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公开(公告)号：US20110106197A1
公开(公告)日：2011-05-05
申请号：US12709867
申请日：2010-02-22
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译： 起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。 监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。 在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。 在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。 在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。
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公开(公告)号：US20100268194A1
公开(公告)日：2010-10-21
申请号：US12825174
申请日：2010-06-28
IPC分类号： A61B17/122 , A61N1/36 , A61M25/00
CPC分类号： A61N1/3606 , A61M25/00 , A61N1/05 , A61N1/36007 , A61N1/36135
摘要： Renal function may be modulated by an implantable device having one or more leads or catheters disposed near the kidney via the lymphatic system. In one embodiment, lymphatic drainage from the kidney is modulated to increase or decrease tubular reabsorption of salt and water. The renal function modulation therapy may be delivered in an open-loop or closed-loop fashion, with the latter dependent upon a physiological variable such as blood pressure or cardiac output.
摘要翻译： 肾功能可以由具有通过淋巴系统设置在肾附近的一个或多个引线或导管的可植入装置调节。 在一个实施方案中，来自肾脏的淋巴引流被调节以增加或减少盐和水的管状再吸收。 肾功能调节治疗可以以开环或闭环方式递送，后者取决于诸如血压或心输出量的生理变量。
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公开(公告)号：US20100256700A1
公开(公告)日：2010-10-07
申请号：US12755041
申请日：2010-04-06
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/365 , A61N1/3702
摘要： A method and device are described for delivering cardiac therapy in which an implantable device for delivering such cardiac therapy is additionally configured to detect the presence of inflammation. Upon detection of inflammation, the device may be configured to modify its delivery of therapy in various ways and/or to communicate the information to an external agent for other types of interventions.
摘要翻译： 描述了用于递送心脏疗法的方法和装置，其中用于递送这种心脏治疗的可植入装置另外配置为检测炎症的存在。 在检测到炎症时，该装置可以被配置为以各种方式修改其治疗递送和/或将信息传达给外部代理以用于其他类型的干预。
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公开(公告)号：US20100249860A1
公开(公告)日：2010-09-30
申请号：US12720246
申请日：2010-03-09
申请人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
发明人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
CPC分类号： A61N1/3625 , A61N1/3627 , A61N1/37247 , A61N1/3925 , A61N1/3968 , A61N1/3993
摘要： An external cardiac stimulation patch integrates a transcutaneous cardiac stimulation device and body-surface electrodes with a skin patch. The skin patch is to be attached onto a patient to provide for electrical contacts between the body-surface electrodes and a patient. The transcutaneous cardiac stimulation device delivers pacing pulses to the heart of the patient through pacing electrodes selected from the body-surface electrodes.
摘要翻译： 外部心脏刺激贴片将经皮心脏刺激装置和体表电极与皮肤贴片集成。 将皮肤贴片贴在患者身上，以提供身体表面电极与患者之间的电接触。 经皮心脏刺激装置通过选自身体表面电极的起搏电极将起搏脉冲提供给患者的心脏。
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65.发明申请公开(公告)号：US20100087881A1
公开(公告)日：2010-04-08
申请号：US12573520
申请日：2009-10-05
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3684 , A61N1/395 , A61N1/3962
摘要： A pacing device and method for operating same is disclosed in which the point of origin of an arrhythmia is estimated in order to more provide more effective treatment. The origin of an arrhythmia may be estimated by analyzing the timing of electrical events as detected at different electrode sites and/or using different sensing vectors. Anti-tachycardia pacing (ATP) may then be delivered to the most appropriate location.
摘要翻译： 公开了用于操作的起搏装置和方法，其中估计心律失常的起点，以便更有效地提供治疗。 可以通过分析在不同电极位置处检测到的电气事件的定时和/或使用不同的感测向量来估计心律失常的起因。 然后将抗心动过速起搏（ATP）送至最合适的位置。
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66.发明申请HEMODYNAMIC MORPHOLOGICAL ANALYSIS FOR RHYTHM IDENTIFICATION 审中-公开用于RHYTHM识别的HEMODYMM MORPHOLOGICAL ANALYSIS公开(公告)号：US20090264716A1
公开(公告)日：2009-10-22
申请号：US12425193
申请日：2009-04-16
申请人： Allan C. Shuros , Dan Li
发明人： Allan C. Shuros , Dan Li
IPC分类号： A61N1/365 , A61B5/0205 , A61B5/00 , A61N1/39
CPC分类号： A61N1/36585 , A61B5/02028 , A61B5/04525 , A61B5/0464 , A61N1/3962
摘要： This document discusses, among other things, an apparatus comprising an implantable hemodynamic sensor circuit that provides a hemodynamic signal representative of mechanical function of a cardiovascular system of a subject and a controller circuit communicatively coupled to the hemodynamic sensor circuit. The controller circuit includes a detection module configured to detect an onset of tachyarrhythmia, a signal analyzer module configured to determine a measure of morphological variability of the hemodynamic signal during the episode of tachyarrhythmia, and a rhythm discrimination module configured to deem whether the tachyarrhythmia episode is indicative of ventricular tachycardia (VT) according to the measure of morphological variability.
