公开(公告)号：US07125881B2

公开(公告)日：2006-10-24

申请号：US10518817

申请日：2003-06-23

申请人： Andrew Bailey ,  Garry Pairaudeau ,  Anil Patel ,  Stephen Thom

发明人： Andrew Bailey ,  Garry Pairaudeau ,  Anil Patel ,  Stephen Thom

IPC分类号： A61K31/505 ,  A61K31/506 ,  A61P19/02 ,  C07D239/42

CPC分类号： C07D239/47 ,  A61K31/506 ,  A61K31/53 ,  C07D239/48 ,  C07D239/50 ,  C07D251/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/14 ,  C07D487/08

摘要： The present invention therefore provides use of a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition, this invention also discloses processes for the preparation of such inhibitors

摘要翻译： 因此，本发明提供式（I）化合物和组合物用于治疗与半胱氨酸蛋白酶活性相关的疾病的用途。 这些化合物是半胱氨酸蛋白酶S，K，F，L和B的可逆抑制剂。特别关注的是与组织蛋白酶S相关的疾病。此外，本发明还公开了制备这种抑制剂的方法

公开(公告)号：US20060128152A1

公开(公告)日：2006-06-15

申请号：US11076725

申请日：2005-03-09

申请人： Yunsang Kim ,  Andrew Bailey ,  Hyungsuk Yoon ,  Arthur Howald

发明人： Yunsang Kim ,  Andrew Bailey ,  Hyungsuk Yoon ,  Arthur Howald

IPC分类号： H01L21/302 ,  H01L21/461

CPC分类号： H01L21/32136 ,  H01L21/31683 ,  H01L21/321 ,  H01L21/32115 ,  H01L21/32135 ,  H01L21/32138 ,  H01L21/32139 ,  H01L21/7684 ,  H01L21/76865 ,  H01L21/76885

摘要： A method of etching a conductive layer includes converting at least a portion of the conductive layer and etching the conductive layer to substantially remove the converted portion of the conductive layer and thereby expose a remaining surface. The remaining surface has an average surface roughness of less than about 10 nm. A system for etching a conductive layer is also disclosed.

公开(公告)号：US20060005928A1

公开(公告)日：2006-01-12

申请号：US10966549

申请日：2004-10-15

申请人： Arthur Howald ,  Andras Kuthi ,  Andrew Bailey

发明人： Arthur Howald ,  Andras Kuthi ,  Andrew Bailey

IPC分类号： C23F1/00 ,  G09G3/16 ,  B44C1/22 ,  H01J7/24

CPC分类号： H01J37/32082 ,  H01J37/32183 ,  H01J37/3299 ,  H03H7/40 ,  H05H1/46

摘要： Methods for improving the stability of RF power delivery to a plasma load are disclosed. The method includes adding an RF resistor and/or a power attenuator at one of many specific locations in the RF power system to lower the impedance derivatives while keeping the matching circuit substantially in tune with the RF transmission line.

公开(公告)号：US5665866A

公开(公告)日：1997-09-09

申请号：US367313

申请日：1995-03-14

申请人： Andrew Neil Charles Weir ,  Neil Andrew Bailey

发明人： Andrew Neil Charles Weir ,  Neil Andrew Bailey

IPC分类号： C07K16/30 ,  C07K16/46 ,  C12N15/13 ,  C12N15/69 ,  C12N15/70 ,  C12P21/02 ,  C12P21/08 ,  C07K16/00

CPC分类号： C07K16/3007 ,  C07K16/3046 ,  C07K16/461 ,  C12N15/69 ,  C12N15/70 ,  C12P21/02 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02

摘要： This invention relates to a process for obtaining antibodies in soluble and correctly folded and assembled form. It comprises a step to raise the temperature at a time in the process selected to facilitate the subsequent isolation of soluble, correctly folded and assembled antibody, substantially free of other antibody-related material. The operating temperature may be raised at any stage in the microbial fermentation or eukaryotic cell culture, or at any stage during extraction and purification of the antibodies.

摘要翻译： PCT No.PCT / GB93 / 01548 Sec。 371日期：1995年3月14日 102（e）1995年3月14日PCT 1993年7月22日PCT公布。 出版物WO94 / 02608 日期1994年2月3日本发明涉及一种获得可溶性和正确折叠和组装形式的抗体的方法。 其包括在选择的方法中一次升高温度的步骤，以便于随后分离可溶的，正确折叠和组装的抗体，基本上不含其它抗体相关材料。 在微生物发酵或真核细胞培养中的任何阶段，或在抗体的提取和纯化期间的任何阶段，操作温度可以升高。

公开(公告)号：US10605875B2

公开(公告)日：2020-03-31

申请号：US15688134

申请日：2017-08-28

申请人： Brent Andrew Bailey

发明人： Brent Andrew Bailey

IPC分类号： G06K9/00 ,  G01R33/28 ,  G01R33/56 ,  A61B34/00 ,  A61B90/00 ,  A61B34/20 ,  G01R33/58

摘要： A contrast system and methods for improving optical detection during a medical procedure, the system involving: a tracking marker, each tracking marker comprising a tracking marker coupling feature; and a contrast element, each contrast element comprising a contrast element coupling feature and an optically non-reflective feature, the contrast element coupling feature configured to complement the tracking marker coupling feature, each contrast element configured to respectively accommodate, by backing, each tracking marker, and contrast element configured to respectively facilitate coupling each tracking marker with a trackable object through a background object via at least one of a contrast element fastening feature and a trackable object fastening feature, whereby at least one of optical contrast and imaging in relation to the tracking marker and the background object is enhanced, false detection of the tracking marker is minimized, and optical detection of the tracking marker is improved.

