公开(公告)号：US07796261B2

公开(公告)日：2010-09-14

申请号：US11792097

申请日：2005-12-01

Applicant: Henrik Vilstrup Juhl

Inventor： Henrik Vilstrup Juhl

IPC: G01N21/00

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01N2021/036 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/1293

Abstract: A spectrophotometer (2) comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest withiA spectrophotometer (2) comprise a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest within the retained sample can be obtained.

Abstract translation: 一种分光光度计（2），包括辐射源（6），优选光辐射，被设置成朝向样品保持器（4）中的样品发射多个波长的辐射;以及检测装置8，用于在与 例子。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，用分光光度计（2）存在感兴趣的物质的指示包括辐射源（6）， 优选地，光辐射被设置为以多个波长朝向样品保持器（4）中的样品发射辐射;以及检测装置8，用于在与样品相互作用之后检测辐射。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，可以获得在保留的样品内存在感兴趣物质的指示。

公开(公告)号：US20250076292A1

公开(公告)日：2025-03-06

申请号：US18561163

申请日：2022-07-12

Applicant: Foss Analytical A/S

Inventor： Tamir GIL ,  Steen Hauge MATTHIESEN ,  Erika Claudia LANTOS ,  Gyorgy NAGYERI

IPC: G01N33/543 ,  G01N33/58

Abstract: A device for determining one or more of multiple analytes in a sample liquid includes a detection surface having thereon a microarray of elements, comprising: a plurality of binding elements immobilized by insoluble binding at discrete locations on the detection surface and a plurality of dissolvable elements immobilized by soluble binding at other discrete locations on the detection surface. The elements being arranged in the microarray such that at least a portion of the dissolvable elements is located closer to the center of the microarray and/or at least a portion of the dissolvable elements is located closer to the periphery of the microarray than each of the binding elements. Alternatively, the dissolvable and immovable elements may be provided similarly or mirrored in areas which may be duplicated.

公开(公告)号：US12216035B2

公开(公告)日：2025-02-04

申请号：US18004565

申请日：2021-05-11

Applicant: Foss Analytical A/S

Inventor： Ahmed Fadil

IPC: G01N1/44 ,  G01N21/71

Abstract: An organic material sample is prepared for LIBS analysis based on searing a sample of granular organic material having an organic matrix. The searing includes supplying heat to the sample for one or more known exposure times to produce a same number of searing instances, measuring reflectance values of the sample before and after one or more of the searing instances, determining a searing parameter as an indicator of a susceptibility of the organic matrix to searing determined based on the measured reflectance values, calculating a time value from an application of a predictive model derived from an empirical analysis of reference data comprising time values indexed against searing parameter to the searing parameter, the predictive model linking the searing parameter to the time value, generating a new exposure time using the time value, and heating the sample for the new exposure time to produce a new searing instance.

公开(公告)号：US12117401B2

公开(公告)日：2024-10-15

申请号：US18455983

申请日：2023-08-25

Applicant: Foss Analytical A/S

Inventor： Daniel Aden ,  Ahmed Fadil

IPC: G01N21/71

CPC classification number: G01N21/718 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/126

Abstract: A LIBS analysis system comprises a focusing lens arrangement having a focal plane; a laser for propagating a laser beam through the focusing lens arrangement to be focused at the focal plane; a detector for generating an output that is proportional to an intensity of incident electromagnetic radiation that is incident on the detector; a translation mechanism configured to cause a relative movement of the sample holder and the focusing lens arrangement to vary a position of the focal plane along the optical path with respect to the sample holder; and a controller configured to automatically control the translation mechanism to cause the relative movement of the sample holder and the focusing lens arrangement to achieve an optimum position at which the focal plane and an analysis region of the upper surface intersecting the optical path are at or are close to coincidence.

公开(公告)号：US12111243B2

公开(公告)日：2024-10-08

申请号：US17779344

申请日：2020-12-01

Applicant: Foss Analytical A/S

Inventor： Christer Zoffmann Bisgaard ,  Anders Brask ,  Miguel Carro Temboury

IPC: G01N15/1404 ,  G01N15/1434

CPC classification number: G01N15/1404 ,  G01N15/1436 ,  G01N2015/1413

Abstract: A hydrodynamic focusing device comprises first and second flow channels; a wall at least partially defining an envelopment region connected in-line between the first and second flow channels which collectively define a flow direction extending therethrough; and a chimney comprising a body and a sample fluid inlet, extending from the wall and into the envelopment region. The sample fluid inlet faces at least partially perpendicular to the flow direction in the envelopment region, such that the sample fluid inlet is configured to supply a sample fluid into the envelopment region in a direction that is at least partially perpendicular to the flow direction. The body and the sample fluid inlet each have an elongate profile which has a rounded leading edge facing the first flow channel and opposing long edges connecting the leading and trailing edges and tapered towards the trailing edge.

