公开(公告)号：US08324365B2

公开(公告)日：2012-12-04

申请号：US10551466

申请日：2003-04-03

Applicant: Ji Hoon Jeong ,  Tae Gwan Park

Inventor： Ji Hoon Jeong ,  Tae Gwan Park

IPC: C07H21/04

CPC classification number: C12N15/113 ,  A61K47/60 ,  A61K47/6907 ,  A61K48/0041 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/351 ,  C12N2320/32

Abstract: Disclosed is a conjugate for gene transfer, which is capable of being used for treatment of incurable diseases, comprising an oligonucleotide intended to be transferred into target cells and a hydrophilic polymer, wherein an end of the oligonucleotide is covalently conjugated to the hydrophilic polymer. Also, the present invention discloses polyelectrolyte complex micelles formed from such a conjugate and a cationic polymer or cationic peptide. Such polyelectrolyte complex micelles can effectively transfer oligonucleotides as therapeutic agents into target cells, making it possible to obtain desired activities of the delivered oligonucleotides in target cells even when the micelles are clinically applied at a relatively low concentration. Therefore, the conjugate and the polyelectrolyte complex micelle are very useful in basic life science research and the medical field.

Abstract translation: 公开了用于基因转移的缀合物，其能够用于治疗不可治愈的疾病，包括旨在转移到靶细胞中的寡核苷酸和亲水性聚合物，其中寡核苷酸的末端与亲水性聚合物共价缀合。 此外，本发明公开了由这种缀合物和阳离子聚合物或阳离子肽形成的聚电解质复合胶束。 这样的聚电解质复合物胶束可以有效地将作为治疗剂的寡核苷酸转移到靶细胞中，使得即使当胶束以相对低的浓度临床施用时，也可以在靶细胞中获得递送的寡核苷酸的所需活性。 因此，缀合物和聚电解质复合物胶束在基础生命科学研究和医学领域非常有用。

公开(公告)号：US20120295376A1

公开(公告)日：2012-11-22

申请号：US13473300

申请日：2012-05-16

Applicant: Keon Jae LEE ,  So Young PARK ,  Seung Hyun LEE ,  Kwi Il PARK ,  Min KOO

Inventor： Keon Jae LEE ,  So Young PARK ,  Seung Hyun LEE ,  Kwi Il PARK ,  Min KOO

IPC: H01L33/30 ,  H01L33/08

CPC classification number: H01L25/0753 ,  A61N5/0622 ,  A61N2005/0652 ,  A61N2005/0662 ,  H01L24/19 ,  H01L33/62 ,  H01L2224/24137 ,  H01L2224/32225 ,  H01L2224/73267 ,  H01L2224/92244 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/00

Abstract: Disclosed are a method for fabricating a GaN LED array device for optogenetics and a GaN LED array device fabricated thereby.

Abstract translation: 公开了一种用于制造用于光遗传学的GaN LED阵列器件和由其制造的GaN LED阵列器件的方法。

公开(公告)号：US20120281810A1

公开(公告)日：2012-11-08

申请号：US13465012

申请日：2012-05-06

Applicant: Dong-goo Kang ,  Jong-chul Ye ,  Ji-young Choi ,  Young-hun Sung ,  Seok-min Han

Inventor： Dong-goo Kang ,  Jong-chul Ye ,  Ji-young Choi ,  Young-hun Sung ,  Seok-min Han

IPC: A61B6/02

CPC classification number: A61B6/482 ,  A61B6/5217 ,  A61B6/583

Abstract: An apparatus for capturing a radiation image of a subject including at least two materials includes a radiation irradiating unit configured to irradiate multi-energy radiation including at least two energy bands to a calibration model including a plurality of thicknesses of each of the at least two materials; an attenuation-coefficient estimating unit configured to estimate attenuation coefficients for each of the at least two materials for each of the at least two energy bands based on values obtained by passing the multi-energy radiation through the calibration model; and an energy-band determining unit configured to determine an optimal combination of at least two energy bands to be included in multi-energy radiation to be irradiated to the subject from a plurality of different combinations of at least two energy bands based on the estimated attenuation coefficients and the values obtained by passing the multi-energy radiation through the calibration model.

