公开(公告)号：US20120142787A1

公开(公告)日：2012-06-07

申请号：US12973967

申请日：2010-12-21

申请人： Helen S. M. LU ,  STEVEN W. SHUEY

发明人： Helen S. M. LU ,  STEVEN W. SHUEY

IPC分类号： A61K47/36 ,  A61K47/38 ,  C07K14/62 ,  C07H7/02 ,  C07H3/00

CPC分类号： C08B15/02 ,  C08B31/18 ,  C08B37/00 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/0054 ,  C08B37/0072 ,  C08L1/04 ,  C08L3/10 ,  C08L5/00 ,  C08L5/02 ,  C08L5/08 ,  C08L5/12

摘要： Novel aldehyde-functionalized polysaccharide compositions containing pendant dialdehyde groups are described that are more stable in aqueous solution than oxidized polysaccharides. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.

摘要翻译： 描述了含有侧链二醛基团的新型醛官能化多糖组合物，其在水溶液中比氧化多糖更稳定。 醛官能化多糖可以与各种含胺聚合物反应以形成可用于医学应用的水凝胶组织粘合剂和密封剂，例如伤口闭合，补充或替换缝合或缝合在内部外科手术如肠吻合和血管吻合中 ，组织修复，防止流体如血液，胆汁，胃肠道液体和脑脊液的渗漏，眼科手术，药物递送和预防手术后粘连。

公开(公告)号：US20110275142A1

公开(公告)日：2011-11-10

申请号：US13068283

申请日：2011-05-05

申请人： James Wade ,  Daniel Swiger

发明人： James Wade ,  Daniel Swiger

IPC分类号： C08B37/00 ,  C12P19/04 ,  C08L7/02 ,  C07H1/08 ,  C08F36/02

CPC分类号： C08H8/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/105 ,  A23L33/125 ,  A23L33/22 ,  C08B37/0003 ,  C08B37/0054 ,  C08L7/02 ,  C13K1/02 ,  C13K11/00 ,  C13K13/00

摘要： Dandelion processes, compositions and products are provided. One process is a method of preparing dandelion that utilizes a species of a Taraxacum genus, the process including the steps of extracting and recovering a rubber and a carbohydrate from a dandelion root substantially simultaneously. The process employs a dandelion species that is selected from the group consisting of: Taraxacum officianale, Taraxacum kok-saghyz, a rubber-bearing species of the genus Taraxacum, and a combination of two or more thereof. This Abstract is provided for the sole purpose of complying with the Abstract requirement rules that allow a reader to quickly ascertain the subject matter of the disclosure contained herein. This Abstract is submitted with the explicit understanding that it will not be used to interpret or to limit the scope or the meaning of the claims.

摘要翻译： 提供蒲公英的方法，组合物和产品。 一种方法是制备利用蒲公英种的蒲公英的方法，该方法包括基本上同时从蒲公英根中提取和回收橡胶和碳水化合物的步骤。 该方法采用蒲公英种类，其选自以下组中：蒲公英，蒲公英，蒲公英，蒲公英的含橡胶种，以及两种或更多种的组合。 本摘要仅用于遵守允许读者快速确定本文所包含的披露的主题的抽象要求规则。 本摘要以明确的理解提交，不会用于解释或限制权利要求的范围或含义。

公开(公告)号：US20110172166A1

公开(公告)日：2011-07-14

申请号：US12977690

申请日：2010-12-23

申请人： Richard CHARVET ,  Remi SOULA ,  Olivier SOULA

发明人： Richard CHARVET ,  Remi SOULA ,  Olivier SOULA

IPC分类号： A61K38/02 ,  C08B37/00 ,  C08B37/04 ,  C08B37/08 ,  C08B37/02 ,  C08B3/00 ,  C08B11/12 ,  A61K47/36

CPC分类号： C08B37/0021 ,  A61K47/36 ,  C08B1/00 ,  C08B37/0006 ,  C08B37/0009 ,  C08B37/0018 ,  C08B37/0024 ,  C08B37/0045 ,  C08B37/0054 ,  C08B37/0057 ,  C08B37/006 ,  C08B37/0072 ,  C08B37/0084

摘要： A novel anionic polysaccharides functionalized by at least one hydrophobic acid derivative. These novel anionic polysaccharides including hydrophobic groups have good biocompatibility and their hydrophobicity can be easily adjusted without detrimentally affecting the biocompatibility or the stability. A method of synthesis which makes it possible to produce them and to pharmaceutical compositions including them.

