公开(公告)号：US07550581B2

公开(公告)日：2009-06-23

申请号：US10546107

申请日：2004-02-23

申请人： Hiroshi Sugiyama ,  Yan Xu ,  Reiko Ikeda

发明人： Hiroshi Sugiyama ,  Yan Xu ,  Reiko Ikeda

IPC分类号： C07H21/00 ,  C07H19/04

CPC分类号： C07H19/167

摘要： It is intended to provide a novel monomer unit by which Z type DNA can be more effectively stabilized, a reagent for integrating this monomer unit into an oligonucleotide, and a method of stabilizing Z type DNA by using the reagent. Namely, a guanosine derivative represented by the following general formula [1]: wherein R1 represents acyl; R2 represents lower alkyl; R3 represents tri-substituted silyloxy or tetrahedropyranyloxy; and R4 represents cyanoethyl or allyl; a reagent for stabilizing Z type DNA which contains the guanosine derivative; and a method of stabilizing Z type DNA by using the guanosine derivative. It is also intended to provide a method of transferring guanosine having lower alkyl at the 8-position into an oligonucleotide by using the guanosine derivative; and an oligonucleotide carrying guanosine having lower alkyl at the 8-position transferred thereinto.

摘要翻译： 旨在提供可以更有效地稳定Z型DNA的新单体单元，将该单体单元整合到寡核苷酸中的试剂，以及使用该试剂来稳定Z型DNA的方法。 即，由以下通式[1]表示的鸟苷衍生物：其中R1表示酰基; R2代表低级烷基; R3表示三取代的甲硅烷氧基或四氢吡喃氧基; R4代表氰基乙基或烯丙基; 用于稳定含有鸟苷衍生物的Z型DNA的试剂; 以及使用鸟苷衍生物稳定Z型DNA的方法。 还提供通过使用鸟苷衍生物将在8-位具有低级烷基的鸟苷转移到寡核苷酸中的方法; 和携带转移到其中的8-位具有低级烷基的鸟苷的寡核苷酸。

公开(公告)号：US20070249709A1

公开(公告)日：2007-10-25

申请号：US11787633

申请日：2007-04-17

申请人： Mahmoud Mirmehrabi ,  Qing Yu ,  Abdolsamad Tadayon ,  Marc Tesconi ,  Yan Xu

发明人： Mahmoud Mirmehrabi ,  Qing Yu ,  Abdolsamad Tadayon ,  Marc Tesconi ,  Yan Xu

IPC分类号： C07D319/14 ,  A61K31/335

CPC分类号： C07D319/20

摘要： The present invention is directed to crystal forms of the 5-HT2C agonist (S)-(8-(2,6-dichlorophenyl)-6-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine hydrochloride, as well as compositions, processes of preparation, and uses thereof.

摘要翻译： 本发明涉及5-HT 2C激动剂（S） - （8-（2,6-二氯苯基）-6-氟-2,3-二氢苯并[b] [ 1,4]二恶英-2-基）甲胺盐酸盐，以及组合物，制备方法及其用途。

公开(公告)号：US20060247235A1

公开(公告)日：2006-11-02

申请号：US11412015

申请日：2006-04-26

申请人： Marc Tesconi ,  Mannching Ku ,  Yan Xu

发明人： Marc Tesconi ,  Mannching Ku ,  Yan Xu

IPC分类号： A61K31/538 ,  C07D413/02

CPC分类号： C07D413/04 ,  C07D265/18 ,  C07B2200/13

摘要： Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Form II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. Also provided are methods of contraception, hormone replacement therapy, stimulation of food intake and treating or preventing uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, or carcinomas and adenocarcinomas comprising administering polymorph Form II to a mammalian subject.

