Abstract:
The present invention relates to compounds of the formula I in which substituents R2 and R3 are arranged in trans-configuration: wherein: R1 is H or C1-C6 alkyl; C3-C7 cycloalkyl; R2 is phenyl, optionally substituted with 1 to 5 substituents independently selected from the group comprising OH, C1-C6-alkyl, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkoxy and phenyl, wherein R4 is C1-C6 alkyl; R3 is phenyl substituted with OR5 wherein R5 has the formula (II), (III) or (IV) wherein Y is chosen from NHR4, NR42, NHCOR4, NHSO2R4, CONHR4, CONR4, CONR42, COOH, COOR4, SO2R4, SOR4, SONHR4, SONR42, a C3-C7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group comprising H, OH, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkyl and C1-C6-alkoxy, preferably NHR4, NR24, or a nitrogen heterocycle, wherein R4 is as defined above, and the esters, ethers, and salts of the compounds of formula I, optionally along pharmaceutically acceptable excipients, a process for the preparation of the same, and a method of preventing and/or treating estrogen-related disease conditions in a subject using compounds of formula 1, or its salts, optionally along with pharmaceutically acceptable excipients.
Abstract:
Cobalt thin films were prepared by atomic layer deposition (ALD). The precursor cobalt(II) acetylacetonate [Co(C5H7O2)2] was used to selectively deposit films onto iridium substrates using hydrogen reduction. Cobalt growth was observed on SiO2, silicon, fluorinated silica glass (FSG), and tantalum when silane was used as a reducing agent.
Abstract translation:通过原子层沉积(ALD)制备钴薄膜。 使用乙酸丙酮前体钴(II)[Co(C 5 H 7 O 2)2]使用氢还原将膜选择性地沉积在铱底物上。 当使用硅烷作为还原剂时,在SiO2,硅,氟化石英玻璃(FSG)和钽上观察到钴生长。
Abstract:
Substantially error-free communications is achieved in an optical communication system that includes optical amplifiers by detecting bits transmitted in the amplified optical signal using a detection threshold that is derived as a function of a maximum power level associated with a first bit value, e.g., bit “0”, and a minimum power level associated with a second bit value, e.g., bit “1”. Importantly, this detection scheme can be used to accurately detect bit patterns in the amplified signal even in the presence of nonlinear distortions caused by gain variations, such as inter-modal distortion and saturation induced crosstalk. In a wavelength division multiplexed (WDM) system comprising semiconductor optical amplifiers, for example, the detection threshold can be set at a level corresponding to PTOTAL/2N, where PTOTAL represents the total power in the WDM signal and N represents the number of optical channels in the WDM signal. According to another aspect of the invention, the effect of gain fluctuations becomes smaller as the number of channels increase. In particular, a smoothing effect is realized for the total effective saturation power as gain variations decrease as a function of an increase in the number of channels. As such, the performance of a semiconductor optical amplifier according to the principles of the invention approaches the linear performance of fiber amplifiers as the number of channels increases.
Abstract:
A wideband optical amplifier employs split-band architecture in which an optical signal passes through a common amplification stage and is then split to pass through parallel gain stages, each of which may be optimized for a particular band being traversed. A broadband grating reflector is used after the input gain section to reflect the signals of one of the bands so that they again will pass through the common input gain section before passing through gain section of the split structure dedicated to their particular wavelength. Meanwhile, the other signals pass through the reflector and move on through the gain section pertinent to their wavelength.
Abstract:
A method for determining the optimal design of a gain equalization filter (GEF) used in optical fiber amplifiers. The method is suitable for erbium-doped fiber amplifiers (EDFA) that are widely used in wavelength-division-multiplexed (WDM) optical communication systems and networks.
Abstract:
An optical amplifier that receives an optical signal at an input of the optical amplifier is arranged so that it amplifies the signal and then adjusts the level of the amplified input signal to a predetermined level. The optical amplifier, which includes a filter to substantially decrease the wavelength dependence of the optical amplifier, then amplifies the adjusted signal and supplies the resulting signal to an output.
Abstract:
A process for producing petroleum from subterranean formations is disclosed wherein production from the formation is obtained by driving a fluid from an injection well to a production well. The process involves injecting into the formation via the injection well asphaltenes as sacrificial agents to inhibit the deposition of chemical recovery agents such as surfactant on the reservoir matrix. Normally the process would be carried out by first injecting the asphaltenes into the formation through the injection well and following them with a chemical recovery agent. The chemical recovery agent would then be followed by a drive fluid such as water to push the materials to the production well.
Abstract:
A system includes a gasifier. The gasifier includes a chamber, a first nozzle, and a second nozzle. The first nozzle is configured to output a first fuel and a first oxidant to create a mixture that combusts in a combustion-reduction zone of the chamber. The second nozzle is configured to output a reduction promoter into the combustion-reduction zone to reduce combustion products in the combustion-reduction zone of the chamber.
Abstract:
The present invention provides a system and a method for distending a body tissue cavity of a subject by continuous flow irrigation such that minimal or negligible fluid turbulence is present inside the cavity, such that any desired cavity pressure can be created and maintained for any desired outflow rate. The present invention also provides a method for accurately determining the rate of fluid loss, into the subject's body system, during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation or flow rate sensor. The system and the methods of the present invention described above can be used in any endoscopic procedure requiring continuous flow irrigation few examples of such endoscopic procedures being hysteroscopic surgery, arthroscopic surgery, trans uretheral surgery, endoscopic surgery of the brain and endoscopic surgery of the spine.
Abstract:
Representative embodiments of a distributed processing method of facilitating interactive analytics of streaming data records by receiving the data records at a plurality of distributed computational nodes, establishing and storing dimensions corresponding to attributes of the data records, parsing the streaming data records to identify matches to at least one of the dimensions and based thereon, reducing the number of data records to create a targeted subset of the data, re-distributing the targeted subsets of the streaming data records among the distributed computational nodes in accordance with the dimensions stored on the nodes, updating a database storing measures of the dimensions in accordance with the targeted subsets of the streaming data records, and using the database to respond to a query based on measures associated with one or more of the dimensions.