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    Sulphonium naphthalimides
    61.
    发明授权
    Sulphonium naphthalimides 失效
    硫代吗啉

    公开(公告)号：US3642799A

    公开(公告)日：1972-02-15

    申请号：US3642799D

    申请日：1969-07-29

    申请人： UGINE KUHLMANN

    发明人： MINGASSON GEORGES RAYMOND HENR ,  DOMERGUE ANNICK MARTHE SUZANNE ,  SUREAU ROBERT FREDERIC MICHEL

    IPC分类号： C07D221/14 ,  C07D35/30

    CPC分类号： C07D221/14 ,  Y10S8/927

    摘要： THIS INVENTION RELATES TO NEW SALTS OF SULPHONIUM DERIVATIVES OF NAPHTHALIMIDE. THESE SALTS HAVE THE GENERAL FORMULA:

    1,3-DI(O=),2-(R2-S(+)(-R1)-(CH2)N-),7-(R-O-)-2,3-DIHYDRO-

    1H-BENZ(DE)ISOQUINOLINE

    IN WHICH R AND R1 EACH REPRESENT THE SAME OR DIFFERENT LOWER ALKYL RADICALS, PREFERABLY METHYL OR ETHYL, R2 REPRESENTS A LOWER ALKYL RADICAL WHICH MAY BE SUBSTITUTED BY A NON-IONIC AND NON-CHROMOPHORIC SUBSTITUENT SUCH AS FOR EXAMPLE A LOWER ALKOXYGROUP, N REPRESENTS A WHOLE NUMBER GREATER THAN 1, PREFERABLY 2 OR 3, AND AO REPRESENTS A MONOVALENT ANION.

    NOVEL COMPOUNDS PHOTO-CROSSLINKED BY VISIBLE LIGHT AND USES THEREOF
    69.
    发明公开
    NOVEL COMPOUNDS PHOTO-CROSSLINKED BY VISIBLE LIGHT AND USES THEREOF 审中-公开

    公开(公告)号：US20240182425A1

    公开(公告)日：2024-06-06

    申请号：US17784298

    申请日：2022-04-13

    申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

    发明人： Hyun Woo RHEE

    IPC分类号： C07D221/14 ,  G01N33/68

    CPC分类号： C07D221/14 ,  G01N33/6845 ,  G01N2333/165

    摘要： The present invention relates to novel compounds that are photo-crosslinked by visible light and spatiotemporal proximity photo-crosslinking by visible light activation (spotlight) using the same. When a target nucleic acid or target protein is bound to the novel compounds by the property of being photo-crosslinked to the proximal protein or peptide by irradiation with visible light and it is irradiated with visible light, the novel compounds according to the present invention can be photo-crosslinked with a protein or peptide that physically interacts with the target protein or target nucleic acid, and thus, there are advantages in that it is possible to overcome diffusive labeling, which is a limitation of the conventional proximity labeling technology, by photo-crosslinking by visible light irradiation, which is a safe method for a living body, and to improve the accuracy of protein interactome identification.