摘要翻译： Tanaproget多晶型物II，制备tanaproget多晶型II的方法，包括tanaproget多晶型II，微粉化tanaproget多晶型II的药物组合物，以及将II型转化成tanaproget I型的方法。 还提供了避孕，激素替代疗法，刺激食物摄取和治疗或预防子宫肌层肌瘤，良性前列腺肥大，良性和恶性肿瘤性疾病，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症，多囊卵巢综合征或癌和腺癌的方法，包括 向哺乳动物受试者施用多晶型II。

公开(公告)号：US20060154286A1

公开(公告)日：2006-07-13

申请号：US11327175

申请日：2006-01-05

申请人： Huimin Kong ,  Myriam Vincent ,  Yan Xu ,  Wen Tang

发明人： Huimin Kong ,  Myriam Vincent ,  Yan Xu ,  Wen Tang

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12P19/34 ,  C12N15/1096

摘要： Methods and a kit are provided for selectively and exponentially amplifying nucleic acids and include the use of a single strand helicase preparation or a thermostable helicase in the absence of a single strand binding protein and a DNA polymerase such that the amplification can be performed isothermally.

摘要翻译： 提供了用于选择性和指数扩增核酸的方法和试剂盒，并且包括在不存在单链结合蛋白和DNA聚合酶的情况下使用单链解旋酶制剂或热稳定解旋酶，使得可以等温进行扩增。

公开(公告)号：US20060117321A1

公开(公告)日：2006-06-01

申请号：US10990652

申请日：2004-11-16

申请人： John Lauer ,  Yan Xu

发明人： John Lauer ,  Yan Xu

IPC分类号： G06F9/44

CPC分类号： G06F9/547 ,  G06F2209/541

摘要： Provided are a method, system and article of manufacture, wherein a first application and a second application are executed in a first process space in a node, wherein a third application is capable of executing in a second process space. A common interface to the first, the second, and the third applications are provided by a remote proxy class. The third application is executed in the first process space by securing a plurality of attributes for the third application from the common interface.

摘要翻译： 提供了一种方法，系统和制造品，其中在节点中的第一处理空间中执行第一应用和第二应用，其中第三应用能够在第二处理空间中执行。 第一个，第二个和第三个应用程序的通用接口由远程代理类提供。 通过从公共接口保护用于第三应用的多个属性，在第一处理空间中执行第三应用。

公开(公告)号：US20060102305A1

公开(公告)日：2006-05-18

申请号：US10531790

申请日：2002-10-19

申请人： Yan Xu

发明人： Yan Xu

IPC分类号： D21H11/12 ,  D21H17/28

CPC分类号： D21C5/00 ,  D21H11/12 ,  D21H17/28 ,  D21H27/10

摘要： Environmental friendliness and biodegradability are important considerations of disposable materials, be it packaging or paper, in order to minimize environmental damage. The present invention relates to a method of producing environmental friendly and biodegradable products using mechanically processed agricultural fibres and rightly formulated adhesive. In particular, mechanical treatment takes place in a pressure vessel under hydrothermal conditions using superheated steam. Treated agricultural fibres are mixed with stoichemtric amount of adhesive, through vigorous agitation, a well furnished agricultural fibre slurry is obtained and ready to be fed into manufacturing process to produce, in this invention, moulded shape bodies and paper liners. Unlike synthetic resin, the said adhesive formulation is biodegradable and made of natural renewable resources. The said adhesive has self-retention property. The agricultural fibre slurry can be easily made into moulded products and paper liners using commonly available processes.

摘要翻译： 环保和生物降解性是一次性材料（包装或纸张）的重要考虑因素，以尽量减少环境破坏。 本发明涉及使用机械加工的农业纤维和合适配制的粘合剂生产环保和可生物降解的产品的方法。 特别地，在使用过热蒸汽的水热条件下的压力容器中进行机械处理。 经处理的农用纤维通过剧烈搅拌混合，得到一种设备齐全的农用纤维浆料，并准备喂入制造过程中，在本发明中生产成型的成形体和纸衬里。 与合成树脂不同，所述粘合剂制剂是可生物降解的并且由天然可再生资源制成。 所述粘合剂具有自保持性。 农用纤维浆料可以通过常用的方法容易地制成成型产品和纸衬里。

