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115 条记录 (耗时 0.063 秒)

    Nucleic acid molecules which encode antibodies that bind CD40
    61.
    发明授权
    Nucleic acid molecules which encode antibodies that bind CD40 有权
    编码结合CD40的抗体的核酸分子

    公开(公告)号：US07626012B2

    公开(公告)日：2009-12-01

    申请号：US12284605

    申请日：2008-09-22

    申请人： Vahe Bedian ,  Ronald P. Gladue ,  Jose Corvalan ,  Xiao-Chi Jia ,  Xiao Feng

    发明人： Vahe Bedian ,  Ronald P. Gladue ,  Jose Corvalan ,  Xiao-Chi Jia ,  Xiao Feng

    IPC分类号： C12N15/13 ,  C12N15/12 ,  C12N5/12 ,  C12N15/63

    CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/505 ,  A61N5/062 ,  A61N5/10 ,  C07K16/2878 ,  C07K16/40 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92

    摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

    摘要翻译： 本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。 本发明还涉及人抗CD40抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。 本发明还提供了使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物。

    Human monoclonal antibody against TGF-β type II receptor and medicinal use thereof
    62.
    发明授权
    Human monoclonal antibody against TGF-β type II receptor and medicinal use thereof 失效
    针对TGF-β2型受体的人单克隆抗体及其医药用途

    公开(公告)号：US07579186B1

    公开(公告)日：2009-08-25

    申请号：US10130034

    申请日：2000-11-17

    申请人： Shinji Sakamoto ,  Masafumi Kamada

    发明人： Shinji Sakamoto ,  Masafumi Kamada

    IPC分类号： C12N5/06 ,  C07K16/28

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/74

    摘要： Various human monoclonal antibodies that bind to human TGF-β type II receptor to inhibit the signal transduction of human TGF-β signal into cells are produced by immunizing human antibody-producing transgenic mice generated by genetic engineering techniques with the soluble human TGF-β type II receptor. Further, these human monoclonal antibodies were demonstrated to be effective for preventing and treating various diseases induced by human TGF-β in various organs (for example, tissue fibrosis).

    摘要翻译： 通过用可溶性人TGF-β型的遗传工程技术免疫产生的产生抗体的转基因小鼠，产生与人TGF-β2型受体结合以抑制人TGF-β信号向细胞中信号转导的各种人单克隆抗体 II受体。 此外，这些人单克隆抗体被证明对于预防和治疗各种器官（例如组织纤维化）中由人TGF-β诱导的各种疾病是有效的。

    Antibodies directed to parathyroid hormone (PTH) and uses thereof
    67.
    发明授权
    Antibodies directed to parathyroid hormone (PTH) and uses thereof 失效
    针对甲状旁腺激素（PTH）的抗体及其用途

    公开(公告)号：US07288253B2

    公开(公告)日：2007-10-30

    申请号：US10638265

    申请日：2003-08-08

    申请人： Lorin Roskos ,  Ian Foltz ,  Chadwick King

    发明人： Lorin Roskos ,  Ian Foltz ,  Chadwick King

    IPC分类号： A61K39/395 ,  A61K39/00 ,  A01N37/18

    CPC分类号： C07K16/26 ,  A01K2217/075 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

    摘要： Embodiments of the invention described herein relate to antibodies directed to the antigen parathyroid hormone (PTH) and uses of such antibodies. In particular, in some embodiments, there are provided fully human monoclonal antibodies directed to the antigen PTH. In further embodiments, nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.

    摘要翻译： 本文描述的本发明的实施方案涉及针对抗原甲状旁腺激素（PTH）的抗体和这种抗体的用途。 特别地，在一些实施方案中，提供针对抗原PTH的完全人单克隆抗体。 在另外的实施方案中，编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于横跨框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。

    Antibodies to MAdCAM
    69.
    发明授权
    Antibodies to MAdCAM 有权

    公开(公告)号：US10259872B2

    公开(公告)日：2019-04-16

    申请号：US15086930

    申请日：2016-03-31

    申请人： Pfizer Inc. ,  Amgen Fremont Inc.

    发明人： Nicholas Pullen ,  Elizabeth Molloy ,  Sirid-Aimee Kellermann ,  Larry L. Green ,  Mary Haak-Frendscho

    IPC分类号： C12P21/00 ,  C12N5/20 ,  C07K16/28 ,  G01N33/569 ,  G01N33/68 ,  A61K39/00 ,  C07K14/705

    摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.