摘要翻译： 由至少一种疏水性酸衍生物官能化的新型阴离子多糖。 这些包括疏水基团的新型阴离子多糖具有良好的生物相容性，并且它们的疏水性可以容易地调节而不会不利地影响生物相容性或稳定性。 能够制造它们的合成方法和包括它们的药物组合物。

公开(公告)号：US20110081449A1

公开(公告)日：2011-04-07

申请号：US12995398

申请日：2009-06-12

申请人： Lena De Leenheer ,  Kim Martha Jozefa Frooninckx ,  Francois Alice Alphonse Heroufosse

发明人： Lena De Leenheer ,  Kim Martha Jozefa Frooninckx ,  Francois Alice Alphonse Heroufosse

IPC分类号： C13K11/00 ,  A23L1/09 ,  A23L1/302 ,  A23K1/16 ,  A23L1/304 ,  A23L1/305

CPC分类号： C07H3/06 ,  A23K20/163 ,  A23L5/00 ,  A23L29/244 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/21 ,  C08B37/0054 ,  C12P19/18

摘要： The invention relates to a process for the production of a fructooligosaccharide (FOS) composition on industrial scale, comprising the steps of: a) providing a raw material containing sucrose; b) bringing the raw material together with an enzyme to form a mixture, whereby the enzyme has an endo-inulinase activity and/or a fructosyltransferase activity and is in free, non-immobilized form; c) exposing the mixture to conditions whereby FOS-forming can take place for an amount of time such that the FOS in the mixture constitutes at least 45 wt. % of the total amount of carbohydrates in the mixture, thereby forming the FOS composition; d) optionally deactivating the enzyme; e) recovering the FOS composition. The invention further relates to Fructooligosaccharide composition (FC) wherein: a portion of at most 2 wt. % of the carbohydrates in the FC consists of oligosaccharides that have a degree of polymerisation (DP) of 7 or more; and at least 56 wt. % of the fructooligosaccharides in the FC have a DP of 3 as measured in HPLC; and the FC is obtained from sucrose in an enzymatic process, whereby no enzyme is used that is obtained from a genetically-modified organism.

摘要翻译： 本发明涉及一种以工业规模生产低聚果糖（FOS）组合物的方法，包括以下步骤：a）提供含有蔗糖的原料; b）将原料与酶一起形成混合物，由此该酶具有内切菊糖酶活性和/或果糖基转移酶活性，并且是游离的，非固定的形式; c）将混合物暴露于其中FOS形成可以发生一段时间的条件，使得混合物中的FOS构成至少45重量％ 混合物中碳水化合物总量的百分比，从而形成FOS组合物; d）任选地使酶失活; e）回收FOS组合物。 本发明还涉及低聚果糖组合物（FC），其中：至少2wt。 FC中的碳水化合物的％由具有7或更高的聚合度（DP）的寡糖组成; 和至少56wt。 FC中的低聚果糖的％的DP为3，在HPLC中测得; 并且在酶处理中从蔗糖获得FC，由此不能使用从遗传修饰的生物获得的酶。

公开(公告)号：US07507558B2

公开(公告)日：2009-03-24

申请号：US10490106

申请日：2002-09-26

申请人： Tadashi Wada ,  Masao Ohguchi

发明人： Tadashi Wada ,  Masao Ohguchi

IPC分类号： C12P19/04 ,  C12N9/00 ,  C12N9/10 ,  C12N1/20

CPC分类号： C12P19/18 ,  C08B37/0054 ,  C12P19/04

摘要： The present invention provides a method of producing inulin by bringing inulin synthase into contact with sucrose, wherein: (1) the average polymerization degree of inulin is regulated by controlling the sucrose concentration; (2) the average polymerization degree of inulin is regulated by controlling the temperature upon the above contact; and/or (3) at a stage when the above sucrose is consumed by the above inulin synthase and the reaction reaches an equilibrium state, sucrose is additionally added, and the reaction for generating inulin is further continued. Furthermore, the present invention relates to inulin having a predetermined average polymerization degree, which is obtained by the production method.

