公开(公告)号：US20110263699A1

公开(公告)日：2011-10-27

申请号：US13175807

申请日：2011-07-01

Applicant: Elmar Friderichs ,  Wolfgang Strassburger ,  Ulrich Jahnel ,  Derek Saunders ,  Hagen-Heinrich Hennies ,  Werner Englberger ,  Helmut Buschmann ,  Joerg Holenz ,  Oswald Zimmer

Inventor： Elmar Friderichs ,  Wolfgang Strassburger ,  Ulrich Jahnel ,  Derek Saunders ,  Hagen-Heinrich Hennies ,  Werner Englberger ,  Helmut Buschmann ,  Joerg Holenz ,  Oswald Zimmer

IPC: A61K31/135 ,  C07C291/04 ,  C07C211/17 ,  A61P13/00 ,  C07C305/24 ,  A61K31/255 ,  A61P25/24 ,  A61P29/00 ,  A61K31/351 ,  C07D309/10

CPC classification number: A61K31/137 ,  A61K31/135 ,  A61K31/351 ,  C07C215/64 ,  C07C217/74 ,  C07C291/04 ,  C07C305/24 ,  C07C2601/14 ,  C07D309/10

Abstract: Metabolites of [2-(3-methoxyphenyl)-cyclohexylmethyl]dimethylamine as free bases and/or in the form of physiologically acceptable salts, corresponding medicaments, the use of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for producing a medicament used for treating depression, and related methods of treating depression, pain and urinary incontinence.

Abstract translation: [2-（3-甲氧基苯基） - 环己基甲基]二甲胺作为游离碱和/或生理学上可接受的盐，相应的药物形式的代谢物，使用[2-（3-甲氧基苯基） - 环己基甲基] - 二甲基胺和代谢物 用于制备用于治疗抑郁症的药物，以及治疗抑郁症，疼痛和尿失禁的相关方法。

公开(公告)号：US07790898B2

公开(公告)日：2010-09-07

申请号：US11698195

申请日：2007-01-26

Applicant: Joerg Holenz ,  Helmut Buschmann ,  Michael Finkam

Inventor： Joerg Holenz ,  Helmut Buschmann ,  Michael Finkam

IPC: C07D211/42 ,  A61K31/451

CPC classification number: C07D405/06 ,  C07D211/42 ,  C07D409/06

Abstract: Substituted 3-phenylpiperidine compounds corresponding to Formula I in which R1 and R2 have the meanings defined in the specification, methods for preparing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting various conditions, especially pain.

Abstract translation: 对应于式I的取代的3-苯基哌啶化合物，其中R1和R2具有本说明书中定义的含义，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物用于治疗或抑制各种病症，特别是疼痛的用途。

公开(公告)号：US20100105684A1

公开(公告)日：2010-04-29

申请号：US12593464

申请日：2008-03-28

Applicant: Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut Buschmann

Inventor： Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut Buschmann

IPC: A61K31/5377 ,  C07D231/12 ,  A61K31/415 ,  C07D403/02 ,  A61K31/4155 ,  A61K31/497 ,  C07D401/02 ,  A61K31/445 ,  C07D413/02

CPC classification number: C07D231/12 ,  C07D213/38 ,  C07D261/08 ,  C07D307/52 ,  C07D333/20

Abstract: The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment or prophylaxis of various disorders of humans or animals.

Abstract translation: 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘胺化合物及其组合物，其制备方法以及所述化合物用于治疗或预防人或动物各种疾病的用途。

公开(公告)号：US20100075992A1

公开(公告)日：2010-03-25

申请号：US11663358

申请日：2005-09-20

Applicant: Helmut Buschmann ,  Frank Hay Kong Shum ,  Kim Noel Fisher ,  Anh Ho Ngoc ,  Michel Hamon

Inventor： Helmut Buschmann ,  Frank Hay Kong Shum ,  Kim Noel Fisher ,  Anh Ho Ngoc ,  Michel Hamon

IPC: A61K31/519 ,  A61P25/00

CPC classification number: A61K31/519

Abstract: The present invention refers to the use of a sodium channel blocker such as tetrodotoxin or saxitoxin, their analogues and derivatives as well as their physiologically acceptable salts, in medicinal products for human therapeutics for the treatment of peripheral-nervously derived neuropathic pain.

Abstract translation: 本发明涉及用于治疗周围神经性神经性疼痛的人类治疗剂的药物中使用钠通道阻断剂如河豚毒素或类似物和衍生物及其生理学上可接受的盐。

公开(公告)号：US20100035936A1

公开(公告)日：2010-02-11

申请号：US12525461

申请日：2008-02-06

Applicant: Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut Buschmann

Inventor： Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut Buschmann

IPC: A61K31/44 ,  C07D231/12 ,  A61K31/415 ,  C07D261/06 ,  A61K31/42 ,  C07C211/33 ,  A61K31/135 ,  C07D213/63 ,  A61P29/00 ,  A61P25/00 ,  A61P9/00 ,  A61P13/00 ,  A61P1/00

CPC classification number: C07D231/12 ,  C07D213/64 ,  C07D261/08

Abstract: The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in humans or animals.

