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    MHC CLASS I EPITOPE DELIVERING POLYPEPTIDES AND CELL-TARGETED MOLECULES FOR DIRECT CELL KILLING AND IMMUNE STIMULATION VIA MHC CLASS I PRESENTATION AND METHODS REGARDING THE SAME
    63.
    发明申请
    MHC CLASS I EPITOPE DELIVERING POLYPEPTIDES AND CELL-TARGETED MOLECULES FOR DIRECT CELL KILLING AND IMMUNE STIMULATION VIA MHC CLASS I PRESENTATION AND METHODS REGARDING THE SAME 审中-公开
    MHCⅠ类抗生素递送多核苷酸和细胞定向分子用于直接细胞杀伤和免疫刺激通过MHC类I介绍及其相关方法

    公开(公告)号：US20160347798A1

    公开(公告)日：2016-12-01

    申请号：US15114474

    申请日：2015-01-26

    申请人： MOLECULAR TEMPLATES, INC.

    发明人： Eric Poma ,  Erin Willert

    IPC分类号： C07K14/25 ,  C12N9/10 ,  C07K14/245

    CPC分类号： C07K14/25 ,  A61K2039/6037 ,  C07K14/245 ,  C07K16/00 ,  C07K16/085 ,  C07K16/088 ,  C07K16/1063 ,  C07K16/286 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/32 ,  C07K2319/04 ,  C07K2319/33 ,  C07K2319/40 ,  C07K2319/55 ,  C12N9/1077 ,  C12N9/2497 ,  C12N15/62 ,  C12Y204/02036 ,  C12Y302/02022 ,  Y02A50/489

    摘要： The present invention is directed to T-cell epitope delivering polypeptides which deliver one or more CD8+ T-cell epitopes to the MHC class I presentation pathway of a cell, including toxin-derived polypeptides which comprise embedded T-cell epitopes and are de-immunized. The present invention provides cell-targeted, CD8+ T-cell epitope delivering molecules for the targeted delivery of cytotoxicity to certain cells, e.g., infected or malignant cells, for the targeted killing of specific cell types, and the treatment of a variety of diseases, disorders, and conditions, including cancers, immune disorders, and microbial infections. The present invention also provides methods of generating polypeptides capable of delivering one or more heterologous T-cell epitopes to the MHC class I presentation pathway, including polypeptides which are 1) B-cell and/or CD4+ T-cell de-immunized, 2) comprise embedded T-cell epitopes, and/or 3) comprises toxin effectors which retain toxin functions.

    摘要翻译： 本发明涉及将一种或多种CD8 + T细胞表位递送到细胞的MHC I类呈递途径的T细胞表位递送多肽，所述多肽包括含有嵌入的T细胞表位的毒素衍生的多肽，并且被免疫 。 本发明提供了细胞靶向的CD8 + T细胞表位递送分子，用于靶向递送对特定细胞（例如感染或恶性细胞）的细胞毒性，用于特异性细胞类型的靶向杀伤，以及各种疾病的治疗， 疾病和病症，包括癌症，免疫疾病和微生物感染。 本发明还提供产生能够将一种或多种异源T细胞表位递送至MHC I型呈递途径的多肽的方法，包括1）B细胞和/或CD4 + T细胞去免疫的多肽，2） 包括嵌入的T细胞表位，和/或3）包含保留毒素功能的毒素效应物。