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71.发明申请SCHIZOPHRENIA ASSOCIATED GENES, PROTEINS AND BIALLELIC MARKERS 审中-公开SCHIZOPHRENIA相关基因，蛋白质和BIALLELIC标记公开(公告)号：US20080182268A1
公开(公告)日：2008-07-31
申请号：US12056900
申请日：2008-03-27
申请人： DANIEL COHEN , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： DANIEL COHEN , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
CPC分类号： C12Q1/6883 , A01K2217/075 , C07K14/47 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
摘要翻译： 本发明涉及人sbg1，g34665，sbg2，g35017和g35018基因，多核苷酸，多肽双重标记和人染色体13q31-q33双重标记。 本发明还涉及精神分裂症和双相情感障碍与双重标记和sbg1，g34665，sbg2，g35017和g35018基因和核苷酸序列之间建立的关联。 本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的易感性以及疾病诊断和预后的手段。
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72.发明授权Genomic sequence of the 5-Lipoxygenase-activating protein (FLAP), polymorphic markers thereof and methods for detection of asthma 失效5-脂氧合酶活化蛋白（FLAP）的基因组序列及其多态性标记及哮喘检测方法公开(公告)号：US07118869B2
公开(公告)日：2006-10-10
申请号：US10359512
申请日：2003-02-05
CPC分类号： C12Q1/6883 , A01K2217/05 , A01K2217/075 , C07K14/4705 , C12Q1/6827 , C12Q2600/156
摘要： The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the leukotriene pathway as well as means for the diagnosis of such diseases and for the prognosis/detection of an eventual treatment response to agents acting on the leukotriene pathway.
摘要翻译： 本发明涉及FLAP基因的基因组序列。 本发明还涉及FLAP基因的双重标记和这些标记与涉及白细胞三烯途径如哮喘的疾病之间建立的关联。 本发明提供了确定个体对涉及白细胞三烯途径的疾病的易感性以及用于诊断这些疾病的手段以及对作用于白三烯途径的药剂的最终治疗反应的预后/检测的手段。
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公开(公告)号：US20060189793A1
公开(公告)日：2006-08-24
申请号：US11412373
申请日：2006-04-27
申请人： Frances Yen , Blake Denison , Aymeric Duclert , Lydie Bougueleret , Catherine Clusel , Jean-Baptiste Dumas Milne-Edwards , Bernard Bihain , Barbara Bour , Dana Ebbets-Reed , Luisa Salter-Cid
发明人： Frances Yen , Blake Denison , Aymeric Duclert , Lydie Bougueleret , Catherine Clusel , Jean-Baptiste Dumas Milne-Edwards , Bernard Bihain , Barbara Bour , Dana Ebbets-Reed , Luisa Salter-Cid
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/47 , C07K14/4747 , C07K2319/02 , C07K2319/21 , C07K2319/32 , C12N15/625
摘要： The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptdes. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.
摘要翻译： 本发明提供GSSP-2，GSSP-2 cDNA和GSSP-2多肽的基因组序列。 此外，本发明提供了多核苷酸，其包括衍生自GSSP-2基因的双重标记和来自该基因侧翼的基因组区域。 本发明还提供适用于对含有本发明的一种或多种双重标记物的含有核酸分子的样品进行基因分型的多核苷酸和方法。 此外，本发明提供了检测双标记等位基因和表型之间和/或双重标记单倍型和表型之间的统计学相关性的方法。 本发明还涉及用于杀死肿瘤细胞或抑制肿瘤细胞生长的方法和组合物。 特别地，本发明涉及细胞增殖阻滞/抑制和凋亡/坏死诱导组合物和治疗肿瘤的方法。 本发明涉及新型多肽和编码那些多肽的核酸分子。
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公开(公告)号：US07081515B2
公开(公告)日：2006-07-25
申请号：US10117894
申请日：2002-06-20
申请人： Lydie Bougueleret
发明人： Lydie Bougueleret
IPC分类号： C07K14/435 , C07H21/02 , C07H21/04
CPC分类号： C07K14/4747
摘要： The present invention relates to a purified or isolated polynucleotide encoding human CIDE B protein, the regulatory nucleic acids contained therein, polymorphic markers thereof, and the resulting encoded protein, as well as to methods and kits for detecting this polynucleotide and this protein. The present invention also pertains to a polynucleotide carrying the natural regulatory regions of the CIDE B gene which is useful, for example, to express a heterologous nucleic acid in host cells or host organisms as well as functionally active regulatory polynucleotides derived from said regulatory regions.
