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公开(公告)号:US4988342A
公开(公告)日:1991-01-29
申请号:US255764
申请日:1988-10-11
IPC分类号: A61M1/00
CPC分类号: A61M1/0013 , A61M1/0031 , A61M1/0056 , A61M2205/3348 , A61M2205/59
摘要: A thoracic cavity drainage device includes a first vessel having a plurality of chambers one of which is a regulated drainage chamber, and a separate transfer vessel which receives fluid collected in the drainage chamber of the first vessel. The chambers of both vessels are interconnected in a series by fluid passageways which cooperate to maintain a uniform range of suction in the drainage chamber while preventing passage of water into the drainage chamber and permitting a different level of suction in the transfer vessel. This operation is effective despite relatively large pressure and vacuum impulses caused by stripping of drainage lines, patient coughing, and the like, and despite discrete changes in the physical configuration of the system caused by disconnection of the transfer vessel, connection of the transfer vessel to an infusion line or the opening or closing of fluid lines and ports. A novel transfer vessel empties the drainage device and provides gravity reinfusion of the collected fluids. A mechanism within the transfer vessel provides an effective suction without vacuum connections or pressure regulating adjustments.
摘要翻译: 胸腔引流装置包括具有多个腔室的第一容器,其中一个腔室是受调节的排液室,以及接收收集在第一容器的排液室中的流体的单独转运容器。 两个容器的腔室通过流体通道串联连接,这些通道协作以在排水室中保持均匀的吸力范围,同时防止水进入排水室并允许转移容器中的不同吸力水平。 尽管相当大的压力和排水管线的排出引起的真空冲击,患者咳嗽等,尽管由转移容器的断开引起的系统的物理结构发生离散的变化,但是转移容器连接到 输液管线或流体管线和端口的打开或关闭。 一个新的转移容器排空排水装置,并提供收集的流体的重力回输。 转移容器内的机构提供无需真空连接或压力调节调节的有效吸力。
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公开(公告)号:US4652263A
公开(公告)日:1987-03-24
申请号:US747035
申请日:1985-06-20
IPC分类号: A61F2/06
CPC分类号: A61F2/06 , A61F2002/065
摘要: Disclosed are the product and method for making a macroscopically smooth, microporous, flexible, elastic tubular prosthetic device from a substantially non-elastic woven fabric tube. The method involves axially compressing the substantially non-elastic tube on a tight fitting cylindrical mandrel so that the individual axially oriented threads of the fabric form loops projecting radially outwardly between circumferential threads. The threads are set to return to this loop configuration upon release of tension applied axially to the tube. The exterior of the tube presents an easily deformed, macroscopically smooth surface having a multiplicity of interstices among the threads and among the fibers of the threads into which cells can grow after implantation.
摘要翻译: 公开了用于从基本上非弹性的机织织物管制造宏观平滑,微孔,柔性,弹性的管状假体装置的产品和方法。 该方法包括在紧密配合的圆柱形心轴上轴向压缩基本上非弹性的管,使得织物的各个轴向定向的线形成在圆周螺纹之间径向向外突出的环。 当释放沿轴向施加到管上的张力时,螺纹被设置为返回到该回路结构。 管的外部呈现容易变形的宏观光滑表面,其在螺纹之间以及在植入后细胞能够生长的螺纹的纤维之间具有多个间隙。
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公开(公告)号:US4632842A
公开(公告)日:1986-12-30
申请号:US747011
申请日:1985-06-20
申请人: Theodore Karwoski , Yasuo Matsuzawa
发明人: Theodore Karwoski , Yasuo Matsuzawa
CPC分类号: A61L33/0088 , A61F2/06 , C08F8/22 , C08J7/126
摘要: Disclosed is a method of producing implantable prosthetic devices, e.g., tubular vascular prostheses having a substantially non-thrombogenic inside surface and a biocompatible outside surface. The method involves deposition onto an elongate substrate, e.g., a porous tubular substrate, of a fluorine-containing coating by inducing glow discharge progressively along the length of a tubular reaction vessel. A polymerizable fluorine-containing gas is flowed through the tubular substrate and a portion of the gas migrates radially to traverse the pores of the substrate. An RF field is applied to successive volumes of the gas within the vessel and tube. A substantially non-thrombogenic fluorinated coating with a first fluorine to carbon ratio deposits and bonds to the inside surface of the substrate, and a fluorinated biocompatible cross-linked coating with a lower F/C atomic ratio than the inside coating deposits and bonds to the outside surface of the substrate. The method of the invention can produce uniform coatings containing fluorine over the surface of elongated substrates. The coatings can be engineered to have a very low surface energy and to be essentially non-thrombogenic.
摘要翻译: 公开了一种生产可植入假体装置的方法,例如具有基本上非血栓形成的内表面和生物相容性外表面的管状血管假体。 该方法包括通过沿着管状反应容器的长度逐渐地引起辉光放电而将含氟涂层沉积到诸如多孔管状基底的细长衬底上。 可聚合的含氟气体流过管状衬底,并且一部分气体径向迁移以穿过衬底的孔。 RF场应用于容器和管内的连续体积的气体。 具有第一氟碳比例的基本上非血栓形成的氟化涂层沉积并结合到基底的内表面,并且具有比内部涂层更低的F / C原子比的氟化生物相容性交联涂层沉积并结合到 衬底的外表面。 本发明的方法可以在细长基材的表面上产生含氟的均匀涂层。 涂层可以被设计成具有非常低的表面能并且基本上是非血栓形成的。
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公开(公告)号:US20240207502A1
公开(公告)日:2024-06-27
申请号:US18401961
申请日:2024-01-02
发明人: James CROTEAU , Theodore KARWOSKI , Joanne KRAWCZYK , Marc LAROCHELLE , Patrick LEE , Nicholas WANT
CPC分类号: A61M1/74 , A61B5/00 , A61B5/08 , A61L29/08 , A61M1/69 , A61M1/73 , A61M1/75 , A61M1/84 , A61M25/0045 , A61M25/10 , A61M25/1002 , A61M27/00 , A61B90/39 , A61L2420/00 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2202/0492 , A61M2209/082 , A61M2210/101
摘要: A chest drainage system including a collection device configured to receive fluid from the pleural cavity of a patient. A sensor is included to detect a pressure differential in the fluid. A display is configured to display a trend in occurrences of changes in pressure of the fluid over time in predetermined time increments based on a number of detections of pressure differentials that exceed a predetermined pressure differential during each of the predetermined time increments. The trend is correlative to the percentage of time that the patient is deemed to have an air leak in the pleural cavity in the predetermined time increments. The trend is derived from a ratio of the quantity of respiratory cycles of the patient for which the predetermined pressure differential is detected (QRCleak) in the predetermined time increments to the total quantity of respiratory cycles of the patient in respective predetermined time increments (QRCtotal).
