公开(公告)号：US20110119794A1

公开(公告)日：2011-05-19

申请号：US12741226

申请日：2008-11-19

申请人： Jianbo Yang ,  Yuping Lu ,  Ying Wu ,  Meimei Wang ,  Xuzhong Li ,  Fengshun Song ,  Yi Zhang ,  Xiufeng Wang ,  Ni Dahu

发明人： Jianbo Yang ,  Yuping Lu ,  Ying Wu ,  Meimei Wang ,  Xuzhong Li ,  Fengshun Song ,  Yi Zhang ,  Xiufeng Wang ,  Ni Dahu

IPC分类号： A01H5/10 ,  C07H21/04 ,  C12N15/63 ,  A01H5/00 ,  C12N5/10

CPC分类号： C12N15/8223

摘要： An isolated rice non-endosperm tissue expression promoter, OsTSP I, and the use thereof. The promoter comprises the defined sequence of 1785 by (SEQ ID NO: 1), given in the specification, or its fragment or variant, or a nucleotide sequence If which hybridizes to SEQ ID NO: 1, or its fragment or variant, under stringent conditions. The activity of OsTSP I is comfirmed by transgenic methods. As determined histochemically, OsTSP I reglulates GUS expression in a tissue-specific manner and is not active in endosperm tissues. The OsTSP I can be used as a powerful tool for the investigation and control of gene expression in rice and other crops. It is particularly advantageous for development of safe transgenic foods such as rice.

摘要翻译： 分离的水稻非胚乳组织表达启动子OsTSP I及其用途。 启动子包括在说明书中给出的（SEQ ID NO：1）所定义的序列1785或其片段或变体，或在严格条件下与SEQ ID NO：1或其片段或变体杂交的核苷酸序列 条件。 OsTSP I的活性由转基因方法证实。 按组织学方法测定，OsTSP I以组织特异性方式调节GUS表达，并且在胚乳组织中不起作用。 OsTSP可作为水稻和其他作物基因表达调查和控制的有力工具。 特别有利于开发安全的转基因食品如水稻。

公开(公告)号：US07941206B2

公开(公告)日：2011-05-10

申请号：US12694833

申请日：2010-01-27

申请人： Yi Zhang ,  Marina Brockway ,  Carlos Alberto Ricci ,  Ronald W. Heil ,  Douglas R. Daum ,  Robert J. Sweeney ,  Aaron R. McCabe

发明人： Yi Zhang ,  Marina Brockway ,  Carlos Alberto Ricci ,  Ronald W. Heil ,  Douglas R. Daum ,  Robert J. Sweeney ,  Aaron R. McCabe

IPC分类号： A61B5/04

CPC分类号： A61B5/0006 ,  A61B5/0031 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/7207 ,  A61B5/7217 ,  A61N1/3756 ,  G06K9/624

摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。 信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。 信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。 如果需要或必要，可以更新所选择的向量。 信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。 分离可以包括主成分分析和/或独立成分分析。 可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

公开(公告)号：US20110106199A1

公开(公告)日：2011-05-05

申请号：US12986762

申请日：2011-01-07

申请人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/365

CPC分类号： A61N1/36139 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/365 ,  A61N1/36592 ,  A61N1/3962 ,  A61N1/3987

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

摘要翻译： 本主题的各个方面涉及一种方法。 根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。

公开(公告)号：US07917196B2

公开(公告)日：2011-03-29

申请号：US11125020

申请日：2005-05-09

申请人： Yi Zhang ,  Carlos Alberto Ricci ,  Jeffrey E. Stahmann ,  Aaron R. McCabe ,  Scott A. Meyer ,  Yinghong Yu

发明人： Yi Zhang ,  Carlos Alberto Ricci ,  Jeffrey E. Stahmann ,  Aaron R. McCabe ,  Scott A. Meyer ,  Yinghong Yu

IPC分类号： A61B5/0464

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些能力的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。 实施例一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。 实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。 使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。 使用一个或多个心脏信号载体来区分心律失常。