Abstract translation: 一种用于捕获包括至少两种材料的对象的放射线图像的装置包括：辐射照射单元，被配置为将包括至少两个能带的多能辐射照射到包括至少两种材料中的每一种的多个厚度的校准模型 ; 衰减系数估计单元，被配置为基于通过使多能辐射通过校准模型获得的值来估计至少两个能带中的每一个的至少两种材料中的每一种的衰减系数; 以及能量带确定单元，被配置为基于所估计的衰减，从至少两个能带的多个不同组合中确定要包括在待照射到被摄体的多能辐射中的至少两个能带的最佳组合 系数和通过使多能辐射通过校准模型获得的值。

公开(公告)号：US20120281484A1

公开(公告)日：2012-11-08

申请号：US13342282

申请日：2012-01-03

Applicant: Byung Jin Cho ,  Jong Kyung Park

Inventor： Byung Jin Cho ,  Jong Kyung Park

IPC: G11C16/04 ,  H01L29/78 ,  B82Y99/00

CPC classification number: G11C16/0416 ,  B82Y10/00 ,  B82Y40/00 ,  H01L29/49 ,  H01L29/7881 ,  H01L29/792

Abstract: Disclosed herein is a method of remarkably improving the memory characteristics of a non-volatile memory device and the device reliability of the MOSFET using graphene which is a novel material that has a high work function and does not cause the deterioration of a lower insulating film.

Abstract translation: 这里公开了一种显着改善非易失性存储器件的存储特性的方法以及使用石墨烯的MOSFET的器件可靠性，该石墨烯是具有高功函数且不会导致下绝缘膜劣化的新型材料。

公开(公告)号：US08300744B2

公开(公告)日：2012-10-30

申请号：US12695860

申请日：2010-01-28

Applicant: Sun a Kim ,  Dae-Young Yoon ,  Sang-Gug Lee ,  Hyung-Chul Park ,  Jeong-seon Lee

Inventor： Sun a Kim ,  Dae-Young Yoon ,  Sang-Gug Lee ,  Hyung-Chul Park ,  Jeong-seon Lee

IPC: H03D1/04

CPC classification number: H04L27/3863 ,  H03D3/009 ,  H03D7/166 ,  H03D7/18 ,  H04B1/30

Abstract: The present invention relates to an apparatus for rejecting images in a receiver.The apparatus of the present invention relates to an apparatus for rejecting image signals in a receiver of a direct conversion structure and comprises a signal mismatch compensation unit configured to detect gain error and phase error between an In-phase (I) signal and a Quadrature (Q) signal received through the receiver, to reject image signals existing in the I and Q signals, and to output a result. The signal mismatch compensation unit detects the gain error and the phase error using an adaptive step method of reducing the step size of the gain error and the phase error step by step whenever the gain error and the phase error are converged.According to the present invention, high image rejection ratio is achieved and the adaptation time taken to obtain a high image rejection ratio is reduced simultaneously. Further, a bad influence of the DC offset on the image rejection ratio can be prevented by removing DC offset signals in a digital structure, accordingly, error can be accurately estimated.

Abstract translation: 本发明涉及一种用于拒绝接收机中的图像的装置。 本发明的装置涉及一种用于拒绝直接转换结构的接收机中的图像信号的装置，并且包括：信号失配补偿单元，被配置为检测同相（I）信号和正交（I）信号之间的增益误差和相位误差， Q）信号，以消除存在于I和Q信号中的图像信号，并输出结果。 信号失配补偿单元使用自适应步长法，在增益误差和相位误差收敛的情况下逐步减小增益误差的步长和相位误差来检测增益误差和相位误差。 根据本发明，实现了高的图像抑制比，同时降低了获得高的图像抑制比所需的适应时间。 此外，通过去除数字结构中的DC偏移信号，可以防止DC偏移对图像抑制比的不良影响，因此可以准确地估计误差。