摘要翻译： 本发明涉及编码人CIDE B蛋白的纯化或分离的多核苷酸，其中所含的调节性核酸，其多态性标记和所得编码的蛋白质，以及用于检测该多核苷酸和该蛋白质的方法和试剂盒。 本发明还涉及携带CIDE B基因的天然调节区的多核苷酸，其可用于例如在宿主细胞或宿主生物体中表达异源核酸以及衍生自所述调节区的功能活性调节多核苷酸。
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公开(公告)号：US07056680B2
公开(公告)日：2006-06-06
申请号：US10319763
申请日：2002-12-10
CPC分类号： C07K14/47
摘要： The sequence of a cDNA encoding Claudin-50 and sequence of Claudin-50 protein are disclosed. The cDNA can be used to express the protein or portions thereof or to obtain antibodies capable of specifically binding to the secreted protein. The cDNA may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNA may also be used to design expression vectors and secretion vectors.
摘要翻译： 公开了编码紧密连接蛋白-50和紧密连接蛋白-50蛋白序列的cDNA序列。 cDNA可用于表达蛋白质或其部分或获得能够特异性结合分泌蛋白质的抗体。 该cDNA也可用于诊断，法医，基因治疗和染色体测绘程序。 cDNA也可用于设计表达载体和分泌载体。
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公开(公告)号：US20060073512A1
公开(公告)日：2006-04-06
申请号：US11285466
申请日：2005-11-22
CPC分类号： C12N9/10 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N2500/10
摘要： The invention concerns the genomic sequence of the purH gene. The invention also concerns biallelic markers of a purH gene and the association established between these markers and cancer, particularly prostate cancer. The invention provides means to determine the predisposition of individuals to cancer as well as means for the diagnosis of cancer and for the prognosis/detection of an eventual treatment response to agents acting on cancer.
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公开(公告)号：US20060009633A9
公开(公告)日：2006-01-12
申请号：US09978360
申请日：2001-10-15
申请人： Jean-Baptiste Dumas Milne Edwards , Lydie Bougueleret , Severin Jobert , Catherine Clusel , Aymeric Duclert
发明人： Jean-Baptiste Dumas Milne Edwards , Lydie Bougueleret , Severin Jobert , Catherine Clusel , Aymeric Duclert
CPC分类号： C07K14/47
摘要： The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs may also be used to design expression vectors and secretion vectors.
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公开(公告)号：US06946444B2
公开(公告)日：2005-09-20
申请号：US10060845
申请日：2002-01-29
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , A61P19/06 , A61P35/00 , C07K14/47 , C07K14/705 , C07K14/715 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , C12N15/16
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , C07K14/715
摘要： Methods and pharmaceutical compositions useful for modulating lipoprotein levels in vivo. The invention stems from the discovery that activity of the Lipolysis Stimulated Receptor (LSR) can be inhibited or enhanced by exogenous agents, including polypeptides.
摘要翻译： 用于调节体内脂蛋白水平的方法和药物组合物。 本发明源自发现脂解作用受刺激受体（LSR）的活性可由外源试剂（包括多肽）抑制或增强。
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公开(公告)号：US20050106599A1
公开(公告)日：2005-05-19
申请号：US10930331
申请日：2004-08-30
IPC分类号： C12N15/09 , A61K48/00 , C07K14/47 , C07K16/18 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , G06F17/30 , C07H21/04 , C12N9/00
CPC分类号： C07K14/705 , A61K48/00 , C07K14/47 , Y02A90/26
摘要： The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The extended cDNAs may also be used to design expression vectors and secretion vectors.
摘要翻译： 公开了编码分泌蛋白质的扩展cDNA的序列。 扩展的cDNA可用于表达分泌的蛋白质或其部分，或获得能够特异性结合分泌蛋白质的抗体。 扩展的cDNA也可用于诊断，取证，基因治疗和染色体测绘程序。 扩展的cDNA也可用于设计表达载体和分泌载体。
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80.发明申请Nucleic acids encoding human CIDE-B protein and polymorphic markers thereof 失效编码人CIDE-B蛋白的核酸及其多态性标记公开(公告)号：US20050064399A9
公开(公告)日：2005-03-24
申请号：US10117894
申请日：2002-06-20
申请人： Lydie Bougueleret
发明人： Lydie Bougueleret
CPC分类号： C07K14/4747
摘要： The present invention relates to a purified or isolated polynucleotide encoding human CIDE B protein, the regulatory nucleic acids contained therein, polymorphic markers thereof, and the resulting encoded protein, as well as to methods and kits for detecting this polynucleotide and this protein. The present invention also pertains to a polynucleotide carrying the natural regulatory regions of the CIDE B gene which is useful, for example, to express a heterologous nucleic acid in host cells or host organisms as well as functionally active regulatory polynucleotides derived from said regulatory regions.
摘要翻译： 本发明涉及编码人CIDE B蛋白的纯化或分离的多核苷酸，其中所含的调节性核酸，其多态性标记和所得编码的蛋白质，以及用于检测该多核苷酸和该蛋白质的方法和试剂盒。 本发明还涉及携带CIDE B基因的天然调节区的多核苷酸，其可用于例如在宿主细胞或宿主生物体中表达异源核酸以及衍生自所述调节区的功能活性调节多核苷酸。
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