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公开(公告)号:US11896755B2
公开(公告)日:2024-02-13
申请号:US17141212
申请日:2021-01-04
发明人: James Croteau , Theodore Karwoski , Joanne Krawczyk , Marc Larochelle , Patrick Lee , Nicholas Want
CPC分类号: A61M1/74 , A61B5/00 , A61L29/08 , A61M1/69 , A61M1/73 , A61M1/75 , A61M1/84 , A61M25/0045 , A61M25/10 , A61M25/1002 , A61M27/00 , A61B90/39 , A61L2420/00 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2202/0492 , A61M2209/082 , A61M2210/101
摘要: A chest drainage system including a collection device configured to receive fluid from the pleural cavity of a patient. A sensor is included to detect a pressure differential in the fluid. A display is configured to display a trend in occurrences of changes in pressure of the fluid over time in predetermined time increments based on a number of detections of pressure differentials that exceed a predetermined pressure differential during each of the predetermined time increments. The trend is correlative to the percentage of time that the patient is deemed to have an air leak in the pleural cavity in the predetermined time increments. The trend is derived from a ratio of the quantity of respiratory cycles of the patient for which the predetermined pressure differential is detected (QRCleak) in the predetermined time increments to the total quantity of respiratory cycles of the patient in respective predetermined time increments (QRCtotal).
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公开(公告)号:US11793912B2
公开(公告)日:2023-10-24
申请号:US17066466
申请日:2020-10-08
发明人: Keith M. Faucher , Hui Tang , Paul Martakos , Theodore Karwoski , Alison Sullivan , Greg Melville , Scott E. Corbeil
IPC分类号: A61L31/08 , A61L31/16 , A61K31/4353 , A61L31/14 , A61F2/82
CPC分类号: A61L31/08 , A61K31/4353 , A61L31/148 , A61L31/16 , A61F2/82 , A61F2250/0067 , A61L2300/404 , A61L2300/606 , A61L2420/06 , A61L2430/00
摘要: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
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公开(公告)号:US20220110773A1
公开(公告)日:2022-04-14
申请号:US17560882
申请日:2021-12-23
发明人: Roger LABRECQUE , David HEIM
IPC分类号: A61F2/915
摘要: A stent device is provided. The stent device includes: at least one radially expandable body portion extending along a longitudinal axis of the stent device defining a lumen; and at least one outwardly flarable portion connected to the body portion. The outwardly flarable portion includes at least one radially expandable ring connected to the body portion and at least one flaring connector connected to the at least one ring configured to cause a crown of the at least one ring to automatically flare radially outwardly relative to other portions of the ring upon radial expansion of the body portion so as to form a flared crown. After radial expansion, the outwardly flaring portion may be held in place by a support strut that lessens its ability to collapse. A method of deploying the stent device is also provided.
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公开(公告)号:US20200171213A9
公开(公告)日:2020-06-04
申请号:US15789708
申请日:2017-10-20
发明人: Keith M. FAUCHER , Hui TANG , Joseph FERRARO , Paul MARTAKOS , Theodore KARWOSKI , Scott CORBEIL
IPC分类号: A61L31/08 , A61L31/14 , A61L31/16 , A61K31/225 , A61L29/16 , A61L29/08 , A61K31/355
摘要: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
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公开(公告)号:US10285964B2
公开(公告)日:2019-05-14
申请号:US15216873
申请日:2016-07-22
发明人: Thomas M. Swanick , Joseph Ferraro , Lisa Rogers , Paul Martakos
IPC分类号: A61K31/20 , A61L31/16 , A61K31/7036 , A61K9/16 , A61K31/436 , A61K31/445 , A61L31/08 , A61K35/60 , A61L27/28 , A61L27/54 , A61K31/496 , A61K31/4545 , A61K31/4353 , A61K31/00 , A61K9/70 , A61K9/14 , A61K9/10 , A61K38/13 , A61K31/7028
摘要: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
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公开(公告)号:US10219886B2
公开(公告)日:2019-03-05
申请号:US13833184
申请日:2013-03-15
摘要: A deployment device for a flexible implant includes a housing and one or two chambers formed therein. When two chambers are included, the housing can have two elongate openings formed in its outer sides, each providing side access to one of the chambers, and the flexible implant can be rolled into a double-rolled configuration and placed in the chambers of the deployment device in such a way that a middle portion of the flexible implant is external to the housing. When the flexible implant is rolled and loaded in the deployment device, the flexible implant can extend out through open end(s) of the chamber(s) or can be encapsulated within the chamber(s). The flexible implant can be provided separate from the deployment device. The flexible implant can include a flexible base sheet including a body portion and a tab. A flexible separable layer can be removably disposed on the body portion.
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