公开(公告)号：US20180186878A1

公开(公告)日：2018-07-05

申请号：US15498004

申请日：2017-04-26

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K39/395 ,  C07K14/705 ,  C07K14/725 ,  C07K16/24

CPC classification number: C07K16/2803 ,  A61K39/0011 ,  A61K39/3955 ,  A61K2039/507 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K14/7051 ,  C07K14/70517 ,  C07K16/244 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/033 ,  C07K2319/30 ,  A61K2300/00

Abstract: The present disclosure is related to compositions that include polynucleotides encoding chimeric receptors, methods of delivering polynucleotides encoding chimeric receptors to immune cells, and methods of using immune cells encoding chimeric receptors to treat or prevent cancer.

公开(公告)号：US20180186855A1

公开(公告)日：2018-07-05

申请号：US15466541

申请日：2017-03-22

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL

IPC: C07K14/725 ,  A61K35/14 ,  A61K49/00 ,  C07K14/715 ,  C07K16/18 ,  C07K14/705 ,  A61K39/00

CPC classification number: C07K14/7051 ,  A01K2227/105 ,  A01K2267/0312 ,  A61K35/15 ,  A61K38/00 ,  A61K39/0007 ,  A61K48/00 ,  A61K48/005 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61P25/28 ,  C07K14/4711 ,  C07K14/70517 ,  C07K14/7153 ,  C07K16/18 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33 ,  C12N5/00 ,  C12N2740/16043

Abstract: The present disclosure is related to compositions that include polynucleotides encoding chimeric receptors, methods of delivering polynucleotides encoding chimeric receptors to immune cells, and methods of using immune cells encoding chimeric receptors to treat or prevent a neurological disease, disorder, or injury.

公开(公告)号：US12247073B2

公开(公告)日：2025-03-11

申请号：US17272083

申请日：2019-08-30

Applicant: Alector LLC

Inventor： Patricia Culp ,  Helen Lam ,  Wei-Hsien Ho ,  Leonard G. Presta ,  Arnon Rosenthal

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a CD33 polypeptide, e.g., a mammalian CD33 or human CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US12226482B2

公开(公告)日：2025-02-18

申请号：US18454286

申请日：2023-08-23

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Seung-Joo Lee

IPC: A61K39/395 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28

Abstract: The invention provides anti-SIRPA antibodies, methods of generating such antibodies, and therapeutic uses and methods employing the antibodies.

公开(公告)号：US20240425587A1

公开(公告)日：2024-12-26

申请号：US18686156

申请日：2022-08-24

Applicant: ALECTOR LLC

Inventor： Samuel NALLE ,  Spencer LIANG ,  Ling LEUNG ,  Yong WANG ,  Angie Grace YEE

IPC: C07K16/28

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PILRA and compositions comprising such antibodies or antigen-binding fragments thereof. In a particular aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human PILRA block binding of PILRA to ligand, block binding of soluble PILRA to T cells, and/or decrease cell surface PILRA. In further aspects, the antibodies or antigen-binding fragments can be used to treat diseases or conditions associated with myeloid cell dysfunction.

公开(公告)号：US20240329054A1

公开(公告)日：2024-10-03

申请号：US18656427

申请日：2024-05-06

Applicant: Alector LLC

Inventor： Robert PAUL ,  Michael F. WARD ,  Felix Leejia YEH ,  Yijie LIAO ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: G01N33/68

CPC classification number: G01N33/6854 ,  G01N33/6896 ,  G01N2333/70503 ,  G01N2800/2821 ,  G01N2800/52

Abstract: The present disclosure relates generally to biomarkers of activity and/or therapeutic efficacy of anti-CD33 antibodies for the treatment of a disease or injury in an individual, as well as methods related thereto.

公开(公告)号：US20240294650A1

公开(公告)日：2024-09-05

申请号：US17995189

申请日：2021-03-30

Applicant: Alector LLC

Inventor： Michael KURNELLAS ,  Santiago Viveros SALAZAR ,  Marina ROELL ,  Angie Grace YEE ,  Seung-Joo LEE ,  Tina SCHWABE ,  Maxime CHAPON ,  William Francis ESTACIO ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  G01N33/573

CPC classification number: C07K16/2863 ,  G01N33/573 ,  C07K2317/33 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/9121

Abstract: The present disclosure is generally directed to antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g. a mammalian MerTK or human MerTK, and use of such compositions in preventing, reducing risk, or treating a disease or disorder an individual in need thereof.

公开(公告)号：US20240287204A1

公开(公告)日：2024-08-29

申请号：US18392569

申请日：2023-12-21

Applicant: ALECTOR LLC

Inventor： Seung-Joo LEE ,  Spencer Liang ,  Angie YEE ,  Marina ROELL ,  Arnon ROSENTHAL

IPC: C07K16/40 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g., a mammalian MerTK or human MerTK, and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20240279358A1

公开(公告)日：2024-08-22

申请号：US18570888

申请日：2022-06-15

Applicant: ALECTOR LLC

Inventor： Seung-Joo LEE ,  Tarangsri NIVITCHANYONG ,  Wei-Hsien HO ,  Wei LI ,  Marina K. ROELL ,  Spencer LIANG

IPC: C07K16/40 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K16/2827 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/53 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include monovalent antibodies, e.g., monoclonal monovalent antibodies that specifically bind a MerTK polypeptide, e.g., a mammalian MerTK polypeptide or human MerTK polypeptide, and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20240132597A1

公开(公告)日：2024-04-25

申请号：US18532382

申请日：2023-12-07

Applicant: Alector LLC

Inventor： Robert PAUL ,  Sam JACKSON ,  Omer Rizwan SIDDIQUI ,  Michael F. WARD ,  Felix Leejia YEH ,  Julie Y. HUANG ,  Whedy WANG ,  Yijie LIAO ,  Brian C. MANGAL

IPC: C07K16/28 ,  A61P25/28 ,  G01N33/68

CPC classification number: C07K16/286 ,  A61P25/28 ,  G01N33/6896 ,  A61K2039/505 ,  G01N2800/2814 ,  G01N2800/52

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured or humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.