摘要翻译： 本发明提供了通过使菊粉合成酶与蔗糖接触来生产菊糖的方法，其中：（1）通过控制蔗糖浓度调节菊粉的平均聚合度; （2）菊粉的平均聚合度通过控制上述接触时的温度来调节; 和/或（3）在上述蔗糖被上述菊糖合成酶消耗并且反应达到平衡状态的阶段，另外加入蔗糖，并进一步继续产生菊糖的反应。 此外，本发明涉及通过该制造方法获得的具有预定平均聚合度的菊粉。

公开(公告)号：US20070225483A1

公开(公告)日：2007-09-27

申请号：US10587878

申请日：2005-01-28

申请人： Harry Raaijmakers ,  Ernst Neeleman

发明人： Harry Raaijmakers ,  Ernst Neeleman

IPC分类号： C07H15/00

CPC分类号： C08B37/0054

摘要： A method for the manufacture of carboxyalkylinulin is disclosed comprising preparing an aqueous medium containing dispersed therein a halogenoalkylcarboxylate, adding to the carboxylate containing medium, under substantially neutral pH conditions, an inulin followed by heating this mixture to a temperature in the range of from 60° C. to 90° C. and proceeding with the reaction at alkaline conditions, pH 8-12, while simultaneously adding additional halogenoalkylcarboxylate and alkalihydroxide. The carboxyalkylinulin so formed is recovered in a manner known per sé.

摘要翻译： 公开了制备羧基烷基蛋白的方法，其包括制备含有分散在其中的卤代烷基羧酸盐的水性介质，在基本上中性的pH条件下向所述含羧酸盐的介质中加入菊粉，然后将该混合物加热至60℃ 并在pH8-12的碱性条件下进行反应，同时加入另外的卤代烷基羧酸盐和碱金属氢氧化物。 如此形成的羧基烷基蛋白质以已知的方式回收。

公开(公告)号：US20070105743A1

公开(公告)日：2007-05-10

申请号：US11621910

申请日：2007-01-10

申请人： Karl Booten ,  Bart Levecke ,  Christian Stevens

发明人： Karl Booten ,  Bart Levecke ,  Christian Stevens

IPC分类号： C11D3/37

CPC分类号： C11D17/0017 ,  B01F17/0021 ,  B01F17/0028 ,  B01F17/0042 ,  B01F17/005 ,  C07H3/00 ,  C08B30/18 ,  C08B31/00 ,  C08B37/0054 ,  C08L3/04 ,  C08L5/00 ,  C11D1/662 ,  C08L2666/02

摘要： The invention relates to the use as surfactant, for the preparation of dispersions of multiphase systems that comprise a continuous aqueous phase containing a high concentration of electrolytes, of hydrophobically modified saccharides of general formula (I) and (II) [A]n(-M)s (I) [B]m(-M)s′ (II) wherein [A]n represents a fructan-type saccharide [B]m represents a starch-type saccharide (-M) represents a hydrophobic moiety that substitutes a hydrogen atom of a hydroxyl group of the fructosyl and/or glucosyl units of the fructan-type and starch-type saccharides, which is selected from the group consisting of an alkylcarbamoyl radical of formula R—NH—CO— and an alkylcarbonyl radical of formula R—CO—, wherein R represents a linear or branched, saturated or unsaturated alkyl group with from 4 to 32 carbon atoms, and s and s′, which can have the same value or not, represent the number of said hydrophobic moieties that substitute the fructosyl or glucosyl unit, expressed as average degree of substitution (av. DS) which ranges from 0.01 to 0.5. The invention also relates to a method for the preparation and/or stabilisation of dispersions of multiphase systems that comprise a continuous aqueous phase containing a high concentration of electrolytes, by using as surfactant one or more hydrophobically modified saccharides of general formula (I) and/or (II) defined above. Also dispersions of multiphase systems are disclosed that comprise a continuous aqueous phase containing a high concentration of electrolytes and that comprise as surfactant one or more hydrophobically modified saccharides of general formula (I) and/or (II) defined above.

