公开(公告)号：US08858787B2

公开(公告)日：2014-10-14

申请号：US11876619

申请日：2007-10-22

Applicant: Matthew Muller ,  Donald Busby ,  Justin Rohde ,  Mark Jablonski

Inventor： Matthew Muller ,  Donald Busby ,  Justin Rohde ,  Mark Jablonski

IPC: B01D35/14 ,  B01D35/143 ,  A61M1/36 ,  A61M1/16 ,  A61M1/28 ,  G01F1/708 ,  A61M1/34

CPC classification number: A61M1/1613 ,  A61M1/16 ,  A61M1/1607 ,  A61M1/1645 ,  A61M1/1647 ,  A61M1/1658 ,  A61M1/288 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3649 ,  A61M1/365 ,  A61M1/3656 ,  A61M2205/12 ,  A61M2205/18 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2230/20 ,  G01F1/708

Abstract: A dialysis system includes a dialyzer; a blood pump coupled operably to a dialyzer; a dialysate inlet pump couple operably to a dialysate inlet of the dialyzer; a dialysate outlet pump coupled operably to a dialysate outlet of the dialyzer; a first non-invasive fluid velocity sensor positioned to sensor of inlet flowrate of dialysate pumped to the dialysate inlet by the dialysate inlet pump; and a second non-invasive fluid velocity sensor positioned to sense an outlet flowrate of dialysate pumped from the dialysate outlet by the dialysate outlet pump.

Abstract translation: 透析系统包括透析器; 可操作地耦合到透析器的血泵; 透析液入口泵可操作地耦合到透析器的透析液入口; 透析液出口泵，可操作地耦合到透析器的透析液出口; 第一非侵入性流体速度传感器，定位成由透析液入口泵泵送到透析液入口的透析液的入口流速传感器; 以及第二非侵入性流体速度传感器，其定位成感测由透析液出口泵从透析液出口泵出的透析液的出口流速。

公开(公告)号：US08684959B2

公开(公告)日：2014-04-01

申请号：US13003126

申请日：2009-07-03

Applicant: Francesco Paolini ,  Francesco Fontanazzi ,  Fabio Grandi

Inventor： Francesco Paolini ,  Francesco Fontanazzi ,  Fabio Grandi

IPC: A61M37/00

CPC classification number: A61M1/16 ,  A61M1/1601 ,  A61M1/1613 ,  A61M1/1647 ,  A61M1/361

Abstract: An extracorporeal blood treatment apparatus comprises a sensor (10) for emitting a signal indicating a change of hematic volume of an individual (7) subjected to a treatment and a weight loss system for actuating the individual's weight loss. A control unit (20) receives an effective weight value of the individual and a desired weight loss value and from these values determines a desired value of a change in hematic volume at end of treatment. The weight loss system is controlled on a basis of the hematic volume change signal and the desired value of the hematic volume change. The apparatus enables automatic control of a dialysis operation while preventing some complications arising from hypotension.

Abstract translation: 体外血液处理装置包括用于发出指示经受治疗的个体（7）的血压变化的信号的传感器（10）和用于致动个人体重减轻的减重系统。 控制单元（20）接收个人的有效权重值和期望的体重损失值，并且从这些值确定处理结束时血压变化的期望值。 减肥系统是根据血容量变化信号和血压体积变化的期望值进行控制的。 该装置能够自动控制透析操作，同时防止由低血压引起的一些并发症。

公开(公告)号：US20130075314A1

公开(公告)日：2013-03-28

申请号：US13634656

申请日：2011-03-15

Applicant: Dejan Nikolic ,  Alexander Heide

Inventor： Dejan Nikolic ,  Alexander Heide

IPC: A61M1/14

CPC classification number: F17D1/00 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1647 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/36 ,  A61M1/3607 ,  A61M2205/057 ,  A61M2205/12 ,  A61M2205/3317 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2207/00 ,  G01F1/58

Abstract: The invention relates to the balancing of fluid streams in a dialysis system. In particular the invention relates to a cassette for conveying a first and a second fluid stream in a dialysis system, wherein the first and the second fluid streams can be medical fluid streams such as for example dialysate streams or blood streams, wherein the cassette has a sensor as a device for balancing the first and the second fluid stream, and wherein the sensor has a first channel for the first fluid stream and a second channel for the second fluid stream. The invention further relates to a dialysis system, which is configured to accommodate at least one cassette which is configured as described above. Furthermore, the present invention relates to an arrangement by which two channels for the first and the second fluid streams are formed. In addition, the invention relates to a method for construction of the two channels or the arrangement.

