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公开(公告)号：US07708701B2
公开(公告)日：2010-05-04
申请号：US10323622
申请日：2002-12-18
IPC分类号： A61B5/00
CPC分类号： A61B5/1411 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150221 , A61B5/150358 , A61B5/150412 , A61B5/150427 , A61B5/150503 , A61B5/150519 , A61B5/150572 , A61B5/150664 , A61B5/150824 , A61B5/15087 , A61B5/150916 , A61B5/151 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/1513 , A61B5/15146 , A61B5/15151 , A61B5/15153 , A61B5/15161 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15178 , A61B5/15182 , A61B5/15184 , A61B5/15186 , A61B5/157 , A61M37/0015
摘要： A device for use in penetrating tissue to obtain a body fluid sample is provided. A cartridge may be included. A plurality of penetrating members are slidably coupled to the cartridge. Each penetrating member has a distal end that is sufficiently sharp to pierce tissue. Each penetrating member may be moveable relative to the other ones of the penetrating members so that the sharpened distal ends extend radially outward to penetrate tissue. The penetrating members are elongate members without molded attachments.
摘要翻译： 提供了用于穿透组织以获得体液样品的装置。 可以包括墨盒。 多个穿透构件可滑动地联接到盒。 每个穿透构件具有足够锋利的远端以刺穿组织。 每个穿透构件可以相对于穿透构件中的另一个移动，使得锋利的远端径向向外延伸以穿透组织。 穿透构件是没有模制附件的细长构件。
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72.发明授权公开(公告)号：US07699791B2
公开(公告)日：2010-04-20
申请号：US10363509
申请日：2002-06-12
申请人： Don Alden , Dominique M. Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker , Edward D. Verdonk
发明人： Don Alden , Dominique M. Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker , Edward D. Verdonk
IPC分类号： A61B5/00
CPC分类号： A61B5/150022 , A61B5/150061 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150167 , A61B5/150427 , A61B5/150503
摘要： Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analyzed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniatuized and/or disposable.
摘要翻译： 可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。 该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是微型化和/或一次性的。
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公开(公告)号：US07648469B2
公开(公告)日：2010-01-19
申请号：US12023615
申请日：2008-01-31
申请人： Dirk Boecker , Don Alden , Dominique M. Freeman
发明人： Dirk Boecker , Don Alden , Dominique M. Freeman
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15087 , A61B5/151 , A61B5/15113 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15178 , A61B5/15184 , A61B5/15186 , A61B5/157 , A61B17/32093 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. An analyte detecting member is positioned to receive fluid from a wound created by the penetrating member. The detection member is configured to determine a concentration of an analyte in the fluid using a sample of less than 1 μL of the fluid.
摘要翻译： 本发明的这些和其它目的是在包括电动驱动力发生器的组织部位上使用的体液取样系统中实现的。 穿透构件可操作地联接到力发生器。 力产生器将构件沿着路径移动离开具有穿透构件出口的壳体，进入组织部位，在组织部位停止，并从组织部位抽出。 分析物检测构件定位成从由穿透构件产生的伤口接收流体。 检测构件被配置为使用小于1μl流体的样品来确定流体中分析物的浓度。
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公开(公告)号：US20090204025A1
公开(公告)日：2009-08-13
申请号：US10574242
申请日：2004-09-29
申请人： Travis Marsot , Paul Lum , Don Alden , James Ross , Ron L. Bardell , Bernhard Weigl
发明人： Travis Marsot , Paul Lum , Don Alden , James Ross , Ron L. Bardell , Bernhard Weigl
CPC分类号： A61B5/14865 , A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15107 , A61B5/15121 , A61B5/15146 , A61B5/15153 , A61B5/15161 , A61B5/15176 , A61B5/157 , A61B5/6848 , A61B2560/0223
摘要： A body fluid sampling device is provided. A mesh may be used to guide blood or fluid to travel directly from the wound to an analyte detecting port on the cartridge. Thus the volume of blood or body fluid produced at the wound site irregardless of its droplet geometry can be reliable and substantially completely transported to the analyte detecting member for measurement.
摘要翻译： 提供体液取样装置。 可以使用网格来引导血液或流体直接从伤口行进到药筒上的分析物检测端口。 因此，在伤口部位产生的血液或体液的体积无论其液滴几何形状如何都可以是可靠的并且基本上完全输送到分析物检测构件以进行测量。
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公开(公告)号：US07547287B2
公开(公告)日：2009-06-16
申请号：US10335212
申请日：2002-12-31
申请人： Dirk Boecker , Don Alden , Dominique M. Freeman
发明人： Dirk Boecker , Don Alden , Dominique M. Freeman
IPC分类号： A61B5/00
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15176 , A61B5/15178 , A61B5/15184 , A61B5/157 , A61B17/32093 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.
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公开(公告)号：US07410468B2
公开(公告)日：2008-08-12
申请号：US10335182
申请日：2002-12-31
申请人： Dominique M. Freeman , Dirk Boecker , Don Alden
发明人： Dominique M. Freeman , Dirk Boecker , Don Alden
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15087 , A61B5/151 , A61B5/15113 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15178 , A61B5/15184 , A61B5/15186 , A61B5/157 , A61B17/32093 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： A skin penetrating system includes a housing member and a penetrating member positioned in the housing member. An analyte detecting member is coupled to a sample chamber. The analyte detecting member is configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μL of a body fluid disposed in the sample chamber. A tip of the penetrating member is configured to extend through an opening of the sample chamber.