公开(公告)号：US20120271838A1

公开(公告)日：2012-10-25

申请号：US13304800

申请日：2011-11-28

Applicant: Kyu-Young WHANG ,  Min Soo KIM ,  Jeong-Hoon LEE

Inventor： Kyu-Young WHANG ,  Min Soo KIM ,  Jeong-Hoon LEE

IPC: G06F17/30

CPC classification number: G06F7/22

Abstract: The present invention relates to an algorithm that retrieves only k data elements having the largest (or smallest) key values from a dataset (i.e., top-k results) in a time linearly proportional to the size of the dataset. The proposed method using the algorithm finds the top-k results using a k-sized min (or max) heap structure that maintains candidate elements of the top-k results by scanning all data elements in the dataset only once. In other words, the present invention provides a linear-time top-k sort method that finds top-k results in a time linearly proportional to the size of the dataset (i.e., O(n) time complexity), while conventional sort algorithms for finding top-k results cannot find the top-k results in a time linearly proportional to the size of the dataset (i.e., at least O(n log n) time complexity).

Abstract translation: 本发明涉及在与数据集的大小成线性比例的时间内从数据集中检索具有最大（或最小）密钥值的k个数据元素（即，top-k结果）的算法。 使用该算法的所提出的方法使用k尺寸的最小（或最大）堆结构找到top-k结果，其通过仅扫描数据集中的所有数据元素一次来维护顶部k结果的候选元素。 换句话说，本发明提供一种线性时间top-k分类方法，其以与数据集的大小成线性比例的时间（即，O（n）时间复杂度）来找到top-k结果，而传统的排序算法 找到top-k结果不能在与数据集的大小成线性比例的时间内找到top-k结果（即，至少O（n log n）时间复杂度）。

公开(公告)号：US08296306B1

公开(公告)日：2012-10-23

申请号：US13304800

申请日：2011-11-28

Applicant: Kyu-Young Whang ,  Min Soo Kim ,  Jeong-Hoon Lee

Inventor： Kyu-Young Whang ,  Min Soo Kim ,  Jeong-Hoon Lee

IPC: G06F7/00

CPC classification number: G06F7/22

Abstract: The present invention relates to an algorithm that retrieves only k data elements having the largest (or smallest) key values from a dataset (i.e., top-k results) in a time linearly proportional to the size of the dataset. The proposed method using the algorithm finds the top-k results using a k-sized min (or max) heap structure that maintains candidate elements of the top-k results by scanning all data elements in the dataset only once. In other words, the present invention provides a linear-time top-k sort method that finds top-k results in a time linearly proportional to the size of the dataset (i.e., O(n) time complexity), while conventional sort algorithms for finding top-k results cannot find the top-k results in a time linearly proportional to the size of the dataset (i.e., at least O(n log n) time complexity).

Abstract translation: 本发明涉及在与数据集的大小成线性比例的时间内从数据集中检索具有最大（或最小）密钥值的k个数据元素（即，top-k结果）的算法。 使用该算法的所提出的方法使用k尺寸的最小（或最大）堆结构找到top-k结果，其通过仅扫描数据集中的所有数据元素一次来维护顶部k结果的候选元素。 换句话说，本发明提供一种线性时间top-k分类方法，其以与数据集的大小成线性比例的时间（即，O（n）时间复杂度）来找到top-k结果，而传统的排序算法 找到top-k结果不能在与数据集的大小成线性比例的时间内找到top-k结果（即，至少O（n log n）时间复杂度）。

公开(公告)号：US08295440B2

公开(公告)日：2012-10-23

申请号：US12898274

申请日：2010-10-05

Applicant: Sung Oh Cho ,  Sung Hwan Heo

Inventor： Sung Oh Cho ,  Sung Hwan Heo

IPC: H01J35/06

CPC classification number: H01J35/06

Abstract: A super miniature X-ray tube using the nano material field emitter includes a tip-tip-type cathode electrode having the nano material field emitter formed on one end with a planar section thereof to generate an electron beam, a gate electrode formed in a hollow cylindrical shape and surrounding an outer circumference of the cathode electrode, the gate electrode having a tapered portion formed on one end and inclined from inside to outside, the gate electrode receiving a voltage for generating the electron beam, a high voltage insulating portion formed in a hollow cylindrical shape and surrounding an outer circumference of the gate electrode, a anode electrode formed at a predetermined distance from one end of the high voltage insulating portion and receiving an acceleration voltage to accelerate an electron beam generated at the cathode electrode, and an electric field adjusting electrode formed between the high voltage insulating portion and the anode electrode to vary a pattern of an acceleration electric field, wherein the cathode electrode includes an open portion formed on one side to receive therein the electric field adjusting electrode, and an X-ray generating portion formed on the other side to generate an X-ray by a collision of an accelerated electron beam.

