公开(公告)号：US20150352356A1

公开(公告)日：2015-12-10

申请号：US14760611

申请日：2014-01-14

申请人： FEELIGREEN

发明人： Christophe BIANCHI

IPC分类号： A61N1/32 ,  A61B5/053 ,  A61N1/30 ,  A61N1/36 ,  A61N1/04

CPC分类号： A61B5/0531 ,  A61B5/6833 ,  A61N1/0432 ,  A61N1/0492 ,  A61N1/08 ,  A61N1/30 ,  A61N1/325 ,  A61N1/36014

摘要： The invention concerns an electrostimulation and/or iontophoresis device comprising a patch (10) suitable for application to a user's skin (12) and a voltage generator (22) suitable for applying a low intensity current through the user's skin by a system of electrodes located in said patch; This device is characterised in that it comprises a self-regulator (16) that varies the voltage supplied by the voltage generator as a function of the continuous measurement of the resistivity of the user's skin beneath said patch The resistance value of the skin provided by an element for measuring the resistance of the skin (24) yields the resistivity measurement.

摘要翻译： 本发明涉及一种电刺激和/或离子电渗疗法装置，其包括适于施用于使用者皮肤的贴片（10）和适于通过位于所述电极的电极系统施加低强度电流通过使用者皮肤的电压发生器（22） 在补丁中; 该装置的特征在于，其包括自调节器（16），该自调节器（16）根据在所述贴片之下的用户皮肤的电阻率的连续测量来改变由电压发生器提供的电压。皮肤的电阻值由 用于测量皮肤电阻（24）的元件产生电阻率测量。

公开(公告)号：US20150246226A1

公开(公告)日：2015-09-03

申请号：US14659240

申请日：2015-03-16

申请人： InCube Labs, LLC

发明人： Mir A. Imran ,  Talat Imran ,  Mir Hashim

IPC分类号： A61N1/30

CPC分类号： A61N1/30 ,  A61K9/0009 ,  A61K9/0014 ,  A61K31/465 ,  A61N1/0432 ,  A61N1/0448 ,  A61N1/303 ,  A61N1/325

摘要： Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., nicotine compounds for the treatment of nicotine cravings from tobacco use. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient.

摘要翻译： 本发明的实施方案提供了用于治疗成瘾性渴望的治疗剂的透皮递送方法，例如用于治疗来自烟草使用的尼古丁渴望的尼古丁化合物。 用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。 组合件包括包含被动地扩散入皮肤的治疗剂的溶液。 使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。 在第二时段期间，使用具有吸引剂的特性的第二电流来将药剂保持在组合中，使得药剂递送到皮肤中最小化。 可以根据患者的输入要求递送剂量。

公开(公告)号：US09095706B2

公开(公告)日：2015-08-04

申请号：US13866371

申请日：2013-04-19

申请人： Incline Therapeutics, Inc. ,  Alza Corporation

发明人： Bradley E. White ,  John Lemke ,  Paul Hayter ,  Corinna X. Chen ,  Brian W. Read ,  Jason E. Dougherty

IPC分类号： A61M31/00 ,  A61N1/18 ,  A61N1/30 ,  A61N1/32

CPC分类号： G01R19/145 ,  A61N1/025 ,  A61N1/0416 ,  A61N1/0432 ,  A61N1/08 ,  A61N1/18 ,  A61N1/303 ,  A61N1/325 ,  A61N1/327 ,  G01R19/165 ,  G08B21/182

摘要： Electrotransport drug delivery devices, system and methods of using configured to determine if a current is present between the anode and cathode when drug is not intended to be delivered by the device. These devices/systems may include an off-current module to determine that any current (e.g., which may be inferred by measuring potential difference between the anode and cathode of the device) flowing between the anode and cathode is below a threshold value when the device is not supposed to be delivering drug, thereby preventing unintended delivery of drug and/or alerting a user that unintended delivery of drug may occur.

