入端口，并且被配置为响应于控制信号逐步改变输出电压。

公开(公告)号：USD642978S1

公开(公告)日：2011-08-09

申请号：US29385390

申请日：2011-02-14

申请人： Yutaka Sato ,  Ryuji Kono ,  Mitsuru Koseki ,  Hidemasa Kawai ,  Hideyuki Shibanuma ,  Naoki Kimura ,  Keisuke Sawada ,  Fujio Hirano ,  Takuro Tsunaki ,  Takenori Ishizu ,  Kiyoyuki Sekine ,  Kinya Aota ,  Kouichi Kajiwara ,  Sho Saimaru

设计人： Yutaka Sato ,  Ryuji Kono ,  Mitsuru Koseki ,  Hidemasa Kawai ,  Hideyuki Shibanuma ,  Naoki Kimura ,  Keisuke Sawada ,  Fujio Hirano ,  Takuro Tsunaki ,  Takenori Ishizu ,  Kiyoyuki Sekine ,  Kinya Aota ,  Kouichi Kajiwara ,  Sho Saimaru

公开(公告)号：US07668408B2

公开(公告)日：2010-02-23

申请号：US11398792

申请日：2006-04-06

申请人： Naoki Kimura ,  Toru Kobayashi ,  Norio Ishikawa

发明人： Naoki Kimura ,  Toru Kobayashi ,  Norio Ishikawa

IPC分类号： G06K7/10 ,  G06K9/20

CPC分类号： G01J3/50 ,  G01J3/02 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0289 ,  G01N21/25

摘要： A support apparatus for optical characteristic measurement includes a measurement data inputter configured to input measurement data obtained by an optical characteristic measuring instrument, an image inputter configured to input an image of a measurement object, a measurement table in which the measurement data and the image of the measurement object corresponding to the measurement data are recorded, and a measurement data manager configured to record the measurement data inputted by the measurement data inputter in the measurement table so as to be associated with the image of the measurement object every time an optical characteristic of the measurement object is measured.

摘要翻译： 用于光学特性测量的支持装置包括测量数据输入器，被配置为输入由光学特性测量仪器获得的测量数据，被配置为输入测量对象的图像的图像输入器，测量数据和测量数据的图像 记录与测量数据相对应的测量对象，并且测量数据管理器被配置为将测量数据输入器输入的测量数据记录在测量表中，以便每当测量对象的光学特性 测量对象。

公开(公告)号：US20100041074A1

公开(公告)日：2010-02-18

申请号：US12449778

申请日：2008-02-27

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： G01N33/574 ,  C07K16/18 ,  C07K16/00 ,  C12N5/00 ,  C07K14/00

CPC分类号： C07K16/28 ,  A61K47/6811 ,  A61K47/6817 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77

摘要： An object of the present invention is to provide novel pharmaceutical compositions using anti-GRP78 antibodies. More particularly, the present invention aims to provide a novel method of cancer treatment using anti-GRP78 antibodies, novel cell growth inhibitors and anticancer agents that contain anti-GRP78 antibodies, as well as novel anti-GRP78 antibodies.The present inventor attempted to prepare antitumor antibodies that would target GRP78 the localization of which in cancer cells changed to the cell membrane and the inventor successfully obtained an anti-GRP78 antibody that would bind specifically to the cell surface of cancer cells; this eventually led to the accomplishment of the above-mentioned objects.

摘要翻译： 本发明的目的是提供使用抗GRP78抗体的新型药物组合物。 更具体地，本发明旨在提供一种使用抗GRP78抗体的癌症治疗的新方法，含有抗GRP78抗体的新型细胞生长抑制剂和抗癌剂，以及新的抗GRP78抗体。 本发明人试图制备将靶向GRP78的抗肿瘤抗体，其在癌细胞中的定位转变为细胞膜，并且本发明人成功获得了能够特异性结合癌细胞表面的抗GRP78抗体; 这最终导致了上述目标的实现。

公开(公告)号：US20070280951A1

公开(公告)日：2007-12-06

申请号：US10582304

申请日：2004-12-10

申请人： Naoki Kimura ,  Masayuki Tsuchiya ,  Masahiko Nanami ,  Takashi Tomimatsu ,  Shigeto Kawai

发明人： Naoki Kimura ,  Masayuki Tsuchiya ,  Masahiko Nanami ,  Takashi Tomimatsu ,  Shigeto Kawai

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/00 ,  C07H21/00 ,  C07K16/00 ,  C12N1/00 ,  C12N15/63 ,  C12N5/00 ,  C12P21/00

CPC分类号： C07K16/00 ,  C07K2317/622 ,  C07K2317/73

摘要： The present inventors constructed a DNA expression vector encoding 2D7sc(Fv)2 in which the heavy chain variable region sequence (VH) and the light chain variable region sequence (VL) of the 2D7 antibody is arranged in the order of VH-VL-VH-VL, and these sequences are linked by a 15-mer linker. The vector was introduced into CHO cells and a 2D7sc(Fv)2-producing expression cell line was established. When 2D7sc(Fv)2 was expressed in this cell line, purified, and cell death-inducing experiments performed, 2D7sc(Fv)2 was found to have a concentration-dependent cell death-inducing activity.

摘要翻译： 本发明人构建了编码2D7sc（Fv）2的DNA表达载体，其中2D7抗体的重链可变区序列（VH）和轻链可变区序列（VL）以VH-VL-VH -VL，并且这些序列通过15聚体连接子连接。 将载体导入CHO细胞，并建立产生2D7sc（Fv）2的表达细胞系。 当在该细胞系中表达2D7sc（Fv）2时，发现2D7sc（Fv）2的纯化和细胞死亡诱导实验具有浓度依赖性细胞死亡诱导活性。

公开(公告)号：US20070003556A1

公开(公告)日：2007-01-04

申请号：US10550934

申请日：2004-03-31

申请人： Masayuki Tsuchiya ,  Naoki Kimura ,  Tatsuya Fukuda

发明人： Masayuki Tsuchiya ,  Naoki Kimura ,  Tatsuya Fukuda

IPC分类号： A61K39/395 ,  C07K16/30

CPC分类号： C07K16/2803 ,  C07K2317/622 ,  C07K2317/73

摘要： CD22 diabodies, in which heavy-chain and light-chain variable regions are linked by a 5-mer linker, were produced based on known sequence information for two types of anti-CD22 antibodies. The two diabodies produced were analyzed for their activity of binding to lymphoma cells and inducing lymphoma cell death (apoptosis). As a result, both diabodies were revealed to bind to the B-lymphoma cell line, “Raji”, and to have apoptosis-inducing activity towards Raji cells as well as towards another B-lymphoma cell line: Daudi cells. These results show that minibodies of antibodies that recognize CD22 can be used as apoptosis-inducing agents for tumor cells such as lymphoma cells.

摘要翻译： 基于两种类型的抗-CD22抗体的已知序列信息产生CD22双抗体，其中重链和轻链可变区通过5-聚体连接子连接。 分析所产生的两种双抗体与淋巴瘤细胞结合的活性，诱导淋巴瘤细胞死亡（凋亡）。 结果，双抗体被揭示结合到B淋巴瘤细胞系“Raji”，并且对Raji细胞以及另一B淋巴瘤细胞系具有凋亡诱导活性：Daudi细胞。 这些结果表明识别CD22的抗体的小体抗体可以用作肿瘤细胞如淋巴瘤细胞的凋亡诱导剂。