公开(公告)号：US10588708B2

公开(公告)日：2020-03-17

申请号：US15758029

申请日：2015-09-11

申请人： Brent Andrew Bailey

发明人： Brent Andrew Bailey

IPC分类号： A61B34/00 ,  B25J13/02 ,  G05G9/047 ,  A61B90/00 ,  A61B34/20 ,  A61B34/30 ,  A61B90/14 ,  A61B90/10

摘要： A medical navigation system is provided having a positioning device having a positioning arm with a flange at the end of the positioning arm, a controller at least electrically coupled to the positioning device, and an end effector joystick controller for connecting to the flange of the positioning arm. The controller has a processor coupled to a memory and a display. The end effector joystick controller includes a mating component for connecting to the flange of the positioning arm, and a joystick portion extending from the mating component.

公开(公告)号：US10405991B2

公开(公告)日：2019-09-10

申请号：US15024420

申请日：2014-09-29

申请人： Andrew Bailey

发明人： Andrew Bailey

IPC分类号： A61B17/58 ,  A61B17/60 ,  A61F2/00 ,  A61F2/46 ,  A61F2/30

摘要： An instrument (200) for positioning a hollow cup component (202) of an orthopedic joint prosthesis and assembly thereof are described. The instrument includes a support member (204) having a plurality of jaw members (208) unitarily formed around its periphery. Each of the jaw members has a cup engaging limb (210) extending in a first direction to be received in a recess on an external side wall of the cup component. Each jaw member is pivotable between an engaged position in which the cup engaging limbs are displaced inwardly and a disengaged position in which the cup engaging limbs are displaced outwardly allowing the cup component to be removed from between the jaw members. An actuator (216) is operable to adopt an engaged configuration in which the actuator acts on all the jaw members to urge them into the engaged position or a disengaged configuration in which the actuator does not act on any of the jaw members to urge them into the engaged position and all the jaw members can adopt the disengaged position.

公开(公告)号：US20190060008A1

公开(公告)日：2019-02-28

申请号：US16114323

申请日：2018-08-28

申请人： Brent Andrew BAILEY ,  Trevor James DELL ,  Bart VERZIJLENBERG ,  Adam PHILIP ,  Sean DOWLING ,  Robert LUCAS

发明人： Brent Andrew BAILEY ,  Trevor James DELL ,  Bart VERZIJLENBERG ,  Adam PHILIP ,  Sean DOWLING ,  Robert LUCAS

IPC分类号： A61B34/30 ,  B25J9/02 ,  A61B18/14 ,  A61B17/29

摘要： A motion-assisted positioning arm for a medical procedure. The positioning arm includes a base, an arm coupled to the base, and an end effector coupled to the arm. The arm includes a plurality of arm segments. The arm includes a plurality of joints for connecting the arm segments. The end effector may be manipulable with six degrees of freedom in a task-coordinate space based on motion by at least one joint in the plurality of joints. The positioning arm includes a processor to: detect manipulation of and determine forces or torques acting on the end effector; determine a surgical mode for constraining movement of the end effector in the task-coordinate space; determine an end effector velocity based on the determined forces or torques and the surgical mode for moving end effector; and apply at least one joint space movement based on the end effector velocity.

公开(公告)号：USD839332S1

公开(公告)日：2019-01-29

申请号：US29614777

申请日：2017-08-23

申请人： Brent Andrew Bailey ,  Sean Adrian Conroy

设计人： Brent Andrew Bailey ,  Sean Adrian Conroy

公开(公告)号：US20180344426A1

公开(公告)日：2018-12-06

申请号：US16044959

申请日：2018-07-25

申请人： Brent Andrew BAILEY ,  Mariana Garcia CONI

发明人： Brent Andrew BAILEY ,  Mariana Garcia CONI

IPC分类号： A61B90/57 ,  A61B90/50 ,  A61B34/30 ,  A61B90/10 ,  A61B90/20 ,  H04N5/225 ,  H04N5/232 ,  A61B34/20 ,  A61B90/25 ,  A61B90/00 ,  A61B90/30

CPC分类号： A61B90/57 ,  A61B34/20 ,  A61B34/30 ,  A61B90/10 ,  A61B90/20 ,  A61B90/25 ,  A61B90/50 ,  A61B2034/2055 ,  A61B2090/306 ,  A61B2090/3735 ,  A61B2090/3983 ,  A61B2090/571 ,  H04N5/2253 ,  H04N5/23203

摘要： An end effector is provided for connecting to a positioning arm of a positioning device of a medical navigation system. The end effector comprises a mating component for connecting to an output flange of the positioning arm, a handle portion having a first end and a second end, the first end extending from the mating component, the handle portion including a cable cut-out at the first end, and a camera mount connected to the second end of the handle portion.