公开(公告)号：US07894889B2

公开(公告)日：2011-02-22

申请号：US12484061

申请日：2009-06-12

申请人： Yi Zhang

发明人： Yi Zhang

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/04011 ,  A61B5/7207 ,  A61B5/7285

摘要： A method comprising sensing at least one cardiac signal representative of cardiac activity of a subject using an implantable medical device (IMD), calculating, from the cardiac signal, a first dominant vector corresponding to a direction and magnitude of maximum signal power of an ST-T first segment of a cardiac cycle and a second dominant vector corresponding to a direction and magnitude of maximum signal power of a P-QRS second segment of a cardiac cycle, measuring a change in the first dominant vector, measuring a change in the second dominant vector, and subtracting the change in the second dominant vector from the measured change in the first dominant vector to form a difference.

摘要翻译： 一种方法，包括使用可植入医疗装置（IMD）感测表示对象的心脏活动的至少一个心脏信号，从心脏信号计算对应于ST段的最大信号功率的方向和幅度的第一显性矢量， T心脏周期的第一段和对应于心动周期的P-QRS第二段的最大信号功率的方向和幅度的第二主要矢量，测量第一显性矢量的变化，测量第二主要变化 向量，并从第一显性向量的测量变化中减去第二显性向量中的变化以形成差。

公开(公告)号：US20110027169A1

公开(公告)日：2011-02-03

申请号：US12936729

申请日：2009-04-23

申请人： Jacques Monnier ,  Yi Zhang ,  Andrew McFarlan

发明人： Jacques Monnier ,  Yi Zhang ,  Andrew McFarlan

IPC分类号： C01B3/02

CPC分类号： C01B3/323 ,  C01B2203/0233 ,  C01B2203/0405 ,  C01B2203/047 ,  C01B2203/0475 ,  C01B2203/048 ,  C01B2203/1047 ,  C01B2203/1058 ,  C01B2203/1064 ,  C01B2203/107 ,  C01B2203/1082 ,  C01B2203/1094 ,  C01B2203/1211 ,  C01B2203/1217 ,  C01B2203/1223 ,  C01B2203/148 ,  C01B2203/1623 ,  C01B2203/1638

摘要： The invention provides a process of producing hydrogen that involves aqueous phase reforming of an oxygenated hydrocarbon, preferably one obtained from a renewable source such as biomass. The reaction is carried out in the absence of electrolytes and in the presence of a dispersed particulate heterogeneous catalyst. The reaction is carried out under pressure and relatively low temperature in a stirred tank reactor, preferably a continuous stirred tank reactor.

摘要翻译： 本发明提供一种生产氢的方法，其涉及含氧烃的水相重整，优选由可再生来源（例如生物质）获得的那些。 反应在不存在电解质的情况下进行，并且在分散的颗粒状非均相催化剂的存在下进行。 反应在压力和相对低的温度下在搅拌釜反应器，优选连续搅拌釜反应器中进行。

公开(公告)号：US20100274147A1

公开(公告)日：2010-10-28

申请号：US12761047

申请日：2010-04-15

申请人： Abhilash Patangay ,  Yi Zhang ,  Aaron Lewicke ,  Julie A. Thompson

发明人： Abhilash Patangay ,  Yi Zhang ,  Aaron Lewicke ,  Julie A. Thompson

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/021 ,  A61B5/024 ,  A61B5/02405 ,  A61B7/04 ,  A61B2562/0219 ,  A61N1/3627 ,  G06F19/3418 ,  G16H50/30

摘要： Systems and methods include accessing a plurality of cardiac indications. A heart rate variability metric is produced by analyzing the plurality of cardiac indications using a measurement from a class of nonlinear measurements. Nonlinear measurements include, but are not limited to, approximate entropy, X-Y scatter from a Poincaré plot, fractal dimension, and detrended fluctuation analysis, in various examples. Based on the heart rate variability metric, a cardiac ischemic state is detected.

