利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

72 条记录 (耗时 0.028 秒)

    NEUROTROPHIN-DERIVED PEPTIDE SEQUENCES
    61.
    发明申请
    NEUROTROPHIN-DERIVED PEPTIDE SEQUENCES 有权
    神经营养衍生肽序列

    公开(公告)号：US20090074779A1

    公开(公告)日：2009-03-19

    申请号：US12092919

    申请日：2006-11-07

    申请人： Elisabeth Bock ,  Vladimir Berezin

    发明人： Elisabeth Bock ,  Vladimir Berezin

    IPC分类号： A61K39/395 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  A61K38/08 ,  A61P35/00 ,  A61P25/00 ,  A61K38/10 ,  A61K38/16 ,  C07K16/00

    CPC分类号： C07K14/475

    摘要： The present invention relates to peptide sequences capable of stimulating neuronal cell differentiation, neural cell survival and neuronal plasticity associated with memory and learning. The peptide sequences of the invention are derived from the proteins belonging to neurotrophic factors, such as NGF, NT3, NT4/5 and BDNF. The invention also relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory are beneficial for treatment.

    摘要翻译： 本发明涉及能够刺激与记忆和学习相关的神经元细胞分化，神经细胞存活和神经元可塑性的肽序列。 本发明的肽序列衍生自属于神经营养因子的蛋白质，例如NGF，NT3，NT4 / 5和BDNF。 本发明还涉及包含所述肽片段的药物组合物及其用于治疗疾病或病症的用途，其中刺激神经元细胞分化，神经元细胞存活，刺激与学习和记忆相关的神经可塑性的作用对治疗有益。

    Fgfr binding peptides
    62.
    发明申请
    Fgfr binding peptides 审中-公开
    Fgfr结合肽

    公开(公告)号：US20090074774A1

    公开(公告)日：2009-03-19

    申请号：US11629896

    申请日：2005-06-17

    申请人： Elisabeth Bock ,  Vladimir Berezin

    发明人： Elisabeth Bock ,  Vladimir Berezin

    IPC分类号： A61K39/395 ,  C07K14/00 ,  A61K38/16 ,  A61P25/18 ,  C07K16/18

    CPC分类号： C07K14/70503

    摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.

    摘要翻译： 本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。 本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。 本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。 根据本发明的包含其的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。 因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。

    Heparin Binding Peptide
    63.
    发明申请
    Heparin Binding Peptide 审中-公开
    肝素结合肽

    公开(公告)号：US20080226639A1

    公开(公告)日：2008-09-18

    申请号：US11629077

    申请日：2005-06-10

    申请人： Elisabeth Bock ,  Vladimir Berezin

    发明人： Elisabeth Bock ,  Vladimir Berezin

    IPC分类号： A61K39/395 ,  C07K7/00 ,  C07K2/00 ,  A61K38/03 ,  C07K16/44 ,  A61P35/00 ,  A61P3/10 ,  A61P25/28

    CPC分类号： C07K14/70503

    摘要： The invention relates to new peptide fragments capable of stimulating neurite outgrowth, stimulating of cell survival, stimulating neural plasticity associated with memory and learning, and modulating cell motility. The biological activity of the peptide fragments is associated with their capability of binding and activating a neurotrophin receptor of the Trk family. The peptide fragments of the invention comprise an amino acid motif which is essential for binding and activating a neurotrophin receptor of the Trk family. The invention also concerns pharmaceutical compositions comprising the compounds and uses thereof for prevention and/or treatment of conditions and/or diseases, wherein neurotrophing, Tkr receptors and/or NCAM play an important role, and wherein stimulating of neurite outgrowth, cell survival, neural plasticity associated with memory and learning, and/or modulating cell motility is beneficial for treatment.

    摘要翻译： 本发明涉及能够刺激神经突生长，刺激细胞存活，刺激与记忆和学习相关的神经可塑性以及调节细胞运动性的新肽片段。 肽片段的生物活性与其结合并激活Trk家族的神经营养因子受体的能力相关。 本发明的肽片段包含对于结合并激活Trk家族的神经营养因子受体必需的氨基酸基序。 本发明还涉及包含该化合物的药物组合物及其用于预防和/或治疗病症和/或疾病的用途，其中神经刺激素，Tkr受体和/或NCAM起重要作用，并且其中刺激神经突生长，细胞存活，神经元 与记忆和学习相关的可塑性和/或调节细胞运动性对治疗是有益的。

    Superposed multi-junction color APS
    66.
    发明授权
    Superposed multi-junction color APS 有权
    叠加多交点颜色APS

    公开(公告)号：US07279670B2

    公开(公告)日：2007-10-09

    申请号：US10975075

    申请日：2004-10-28

    申请人： Vladimir Berezin

    发明人： Vladimir Berezin

    IPC分类号： H01L27/00 ,  H04N5/335

    CPC分类号： H01L27/14647 ,  G01J3/50

    摘要： A CMOS image sensor obtains color through the use of two or three superposed layers. Each pixel in the image sensor includes a plurality of superposed photosensitive p-n junctions with individual charge integration regions. The combination of each of the superposed layers provides increased sensitivity and resolution of a single chip color imager.

