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公开(公告)号:US20220211673A1
公开(公告)日:2022-07-07
申请号:US17606542
申请日:2020-04-27
Applicant: HOWARD UNIVERSITY , GEORGETOWN UNIVERSITY
Inventor: Hemayet ULLAH , Sivanesan DAKSHANAMURTHY
IPC: A61K31/4196 , A61K31/522 , A61P31/12 , A61P31/22
Abstract: A combinatorial method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site utilizing virus (IRES-utilizing virus) in a host in need of treatment involves administering the host a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo; and either separately administering another anti-viral drug and/or pro-drug to the anti-viral drug or co-administering the anti-viral drug and/or the pro-drug with the compound, its tautomer, or its pharmaceutically acceptable salt.
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公开(公告)号:US20220168277A1
公开(公告)日:2022-06-02
申请号:US17598543
申请日:2020-03-25
Applicant: HOWARD UNIVERSITY , GEORGETOWN UNIVERSITY
Inventor: Hemayet ULLAH , Sivanesan DAKSHANAMURTHY
IPC: A61K31/4196 , A61P35/00
Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of a cancer involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting metastasis of cancer cells, wherein the compound is represented by the formula (1): wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.
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73.
公开(公告)号:US20210386663A1
公开(公告)日:2021-12-16
申请号:US16897780
申请日:2020-06-10
Applicant: HOWARD UNIVERSITY
Inventor: Yousef TIZABI , Robert L. COPELAND
IPC: A61K9/00 , A61P25/16 , A61K31/465
Abstract: A method for treating or mitigating Parkinson's disease (PD) symptoms or progression, including administering an effective amount of nicotine to a subject in need thereof, via inhalation using a nicotine inhaler or via nasal spray using a nicotine nasal spray. Significant dose-dependent improvement of all symptoms by nicotine inhaler or nicotine nasal spray is expected. A novel treatment in PD is thus provided.
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公开(公告)号:US20210346858A1
公开(公告)日:2021-11-11
申请号:US17307515
申请日:2021-05-04
Applicant: HOWARD UNIVERSITY
Inventor: Moshen MOSLEH , Mousab AHMED , Preethi CHANDRAN , Marjan ALAGHMAND
IPC: B01J13/00 , C10M105/12 , C10M115/04 , C10M125/02 , C10M125/22 , C10M125/20 , C10M125/04 , C10M171/06 , C10M171/02
Abstract: An organogel including a base fluid, cetyl alcohol, and a gelling agent provided in an amount to cause the fluid to change from a liquid state to a gelled state at temperatures below at least 25° C. A nanofluid including an organogel and a nanoparticle component which permits the nanofluid to change from a liquid state to a gelled state at temperatures below at least 25° C., the gelled state helping to maintain the nanoparticle component suspended throughout the base fluid; and a method for preparing a gelled nanofluid.
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公开(公告)号:US20210251879A1
公开(公告)日:2021-08-19
申请号:US17175347
申请日:2021-02-12
Applicant: Colgate-Palmolive Company , Howard University
Inventor: Tongxin WANG , Yanda LEI , James W. MITCHELL , Lynette ZAIDEL , Jian-Hong QIU , Mahmoud HASSAN
IPC: A61K8/90 , A61Q11/00 , C08F293/00 , A61K8/21
Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same.
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公开(公告)号:US10918588B2
公开(公告)日:2021-02-16
申请号:US14441782
申请日:2013-11-08
Applicant: COLGATE-PALMOLIVE COMPANY , HOWARD UNIVERSITY
Inventor: Tongxin Wang , Yanda Lei , James W. Mitchell , Lynette Zaidel , Jian-hong Qiu , Mahmoud Hassan
Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same.
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公开(公告)号:US10849927B2
公开(公告)日:2020-12-01
申请号:US15560131
申请日:2016-03-18
Applicant: HOWARD UNIVERSITY
Inventor: James W. Mitchell , Dazhi Yang
IPC: A61K31/785 , A61K31/738 , B01J20/26 , B01J20/28 , B01J20/30 , C08B15/06 , C08G81/00 , C08G83/00 , C08J9/16 , A61K9/14 , C08F251/02 , C08G73/02 , C08L1/08 , C08L3/20 , C08L5/02 , C08L5/08 , C08G101/00 , A61P7/08
Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.
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公开(公告)号:US10301258B2
公开(公告)日:2019-05-28
申请号:US15114289
申请日:2015-02-26
Applicant: HOWARD UNIVERSITY
Inventor: Xiang Simon Wang
IPC: C07C311/41 , A61K31/18 , C07C311/18
Abstract: Methods for treating retroviral infection or inhibiting HIV integrase in target cells or in a patient involve administering to target cells or to a patient in need of treatment an effective amount of at least one having a disulfonamide scaffold which is represented by the formula: wherein, independent of each other, each X independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, n is an integer of 0, 1, 2, or 3, each Y independently represents hydrocarbyl, halogeno, amino, substituted amino or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, m is an integer of 0, 1, 2, or 3, and R represents di-valent hydrocarbyl, substituted or unsubstituted.
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公开(公告)号:US20180099007A1
公开(公告)日:2018-04-12
申请号:US15560131
申请日:2016-03-18
Applicant: Howard University
Inventor: James W. Mitchell , Dazhi Yang
IPC: A61K31/738 , A61K31/785 , C08L1/08 , C08L3/20 , C08L5/02 , C08L5/08 , C08G73/02 , C08F251/02 , B01J20/26 , B01J20/28
CPC classification number: A61K31/785 , A61K9/14 , A61K31/738 , A61P7/08 , B01J20/264 , B01J20/267 , B01J20/28004 , B01J20/28078 , B01J20/28085 , B01J20/3085 , C08B15/06 , C08F251/02 , C08G73/0206 , C08G81/00 , C08G83/002 , C08G2101/00 , C08G2210/00 , C08J9/16 , C08J2205/022 , C08J2207/10 , C08J2387/00 , C08L1/08 , C08L3/20 , C08L5/02 , C08L5/08
Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.
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80.
公开(公告)号:US20180094080A1
公开(公告)日:2018-04-05
申请号:US15560141
申请日:2016-03-18
Applicant: Howard University
Inventor: James W. Mitchell , Dazhi Yang
Abstract: Microcarriers, matrices and scaffolds for growing mammalian cells are provided which include copolymer particles and matrices comprising of polysaccharide-polyamine copolymers. The copolymeric particles and matrices have a pore size of at least 50 microns and permit the mammalian cells to grow both on an exterior surface of the particles and matrices and within an interior of the particles and matrices. Methods for making such microcarriers, matrices and scaffolds, and compositions are also provided. Methods for growing mammalian cells utilizing such microcarriers, matrices and scaffolds and compositions are also provided.
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