摘要翻译： 本发明涉及用作制备包含含有高浓度电解质的连续水相的多相体系分散体作为表面活性剂的通式（I）和（II）的疏水改性糖类的用途[A] （ - M）（I）其中[A]（I）[B] m（ - M） ]代表果聚糖型糖[B] m表示淀粉型糖（-M）表示取代羟基的氢原子的疏水部分 果糖基型和淀粉型糖的果糖基和/或葡糖基单元，其选自式R-NH-CO-的烷基氨基甲酰基和式​​R-CO-的烷基羰基，其中R 表示具有4至32个碳原子的直链或支链，饱和或不饱和的烷基，s和s'可以具有相同的值或不同，代表所述疏水部分的取代数 e是果糖基或葡糖基单位，表示为平均取代度（av。 DS），其范围为0.01至0.5。 本发明还涉及一种用于制备和/或稳定多相体系分散体的方法，所述多相体系包含含有高浓度电解质的连续水相，通过使用作为表面活性剂的一种或多种通式（I）的疏水改性糖和/ 或（II）。 还公开了多相体系的分散体，其包含含有高浓度电解质的连续水相，并且包含作为表面活性剂的上述通式（I）和/或（II）的一种或多种疏水改性的糖类。

公开(公告)号：US20050215751A1

公开(公告)日：2005-09-29

申请号：US10502683

申请日：2003-01-28

申请人： Evarardus Oostveen ,  John Weijnen ,  Jacco Haveren ,  Michel Gillard

发明人： Evarardus Oostveen ,  John Weijnen ,  Jacco Haveren ,  Michel Gillard

IPC分类号： C08B37/00 ,  C09D105/00 ,  C08G63/02

CPC分类号： C09D105/00 ,  C08B37/0054

摘要： The invention relates to a polyester obtainable by transesterification or interesterification of: (i) inulin of general formula G(F)n or an acyl ester thereof, wherein G represents a glucose moiety, F represents a fructose moiety, and n is at least 2, and (ii) a drying oil, a semi-drying oil or derived alkyl esters thereof. The invention further relates to a method for the preparation of a polyester comprising the step of transesterification or interesterification.

摘要翻译： 本发明涉及通过以下酯交换或酯交换得到的聚酯：（i）通式G（F）N的菊糖或其酰基酯，其中G表示葡萄糖部分，F表示果糖部分 ，和n至少为2，和（ii）干性油，半干性油或其衍生的烷基酯。 本发明还涉及一种制备聚酯的方法，其包括酯交换或酯交换的步骤。

公开(公告)号：US06569488B2

公开(公告)日：2003-05-27

申请号：US10037027

申请日：2001-11-09

申请人： Barnard Stewart Silver

发明人： Barnard Stewart Silver

IPC分类号： A23G300

CPC分类号： C08B37/0054 ,  A23L27/30 ,  A23L27/33 ,  A23L29/244 ,  A23V2002/00 ,  A23V2300/14 ,  A23V2300/18 ,  A23V2250/5062 ,  A23V2250/24 ,  A23V2250/64

摘要： The process for preparing the novel inulin products includes extracting inulin with water from subdivided plant materials, holding the inulin rich extraction water in a settling tank while maintaining the temperature from about 0° C. to 7° C. which causes higher molecular weight polysaccharides to separate from water soluble lower molecular weight polysaccharides, and separating the higher molecular weight inulin fructose fractions from the more water soluble lower molecular weight inulin fractions.

摘要翻译： 制备新型菊粉产品的方法包括用细分的植物材料的水提取菊粉，将菊粉浓缩的提取水保持在沉淀槽中，同时保持温度在约0℃至7℃，这导致较高分子量的多糖 与水溶性低分子量多糖分离，并从更多的水溶性低分子量菊糖馏分中分离较高分子量的菊糖果糖级分。

公开(公告)号：US20030044942A1

公开(公告)日：2003-03-06

申请号：US10127462

申请日：2002-04-23

发明人： Steven J. Catani ,  Kathleen S. Laurenzo ,  Juan L. Navia ,  Robert E. Walkup

IPC分类号： C12P019/34 ,  C12P019/04 ,  C07H021/02 ,  C07H021/04 ,  C08B037/00

CPC分类号： C08B37/0054 ,  B01J19/1881 ,  B01J19/1893 ,  C12M29/18 ,  C12M47/10 ,  C12M47/12 ,  C12P19/18

摘要： A process for preparing functional sugar polymers comprising transferring a monosaccharide or oligosaccharide to an acceptor, removing by-products, separating polymers which have not achieved the desired chain length and recycling these underdeveloped polymers, and an apparatus for producing same.