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    Methods for Measuring Real Time Kinase Activity
    61.
    发明申请
    Methods for Measuring Real Time Kinase Activity 审中-公开
    测量实时激酶活性的方法

    公开(公告)号：US20070196860A1

    公开(公告)日：2007-08-23

    申请号：US11624686

    申请日：2007-01-18

    申请人： Kyle Gee ,  Min Li ,  Xiao-Dong Qian ,  Erik Schaefer

    发明人： Kyle Gee ,  Min Li ,  Xiao-Dong Qian ,  Erik Schaefer

    IPC分类号： G01N33/53 ,  C07K16/46

    CPC分类号： C12Q1/485 ,  G01N33/573

    摘要： The present invention relates to methods for detecting and/or measuring the activity of a specific kinase, with the methods comprising contacting one or more kinases with a binding agent to isolate a specific kinase of interest. The isolated kinase is then contacted with a kinase activity sensor, where the kinase activity sensor is comprised of a kinase recognition motif that is capable of being recognized by the isolated kinase, and at least one phosphorylation site. The isolated kinase phosphorylates the amino acid target of the kinase activity sensor and levels of the phosphorylated target amino acid can then be quantified.

    摘要翻译： 本发明涉及用于检测和/或测量特定激酶活性的方法，其中所述方法包括使一种或多种激酶与结合剂接触以分离特定的目标激酶。 然后将分离的激酶与激酶活性传感器接触，其中激酶活性传感器由能够被分离的激酶识别的激酶识别基序和至少一个磷酸化位点组成。 分离的激酶磷酸化激酶活性传感器的氨基酸靶标，然后可以量化磷酸化靶氨基酸的水平。

    Retaining device for heat sink
    62.
    发明授权
    Retaining device for heat sink 失效
    散热器固定装置

    公开(公告)号：US07190584B2

    公开(公告)日：2007-03-13

    申请号：US11019769

    申请日：2004-12-21

    申请人： Hsieh-Kun Lee ,  Dong-Yun Li ,  Hong-Bo Shi ,  Min Li

    发明人： Hsieh-Kun Lee ,  Dong-Yun Li ,  Hong-Bo Shi ,  Min Li

    IPC分类号： H05K7/20

    CPC分类号： H01L23/4093 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A retainer (20) for a heat sink includes a supporting member (22), a bracket member (24), a pair of locking members (26) and an operating member (28). The supporting member defines a pair of openings (222) at opposite ends thereof. The bracket member is located above the supporting member and has a pair of abutting portions (246) extending therefrom. The locking members respectively pass through the openings of the supporting member and are pivotably attached to the bracket member. Each locking member has a spring portion (264) depressed on one of said abutting portions to maintain the locking member at a releasing position. The operating member is pivotable relative to the bracket member to cause the bracket member and the associated locking members to move upward and the supporting member to drive the locking members to turn toward each other to a locking position.

    摘要翻译： 用于散热器的保持器（20）包括支撑构件（22），支架构件（24），一对锁定构件（26）和操作构件（28）。 支撑构件在其相对端部处限定一对开口（222）。 托架构件位于支撑构件的上方，并且具有从其延伸的一对邻接部分（246）。 锁定构件分别穿过支撑构件的开口并且可枢转地附接到支架构件。 每个锁定构件具有在所述邻接部分之一上压下的弹簧部分（264），以将锁定构件保持在释放位置。 操作构件相对于支架构件可枢转，以使支架构件和相关联的锁定构件向上移动，并且支撑构件驱动锁定构件朝向彼此转动到锁定位置。

    Heat sink retention device
    64.
    发明授权
    Heat sink retention device 失效
    散热片保持装置

    公开(公告)号：US07102890B2

    公开(公告)日：2006-09-05

    申请号：US10990078

    申请日：2004-11-16

    申请人： Hsieh-Kun Lee ,  Dong-Yun Li ,  Hong-Bo Shi ,  Min Li

    发明人： Hsieh-Kun Lee ,  Dong-Yun Li ,  Hong-Bo Shi ,  Min Li

    IPC分类号： H05K7/20

    CPC分类号： H01L23/427 ,  H01L23/4093 ,  H01L2924/0002 ,  H01L2924/00

    摘要： The retention device comprises a clip and a back plate engaging the clip, the clip comprises pressing members for press the heat sink onto the processor and at least a pair of hooks, the back plate is placed below a printed circuit board on which the processor is mounted, and comprises a body and at least a pair of retaining rings mounted thereof. The retaining rings travel through mounting holes in the printed circuit board and beyond the top surface thereof for catching the hooks of the clip.