公开(公告)号：US06839358B2

公开(公告)日：2005-01-04

申请号：US09808093

申请日：2001-03-14

申请人： Kenichi Abiru ,  Kensaku Amou ,  Yan Xu

发明人： Kenichi Abiru ,  Kensaku Amou ,  Yan Xu

IPC分类号： H04L29/04 ,  H04J3/16 ,  H04L12/801 ,  H04L12/815 ,  H04L12/863 ,  H04L12/865 ,  H04L12/873 ,  H04L12/911 ,  H04L29/06 ,  H04L11/20

CPC分类号： H04L47/6215 ,  H04J3/1682 ,  H04L47/50 ,  H04L47/522 ,  H04L47/60

摘要： In a relaying apparatus comprising input side accommodating portions including input side queues, a plurality of output side accommodating portions including output side queues, and a switch fabric for mutually connecting the input side queues and the output side queues in a mesh form, in a time slot of a fixed period, the output side-addressed queue managers corresponding to the output side accommodating portions select a bandwidth guaranteed packet so as to guarantee a bandwidth, and output priority/non-priority signals for indicating which of the bandwidth guaranteed packet and a bandwidth non-guaranteed packet has been selected, and output demand signals of the packet. An inter-output link manager selects the packet having an empty area in the priority queue or non-priority queue of the output side accommodating portion as a destination corresponding to the packet which is demanded to be outputted.

摘要翻译： 在包括输入侧队列的输入侧容纳部分的中继装置中，包括输出侧队列的多个输出侧容纳部分和用于将输入侧队列和输出侧队列以网格形式相互连接的交换结构 对应于输出侧容纳部分的输出侧寻址队列管理器选择带宽保证分组以保证带宽，并输出用于指示哪个带宽保证分组和一个带宽保证分组的优先级/非优先级信号 已经选择了带宽非保证分组，并输出分组的需求信号。 输出间链路管理器选择优先级队列中的空区域或输出侧容纳部分的非优先队列作为与要求输出的分组对应的目的地的分组。

公开(公告)号：US6070252A

公开(公告)日：2000-05-30

申请号：US698465

申请日：1996-08-15

申请人： Yan Xu ,  Murtuza Ali Lakhani

发明人： Yan Xu ,  Murtuza Ali Lakhani

IPC分类号： G01R31/3183 ,  G06F11/27

CPC分类号： G01R31/3183

摘要： Methods and apparatus for interactive built-in self-testing with user-programmable test patterns are disclosed. The present invention operates in the context of an integrated circuit (IC) including built-in self-test (BIST) logic and a test interface circuit resident on the IC. The BIST logic executes a BIST routine for testing the IC, and the test interface achieves the inputting of an external test pattern into the BIST logic from an external logic circuit. The test interface includes a first flag storage element accessible to the BIST logic. The first flag storage element stores a first flag that indicates whether the test pattern will be provided to the IC from the external logic. A test data storage element in the test interface stores the external test pattern, and is also accessible to the BIST logic. A second flag storage element accessible to the BIST logic stores a second flag to indicate whether the test pattern is available in the test data storage element. Test control logic receives a first instruction from the external logic, and executes the first instruction to set the first flag. The test control logic reads the test pattern and sets the second flag after the test pattern is stored in the test data storage element. If the first flag is not set, the BIST logic executes the BIST routine using a test pattern internally generated on the IC. On the other hand, if the first flag is set, then the BIST logic executes the BIST routine using the test patterns stored in the test data storage element.

摘要翻译： 公开了用于用户可编程测试模式的用于交互式内置自检的方法和装置。 本发明在包括内置自测（BIST）逻辑的集成电路（IC）和驻留在IC上的测试接口电路的上下文中进行操作。 BIST逻辑执行用于测试IC的BIST例程，测试接口实现从外部逻辑电路将外部测试模式输入BIST逻辑。 测试接口包括BIST逻辑可访问的第一标志存储元件。 第一标志存储元件存储指示测试图案是否将从外部逻辑提供给IC的第一标志。 测试接口中的测试数据存储单元存储外部测试模式，也可以被BIST逻辑访问。 BIST逻辑可访问的第二标志存储元件存储用于指示测试数据在测试数据存储元件中是否可用的第二标志。 测试控制逻辑从外部逻辑接收第一指令，并执行第一指令以设置第一标志。 测试控制逻辑读取测试模式，并在测试模式存储在测试数据存储元件中之后设置第二个标志。 如果第一个标志未设置，则BIST逻辑使用IC上内部生成的测试模式来执行BIST程序。 另一方面，如果设置了第一标志，则BIST逻辑使用存储在测试数据存储元件中的测试模式来执行BIST例程。