Abstract translation: 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘化合物，其制备方法和包含这些化合物的组合物及其用于治疗或预防人或动物各种疾病的用途。

公开(公告)号：US07569585B2

公开(公告)日：2009-08-04

申请号：US10866088

申请日：2004-06-14

Applicant: Heinz Uragg ,  Corinna Maul ,  Helmut Buschmann ,  Bernd Sundermann ,  Werner Englberger

Inventor： Heinz Uragg ,  Corinna Maul ,  Helmut Buschmann ,  Bernd Sundermann ,  Werner Englberger

IPC: A61K31/445 ,  C07D401/06

CPC classification number: A61K31/133 ,  A61K31/44 ,  C07D295/088 ,  C07D333/16

Abstract: Substituted 1,5-diaminopentan-3-ol compounds and methods of making the same. Pharmaceutical compositions containing these compounds and methods of treatment using these pharmaceutical compositions.

Abstract translation: 取代的1,5-二氨基戊烷-3-醇化合物及其制备方法。 含有这些化合物的药物组合物和使用这些药物组合物的治疗方法。

公开(公告)号：US07507816B2

公开(公告)日：2009-03-24

申请号：US10866099

申请日：2004-06-14

Applicant: Heinz Uragg ,  Corinna Maul ,  Helmut Buschmann ,  Bernd Sundermann ,  Hagen-Heinrich Hennies

Inventor： Heinz Uragg ,  Corinna Maul ,  Helmut Buschmann ,  Bernd Sundermann ,  Hagen-Heinrich Hennies

IPC: C07D267/02 ,  C07D267/04 ,  C07D267/06 ,  C07D267/08 ,  C07D267/10 ,  C07D281/02 ,  C07D281/04 ,  C07D281/06

CPC classification number: C07D295/096 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  A61K31/55

Abstract: Pharmaceutical compositions containing substituted aminoalcohols, the use of preparations containing substituted aminoalcohols for treatment of conditions such as pain, emesis, neurotropic conditions, cardiovascular diseases, urinary incontinence, diarrhea, pruritus, alcohol or drug dependency, inflammation, depression, decreased vigilance, or depressed libido, as well as 2-(aminomethyl)cycloalkane-1-ol compounds and a process for their preparation.

Abstract translation: 含有取代氨基醇的药物组合物，含有取代氨基醇的制剂用于治疗诸如疼痛，呕吐，神经营养状况，心血管疾病，尿失禁，腹泻，瘙痒，酒精或药物依赖性，炎症，抑郁，降低的警惕性或抑郁症 性状，以及2-（氨基甲基）环烷烃-1-醇化合物及其制备方法。

公开(公告)号：US07271192B2

公开(公告)日：2007-09-18

申请号：US10861426

申请日：2004-06-07

Applicant: Corinna Sundermann ,  Bernd Sundermann ,  Helmut Buschmann ,  Hagen-Heinrich Hennies

Inventor： Corinna Sundermann ,  Bernd Sundermann ,  Helmut Buschmann ,  Hagen-Heinrich Hennies

IPC: A61K31/404 ,  C07D209/04

CPC classification number: C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D493/08

Abstract: Novel 2-pyrrolidin-2-yl-1H-indole compounds corresponding to formula (I) wherein R1, R2, R3 and R4 have the meanings given in the description, and pharmaceutical compositions containing these compounds, as well as processes for the preparation of such compounds and intermediate products of this process, and related methods of treatment.

Abstract translation: 对应于式（I）的新的2-吡咯烷-2-基-1H-吲哚化合物，其中R 1，R 2，R 3和R 3， R 4具有本说明书中给出的含义，含有这些化合物的药物组合物，以及该方法的这种化合物和中间产物的制备方法以及相关的治疗方法。

公开(公告)号：US20060084664A1

公开(公告)日：2006-04-20

申请号：US11218570

申请日：2005-09-06

Applicant: Bernd Sundermann ,  Hagen-Heinrich Hennies ,  Helmut Buschmann ,  Ullvi Bluhm ,  Bernd Clement ,  Dieter Heber ,  Ulrich Wolschendorf

Inventor： Bernd Sundermann ,  Hagen-Heinrich Hennies ,  Helmut Buschmann ,  Ullvi Bluhm ,  Bernd Clement ,  Dieter Heber ,  Ulrich Wolschendorf

IPC: A61K31/519 ,  C07D487/04

CPC classification number: C07D471/04 ,  A61K31/517 ,  A61K31/519

Abstract: The invention relates to substituted pyrido[1,2-a]pyrimidine compounds corresponding to formula (I) wherein: R1, R2 and R3 are as defined in the specification. Related pharmaceutical formulations and methods for inhibiting nitrogen oxide synthesis (NOS) and other treatments are also provided.

Abstract translation: 本发明涉及对应于式（I）的取代的吡啶并[1,2-a]嘧啶化合物，其中：R 1，R 2和R 3， SUP>如说明书中所定义。 还提供了用于抑制氮氧化物合成（NOS）和其它处理的相关药物制剂和方法。

公开(公告)号：US20060040977A1

公开(公告)日：2006-02-23

申请号：US10920671

申请日：2004-08-18

Applicant: Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Buschmann

Inventor： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Buschmann

IPC: C07D217/12 ,  A61K31/47

CPC classification number: C07D401/12 ,  C07D217/04

Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

Abstract translation: 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。