摘要翻译： 系统和方法包括访问多个心脏指示。 通过使用来自一类非线性测量的测量来分析多个心脏指征来产生心率变异性度量。 在各种实施例中，非线性测量包括但不限于近似熵，Poincaré图中的X-Y散射，分形维数和去趋势波动分析。 基于心率变异性度量，检测到心脏缺血状态。

公开(公告)号：US20100267578A1

公开(公告)日：2010-10-21

申请号：US12708362

申请日：2010-02-18

申请人： MICHAEL SEUL ,  Yi Zhang ,  Sukanta Banerjee ,  Jiacheng Yang ,  Chiu Chau

发明人： MICHAEL SEUL ,  Yi Zhang ,  Sukanta Banerjee ,  Jiacheng Yang ,  Chiu Chau

IPC分类号： C40B30/04

CPC分类号： C12Q1/6837 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q2565/1015 ,  C12Q2537/143 ,  C12Q2533/101 ,  C12Q2535/125 ,  C12Q2525/301

摘要： In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps:adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.

摘要翻译： 在溶液中进行的多重测定方法中，其中溶液含有核酸靶，并且其中使用几个不同类型的寡核苷酸探针，每个类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸 目标，所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加有效 通过一种或多种以下方法可用于结合探针的靶的浓度：（i）在珠的表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

公开(公告)号：US07775983B2

公开(公告)日：2010-08-17

申请号：US11229316

申请日：2005-09-16

申请人： Yi Zhang ,  John D. Hatlestad ,  Yousufali H. Dalal ,  Marina Brockway

发明人： Yi Zhang ,  John D. Hatlestad ,  Yousufali H. Dalal ,  Marina Brockway

IPC分类号： A61B5/02 ,  A61B5/08

CPC分类号： A61B5/091 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/411 ,  A61B2562/0219 ,  A61N1/3627 ,  A61N1/36521

摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.

摘要翻译： 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。

公开(公告)号：US20100185271A1

公开(公告)日：2010-07-22

申请号：US12686988

申请日：2010-01-13

申请人： Yi Zhang

发明人： Yi Zhang

IPC分类号： A61F2/84

CPC分类号： A61F2/915 ,  A61F2/07 ,  A61F2/95 ,  A61F2/966 ,  A61F2002/91525 ,  A61F2002/91558 ,  A61F2002/9505 ,  A61F2002/9665 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61F2250/0098

摘要： The present invention relates to a delivery apparatus for delivering a self-expanding neurovascular stent that allows for smooth movement of the apparatus along a typically tortuous vascular path, ease of stent deployment, and ease of stent retractability being pushed and pulled through the delivery apparatus. The apparatus includes an outer catheter, and an inner shaft located coaxially within the outer catheter. The stent is mounted on the distal section of the inner shaft and preloaded within the outer catheter distal region. The inner shaft includes at least one stent blocking member disposed in the distal section. The self-expanding stent has proximal, middle and distal ends and is comprised of a plurality of closed cells. The self-expanding stent includes locking members which interlock with the blocking member(s) disposed on the inner shaft so as to lock the stent onto the inner shaft within the outer catheter, and to enable the stent retractable together with the inner shaft being out of and retrieved back to the outer catheter. More specially, the invention may be used in the treatment of blood vessel blockage and aneurysms which occur in the brain.

摘要翻译： 本发明涉及一种用于递送自扩张神经血管支架的输送装置，其允许沿着典型曲折的血管路径平滑移动装置，容易地进行支架展开，并且通过推送装置推动和拉动支架缩回容易。 该装置包括外导管和同轴地位于外导管内的内轴。 支架安装在内轴的远端部分上，并预先装在外导管远端区域内。 内轴包括设置在远端部分中的至少一个支架阻挡构件。 自扩张支架具有近端，中部和远端，并且由多个闭孔组成。 自扩张支架包括与设置在内轴上的阻挡构件互锁的锁定构件，以将支架锁定在外导管内的内轴上，并且使支架能够与内轴一起伸出 并返回到外导管。 更具体地，本发明可用于治疗发生在脑中的血管阻塞和动脉瘤。