    摘要翻译： CMOS图像传感器通过使用两个或三个叠加层来获得颜色。 图像传感器中的每个像素包括具有各个电荷积分区域的多个重叠的光敏p-n结。 每个叠加层的组合提供了增加的单芯片彩色成像器的灵敏度和分辨率。

    Active pixel sensor with mixed analog and digital signal integration
    67.
    发明申请
    Active pixel sensor with mixed analog and digital signal integration 有权
    有源像素传感器具有混合的模拟和数字信号集成

    公开(公告)号：US20070024727A1

    公开(公告)日：2007-02-01

    申请号：US11529634

    申请日：2006-09-29

    申请人： Vladimir Berezin

    发明人： Vladimir Berezin

    IPC分类号： H04N5/335

    CPC分类号： H04N5/378 ,  H04N5/35572 ,  H04N5/374

    摘要： An active pixel sensor includes mixed analog and digital signal integration on the same substrate. The analog part of the array forms the active pixel sensor, and the digital part of the array does digital integration of the signal.

    摘要翻译： 有源像素传感器包括在同一衬底上的混合模拟和数字信号集成。 阵列的模拟部分形成有源像素传感器，阵列的数字部分对信号进行数字积分。

    Metod of modulation of interaction between receptor and ligand
    68.
    发明申请
    Metod of modulation of interaction between receptor and ligand 审中-公开
    受体和配体之间相互作用调制的曲线

    公开(公告)号：US20060281130A1

    公开(公告)日：2006-12-14

    申请号：US10539440

    申请日：2003-12-18

    申请人： Elisabeth Bock ,  Vladimir Berezin ,  Morten Albrechtsen

    发明人： Elisabeth Bock ,  Vladimir Berezin ,  Morten Albrechtsen

    IPC分类号： G01N33/53 ,  G01N33/574 ,  A61K38/17 ,  A61K38/10 ,  A61K39/395 ,  A61K31/727 ,  C07K7/08

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K16/22 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/50

    摘要： The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the receptor ligand and discloses a series of amino acid sequences, which are part of the structure of said binding site and/or involved in the interaction between the receptor and the ligand. Moreover, the present invention features methods for molecular design and screening of a candidate compound capable of modulating the interaction between the functional cell-surface receptor and receptor ligand through the described binding site, and provides a screening assay for identification of such a compound. The invention further describes an antibody capable of binding to the above binding site and/or to an epitope comprising an amino acid sequence essential for executing the receptor ligand interaction through said binding site. The invention also concerns a variety of uses of the disclosed methods, peptide sequences and antibodies. The invention in preferred embodiments concerns the binding site of the fibroblast growth factor receptor (FGFR) on FGFR ligands, compounds capable of modulating the receptor ligand interaction through said binding site, and antibody capable of recognition of said binding site.

    摘要翻译： 本发明涉及调节至少两种蛋白质之间的相互作用的方法，其中两种蛋白质中的至少一种是功能性细胞表面受体，而另一种蛋白质是受体配体。 本发明的特征在于所述功能性细胞表面受体在受体配体上的结合位点，并公开了一系列氨基酸序列，其是所述结合位点结构的一部分和/或参与受体和配体之间的相互作用。 此外，本发明具有分子设计和筛选能够通过所述结合位点调节功能性细胞表面受体和受体配体之间的相互作用的候选化合物的方法，并提供了鉴定这种化合物的筛选试验。 本发明还描述了能够结合上述结合位点和/或包含通过所述结合位点执行受体配体相互作用所必需的氨基酸序列的表位的抗体。 本发明还涉及所公开的方法，肽序列和抗体的各种用途。 本发明在优选实施方案中涉及成纤维细胞生长因子受体（FGFR）对FGFR配体的结合位点，能够通过所述结合位点调节受体配体相互作用的化合物和能够识别所述结合位点的抗体。

    Dynamic range enlargement in CMOS image sensors
    70.
    发明申请
    Dynamic range enlargement in CMOS image sensors 审中-公开
    CMOS图像传感器中的动态范围放大

    公开(公告)号：US20050083421A1

    公开(公告)日：2005-04-21

    申请号：US10685792

    申请日：2003-10-16

    申请人： Vladimir Berezin ,  Richard Tsai

    发明人： Vladimir Berezin ,  Richard Tsai

    IPC分类号： H04N3/14 ,  H04N5/202 ,  H04N5/355 ,  H04N5/365 ,  H04N5/3745 ,  H04N5/335

    CPC分类号： H04N5/37457 ,  H04N5/35527 ,  H04N5/35554

    摘要： A method for operating a pixel circuit is disclosed, wherein a saturation control signal is used to control the photoresponse of four-transistor (4-T), five-transistor (5-T) and shared floating diffusion pixel circuits. The saturation control signal is a variable voltage signal, and is transmitted to a transfer transistor or anti-blooming transistor, wherein the signal opens or partially opens the transistor to allow excess electrons to flow from the photodiode region during an integration period. As a result, the effective dynamic range of the pixel circuit can be extended.

    摘要翻译： 公开了一种用于操作像素电路的方法，其中使用饱和控制信号来控制四晶体管（4 -T），五晶体管（5 -T）和共享浮动扩散像素电路的光响应。 饱和度控制信号是可变电压信号，并被传送到传输晶体管或防喷射晶体管，其中信号打开或部分地打开晶体管，以在积分期间允许多余的电子从光电二极管区域流出。 结果，可以延长像素电路的有效动态范围。