摘要翻译： 皮肤穿透系统包括壳体构件和定位在壳体构件中的穿透构件。 分析物检测部件耦合到样品室。 分析物检测构件被配置为使用设置在样品室中的小于1μl体液的样品来确定体液中的分析物的浓度。 穿透构件的尖端构造成延伸穿过样品室的开口。
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公开(公告)号：US07374544B2
公开(公告)日：2008-05-20
申请号：US10335142
申请日：2002-12-31
申请人： Dominique M. Freeman , Dirk Boecker , Don Alden
发明人： Dominique M. Freeman , Dirk Boecker , Don Alden
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150251 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/15087 , A61B5/15107 , A61B5/15123 , A61B5/15151 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15178 , A61B5/157 , A61B17/32093 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. An analyte detecting member is positioned to receive fluid from a wound created by the penetrating member. The detection member is configured to determine a concentration of an analyte in the fluid using a sample of less than 1 mL of the fluid.
摘要翻译： 本发明的这些和其它目的是在包括电动驱动力发生器的组织部位上使用的体液取样系统中实现的。 穿透构件可操作地联接到力发生器。 力产生器将构件沿着路径移动离开具有穿透构件出口的壳体，进入组织部位，在组织部位停止，并从组织部位抽出。 分析物检测构件定位成从由穿透构件产生的伤口接收流体。 检测构件被配置为使用小于1mL的流体的样品来确定流体中的分析物的浓度。
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公开(公告)号：US07248109B2
公开(公告)日：2007-07-24
申请号：US11060052
申请日：2005-02-16
申请人： Lawrence Burns , Chong Woo , David Sorensen
发明人： Lawrence Burns , Chong Woo , David Sorensen
IPC分类号： H03F3/68
CPC分类号： H03F3/602
摘要： A power amplifier has an input conditioning circuit. At least first and second amplifiers are in parallel with each other and have inputs and outputs. An input signal is coupled to the inputs of the first and second amplifiers. A multi-input power combiner is provided. The outputs of the first and second parallel amplifiers are combined by the multi-input power combiner to add signals of the outputs constructively.
摘要翻译： 功率放大器具有输入调节电路。 至少第一和第二放大器彼此并联并具有输入和输出。 输入信号耦合到第一和第二放大器的输入。 提供多输入功率组合器。 第一和第二并联放大器的输出由多输入功率组合器组合，以便建议地添加输出信号。
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公开(公告)号：US07244265B2
公开(公告)日：2007-07-17
申请号：US10335099
申请日：2002-12-31
申请人： Dominique M. Freeman , Dirk Boecker , Don Alden
发明人： Dominique M. Freeman , Dirk Boecker , Don Alden
IPC分类号： A61B17/14
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150251 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/15087 , A61B5/15107 , A61B5/15123 , A61B5/15151 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15178 , A61B5/157 , A61B17/32093 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. The drive force generator is configured to be controlled to follow a predetermined velocity trajectory into the tissue and out of the tissue. A tissue stabilizing member is associated with the device and at least partially surrounds an impact location of the penetrating member on the tissue site. A user interface is configured to relay at least one of, penetrating member performance or a penetrating member setting.
摘要翻译： 本发明的这些和其它目的在体液采集系统中实现，该体液采样系统用于组织部位，其包括驱动力发生器和可操作地联接到力发生器的穿透构件。 力产生器沿着路径将构件沿着穿过构件出口的壳体移动到组织部位中，停止在组织部位中，并从组织部位抽出。 驱动力发生器被配置为被控制以遵循预定的速度轨迹进入组织并离开组织。 组织稳定构件与装置相关联并且至少部分地围绕穿刺构件在组织部位上的冲击位置。 用户界面被配置为中继穿透构件性能或穿透构件设置中的至少一种。
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公开(公告)号：US20070129650A1
公开(公告)日：2007-06-07
申请号：US10558865
申请日：2004-06-01
申请人： Dominique Freeman , Dirk Boecker , Don Alden
发明人： Dominique Freeman , Dirk Boecker , Don Alden
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150183 , A61B5/150305 , A61B5/150358 , A61B5/150412 , A61B5/150824 , A61B5/150954 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/1513 , A61B5/15151 , A61B5/15161 , A61B5/15169 , A61B5/15171 , A61B5/15176 , A61B5/15182 , A61B5/7445 , A61M5/20 , A61M5/282 , A61M5/3291 , A61M2005/004 , A61M2005/005 , A61M2005/206 , A61N2/002
摘要： A device is provided for fluid delivery. The device comprises a cartridge having a plurality of cavities and a plurality of penetrating members. The plurality of penetrating members are each at least partially contained in cavities of the cartridge wherein the penetrating members are slidably movable to extend outward from openings on said cartridge to penetrate tissue. Each of the penetrating members comprises a needle with a lumen coupled to a canister containing a material to be injected.
摘要翻译： 提供了用于流体输送的装置。 该装置包括具有多个空腔和多个穿透构件的盒。 多个穿透构件各自至少部分地容纳在盒的空腔中，其中穿透构件可滑动地移动以从所述盒上的开口向外延伸以穿透组织。 每个穿透构件包括具有与容纳待注射材料的罐连接的腔的针。
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