公开(公告)号：US10120049B2

公开(公告)日：2018-11-06

申请号：US14715367

申请日：2015-05-18

申请人： The Johns Hopkins University

发明人： Yi Zhang ,  Jinyuan Zhou ,  Paul A. Bottomley

IPC分类号： G01V3/00 ,  G01R33/483 ,  G01R33/485 ,  G01R33/50 ,  G01R33/56 ,  G01R33/563 ,  G01R33/561

摘要： An NMR method and system for acquiring and reconstructing a value of an NMR parameter spatially localized to a compartment of interest including performing a first MM of a portion of a sample with a first MRI pulse sequence using the NMR system and using a set of k-space spatial encoding gradients or coil sensitivity encoding maps to obtain a first magnetic resonance image to identify a compartment of interest; generating a second MRI pulse sequence that encodes the NMR parameter with a subset of the set of k-space spatial encoding gradients or the coil sensitivity encoding maps; applying the second MRI pulse sequence using the NMR system to acquire spatial information relating to the NMR parameter from the compartment of interest; segmenting the first magnetic resonance image into a plurality of compartments that includes the compartment of interest; and reconstructing a value of the NMR parameter in the compartment.

公开(公告)号：US20180267114A1

公开(公告)日：2018-09-20

申请号：US15848494

申请日：2017-12-20

申请人： Board of Regents of the University of Texas System

发明人： Floyd D. Settles ,  Erika M. Ripley ,  Geoffrey D. Clarke

IPC分类号： G01R33/00 ,  G01R33/341 ,  A63B23/035 ,  G01R33/485

CPC分类号： G01R33/0047 ,  A63B23/03508 ,  G01R33/34007 ,  G01R33/341 ,  G01R33/3635 ,  G01R33/46 ,  G01R33/4835 ,  G01R33/485 ,  G01R33/56391

摘要： A surface coil holder having four degrees of freedom is provided. The surface coil holder is capable of being attached to a scanner table of an exercise apparatus. The surface coil holder includes a coil cradled in the coil holder and secured by hook and loop strips.

公开(公告)号：US10024941B2

公开(公告)日：2018-07-17

申请号：US14713339

申请日：2015-05-15

申请人： Siemens Aktiengesellschaft

发明人： Radhouene Neji ,  Nashiely Sofia Pineda Alonso

IPC分类号： G01V3/00 ,  G01R33/483 ,  G01R33/567 ,  G01R33/48 ,  G01R33/565 ,  G01R33/485

摘要： In a method and apparatus for generating magnetic resonance spectroscopy data from a VOI, in particular in the liver, image data are acquired from an examination area, which contains an organ affected by breathing, and the image data are evaluated until the position of the organ lies within a specific region. One or more of the eight acquisition cycles of an ISIS sequence are executed in order to acquire magnetic resonance spectroscopy data from the VOI, with repetitions until all eight acquisition cycles of the ISIS sequence have been executed. The magnetic resonance spectroscopy data acquired with the ISIS sequence are reconstructed to form a spectrum. The data acquisition has an ultra-short echo time.

公开(公告)号：US09901285B2

公开(公告)日：2018-02-27

申请号：US13680612

申请日：2012-11-19

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Sharmila Majumdar ,  John Kurhanewicz ,  Jeffrey C. Lotz ,  David S. Bradford ,  Kayvan Keshari

IPC分类号： A61B5/00 ,  A61B5/055 ,  G01N24/08 ,  G01R33/483 ,  G01R33/465 ,  G01R33/485

CPC分类号： A61B5/055 ,  A61B5/4514 ,  A61B5/4528 ,  A61B5/4824 ,  G01N24/08 ,  G01R33/465 ,  G01R33/483 ,  G01R33/485

摘要： NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl/cho and cho/carb, are readily acquired and analyzed to predict degree of tissue degeneration and/or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3T MRI systems with a surface spine coil, thus providing a completely non-invasive diagnostic toolset and method to image and localize degeneration and/or pain.

公开(公告)号：US09823322B2

公开(公告)日：2017-11-21

申请号：US14476968

申请日：2014-09-04

申请人： Siemens Aktiengesellschaft

发明人： Stephan Kannengiesser ,  Marcel Dominik Nickel ,  Xiaodong Zhong

IPC分类号： G01R33/485 ,  A61B5/055 ,  G01R33/46 ,  G01R33/48 ,  G01R33/565

CPC分类号： G01R33/485 ,  A61B5/055 ,  G01R33/46 ,  G01R33/4828 ,  G01R33/56518 ,  G01R33/56563

摘要： In a method and magnetic resonance (MR) apparatus to acquire MR data from a subject, a predetermined spectral model of a multipoint Dixon technique is used that includes at least two spectral components with respective associated relaxation rates, a first phase due to field inhomogeneities; and a second phase due to eddy current effects. MR data are acquired using a bipolar multi-echo MR measurement sequence for multiple image points wherein, for each image point, the multi-echo MR measurement sequence alternately uses positive and negative readout gradient fields for the readout of MR signals of the MR data at at least three echo times. The at least two spectral components are determined based on the MR data.

公开(公告)号：US09775557B2

公开(公告)日：2017-10-03

申请号：US14244462

申请日：2014-04-03

申请人： Zhu He

发明人： Zhu He

IPC分类号： G01V3/00 ,  A61B5/00 ,  A61B5/055 ,  G01R33/485 ,  G01R33/56 ,  G01R33/563

CPC分类号： A61B5/4312 ,  A61B5/055 ,  A61B5/4848 ,  G01R33/485 ,  G01R33/5605 ,  G01R33/5607 ,  G01R33/56341

摘要： Systems and methods for magnetic resonance analysis and imaging are provided. IN particular, pulse sequences for DWI, APT, and MRS analysis and imaging are provided which rely on an RF excitation pulse for the signal of interest, followed by one or more refocusing pulses and acquisition steps, based on the type of imaging.