摘要翻译： 本文件尤其涉及一种包括可植入血液动力学传感器电路的装置，其提供表示受试者的心血管系统的机械功能的血液动力学信号和通信地耦合到血液动力学传感器电路的控制器电路。 所述控制器电路包括检测模块，所述检测模块被配置为检测快速性心律失常的发作，信号分析器模块被配置为确定在快速性心律失常发作期间的血液动力学信号的形态变异性的度量;以及节律辨别模块，其被配置为认为是否发生快速性心律失常发作 根据形态变异性的测量指示室性心动过速（VT）。
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公开(公告)号：US20090234409A1
公开(公告)日：2009-09-17
申请号：US12396132
申请日：2009-03-02
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/02405 , A61B5/0452 , A61B5/4035 , A61B5/4047 , A61N1/36114 , A61N1/36514 , A61N1/36592
摘要： Various system embodiments comprise a myocardial stimulator, at least one sensor adapted for use in detecting heart rate to determine heart rate turbulence (HRT), and a controller connected to the myocardial stimulator and the at least one sensor. The myocardial stimulator is adapted to deliver pacing pulses through at least one electrode to provide cardiac pacing. The controller is adapted to intermittently deliver a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The controller is further adapted to determine HRT from the detected heart rate to assess cardiac stress to the stress-inducing pacing pulses, and adjust at least one parameter of the stress-inducing pacing pulses to adjust cardiac stress if the cardiac stress to the stress-inducing pacing pulses is undesirable.
摘要翻译： 各种系统实施例包括心肌刺激器，适于用于检测心率以确定心率湍流（HRT）的至少一个传感器，以及连接到心肌刺激器和至少一个传感器的控制器。 心肌刺激器适于通过至少一个电极输送起搏脉冲以提供心脏起搏。 控制器适于间歇地递送一系列应力诱导起搏脉冲，其适于在应力引发起搏期间增加交感神经张力。 所述控制器进一步适于根据检测到的心率来确定HRT以评估心脏应激对应激引起的起搏脉冲，并且如果对于应力诱发起搏脉冲的心脏应力，则调整应力诱发起搏脉冲的至少一个参数以调节心脏应激， 引起起搏脉冲是不期望的。
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公开(公告)号：US07526337B2
公开(公告)日：2009-04-28
申请号：US11422417
申请日：2006-06-06
申请人： Allan C. Shuros , Michael J. Kane
发明人： Allan C. Shuros , Michael J. Kane
IPC分类号： A61N1/365
CPC分类号： A61B5/03 , A61B5/0031 , A61B5/076 , A61B5/14546 , A61B5/415 , A61B5/418 , A61B5/4839 , A61N1/3627 , A61N1/36514
摘要： A device and method are disclosed for physiological monitoring of the lymphatic system. An implantable device is configured with a lymphatic sensor disposed in a lymphatic vessel for sensing pressure, flow, and/or the concentration of particular markers within the vessel. The device may be further configured to deliver appropriate therapy in accordance with the lymphatic monitoring.
摘要翻译： 公开了用于淋巴系统的生理监测的装置和方法。 可植入装置配置有设置在淋巴管中的淋巴传感器，用于感测容器内的特定标记物的压力，流量和/或浓度。 该装置还可以被配置成根据淋巴监测进行适当的治疗。
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公开(公告)号：US20080119904A1
公开(公告)日：2008-05-22
申请号：US11561049
申请日：2006-11-17
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译： 描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。 在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。 在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。
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公开(公告)号：US09186512B2
公开(公告)日：2015-11-17
申请号：US12565233
申请日：2009-09-23
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/01 , A61B5/036 , A61B5/053 , A61B5/1076 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4205 , A61B5/4878 , A61B5/7275 , A61B8/488 , A61N1/36521
摘要： An apparatus comprises an implantable sensor and a detection circuit. The implantable sensor provides a physiologic sensor signal and is to be positioned at a lymph node of a subject. The detection circuit detects a change in a physiologic parameter of the lymph node that exceeds a threshold change, and deems that the change in the physiologic parameter indicates a change in inflammation of an organ associated with the lymph node.
摘要翻译： 一种装置包括可植入传感器和检测电路。 植入式传感器提供生理传感器信号并且被定位在受试者的淋巴结处。 检测电路检测超过阈值变化的淋巴结生理参数的变化，认为生理参数的变化表示与淋巴结相关的器官的炎症变化。
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