Abstract translation: 本发明涉及透析系统中流体流的平衡。 特别地，本发明涉及用于在透析系统中输送第一和第二流体流的盒，其中第一和第二流体流可以是医用流体流，例如透析液流或血液流，其中盒具有 传感器作为用于平衡第一和第二流体流的装置，并且其中传感器具有用于第一流体流的第一通道和用于第二流体流的第二通道。 本发明还涉及透析系统，其被配置为容纳至少一个如上所述构造的盒。 此外，本发明涉及一种用于形成第一和第二流体流的两个通道的装置。 此外，本发明涉及一种用于构造两个通道或装置的方法。

公开(公告)号：US20120297869A1

公开(公告)日：2012-11-29

申请号：US13479850

申请日：2012-05-24

Applicant: Alfred GAGEL

Inventor： Alfred GAGEL

IPC: G01F1/34 ,  G01F7/00

CPC classification number: A61M1/342 ,  A61M1/1647 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3465 ,  A61M1/3635 ,  A61M1/3663 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50

Abstract: The present invention relates to a method for determining at least a first volume flow in a blood treatment apparatus which comprises: a primary circuit for conducting the blood to be treated; a secondary circuit for conducting a fluid that is used for the blood treatment; a blood treatment module provided for exchanging fluids and/or substances between the primary circuit and the secondary circuit; and an optionally provided fluid connection between the primary circuit and the secondary circuit, provided for introducing the first volume flow from the secondary circuit into the primary circuit; wherein the method encompasses determining the first volume flow of the secondary circuit taking into account a first pressure value or pressure measurement and a second pressure value or pressure measurement in the secondary circuit. The present invention further relates to a calculating device and a blood treatment apparatus.

Abstract translation: 本发明涉及一种用于确定血液处理设备中的至少第一体积流量的方法，该方法包括：用于进行待处理血液的初级回路; 用于进行用于血液处理的流体的次级回路; 血液处理模块，用于在一次回路和二次回路之间交换流体和/或物质; 以及在所述主电路和所述次级电路之间可选地提供的流体连接，用于将所述第一体积流从所述次级电路引入所述初级电路; 其中所述方法包括在二次回路中考虑第一压力值或压力测量值以及第二压力值或压力测量值来确定次级回路的第一体积流量。 本发明还涉及计算装置和血液处理装置。

公开(公告)号：US20110118647A1

公开(公告)日：2011-05-19

申请号：US13003126

申请日：2009-07-03

Applicant: Francesco Paolini ,  Francesco Fontanazzi ,  Fabio Grandi

Inventor： Francesco Paolini ,  Francesco Fontanazzi ,  Fabio Grandi

IPC: A61M1/34

CPC classification number: A61M1/16 ,  A61M1/1601 ,  A61M1/1613 ,  A61M1/1647 ,  A61M1/361

Abstract: An extracorporeal blood treatment apparatus comprises a sensor (10) for emitting a signal indicating a change of hematic volume of an individual (7) subjected to a treatment and a weight loss system for actuating the individual's weight loss. A control unit (20) receives an effective weight value of the individual and a desired weight loss value and from these values determines a desired value of a change in hematic volume at end of treatment. The weight loss system is controlled on a basis of the hematic volume change signal and the desired value of the hematic volume change. The apparatus enables automatic control of a dialysis operation while preventing some complications arising from hypotension.

Abstract translation: 体外血液处理装置包括用于发出指示经受治疗的个体（7）的血压变化的信号的传感器（10）和用于致动个人体重减轻的减重系统。 控制单元（20）接收个人的有效权重值和期望的体重损失值，并且从这些值确定处理结束时血压变化的期望值。 减肥系统是根据血容量变化信号和血压体积变化的期望值进行控制的。 该装置能够自动控制透析操作，同时防止由低血压引起的一些并发症。

公开(公告)号：US20110089112A1

公开(公告)日：2011-04-21

申请号：US12976653

申请日：2010-12-22

Applicant: Jan Sternby ,  Berit Sternby

Inventor： Jan Sternby ,  Berit Sternby

IPC: B01D61/26 ,  B01D61/28

CPC classification number: B01D61/243 ,  A61M1/16 ,  A61M1/1607 ,  A61M1/1633 ,  A61M1/1647 ,  A61M1/165 ,  A61M1/1692 ,  A61M1/1696 ,  A61M1/341 ,  A61M1/3431 ,  A61M1/3465 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/3393

Abstract: A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significant increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis.

Abstract translation: 一种提高透析效率的方法和装置，用于从血液中去除或多或少紧密结合载体如白蛋白的物质。 根据本发明，这是通过与常规透析相比，同时显着增加透析流体的流速和从透析液分离血液的膜的面积而实现的。

公开(公告)号：US07857976B2

公开(公告)日：2010-12-28

申请号：US12581599

申请日：2009-10-19

Applicant: John J. Bissler ,  Marios M. Polycarpou ,  Nat Hemasilpin ,  Efrain O. Morales

Inventor： John J. Bissler ,  Marios M. Polycarpou ,  Nat Hemasilpin ,  Efrain O. Morales

IPC: B01D61/22

CPC classification number: G05B13/0275 ,  A61M1/16 ,  A61M1/1603 ,  A61M1/1605 ,  A61M1/1611 ,  A61M1/1615 ,  A61M1/1643 ,  A61M1/1647 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3451 ,  A61M1/3496 ,  A61M1/3607 ,  A61M1/3639 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3393 ,  A61M2205/50 ,  Y10S210/929

Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller can monitor patient parameters, such as heart rate and blood pressure, and adjust the pumping rates accordingly. The supervisory controller uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller corrects temporal variations in the flow rate based upon an adaptive law and a control law.