公开(公告)号：US09724013B2

公开(公告)日：2017-08-08

申请号：US14872986

申请日：2015-10-01

申请人： NociMed, LLC

发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

IPC分类号： A61B5/00 ,  A61B5/055 ,  G01R33/485

CPC分类号： A61B5/055 ,  A61B5/4514 ,  A61B5/4566 ,  A61B5/4824 ,  A61B5/743 ,  A61B5/748 ,  A61B2576/02 ,  G01R33/485

摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.

公开(公告)号：US09678187B2

公开(公告)日：2017-06-13

申请号：US14240171

申请日：2012-07-27

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

IPC分类号： G01R33/46 ,  G01R33/485 ,  G01R33/565 ,  A61B5/055

CPC分类号： G01R33/4625 ,  A61B5/055 ,  G01R33/485 ,  G01R33/56518

摘要： An object of the present invention is to suppress artifacts generated by correction of spectral distortion induced by eddy currents in MRI devices with a simple method, and thereby improve accuracy of the correction.

公开(公告)号：US09529064B2

公开(公告)日：2016-12-27

申请号：US13984910

申请日：2012-01-10

申请人： Baolian Yang ,  David Leslie Foxall

发明人： Baolian Yang ,  David Leslie Foxall

IPC分类号： G01R33/32 ,  G01R33/46 ,  G01R33/483 ,  G01R33/485

CPC分类号： G01R33/32 ,  G01R33/4608 ,  G01R33/4616 ,  G01R33/483 ,  G01R33/485

摘要： A magnetic resonance (MR) generating a static (BO) magnetic field of 5 Tesla or higher controller is configured to control an MR scanner to perform an MR sequence (14) including: performing an excitation/localization sub-sequence (30) on a subject disposed in the static (BO) magnetic field generated by the MR scanner to excite 1H polarization in a selected spatial region of the subject; performing 5 a polarization transfer sub-sequence (32) to transfer localized 1H polarization generated by the excitation/localization sub-sequence to a selected species of non-proton nuclei; and performing a magnetic resonance spectroscopy (MRS) readout sub-sequence (40) to acquire MRS data for the selected species of non-proton nuclei in the selected spatial region of the subject. The polarization transfer sub-sequence includes a pair of phase 10 distortion canceling trapezoidal 180° refocusing pulses (36, 37) operating on the selected species of non-proton nuclei.

摘要翻译： 产生5特斯拉或更高控制器的静态（BO）磁场的磁共振（MR）被配置为控制MR扫描器执行MR序列（14），包括：在一个（或多个）磁带上执行激励/定位子序列（30） 被放置在由MR扫描仪产生的静态（BO）磁场中，以激发被摄体的选定空间区域中的1H偏振; 执行5个偏振转移子序列（32）以将由激发/定位子序列产生的局部1H偏振转移到选定种类的非质子核; 以及执行磁共振波谱（MRS）读出子序列（40）以获取所选择的所述对象空间区域中所选择的非质子核物种的MRS数据。 极化转移子序列包括在所选择的非质子核的种类上操作的一对相位10失真消除梯形180°重聚焦脉冲（36,37）。

公开(公告)号：US20160231406A1

公开(公告)日：2016-08-11

申请号：US15022008

申请日：2014-09-02

申请人： KONINKLIJKE PHILIPS N.V. ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： IVAN PEDROSA ,  ANANTH MADHURANTHAKAM ,  IVAN DIMITROV

IPC分类号： G01R33/483 ,  G01R33/32 ,  G01R33/485 ,  G01R33/30 ,  G01R33/561 ,  G01R33/48

CPC分类号： G01R33/4833 ,  G01R33/307 ,  G01R33/32 ,  G01R33/4828 ,  G01R33/485 ,  G01R33/5615

摘要： A magnetic resonance imaging (MRI) system (500), the system includes at least one controller (510) which performs a modified rotated slab excitation (mROSE) sequence for volume selection to exclude portions of a subject under exam which are within the scanning volume and outside of a field-of-view (FOV) so as to reduce foldover artifacts which originate from the excluded portions of the subject under exam, where the mROSE sequence performs volume excitation based upon either optimized symmetrical, minimum-phase, or stretched minimum-phase radio-frequency (RF) pulses in a sagittal plane and encodes the scanning volume in a coronal plane. The controller also performs a chemical-shift sequence including a modified DIXON (mDIXON) sequence for substantially uniform fat/water separation within a FOV which lies within the scanning volume; and/or acquires echo information for reconstructing at least a part of an image.

摘要翻译： 一种磁共振成像（MRI）系统（500），该系统包括至少一个控制器（510），其执行用于体积选择的修改的旋转平板激励（mROSE）序列，以排除在扫描体积内的检查对象的部分 并且在视场外（FOV）之外，以便减少起源于所检查对象被排除部分的折叠伪像，其中mROSE序列基于优化的对称，最小相位或拉伸最小值进行音量激励 相位射频（RF）脉冲，并编码冠状平面中的扫描体积。 控制器还执行化学位移序列，其包括修改的DIXON（mDIXON）序列，用于在位于扫描体积内的FOV内基本均匀的脂肪/水分离; 和/或获取用于重建图像的至少一部分的回波信息。