公开(公告)号：US11869636B2

公开(公告)日：2024-01-09

申请号：US17052059

申请日：2019-05-20

Applicant: Foss Analytical A/S

Inventor： Rasmus Lundgaard Christensen ,  Tamir Gil ,  Rasmus Vistisen ,  Malin Damm

IPC: G16H10/40 ,  G01N35/00

CPC classification number: G16H10/40 ,  G01N35/00732 ,  G01N2035/00831 ,  G01N2035/00891

Abstract: An analysis instrument comprises a sample receiving section for receiving samples provided by a plurality of users, an analysis section operable to receive an aliquot of each received sample, perform an analysis of each received aliquot, and generate an output based on the analysis, and a presentation section adapted to present the output in a human discernable format. The analysis instrument further includes an identification section adapted to autonomously generate an identifier unique to each user and each sample provided thereby and to supply each identifier for presentation by the presentation section in a human discernable format together with a portion of the output that corresponds with one or more samples provided by a user to which the identifier is unique. Each identifier consists of one or more graphic symbols, one or more colours, and/or one or more numbers.

公开(公告)号：US11781990B2

公开(公告)日：2023-10-10

申请号：US17441910

申请日：2020-04-05

Applicant: Foss Analytical A/S

Inventor： Daniel Aden ,  Ahmed Fadil

IPC: G01N21/71

CPC classification number: G01N21/718 ,  G01N2201/068 ,  G01N2201/06113 ,  G01N2201/126

Abstract: A LIBS analysis system comprises a focusing lens arrangement having a focal plane; a laser for propagating a laser beam through the focusing lens arrangement to be focused at the focal plane; a detector for generating an output that is proportional to an intensity of incident electromagnetic radiation that is incident on the detector; a translation mechanism configured to cause a relative movement of the sample holder and the focusing lens arrangement to vary a position of the focal plane along the optical path with respect to the sample holder; and a controller configured to automatically control the translation mechanism to cause the relative movement of the sample holder and the focusing lens arrangement to achieve an optimum position at which the focal plane and an analysis region of the upper surface intersecting the optical path are at or are close to coincidence.

公开(公告)号：US20230160792A1

公开(公告)日：2023-05-25

申请号：US18158054

申请日：2023-01-23

Applicant: Foss Analytical A/S

Inventor： Thomas NIKOLAJSEN ,  Daniel ADEN

IPC: G01N1/28 ,  G01N1/44 ,  G01N33/483 ,  G01N21/71

CPC classification number: G01N1/286 ,  G01N1/44 ,  G01N33/4833 ,  G01N21/718 ,  G01N2223/6126 ,  G01N2223/618 ,  G01N2223/312 ,  G01N2001/2886

Abstract: A method for preparing a sample of organic material for laser induced breakdown spectroscopy (LIBS) may include obtaining granular organic material, forming a portion of the granular organic material into a sample pellet, and searing the organic material. The searing may include searing only an exposed end surface of the sample pellet on which LIBS analysis is to be performed. The method may include pressing the seared sample pellet to consolidate the material comprising the seared end surface.

公开(公告)号：US20220276189A1

公开(公告)日：2022-09-01

申请号：US17632043

申请日：2020-05-28

Applicant: Foss Analytical A/S

Inventor： Per Waaben HANSEN ,  Mads Lykke ANDERSEN

IPC: G01N27/06 ,  G01N33/04 ,  G01N21/3577

Abstract: A method of standardizing an output of an electrical property sensor includes calculating a reference magnitude (Condr) of an electrical property of an electrically conductive liquid, based on obtaining, by a spectrometer, spectral data resulting from an interaction of light with the electrically conductive liquid, and applying, in a data processor, a mathematical model to the spectral data to calculate the reference magnitude (Condr) of the electrical property, wherein the mathematical model links the spectral data to magnitudes of the electrical property; comparing, in the data processor, a measured magnitude (Condm) of the electrical property of the electrically conductive liquid with a reference magnitude (Condr) of the electrical property, wherein the measured magnitude (Condm) of the electrical property is obtained with the electrical property sensor; determining, in the data processor, a standardization factor (F) dependent on a ratio of the reference magnitude (Condr) and the measured magnitude (Condm).

公开(公告)号：US20220146432A1

公开(公告)日：2022-05-12

申请号：US17441910

申请日：2020-04-05

Applicant: Foss Analytical A/S

Inventor： Daniel ADEN ,  Ahmed FADIL

IPC: G01N21/71

Abstract: A LIBS analysis system comprises a focusing lens arrangement having a focal plane; a laser for propagating a laser beam through the focusing lens arrangement to be focused at the focal plane; a detector for generating an output that is proportional to an intensity of incident electromagnetic radiation that is incident on the detector; a translation mechanism configured to cause a relative movement of the sample holder and the focusing lens arrangement to vary a position of the focal plane along the optical path with respect to the sample holder; and a controller configured to automatically control the translation mechanism to cause the relative movement of the sample holder and the focusing lens arrangement to achieve an optimum position at which the focal plane and an analysis region of the upper surface intersecting the optical path are at or are close to coincidence.