摘要翻译： 电传送药物递送装置，使用的系统和方法被配置为确定当药物不意图由装置递送时阳极和阴极之间是否存在电流。 这些装置/系统可以包括一个截止模块，用于确定当该装置在阳极和阴极之间流动时，在阳极和阴极之间流动的任何电流（例如，可以通过测量装置的阳极和阴极之间的电位差来推断） 不应该是递送药物，从而防止药物的意外递送和/或警告用户可能发生意外的药物递送。

公开(公告)号：US09061128B2

公开(公告)日：2015-06-23

申请号：US14214188

申请日：2014-03-14

申请人： SONOVIA HOLDINGS LLC

发明人： Michael R. Hall ,  John C. Castel ,  Dawn Castel

IPC分类号： A61M37/00 ,  A61N1/36 ,  A61N7/00 ,  A61N1/32 ,  A61N5/06 ,  A61N1/04 ,  A61F7/00 ,  A61F7/02

CPC分类号： A61N1/328 ,  A61F7/007 ,  A61F2007/0052 ,  A61F2007/0071 ,  A61F2007/0261 ,  A61M37/0092 ,  A61N1/0432 ,  A61N1/0452 ,  A61N1/30 ,  A61N1/36014 ,  A61N5/0613 ,  A61N5/0616 ,  A61N7/00 ,  A61N2005/0653 ,  A61N2007/0034 ,  A61N2007/0073

摘要： A system for delivering light and/or ultrasound across a skin surface is provided. The system includes a device having a layered structure comprising one or both of a light source and an ultrasonic transducer. The light source comprises a flexible light emitter layer electrically coupled to a first conductive layer and a second conductive layer, wherein at least one of the first and second conductive layers is transparent. The ultrasonic transducer comprises a flexible ultrasound emitter layer electrically coupled to a third conductive layer and a fourth conductive layer. The system also includes one or more sensors in contact with the skin surface and a controller electrically coupled to the device and the sensor. The controller is operable to receive sensor data from the sensor and dynamically control the device in response to the received sensor data.

摘要翻译： 提供了一种用于在皮肤表面上传递光和/或超声波的系统。 该系统包括具有包括光源和超声换能器中的一个或两个的分层结构的装置。 光源包括电耦合到第一导电层和第二导电层的柔性光发射极层，其中第一和第二导电层中的至少一个是透明的。 超声换能器包括电耦合到第三导电层和第四导电层的柔性超声发射体层。 该系统还包括与皮肤表面接触的一个或多个传感器和电耦合到该装置和传感器的控制器。 控制器可操作以从传感器接收传感器数据并且响应于所接收的传感器数据来动态地控制设备。

公开(公告)号：US20150122253A1

公开(公告)日：2015-05-07

申请号：US14591153

申请日：2015-01-07

申请人： InCube Labs, LLC

发明人： Mir A. Imran ,  Talat Imran ,  Mir Hashim

IPC分类号： A61N1/08 ,  A61N1/04 ,  A24F47/00 ,  A61N1/32

CPC分类号： A61N1/08 ,  A24F47/002 ,  A61K9/0009 ,  A61K9/0014 ,  A61K9/0021 ,  A61K31/465 ,  A61N1/0432 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/303 ,  A61N1/325

摘要： Embodiments of the invention provide methods for transdermal delivery of therapeutic agents for treatment of addictive cravings e.g., from nicotine. Embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into skin. A dose of agent is delivered from the assembly into skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel agent out of the assembly. During a second period, a second current having a characteristic to attract agent is used to retain agent in the assembly such that delivery of agent into skin is minimized. In particular embodiments, a dose of agent may be delivered on-demand using an input from the patient using an inhalation sensing device which mimics an inhaled form of tobacco.

摘要翻译： 本发明的实施方案提供了用于透皮递送用于治疗成瘾性渴望（例如来自尼古丁）的治疗剂的方法。 用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者皮肤电连通。 组合件包括包含被动扩散到皮肤中的治疗剂的溶液。 使用具有例如极性和大小的特性的第一电流在第一时段期间将剂量的药剂从组合物递送到皮肤中，以将药剂排斥出组合体。 在第二时段期间，使用具有吸引剂特性的第二电流来将组分保留在组件中，使得药剂递送到皮肤中最小化。 在具体实施方案中，可以使用来自患者的输入使用模拟吸入烟草形式的吸入感测装置按需递送剂量的药剂。

公开(公告)号：US08652522B2

公开(公告)日：2014-02-18

申请号：US13388295

申请日：2010-07-28

申请人： Akihiro Hasui ,  Takamitsu Miyagi

发明人： Akihiro Hasui ,  Takamitsu Miyagi

IPC分类号： A61K9/14 ,  A61N1/30

CPC分类号： A61K31/573 ,  A61K9/0009 ,  A61K47/18 ,  A61K47/32 ,  A61N1/0428 ,  A61N1/0432 ,  A61N1/0448 ,  A61N1/30

摘要： It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured and it is possible to manufacture at low cost. A pharmaceutical composition for an iontophoresis according to the present invention, is characterized in that the composition contains a nonionic synthetic polymer, betamethasone sodium phosphate and solvent. Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the nonionic synthetic polymer is polyvinyl alcohol (PVA). Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the mixing amount of the polyvinyl alcohol (PVA) is 0.5 to 30.0 percent by weight.