Abstract translation: 公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。 系统连续监测排出的液体，血液和灌注液的流量。 必要时，调节输注液，排出的液体和血液的泵送速率，以在预选的时间段内从血液中除去预选量的流体。 监督控制器可以监测患者的参数，如心率和血压，并相应地调整泵送速率。 监督控制器使用模糊逻辑来基于一组监督规则做出专家决定，以控制每个泵送速率以实现期望的流量并响应故障状况。 自适应控制器基于自适应法和控制律来校正流量的时间变化。

公开(公告)号：US20100044313A1

公开(公告)日：2010-02-25

申请号：US12567994

申请日：2009-09-28

Applicant: Jan Sternby ,  Berit Sternby

Inventor： Jan Sternby ,  Berit Sternby

IPC: B01D61/26 ,  B01D61/28

CPC classification number: B01D61/243 ,  A61M1/16 ,  A61M1/1607 ,  A61M1/1633 ,  A61M1/1647 ,  A61M1/165 ,  A61M1/1692 ,  A61M1/1696 ,  A61M1/341 ,  A61M1/3431 ,  A61M1/3465 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/3393

Abstract: A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significant increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis.

Abstract translation: 一种提高透析效率的方法和装置，用于从血液中去除或多或少紧密结合载体如白蛋白的物质。 根据本发明，这是通过与常规透析相比，同时显着增加透析流体的流速和从透析液分离血液的膜的面积而实现的。

公开(公告)号：US07246530B2

公开(公告)日：2007-07-24

申请号：US10544671

申请日：2004-01-26

Applicant: Hans Hallstadius ,  Göran Ohlsson ,  Sven Gustafson ,  Bengt Jonasson ,  Gert-Inge Bertinsson

Inventor： Hans Hallstadius ,  Göran Ohlsson ,  Sven Gustafson ,  Bengt Jonasson ,  Gert-Inge Bertinsson

IPC: G01F1/56

CPC classification number: A61M1/16 ,  A61M1/1647 ,  A61M1/341 ,  G01F1/588 ,  G01F1/60

Abstract: The invention relates to measurement of a fluid flow, wherein a flow rate component of the fluid is measured along a selected direction. A magnetic field whose polarity varies over time is applied to the fluid, which presumed to contain electrically charged elements. First and second sensor electrodes (120, 121) are arranged to be wetted by the flowing fluid. The electrodes (120, 121) are spaced apart from one another along a line being substantially perpendicular both to the selected flow direction and a magnetic axis of the magnetic field. A DC-level drift of the sensor electrodes (120, 121) is prevented by supplying a control current (Ictrl-0; Ictrl-1) to each of the sensor electrode (120, 121), which has such sign and magnitude that a direct-current voltage level at the sensor electrodes (120, 121) relative areference potential is controled towards a predetermined voltage (DCset).

Abstract translation: 本发明涉及流体流动的测量，其中沿所选方向测量流体的流速分量。 极性随时间变化的磁场被施加到被认为包含带电元件的流体。 第一和第二传感器电极（120,121）布置成被流动的流体润湿。 电极（120,121）沿着基本上垂直于选定的流动方向和磁场的磁轴的线彼此间隔开。 传感器电极（120,121）的直流电平漂移通过向每一个的每一个提供控制电流（I ctrl-0; I ctrl-1＆lt; 传感器电极（120,121）具有这样的符号和大小，使得传感器电极（120,121）的相对相对电位的直流电压电平被控制到预定电压（DC SET） 。

公开(公告)号：US4486303A

公开(公告)日：1984-12-04

申请号：US482141

申请日：1983-04-05

Applicant: Donald W. Brous

Inventor： Donald W. Brous

IPC: A61M1/16 ,  B01D31/00

CPC classification number: A61M1/16 ,  A61M1/1647 ,  Y10S210/929

Abstract: Control of ultrafiltration by the use of two flowmeters which include fluid flow controls, one between the dialysate supply and the dialyzer input, and a second such flowmeter between the dialyzer output and the effluent. Alternatively, a smaller capacity flowmeter may be placed in parallel with the output flowmeter, to be read as a "vernier".

Abstract translation: 通过使用两个流量计进行超滤控制，这两个流量计包括流体流量控制，透析液供应和透析器输入之间的一个，以及在透析器输出和流出物之间的第二个这样的流量计。 或者，较小容量的流量计可以与输出流量计平行放置，被读取为“游标”。