公开(公告)号：US08999332B2

公开(公告)日：2015-04-07

申请号：US13916633

申请日：2013-06-13

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit Sagi ,  Gabriel Rosenblum

IPC: A61K39/395 ,  C12N9/64 ,  A61K38/00

CPC classification number: C07K16/40 ,  A61K38/005 ,  A61K39/3955 ,  C07K2299/00 ,  C12N9/6491 ,  C12Q1/37 ,  C12Y304/24035 ,  G01N33/573 ,  G01N2333/96494 ,  G01N2500/04 ,  G01N2500/20

Abstract: A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.

Abstract translation: 公开了一种调节金属蛋白酶9（MMP-9）活性的方法。 该方法包括使MMP-9与与MMP-9的OG结构域特异性相互作用的试剂接触。 还可以公开能够与OG结构域特异性相互作用的分子，鉴定其的方法，包含其的药物组合物及其用途。

公开(公告)号：US20150068888A1

公开(公告)日：2015-03-12

申请号：US14493111

申请日：2014-09-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Igor Lubomirsky ,  Valery Kaplan

IPC: C25B1/02 ,  C25B11/12 ,  C25B13/02 ,  C25B11/04

CPC classification number: C25B1/02 ,  C10G2/30 ,  C25B1/00 ,  C25B11/04 ,  C25B11/12 ,  C25B13/02

Abstract: The present invention relates to an electrolytic process, methods and apparatus for the preparation of carbon monoxide and in particular to electrolysis of molten carbonates to yield carbon monoxide which may be used for chemical storage of electrical energy and further as chemical feedstock for other organic products.

Abstract translation: 本发明涉及一种用于制备一氧化碳的电解方法，方法和装置，特别是电解熔融碳酸盐以产生一氧化碳，其可用于电能的化学储存，并且还用作其它有机产物的化学原料。

公开(公告)号：US20140363437A1

公开(公告)日：2014-12-11

申请号：US14367917

申请日：2012-12-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Esther Bachar-Lustig

IPC: A61K35/28 ,  A61K31/7076 ,  A61K31/661 ,  A61K39/395

CPC classification number: A61K35/28 ,  A61K31/198 ,  A61K31/255 ,  A61K31/661 ,  A61K31/675 ,  A61K31/7076 ,  A61K35/22 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42 ,  A61K39/3955 ,  A61K2035/124 ,  A61K2039/507 ,  A61K2039/515 ,  C12N5/0087 ,  A61K2300/00

Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.

Abstract translation: 公开了一种治疗需要非同基因细胞或组织移植物的受试者的方法。 该方法包括：（a）向受试者移植一定剂量的T细胞耗尽的未成熟造血细胞，其中所述T细胞耗尽的未成熟造血细胞每个体重为每公斤体重小于5×10 5个CD3 + T细胞，其中所述剂量 每公斤体重至少约5×106个CD34 +细胞; 并且随后（b）向受试者施用治疗有效量的环磷酰胺，其中治疗有效量包含25-200mg /千克体重，从而治疗受试者。

公开(公告)号：US20140363411A1

公开(公告)日：2014-12-11

申请号：US14303212

申请日：2014-06-12

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Michal Eisenbach-Schwartz ,  Ester Yoles ,  Ravid Schechter ,  Omer Miller

IPC: A61K35/14

CPC classification number: A61K35/15 ,  A61K35/14 ,  A61K2035/124 ,  C12N5/0645

Abstract: A subpopulation of peripheral blood mononuclear cells (PBMCs) that is substantially devoid of CD3+ cells, CD19+ cells, CD56+ cells and optionally of CD16+ cells, for use in treatment of CNS injury is provided.

Abstract translation: 提供了用于治疗CNS损伤的基本上没有CD3 +细胞，CD19 +细胞，CD56 +细胞和任选的CD16 +细胞的外周血单核细胞（PBMC）的亚群。

公开(公告)号：US20140356335A1

公开(公告)日：2014-12-04

申请号：US14363814

申请日：2012-12-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Elias Shezen ,  Chava Rosen

IPC: A61K35/54

CPC classification number: A61K35/54 ,  A61K35/42 ,  C12N5/0688

Abstract: A pharmaceutical composition comprising as an active ingredient an isolated population of cell suspension from a mammalian fetal pulmonary tissue is disclosed. The fetal pulmonary tissue is at a developmental stage corresponding to that of a human pulmonary organ/tissue at a gestational stage selected from a range of about 20 to about 22 weeks of gestation. Methods of using the pharmaceutical composition are also disclosed.

Abstract translation: 公开了一种药物组合物，其包含来自哺乳动物胎儿肺组织的分离的细胞悬液群作为活性成分。 胎儿肺组织处于与选自妊娠约20至约22周的妊娠阶段的人肺器官/组织相对应的发育阶段。 还公开了使用该药物组合物的方法。

公开(公告)号：US20140315293A1

公开(公告)日：2014-10-23

申请号：US14318775

申请日：2014-06-30

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Ron NAAMAN ,  Amos BARDEA ,  Alexander YOFFE

IPC: C12M1/12 ,  C12M1/02 ,  H01F41/16

CPC classification number: C12M23/06 ,  B81C1/00031 ,  B81C2201/0154 ,  B81C2201/0198 ,  C12M27/00 ,  H01F41/16

Abstract: The present invention relates to a method and apparatus for patterning a substrate. The method comprises providing at least one magnetic pattern generator configured and operable to modulate the magnetic field to induce varying magnetic properties to a magnetic field according to a desired pattern; applying the modulated magnetic field in the vicinity of the substrate creating a certain pattern of regions of interaction to be obtained on top of the substrate; and; interacting the substrate with magnetic particles, while under the application of the modulated magnetic field, the magnetic particles being attracted to selected regions of interaction defined by the certain pattern while being substantially not attracted to regions outside the regions of interaction, thus creating on top of the substrate the certain pattern of regions interacted with the magnetic particles. The desired pattern corresponds to a certain pattern for a predetermined magnetic field profile and at a predetermined distance from the magnetic pattern generator, where the sample is to be located.