摘要翻译： 本发明的目的是制备用于离子电渗疗法的药物组合物，其中药物稳定性优异，并且在制造时容易混合和填充，并且可以以低成本制造。 根据本发明的用于离子电渗疗法的药物组合物的特征在于，所述组合物含有非离子合成聚合物，倍他米松磷酸钠和溶剂。 此外，在本发明的离子电渗疗法用药物组合物的优选实施方式中，所述组合物的特征在于，所述非离子型合成聚合物为聚乙烯醇（PVA）。 此外，在本发明的离子电渗用药物组合物的优选实施方式中，所述组合物的特征在于，所述聚乙烯醇（PVA）的混合量为0.5〜30.0重量％。

公开(公告)号：US20130023850A1

公开(公告)日：2013-01-24

申请号：US13466116

申请日：2012-05-07

申请人： Mir Imran ,  Talat Imran ,  Mir Hashim

发明人： Mir Imran ,  Talat Imran ,  Mir Hashim

IPC分类号： A61N1/30

CPC分类号： A61N1/30 ,  A61K9/0009 ,  A61K9/0014 ,  A61K31/465 ,  A61N1/0432 ,  A61N1/0448 ,  A61N1/303 ,  A61N1/325

摘要： Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., nicotine compounds for the treatment of nicotine cravings from tobacco use. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient.

公开(公告)号：US20120118741A1

公开(公告)日：2012-05-17

申请号：US12669068

申请日：2008-07-30

申请人： Gary R. Tucholski

发明人： Gary R. Tucholski

IPC分类号： C25B7/00 ,  H01R43/00

CPC分类号： H01M2/08 ,  A61N1/0432 ,  A61N1/0436 ,  A61N1/303 ,  H01M2/1626 ,  H01M2/1673 ,  H01M4/0404 ,  H01M4/0414 ,  H01M4/244 ,  H01M4/26 ,  H01M4/661 ,  H01M4/663 ,  H01M6/40 ,  Y10T29/49117

摘要： An integrated electronic device, and its method of manufacture, are provided. The integrated electronic device can include Iontophoresis electrodes that are electrically coupled to a thin printed flexible electrochemical cell. In one example, the Iontophoresis electrodes and the electrochemical battery are provided on a single substrate. In one example method of manufacture, the entire cell can be made on a printing press to integrate the battery directly with the electronic assembly of the Iontophoresis electrodes.

摘要翻译： 提供集成电子设备及其制造方法。 集成电子设备可以包括电耦合到薄印刷柔性电化学电池的离子渗透电极。 在一个示例中，离子渗透电极和电化学电池设置在单个衬底上。 在一个示例性制造方法中，整个电池可以在印刷机上制造以将电池直接与离子电渗电极的电子组件集成。

公开(公告)号：US20060015053A1

公开(公告)日：2006-01-19

申请号：US11130800

申请日：2005-05-17

申请人： William Crisp

发明人： William Crisp

IPC分类号： A61F13/00 ,  A61F15/00

CPC分类号： A61F13/00063 ,  A61F2013/00157 ,  A61F2013/00519 ,  A61F2013/00561 ,  A61F2013/00761 ,  A61F2013/00936 ,  A61N1/0428 ,  A61N1/0432 ,  A61N1/0456 ,  A61N1/0468 ,  A61N1/205

摘要： A wound dressing or bandage that provides a galvanic current for extended periods of time before having to change the dressing or bandage is addressed in the present invention. The present invention is directed to a galvanic current wound dressing having antimicrobial properties and to a method for treating a patient with the wound dressing.

公开(公告)号：US20060015052A1

公开(公告)日：2006-01-19

申请号：US10891566

申请日：2004-07-15

申请人： William Crisp

发明人： William Crisp

IPC分类号： A61F13/00 ,  A61F15/00

CPC分类号： A61N1/0432 ,  A61F13/00063 ,  A61F2013/00157 ,  A61F2013/00519 ,  A61F2013/00561 ,  A61F2013/00761 ,  A61F2013/00936 ,  A61N1/0456 ,  A61N1/0468 ,  A61N1/205

摘要： A wound dressing or bandage that provides a galvanic current for extended periods of time before having to change the dressing or bandage is addressed in the present invention. The present invention is directed to a galvanic current wound dressing having antimicrobial properties and to a method for treating a patient with the wound dressing.