公开(公告)号：US5824555A

公开(公告)日：1998-10-20

申请号：US655551

申请日：1996-05-30

申请人： Yan Xu ,  Graham Casey

发明人： Yan Xu ,  Graham Casey

IPC分类号： G01N30/02 ,  G01N33/48 ,  G01N33/49 ,  G01N33/574 ,  G01N33/92 ,  G01N33/50

CPC分类号： G01N33/491 ,  G01N33/57407 ,  G01N33/57449 ,  G01N33/57488 ,  G01N33/92 ,  G01N2030/025 ,  Y10T436/16 ,  Y10T436/163333 ,  Y10T436/166666 ,  Y10T436/25375

摘要： The present invention provides a new method for detecting the presence of gynecological carcinomas in a patient. The method, which comprises detecting the presence of lysophosphatidic acid in a plasma sample of the patient, is useful for detecting ovarian carcinoma, cervical carcinoma, endometrial carcinoma, and peritoneal carcinoma. In a preferred embodiment the method comprises: providing a blood specimen from the patient, obtaining a plasma sample for the blood specimen under conditions which minimize the release of lysophosphatidic acid from the platelets in the blood specimen into the plasma, extracting lipids from the plasma, and detecting the presence of lysophosphatidic acid in the lipid extract. A new method for extracting lysophosphatidic acid from a biological fluid is also provided. The method which comprises acidifying the biological fluid and extracting the lysophosphatidic acid from the acidified sample with an organic solvent is useful for extracting greater than 80% of the lysophosphatidic acid in the biological fluid.

摘要翻译： 本发明提供了一种用于检测患者中妇科癌存在的新方法。 该方法包括检测患者血浆样品中溶血磷脂酸的存在，可用于检测卵巢癌，子宫颈癌，子宫内膜癌和腹膜癌。 在优选实施方案中，该方法包括：提供来自患者的血液标本，在使溶血磷脂酸从血液样本中的血小板释放到血浆中的条件下获得用于血液样本的血浆样品，从血浆中提取脂质， 并检测脂质提取物中溶血磷脂酸的存在。 还提供了一种从生物液体中提取溶血磷脂酸的新方法。 包括酸化生物流体并用有机溶剂从酸化样品中提取溶血磷脂酸的方法可用于提取生物流体中大于80％的溶血磷脂酸。

公开(公告)号：US20180265876A1

公开(公告)日：2018-09-20

申请号：US15995134

申请日：2018-06-01

申请人： Xiaowei Yu ,  Yan Xu

发明人： Xiaowei Yu ,  Yan Xu

IPC分类号： C12N15/62 ,  C12N9/20 ,  C12N9/50

CPC分类号： C12N15/62 ,  C07K14/38 ,  C07K2319/61 ,  C12N9/20 ,  C12N9/50 ,  C12N15/81 ,  C12N15/815 ,  C12Y301/01004

摘要： The invention discloses a method for improving the extracellular expression level of a foreign protein by means of phospholipase fusion expression. Four proteins, PLA2, MBP, CBD and SUMO, are used as a fusion tag to construct a fusion gene. Compared with an original protein MOH without any fusion tag, the extracellular expression level and enzymatic activity of all the four fusion proteins are increased to some degree. Among them, the fusion protein using PLA2 as the fusion tag has the highest expression level, which is 7.4 times higher than that of the original protein. Compared with other fusion tags, PLA2 has a low molecular weight and the fusion protein having PLA2 as the fusion tag has the highest expression level (up to 12 g·L−1 in a 7 L fermentation tank for high-density fermentation). It is shown that the secretory expression of a foreign protein can be effectively increased by using PLA2 as a fusion tag.