Abstract translation: 本发明涉及一种用于图案化衬底的方法和装置。 该方法包括提供至少一个磁图案发生器，其被配置和可操作以根据期望的图案调制磁场以对磁场引起变化的磁特性; 将调制的磁场施加在衬底附近，产生在衬底的顶部上获得的相互作用区域的特定图案; 和; 在将基底与磁性颗粒相互作用的同时，在调制磁场的应用下，磁性颗粒被吸引到由特定图案定义的相互作用区域之间，同时基本上不被吸引到相互作用区域之外的区域，从而在 基板的某些图案区域与磁性颗粒相互作用。 期望的图案对应于预定磁场分布的特定图案，并且距离磁图案发生器预定距离处，其中样本将被定位。

公开(公告)号：US20140288306A1

公开(公告)日：2014-09-25

申请号：US14297116

申请日：2014-06-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Milstein ,  Chidambaram Gunanathan

IPC: C07C209/16 ,  B01J31/14 ,  C07D305/06 ,  C07D213/38 ,  C07D307/52

CPC classification number: C07C209/16 ,  B01J31/146 ,  C07B43/04 ,  C07C213/02 ,  C07C2601/14 ,  C07D213/38 ,  C07D305/06 ,  C07D307/52 ,  C07F9/60 ,  C07F9/64 ,  C07F15/0046 ,  C07C211/07 ,  C07C211/17 ,  C07C211/27 ,  C07C217/08 ,  C07C217/58

Abstract: The present invention provides novel ruthenium based catalysts, and a process for preparing amines, by reacting a primary alcohol and ammonia in the presence of such catalysts, to generate the amine and water. According to the process of the invention, primary alcohols react directly with ammonia to produce primary amines and water in high yields and high turnover numbers. This reaction is catalyzed by novel ruthenium complexes, which are preferably composed of quinolinyl or acridinyl based pincer ligands.

Abstract translation: 本发明提供新型的钌基催化剂，以及通过在这种催化剂存在下使伯醇和氨反应制备胺的方法，以产生胺和水。 根据本发明的方法，伯醇直接与氨反应，以高产率和高的周转数产生伯胺和水。 该反应由新的钌络合物催化，其优选由喹啉基或吖啶基的钳形配体组成。

公开(公告)号：US20140287264A1

公开(公告)日：2014-09-25

申请号：US14352404

申请日：2012-10-18

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Reshef Tenne ,  Gal Radovsky ,  Ronit Popovitz-Biro

IPC: B01J27/02 ,  H01L29/06 ,  H01B1/18 ,  B01J35/00

CPC classification number: B01J27/02 ,  B01J35/004 ,  B82Y30/00 ,  B82Y40/00 ,  C01B19/002 ,  C01G1/12 ,  C01G19/00 ,  C01P2002/01 ,  C01P2002/22 ,  C01P2002/76 ,  C01P2002/77 ,  C01P2002/78 ,  C01P2002/85 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2004/10 ,  C01P2004/13 ,  C01P2004/133 ,  C01P2004/136 ,  C01P2004/45 ,  C01P2004/64 ,  C30B23/00 ,  C30B29/46 ,  C30B29/602 ,  H01B1/18 ,  H01L29/0665 ,  Y10S977/762 ,  Y10S977/814 ,  Y10S977/891

Abstract: Provided is a nanostructure including ordered stacked sheets and processes for its preparation and use.

Abstract translation: 提供了包括有序堆叠的片材的纳米结构及其制备和使用的方法。

公开(公告)号：US20140220074A1

公开(公告)日：2014-08-07

申请号：US14249709

申请日：2014-04-10

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Yechiel Shai ,  Yosef Rosenfeld ,  Neta Sal-Man

IPC: A61K39/39 ,  A61K45/06 ,  C07K7/08

CPC classification number: A61K39/39 ,  A61K38/00 ,  A61K45/06 ,  C07K7/08 ,  C07K14/705

Abstract: Peptides including an amino acid sequence of a fragment of mammalian Toll-like receptor-4 (TLR-4), analogs and derivatives thereof, and pharmaceutical compositions including these peptides. Methods for modulating a TLR-4 mediated immune response, particularly stimulating TLR-4 mediated immune response, thereby treating infectious diseases and cancer.

Abstract translation: 包括哺乳动物Toll样受体-4（TLR-4）片段的氨基酸序列，其类似物及其衍生物的肽和包括这些肽的药物组合物。 用于调节TLR-4介导的免疫应答的方法，特别是刺激TLR-4介导的免疫应答，从而治疗感染性疾病和癌症。

公开(公告)号：US20140212438A1

公开(公告)日：2014-07-31

申请号：US14243923

申请日：2014-04-03

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Rony SEGER ,  Dana Chuderland

IPC: C07K7/08 ,  C07K16/18 ,  C12N15/113

CPC classification number: C12N15/87 ,  A61K48/0041 ,  C07K7/08 ,  C07K14/47 ,  C07K16/18 ,  C07K16/2866 ,  C07K2319/09 ,  C12N15/113 ,  C12N2810/85

Abstract: Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed.

Abstract translation: 公开了包含核靶向活性或能够预防内源性核靶向活性的分离的肽。 编码相同的多核苷酸，包含其的药物组合物及其用途也被公开。