    摘要翻译： 保持装置包括夹子和接合夹子的后板，夹子包括用于将散热器压入处理器和至少一对钩子的按压构件，该后板放置在印刷电路板的下方，处理器 并且包括主体和至少一对安装的保持环。 保持环穿过印刷电路板中的安装孔并超过其顶表面以捕获夹子的钩。

    Hemiterpene glycosides with anti-platelet aggregation activities from Ilex pubescens
    65.
    发明申请
    Hemiterpene glycosides with anti-platelet aggregation activities from Ilex pubescens 有权
    槲皮苷具有抗血小板聚集活性

    公开(公告)号：US20060154877A1

    公开(公告)日：2006-07-13

    申请号：US11031415

    申请日：2005-01-07

    申请人： Liang Liu ,  Zhihong Jiang ,  Min Li ,  Jingrong Wang ,  Zhongqiu Liu

    发明人： Liang Liu ,  Zhihong Jiang ,  Min Li ,  Jingrong Wang ,  Zhongqiu Liu

    IPC分类号： A61K31/7034 ,  C07H15/04

    CPC分类号： C07H15/04

    摘要： Two hitherto unreported novel hemiterpene glycosides were isolated in substantially pure form from the root of Ilex pubescens. The chemical structures and some properties of these hemiterpenes have been elucidated. These hemiterpene glycosides possess anti-platelet aggregation activity more potent than those of salvianolic acid B and aspirin and may be used in pharmaceutical compositions in humans and mammals in need of such treatment.

    摘要翻译： 迄今尚未报道的两种新颖的楝树甙以基本上纯的形式从白桦根中分离出来。 已经阐明了这些半萜烯的化学结构和一些性质。 这些半萜糖苷具有比丹酚酸B和阿司匹林更有效的抗血小板聚集活性，并且可以用于需要这种治疗的人和哺乳动物的药物组合物中。

    Novel hard bias design for sensor applications
    68.
    发明申请
    Novel hard bias design for sensor applications 有权
    传感器应用的新型硬偏置设计

    公开(公告)号：US20060132988A1

    公开(公告)日：2006-06-22

    申请号：US11016506

    申请日：2004-12-17

    申请人： Kunliang Zhang ,  Mao-Min Chen ,  Chyu-Jiuh Torng ,  Min Li ,  Chen-Jung Chien

    发明人： Kunliang Zhang ,  Mao-Min Chen ,  Chyu-Jiuh Torng ,  Min Li ,  Chen-Jung Chien

    IPC分类号： G11B5/33 ,  G11B5/127

    CPC分类号： B82Y25/00 ,  B82Y10/00 ,  G11B5/3932 ,  G11B2005/3996 ,  Y10T29/49032

    摘要： A hard bias structure for biasing a free layer in a MR element within a magnetic read head is comprised of a soft magnetic underlayer such as NiFe and a hard bias layer comprised of Co78.6Cr5.2Pt16.2 or Co65Cr15Pt20 that are rigidly exchange coupled to ensure a well aligned longitudinal biasing direction with minimal dispersions. The hard bias structure is formed on a BCC seed layer such as CrTi to improve lattice matching. The hard bias structure may be laminated in which each of the underlayers and hard bias layers has a thickness that is adjusted to optimize the total HC, Mrt, and S values. The present invention encompasses CIP and CPP spin values, MTJ devices, and multi-layer sensors. A larger process window for fabricating the hard bias structure is realized and lower asymmetry output and NBLW reject rates during a read operation are achieved.

    摘要翻译： 用于偏置磁读头内的MR元件中的自由层的硬偏压结构由诸如NiFe的软磁性底层和由Co ++ 78.6Cr 5.2构成的硬偏置层组成， 或刚性交换耦合以确保良好对准的/SUB>Pt16.2 或Co 15 Cr 15 纵向偏置方向最小分散。 在诸如CrTi的BCC种子层上形成硬偏压结构以改善晶格匹配。 可以层压硬偏压结构，其中每个底层和硬偏压层具有被调节以使总H C，M L t和S的最大化的厚度 价值观。 本发明包括CIP和CPP旋转值，MTJ装置和多层传感器。 实现了用于制造硬偏置结构的更大的工艺窗口，并且实现了读操作期间较低的不对称输出和NBLW废弃率。

    Water-soluble derivatives of lipophilic drugs
    69.
    发明授权
    Water-soluble derivatives of lipophilic drugs 失效
    亲脂性药物的水溶性衍生物

    公开(公告)号：US07029918B2

    公开(公告)日：2006-04-18

    申请号：US10057762

    申请日：2002-01-25

    申请人： Min Li ,  Robert S. Wu ,  Jane S. C. Tsai

    发明人： Min Li ,  Robert S. Wu ,  Jane S. C. Tsai

    IPC分类号： G01N33/548 ,  G01N30/90 ,  C07D243/24

    CPC分类号： G01N33/9473 ,  A61K47/643 ,  A61K47/646 ,  C07D243/24 ,  G01N33/5306 ,  G01N33/948 ,  Y10S436/815 ,  Y10T436/10

    摘要： A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I): G-(L)n—Y;  (I) where G is a lipophilic drug; L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms; n is 0 or 1; and Y is a water-solubilizing group such as —SO3−, —NR—SO3−, —P(═O)(OH)(O−), or —O—P(═O)(OH)(O−); where R is H or an alkyl group of 1 to 10 carbon atoms.

    摘要翻译： 水溶性参考标准对亲脂性药物的免疫测定是有用的。 参考标准是式（I）的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> G-（L） （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中G是亲脂性药物; L是含有1至20个碳原子的烷基或杂烷基的连接体; n为0或1; Y是水溶性基团，例如-SO 3 - ， - SO 2 SO 3 - ， - SO 2 - -P（-O）（OH）（O-O）或-OP（-O）（OH）（O-O） 其中R是H或1-10个碳原子的烷基。