Abstract translation: 使用纳米材料场发射体的超小型X射线管包括尖端型阴极，其具有在其一端形成有纳米材料场发射体的平面部分以产生电子束，形成在中空的栅电极 圆筒状，并且围绕阴极电极的外周，栅电极具有形成在一端上并从内到外倾斜的锥形部分，栅电极接收用于产生电子束的电压，形成在阴极电极的高压绝缘部分 围绕所述栅电极的外周，形成在与所述高压绝缘部的一端隔开预定距离并接收加速电压以加速在所述阴极产生的电子束的阳极，以及电场 形成在高压绝缘部分和阳极电极之间的调节电极，以改变图案 加速电场，其中所述阴极包括形成在一侧的开口部分，以在其中容纳电场调节电极;以及X射线产生部分，其形成在另一侧以通过加速电子的碰撞产生X射线 光束。

公开(公告)号：US20120258529A1

公开(公告)日：2012-10-11

申请号：US13272338

申请日：2011-10-13

Applicant: Hee-kyun LIM ,  Joon-ho KIM ,  Myung-gwon LEE ,  Je-kyun PARK

Inventor： Hee-kyun LIM ,  Joon-ho KIM ,  Myung-gwon LEE ,  Je-kyun PARK

IPC: C12N5/078 ,  C12M1/12

CPC classification number: B01L3/502746 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2400/0655 ,  B01L2400/086

Abstract: An apparatus for separating target molecules includes a plurality of protruding portions on a first sidewall of a fluid channel to control a flow of a fluid containing the target molecules, and a fluid channel portion having a variable height for separating the target molecules depending on sizes of the target molecules.

Abstract translation: 用于分离目标分子的装置包括在流体通道的第一侧壁上的多个突出部分，以控制含有目标分子的流体的流动，以及具有可变高度的流体通道部分，用于根据 目标分子。

公开(公告)号：US08285353B2

公开(公告)日：2012-10-09

申请号：US12445212

申请日：2007-07-11

Applicant: Chulhee Choi ,  Yujung Kang ,  Myunghwan Choi

Inventor： Chulhee Choi ,  Yujung Kang ,  Myunghwan Choi

IPC: A61B5/00

CPC classification number: A61B5/0261 ,  A61B5/0059 ,  A61B5/0275

Abstract: The present invention relates, in general, to a system for analyzing tissue perfusion using the concentration of indocyanine green and a method of measuring the perfusion rate using the system and, more particularly, to a system for measuring tissue perfusion by injecting indocyanine green into a living body, detecting variation in the concentration of indocyanine green with the passage of time, and analyzing the detected variation, and a method of measuring the perfusion rate using the system. The present invention provides a method of measuring perfusion in a living body, which enables accurate measurement for respective regions in a wide range from a perfusion rate decreased to less than 10% of normal perfusion to a perfusion rate increased to greater than normal perfusion using the above-described mechanism of ICG in a living body, which cannot be conducted using the conventional technology.

Abstract translation: 本发明一般涉及使用吲哚青绿的浓度来分析组织灌注的系统和使用该系统测量灌注速率的方法，更具体地，涉及通过将吲哚青绿注入到组织灌注中来测量组织灌注的系统 生物体，随着时间的推移检测吲哚青绿浓度的变化，分析检测到的变异，以及使用该系统测量灌注速率的方法。 本发明提供了一种测量生物体中的灌注的方法，其能够在从正常灌注的灌注速率降低到小于10％的灌注速率的范围内的各个区域的精确测量到使用 ICG在生物体中的上述机理，其不能用传统技术进行。