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    METHODS FOR TREATING AGAINST VIRUSES
    71.
    发明申请
    METHODS FOR TREATING AGAINST VIRUSES 有权

    公开(公告)号：US20220211673A1

    公开(公告)日：2022-07-07

    申请号：US17606542

    申请日：2020-04-27

    Applicant: HOWARD UNIVERSITY ,  GEORGETOWN UNIVERSITY

    Inventor： Hemayet ULLAH ,  Sivanesan DAKSHANAMURTHY

    IPC: A61K31/4196 ,  A61K31/522 ,  A61P31/12 ,  A61P31/22

    Abstract: A combinatorial method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site utilizing virus (IRES-utilizing virus) in a host in need of treatment involves administering the host a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo; and either separately administering another anti-viral drug and/or pro-drug to the anti-viral drug or co-administering the anti-viral drug and/or the pro-drug with the compound, its tautomer, or its pharmaceutically acceptable salt.

    Benzende sulfonamide derivatives as HIV integrase inhibitors
    78.
    发明授权
    Benzende sulfonamide derivatives as HIV integrase inhibitors 有权

    公开(公告)号：US10301258B2

    公开(公告)日：2019-05-28

    申请号：US15114289

    申请日：2015-02-26

    Applicant: HOWARD UNIVERSITY

    Inventor： Xiang Simon Wang

    IPC: C07C311/41 ,  A61K31/18 ,  C07C311/18

    Abstract: Methods for treating retroviral infection or inhibiting HIV integrase in target cells or in a patient involve administering to target cells or to a patient in need of treatment an effective amount of at least one having a disulfonamide scaffold which is represented by the formula: wherein, independent of each other, each X independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, n is an integer of 0, 1, 2, or 3, each Y independently represents hydrocarbyl, halogeno, amino, substituted amino or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, m is an integer of 0, 1, 2, or 3, and R represents di-valent hydrocarbyl, substituted or unsubstituted.

    Microcarriers, Matrices And Scaffolds For Culturing Mammalian Cells And Methods Of Manufacture
    80.
    发明申请
    Microcarriers, Matrices And Scaffolds For Culturing Mammalian Cells And Methods Of Manufacture 审中-公开

    公开(公告)号：US20180094080A1

    公开(公告)日：2018-04-05

    申请号：US15560141

    申请日：2016-03-18

    Applicant: Howard University

    Inventor： James W. Mitchell ,  Dazhi Yang

    IPC: C08B15/00 ,  C08B15/02 ,  C08B15/06 ,  C08H1/00 ,  C12N5/00

    Abstract: Microcarriers, matrices and scaffolds for growing mammalian cells are provided which include copolymer particles and matrices comprising of polysaccharide-polyamine copolymers. The copolymeric particles and matrices have a pore size of at least 50 microns and permit the mammalian cells to grow both on an exterior surface of the particles and matrices and within an interior of the particles and matrices. Methods for making such microcarriers, matrices and scaffolds, and compositions are also provided. Methods for growing mammalian cells utilizing such microcarriers, matrices and scaffolds and compositions are also provided.

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